{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T05:35:06Z","timestamp":1778996106926,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H00382"],"award-info":[{"award-number":["19H00382"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H00386"],"award-info":[{"award-number":["18H00386"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.mce.2024.112277","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T14:39:43Z","timestamp":1716475183000},"page":"112277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta"],"prefix":"10.1016","volume":"591","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6223-2101","authenticated-orcid":false,"given":"Rika","family":"Miki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Ushida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Tano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Nawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kajiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3082-6116","authenticated-orcid":false,"given":"Tomomi","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2024.112277_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jri.2012.03.488","article-title":"Trophoblast debris modulates the expression of immune proteins in macrophages: a key to maternal tolerance of the fetal allograft?","volume":"94","author":"Abumaree","year":"2012","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.mce.2024.112277_bib2","doi-asserted-by":"crossref","first-page":"443 e1","DOI":"10.1016\/j.ajog.2023.10.001","article-title":"Placenta accreta spectrum disorder at single-cell resolution: a loss of boundary limits in the decidua and endothelium","volume":"230","author":"Afshar","year":"2024","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1412\u20138.10","key":"10.1016\/j.mce.2024.112277_bib3","article-title":"Differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial-mesenchymal transition","volume":"36","author":"DaSilva-Arnold","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2024.112277_bib4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/biolre\/ioy042","article-title":"Human trophoblast epithelial-mesenchymal transition in abnormally invasive placenta","volume":"99","author":"DaSilva-Arnold","year":"2018","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2024.112277_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235972","article-title":"Tight junctions in cell proliferation","volume":"20","author":"Diaz-Coranguez","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2024.112277_bib6","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gku1111","article-title":"The Eukaryotic Promoter Database: expansion of EPDnew and new promoter analysis tools","volume":"43","author":"Dreos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mce.2024.112277_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/hr.2016.97","article-title":"Mesenchymal-to-epithelial transition in the placental tissues of patients with preeclampsia","volume":"40","author":"Du","year":"2017","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.mce.2024.112277_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/molehr\/gag033","article-title":"Gene expression regulating epithelial intercellular junction biogenesis during human blastocyst development in vitro","volume":"9","author":"Ghassemifar","year":"2003","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2024.112277_bib9","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1080\/21655979.2021.2023793","article-title":"E2F transcription factor 1 (E2F1) enhances the proliferation, invasion and EMT of trophoblast cells by binding to Zinc Finger E-Box Binding Homeobox 1 (ZEB1)","volume":"13","author":"Gong","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.mce.2024.112277_bib10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan","volume":"206","author":"Graham","year":"1993","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mce.2024.112277_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.placenta.2020.01.004","article-title":"Trophoblast invasion: lessons from abnormally invasive placenta (placenta accreta)","volume":"102","author":"Illsley","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2024.112277_bib12","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.placenta.2015.06.007","article-title":"Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14","volume":"36","author":"Kaitu'u-Lino","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2024.112277_bib13","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1091\/mbc.e07-12-1215","article-title":"Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells","volume":"19","author":"Katsuno","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mce.2024.112277_bib14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2024.112277_bib15","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/uog.13190","article-title":"Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)","volume":"42","author":"Lees","year":"2013","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.mce.2024.112277_bib16","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1080\/14767058.2019.1636371","article-title":"Placental weight and size in relation to fetal growth restriction: a case-control study","volume":"34","author":"Liu","year":"2021","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.mce.2024.112277_bib17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.mce.2024.112277_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1044198","article-title":"The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing","volume":"10","author":"Ma","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mce.2024.112277_bib19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.semcdb.2014.09.008","article-title":"The role of tight junctions in cancer metastasis","volume":"36","author":"Martin","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.mce.2024.112277_bib20","doi-asserted-by":"crossref","first-page":"15852","DOI":"10.1073\/pnas.1920776117","article-title":"Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum","volume":"117","author":"McNally","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2024.112277_bib21","first-page":"293","article-title":"The role of E2F8 in the human placenta","volume":"19","author":"Mizuno","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mce.2024.112277_bib22","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.devcel.2012.01.013","article-title":"Atypical E2F repressors and activators coordinate placental development","volume":"22","author":"Ouseph","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mce.2024.112277_bib23","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/ncb2585","article-title":"E2F8 is essential for polyploidization in mammalian cells","volume":"14","author":"Pandit","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mce.2024.112277_bib24","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1006\/dbio.1999.9206","article-title":"Zonula occludens-1 and E-cadherin are coordinately expressed in the mouse uterus with the initiation of implantation and decidualization","volume":"208","author":"Paria","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mce.2024.112277_bib25","doi-asserted-by":"crossref","first-page":"C1517","DOI":"10.1152\/ajpcell.00484.2008","article-title":"ZO-1 is involved in trophoblastic cell differentiation in human placenta","volume":"298","author":"Pidoux","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mce.2024.112277_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","article-title":"The two-stage placental model of preeclampsia: an update","volume":"134\u2013135","author":"Staff","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.mce.2024.112277_bib28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ydbio.2008.03.008","article-title":"Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse","volume":"318","author":"Wang","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mce.2024.112277_bib30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/onc.2017.336","article-title":"Atypical E2Fs inhibit tumor angiogenesis","volume":"37","author":"Weijts","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2024.112277_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.placenta.2022.01.002","article-title":"Uterine damage induces placenta accreta and immune imbalance at the maternal-fetal interface in the mouse","volume":"119","author":"Zhou","year":"2022","journal-title":"Placenta"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724001333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724001333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:56:20Z","timestamp":1777550180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720724001333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":29,"alternative-id":["S0303720724001333"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2024.112277","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2024.112277","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112277"}}