{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:20:35Z","timestamp":1777868435676,"version":"3.51.4"},"reference-count":215,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LD22H090002"],"award-info":[{"award-number":["LD22H090002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174038"],"award-info":[{"award-number":["82174038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["KYY-HX-20180348"],"award-info":[{"award-number":["KYY-HX-20180348"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.mce.2024.112346","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T19:46:38Z","timestamp":1723664798000},"page":"112346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["\u201cNO\u201d controversy?: A controversial role in insulin signaling of diabetic encephalopathy"],"prefix":"10.1016","volume":"593","author":[{"given":"Xi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-7782","authenticated-orcid":false,"given":"Ying","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qisong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2024.112346_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104707","article-title":"Insulin signaling pathway and related molecules: role in neurodegeneration and Alzheimer's disease","volume":"135","author":"Akhtar","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.mce.2024.112346_bib2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.mce.2024.112346_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrneurol.2017.185","article-title":"Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums","volume":"14","author":"Arnold","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.mce.2024.112346_bib4","first-page":"3","article-title":"Class I PI3K biology","volume":"436","author":"Aytenfisu","year":"2022","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.mce.2024.112346_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tem.2019.10.001","article-title":"Role of nitric oxide in insulin secretion and glucose metabolism","volume":"31","author":"Bahadoran","year":"2020","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2024.112346_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11064-018-2695-4","article-title":"Molecular mechanisms of early and late LTP","volume":"44","author":"Baltaci","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mce.2024.112346_bib7","doi-asserted-by":"crossref","first-page":"889","DOI":"10.4239\/wjd.v5.i6.889","article-title":"Type 2 diabetes mellitus and Alzheimer's disease","volume":"5","author":"Barbagallo","year":"2014","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.mce.2024.112346_bib8","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3390\/ijms23020963","article-title":"Inflammation as A Precursor of atherothrombosis, diabetes and early vascular aging","volume":"23","author":"Barbu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2024.112346_bib9","first-page":"147","article-title":"The blood-brain barrier: an overview with special reference to insulin effects on glucose transport","volume":"78","author":"Barry","year":"1980","journal-title":"Acta Neurol. Scand. Suppl."},{"key":"10.1016\/j.mce.2024.112346_bib10","first-page":"751","article-title":"Molecular and biochemical mechanisms of diabetic encephalopathy","volume":"70","author":"Belenichev","year":"2023","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.mce.2024.112346_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/er.2017-00073","article-title":"Insulin receptor isoforms in physiology and disease: an updated view","volume":"38","author":"Belfiore","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2024.112346_bib12","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1042\/BST0331041","article-title":"Utrecht Diabetic Encephalopathy Study Group, Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?","volume":"33","author":"Biessels","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mce.2024.112346_bib13","doi-asserted-by":"crossref","first-page":"a009191","DOI":"10.1101\/cshperspect.a009191","article-title":"Insulin receptor signaling in normal and insulin-resistant states","volume":"6","author":"Boucher","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.mce.2024.112346_bib14","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/347768a0","article-title":"Localization of nitric oxide synthase indicating a neural role for nitric oxide","volume":"347","author":"Bredt","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.mce.2024.112346_bib15","first-page":"782","article-title":"Insulin effect on metabolism in skeletal muscles and the role of muscles in regulation of glucose homeostasis","volume":"58","author":"Buczkowska","year":"2001","journal-title":"Przegl. Lek."},{"key":"10.1016\/j.mce.2024.112346_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114584","article-title":"Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: a focus on oxidative stress, inflammation, and apoptosis","volume":"452","author":"Bulut","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.mce.2024.112346_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ando.2013.02.003","article-title":"Cross-talk between insulin signaling and cell proliferation pathways","volume":"74","author":"Burnol","year":"2013","journal-title":"Ann. Endocrinol."},{"key":"10.1016\/j.mce.2024.112346_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110763","article-title":"Resveratrol ameliorates diabetic encephalopathy through PDE4D\/PKA\/Drp1 signaling","volume":"203","author":"Cao","year":"2023","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mce.2024.112346_bib19","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s004240100607","article-title":"G-protein- and cAMP-dependent L-channel gating modulation: a manyfold system to control calcium entry in neurosecretory cells","volume":"442","author":"Carbone","year":"2001","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.mce.2024.112346_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ceb.2017.01.005","article-title":"AMPK signalling in health and disease","volume":"45","author":"Carling","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.mce.2024.112346_bib21","doi-asserted-by":"crossref","first-page":"E476","DOI":"10.1152\/ajpendo.00422.2005","article-title":"Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta\/IRS-1 and Akt and insulin resistance in muscle of mice","volume":"291","author":"Carvalho-Filho","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2024.112346_bib22","doi-asserted-by":"crossref","first-page":"11754","DOI":"10.7150\/thno.43163","article-title":"Cardiomyocyte-derived small extracellular vesicles can signal eNOS activation in cardiac microvascular endothelial cells to protect against Ischemia\/Reperfusion injury","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.mce.2024.112346_bib23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.14336\/AD.2021.0823","article-title":"Autophagy and diabetic encephalopathy: mechanistic insights and potential therapeutic implications","volume":"13","author":"Cheng","year":"2022","journal-title":"Aging and Disease"},{"key":"10.1016\/j.mce.2024.112346_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12964-023-01097-1","article-title":"mTOR-dependent TFEB activation and TFEB overexpression enhance autophagy-lysosome pathway and ameliorate Alzheimer's disease-like pathology in diabetic encephalopathy","volume":"21","author":"Cheng","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.mce.2024.112346_bib25","doi-asserted-by":"crossref","first-page":"23223","DOI":"10.1074\/jbc.274.33.23223","article-title":"Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion","volume":"274","author":"Cherny","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112346_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2019.08.004","article-title":"Distribution of neuronal nitric oxide synthase immunoreactivity in adult male Sprague-Dawley rat brain","volume":"121","author":"Chong","year":"2019","journal-title":"Acta Histochem."},{"key":"10.1016\/j.mce.2024.112346_bib27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/med.21599","article-title":"Inducible nitric oxide synthase: regulation, structure, and inhibition","volume":"40","author":"Cinelli","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.mce.2024.112346_bib28","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s00244-016-0352-y","article-title":"Modulation of N-Methyl-D-Aspartate receptors (NMDAR), Bcl-2 and C-Fos gene expressions on exposure to individual and mixtures of low concentration metals in zebrafish (Danio rerio)","volume":"72","author":"Cobbina","year":"2017","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.mce.2024.112346_bib29","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1523\/JNEUROSCI.21-04-01179.2001","article-title":"beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis","volume":"21","author":"Combs","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2024.112346_bib30","first-page":"511","article-title":"Anti-inflammatory effects of insulin","volume":"10","author":"Dandona","year":"2007","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.mce.2024.112346_bib31","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1007\/s11011-022-01060-y","article-title":"Rolipram and pentoxifylline combination ameliorates experimental diabetic neuropathy through inhibition of oxidative stress and inflammatory pathways in the dorsal root ganglion neurons","volume":"37","author":"Dastgheib","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.mce.2024.112346_bib32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/nu13020395","article-title":"Vitamin B12 supplementation in diabetic neuropathy: a 1-year, randomized, double-blind, placebo-controlled trial","volume":"13","author":"Didangelos","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2024.112346_bib33","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1073\/pnas.91.10.4214","article-title":"Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity","volume":"91","author":"Dinerman","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2024.112346_bib34","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00428-005-1264-9","article-title":"NF-kB in development and progression of human cancer","volume":"446","author":"Dolcet","year":"2005","journal-title":"Virchows Arch."},{"key":"10.1016\/j.mce.2024.112346_bib35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s11892-017-0955-3","article-title":"Insulin and its cardiovascular effects: what is the current evidence?","volume":"17","author":"Dongerkery","year":"2017","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.mce.2024.112346_bib36","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1210\/jc.2011-0599","article-title":"The safety of incretin-based therapies--review of the scientific evidence","volume":"96","author":"Drucker","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2024.112346_bib37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000072814","article-title":"Dexamethasone inhibits TNF-alpha synthesis more effectively in Alzheimer's disease patients than in healthy individuals","volume":"16","author":"Dziedzic","year":"2003","journal-title":"Dement. Geriatr. Cogn. Disord"},{"key":"10.1016\/j.mce.2024.112346_bib38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.neubiorev.2006.11.001","article-title":"New perspectives on the mechanisms through which nitric oxide may affect learning and memory processes","volume":"31","author":"Edwards","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.mce.2024.112346_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121184","article-title":"Glimepiride ameliorates renal toxicity induced by cadmium in mice: modulation of Jun N terminal kinase (JNK)\/nuclear factor kappa B (NF-\u03baB) and phosphatidylinositol 3-kinases (PI3K)\/protein kinase (AKT) pathways","volume":"311","author":"ElMahdy","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2024.112346_bib40","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.2337\/dc23-S002","article-title":"Classification and diagnosis of diabetes: standards of care in diabetes-2023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2024.112346_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112563","article-title":"AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation","volume":"146","author":"Entezari","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mce.2024.112346_bib42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1523\/JNEUROSCI.18-03-00923.1998","article-title":"Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation","volume":"18","author":"Est\u00e9vez","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2024.112346_bib43","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tem.2021.01.006","article-title":"Cardiolipin, mitochondria, and neurological disease","volume":"32","author":"Falabella","year":"2021","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2024.112346_bib44","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/CIRCULATIONAHA.122.059785","article-title":"EMPEROR-preserved trial committees and investigators, empagliflozin for heart failure with preserved left ventricular ejection fraction with and without diabetes","volume":"146","author":"Filippatos","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2024.112346_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/157488408784293723","article-title":"Amyloid beta protein and tau in cerebrospinal fluid and plasma as biomarkers for dementia: a review of recent literature","volume":"3","author":"Frankfort","year":"2008","journal-title":"Curr. Clin. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib46","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ctrv.2003.07.007","article-title":"PI3K\/Akt signalling pathway and cancer","volume":"30","author":"Fresno Vara","year":"2004","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.mce.2024.112346_bib47","doi-asserted-by":"crossref","first-page":"8640","DOI":"10.18632\/aging.103181","article-title":"Exenatide inhibits NF-\u03baB and attenuates ER stress in diabetic cardiomyocyte models","volume":"12","author":"Fu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mce.2024.112346_bib48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2174\/1567205014666170417111859","article-title":"Tau in alzheimer's disease: mechanisms and therapeutic strategies","volume":"15","author":"Gao","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.mce.2024.112346_bib49","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2016.12.019","article-title":"Divergent roles of endothelial nitric oxide synthases system in maintaining cardiovascular homeostasis","volume":"109","author":"Godo","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mce.2024.112346_bib50","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1523\/JNEUROSCI.18-06-02040.1998","article-title":"Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity","volume":"18","author":"Gonzalez-Zulueta","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2024.112346_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115783","article-title":"Repaglinide induces ATF6 processing and neuroprotection in transgenic SOD1G93A mice","volume":"24","author":"Gonzalo-Gobernado","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2024.112346_bib52","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1056\/NEJMoa2200433","article-title":"Glycemia reduction in type 2 diabetes - glycemic outcomes","volume":"387","author":"Nathan","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2024.112346_bib53","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1093\/jxb\/ery119","article-title":"Interaction of nitric oxide with the components of the plant mitochondrial electron transport chain","volume":"69","author":"Gupta","year":"2018","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.mce.2024.112346_bib54","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.molp.2021.12.012","article-title":"Nitric oxide regulation of plant metabolism","volume":"15","author":"Gupta","year":"2022","journal-title":"Mol. Plant"},{"key":"10.1016\/j.mce.2024.112346_bib55","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1136\/jnnp-2021-328158","article-title":"Cognitive decline and diabetes: a systematic review of the neuropathological correlates accounting for cognition at death","volume":"93","author":"Hadley","year":"2022","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.mce.2024.112346_bib56","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/jnr.24098","article-title":"Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat","volume":"96","author":"Han","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mce.2024.112346_bib57","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1586\/14779072.6.2.153","article-title":"Acarbose: oral anti-diabetes drug with additional cardiovascular benefits","volume":"6","author":"Hanefeld","year":"2008","journal-title":"Expert Rev. Cardiovasc Ther."},{"key":"10.1016\/j.mce.2024.112346_bib58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.13435","article-title":"Insulin regulation of gluconeogenesis","volume":"1411","author":"Hatting","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mce.2024.112346_bib59","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2024.112346_bib60","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(20)30258-0","article-title":"ESCAPE-NA1 Investigators, Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial","volume":"395","author":"Hill","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.mce.2024.112346_bib61","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00004728-198008000-00006","article-title":"Computed tomography in perinatal hypoxic and hypoglycemic encephalopathy with emphasis on follow-up studies","volume":"4","author":"Hirabayashi","year":"1980","journal-title":"J. Comput. Assist. Tomogr."},{"key":"10.1016\/j.mce.2024.112346_bib62","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/(SICI)1097-4547(19991001)58:1<62::AID-JNR7>3.0.CO;2-G","article-title":"Synaptic plasticity and learning and memory: LTP and beyond","volume":"58","author":"H\u00f6lscher","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mce.2024.112346_bib63","doi-asserted-by":"crossref","first-page":"T31","DOI":"10.1530\/JOE-13-0221","article-title":"Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases","volume":"221","author":"H\u00f6lscher","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2024.112346_bib64","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2174\/1389203723666220823151326","article-title":"Structure, distribution, regulation, and function of splice variant isoforms of nitric oxide synthase family in the nervous system","volume":"23","author":"Hosseini","year":"2022","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.mce.2024.112346_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101802","article-title":"Disturbed neurovascular coupling in type 2 diabetes mellitus patients: evidence from a comprehensive fMRI analysis","volume":"22","author":"Hu","year":"2019","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.mce.2024.112346_bib66","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1111\/jcmm.15026","article-title":"Quercetin protects against diabetic encephalopathy via SIRT1\/NLRP3 pathway in db\/db mice","volume":"24","author":"Hu","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mce.2024.112346_bib67","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jvs.2013.03.023","article-title":"The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes","volume":"59","author":"Huang","year":"2014","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.mce.2024.112346_bib68","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7839101","article-title":"Macrovascular complications in patients with diabetes and prediabetes","volume":"2017","author":"Huang","year":"2017","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.mce.2024.112346_bib69","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/10715769309145868","article-title":"The reaction of no with superoxide","volume":"18","author":"Huie","year":"1993","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.mce.2024.112346_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127287","article-title":"Pioglitazone ameliorates cisplatin-induced testicular toxicity by attenuating oxidative stress and inflammation via TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"80","author":"Hussein","year":"2023","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.mce.2024.112346_bib71","unstructured":"Insulin Signaling Pathway, Cell Signaling Technology (n.d.). https:\/\/www.cellsignal.com\/pathways\/insulin-receptor-signaling-pathway (accessed October 13, 2023)."},{"key":"10.1016\/j.mce.2024.112346_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph182211970","article-title":"Pathogenesis and clinical significance of in-stent restenosis in patients with diabetes","volume":"18","author":"Jakubiak","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.mce.2024.112346_bib73","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/s41388-023-02661-2","article-title":"KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1\/YBX1 mediated NF-\u03baB pathway in cholangiocarcinoma","volume":"42","author":"Jiang","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2024.112346_bib74","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejphar.2008.06.050","article-title":"Pyritinol reduces nociception and oxidative stress in diabetic rats","volume":"590","author":"Jim\u00e9nez-Andrade","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib75","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.me.36.020185.002241","article-title":"The molecular mechanism of insulin action","volume":"36","author":"Kahn","year":"1985","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.mce.2024.112346_bib76","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/ars.2006.1464","article-title":"Nitrosative stress and pathogenesis of insulin resistance","volume":"9","author":"Kaneki","year":"2007","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mce.2024.112346_bib77","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2183\/pjab.95.039","article-title":"Structure and function of the insulin receptor-a personal perspective","volume":"95","author":"Kasuga","year":"2019","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.mce.2024.112346_bib78","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/STROKEAHA.122.041444","article-title":"Emerging roles of endothelial nitric oxide in preservation of cognitive health","volume":"54","author":"Katusic","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.mce.2024.112346_bib79","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S1474-4422(20)30231-3","article-title":"Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches","volume":"19","author":"Kellar","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mce.2024.112346_bib80","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/biom12040542","article-title":"Advanced glycation end products and diabetes mellitus: mechanisms and perspectives","volume":"12","author":"Khalid","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.mce.2024.112346_bib81","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.3390\/ijms23074004","article-title":"Epigallocatechin gallate protects against hypoxia-induced inflammation in microglia via NF-\u03baB suppression and Nrf-2\/HO-1 activation","volume":"23","author":"Kim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2024.112346_bib82","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbamcr.2010.09.013","article-title":"Is mPTP the gatekeeper for necrosis, apoptosis, or both?","volume":"1813","author":"Kinnally","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2024.112346_bib83","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1523\/JNEUROSCI.20-12-04686.2000","article-title":"Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system","volume":"20","author":"Kirik","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2024.112346_bib84","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12916-020-01688-6","article-title":"Insulin: too much of a good thing is bad","volume":"18","author":"Kolb","year":"2020","journal-title":"BMC Med."},{"key":"10.1016\/j.mce.2024.112346_bib85","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1139\/cjpp-2016-0294","article-title":"Distribution pattern of dorsal root ganglion neurons synthesizing nitric oxide synthase in different animal species","volume":"95","author":"Koles\u00e1r","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib86","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2015.12.059","article-title":"Major dorsoventral differences in the modulation of the local CA1 hippocampal network by NMDA, mGlu5, adenosine A2A and cannabinoid CB1 receptors","volume":"317","author":"Kouvaros","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.mce.2024.112346_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1254\/jjp.69.1","article-title":"Role of nitric oxide in central synaptic transmission: effects on neurotransmitter release","volume":"69","author":"Kuriyama","year":"1995","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib88","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1172\/JCI25385","article-title":"Intensive insulin therapy protects the endothelium of critically ill patients","volume":"115","author":"Langouche","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2024.112346_bib89","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1474-4422(08)70167-4","article-title":"PBT2-201-EURO study group, Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial","volume":"7","author":"Lannfelt","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mce.2024.112346_bib90","first-page":"466","article-title":"Cerebral proteolysis of amiloid-b peptide: relevance of insulin-degrading enzyme in Alzheimer's disease","volume":"69","author":"Leal","year":"2009","journal-title":"Medicina (B Aires)"},{"key":"10.1016\/j.mce.2024.112346_bib91","doi-asserted-by":"crossref","first-page":"C319","DOI":"10.1152\/ajpcell.1994.266.2.C319","article-title":"The insulin receptor: structure, function, and signaling","volume":"266","author":"Lee","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mce.2024.112346_bib92","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.3390\/cells11193001","article-title":"Macrophages, chronic inflammation, and insulin resistance","volume":"11","author":"Li","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.mce.2024.112346_bib93","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12906-023-04195-2","article-title":"Protective effects of GuanXinNing tablet (GXNT) on diabetic encephalopathy in zucker diabetic obesity (ZDF) rats","volume":"23","author":"Li","year":"2023","journal-title":"BMC Complement Med. Ther."},{"key":"10.1016\/j.mce.2024.112346_bib94","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.kint.2017.05.013","article-title":"Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism","volume":"93","author":"Liang","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2024.112346_bib95","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/2211-5463.13194","article-title":"Phosphorylation of Akt at Thr308 regulates p-eNOS Ser1177 during physiological conditions","volume":"11","author":"Liang","year":"2021","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.mce.2024.112346_bib96","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1089\/lrb.2018.0013","article-title":"Inducible nitric oxide synthase and CD11b+Gr1+ cells impair lymphatic contraction of tumor-draining lymphatic vessels","volume":"17","author":"Liao","year":"2019","journal-title":"Lymphatic Res. Biol."},{"key":"10.1016\/j.mce.2024.112346_bib97","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pbb.2013.11.027","article-title":"Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats","volume":"117","author":"Liu","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.mce.2024.112346_bib98","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.etap.2017.09.018","article-title":"The \u03b1-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction","volume":"56","author":"Liu","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib99","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1165\/rcmb.2020-0153OC","article-title":"Transforming growth factor-induced protein promotes NF-\u03baB-mediated angiogenesis during postnatal lung development","volume":"64","author":"Liu","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.mce.2024.112346_bib100","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/andr.12875","article-title":"Icariin modulates eNOS activity via effect on post-translational protein-protein interactions to improve erectile function of spontaneously hypertensive rats","volume":"9","author":"Liu","year":"2021","journal-title":"Andrology"},{"key":"10.1016\/j.mce.2024.112346_bib101","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.intimp.2019.05.017","article-title":"Adiponectin inhibits proliferation of vascular endothelial cells induced by Ox-LDL by promoting dephosphorylation of Caveolin-1 and depolymerization of eNOS and up-regulating release of NO","volume":"73","author":"Lu","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.mce.2024.112346_bib102","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.cell.2022.06.010","article-title":"Nitric oxide signaling in health and disease","volume":"185","author":"Lundberg","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.mce.2024.112346_bib103","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-022-04431-8","article-title":"Low-dose metformin targets the lysosomal AMPK pathway through PEN2","volume":"603","author":"Ma","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mce.2024.112346_bib104","article-title":"The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3\/phosphoinositide 3-kinase\/protein kinase B pathway","volume":"74","author":"Ma","year":"2023","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.mce.2024.112346_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125817","article-title":"Neuroprotective effects of terpenoids against streptozotocin-nicotinamide-induced diabetic rats: an in silico, in vitro and in vivo study","volume":"247","author":"Madeswaran","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mce.2024.112346_bib107","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/prot.26417","article-title":"N-glycosylation induced changes in tau protein dynamics reveal its role in tau misfolding and aggregation: a microsecond long molecular dynamics study","volume":"91","author":"Mathew","year":"2023","journal-title":"Proteins"},{"key":"10.1016\/j.mce.2024.112346_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-160761","article-title":"Cholinergic modification of neurogenesis and gliosis improves the memory of A\u03b2PPswe\/PSEN1dE9 Alzheimer's disease model mice fed a high-fat diet","volume":"56","author":"Matsuda","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mce.2024.112346_bib109","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1540\/jsmr.57.94","article-title":"Relationships between advanced glycation end products (AGEs), vasoactive substances, and vascular function","volume":"57","author":"Matsumoto","year":"2021","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.mce.2024.112346_bib110","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0024-3205(01)01196-1","article-title":"Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells","volume":"69","author":"Matsumura","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2024.112346_bib111","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2174\/0929867322666150227153308","article-title":"Mechanisms of neurodegeration in type 2 diabetes and the neuroprotective potential of dipeptidyl peptidase 4 inhibitors","volume":"22","author":"Matteucci","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mce.2024.112346_bib112","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12291-022-01107-y","article-title":"Diabetic encephalopathy: role of oxidative and nitrosative factors in type 2 diabetes","volume":"39","author":"Mazumdar","year":"2024","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.mce.2024.112346_bib113","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1111\/j.1742-4658.2011.08395.x","article-title":"Rate, affinity and calcium dependence of nitric oxide synthase isoform binding to the primary physiological regulator calmodulin","volume":"278","author":"McMurry","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.mce.2024.112346_bib114","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-42665-2","article-title":"Galantamine improves glycemic control and diabetic nephropathy in Leprdb\/db mice","volume":"13","author":"Meng","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2024.112346_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101234","article-title":"The brain as an insulin-sensitive metabolic organ","volume":"52","author":"Milstein","year":"2021","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.mce.2024.112346_bib116","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-0043-112351","article-title":"Prostaglandin E1 protects the peripheral nerve in diabetics through preventing vascular permeability changes","volume":"126","author":"Mo","year":"2018","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.mce.2024.112346_bib117","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.cmet.2019.03.010","article-title":"Insulin-driven PI3K-AKT signaling in the hepatocyte is mediated by redundant PI3K\u03b1 and PI3K\u03b2 activities and is promoted by RAS","volume":"29","author":"Molinaro","year":"2019","journal-title":"Cell Metabol."},{"key":"10.1016\/j.mce.2024.112346_bib118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.apha.2016.05.001","article-title":"The endothelium-dependent nitric oxide-cGMP pathway","volume":"77","author":"M\u00f3nica","year":"2016","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib119","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s12035-016-9765-x","article-title":"A therapeutic insight of niacin and coenzyme Q10 against diabetic encephalopathy in rats","volume":"54","author":"Motawi","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mce.2024.112346_bib120","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1748-1716.2006.01582.x","article-title":"Nitric oxide in the kidney: functions and regulation of synthesis","volume":"187","author":"Mount","year":"2006","journal-title":"Acta Physiol."},{"key":"10.1016\/j.mce.2024.112346_bib121","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1111\/febs.16151","article-title":"AMPK in the brain: its roles in glucose and neural metabolism","volume":"289","author":"Muraleedharan","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.mce.2024.112346_bib122","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1161\/01.ATV.0000251615.61858.33","article-title":"Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt\/NF-kappaB pathway","volume":"27","author":"Nakata","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mce.2024.112346_bib123","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.974690","article-title":"Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice","volume":"14","author":"Nan","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.mce.2024.112346_bib124","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1172\/JCI119782","article-title":"Inducible nitric oxide synthase: what difference does it make?","volume":"100","author":"Nathan","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2024.112346_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105510","article-title":"Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease","volume":"159","author":"Ochiai","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mce.2024.112346_bib126","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mce.2024.112346_bib127","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2016.05.013","article-title":"Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice","volume":"1644","author":"Oliveira","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2024.112346_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105208","article-title":"Aggregation and structure of amyloid \u03b2-protein","volume":"151","author":"Ono","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.mce.2024.112346_bib129","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2024.112346_bib130","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/333664a0","article-title":"Vascular endothelial cells synthesize nitric oxide from L-arginine","volume":"333","author":"Palmer","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.mce.2024.112346_bib131","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s10571-016-0418-4","article-title":"Piracetam facilitates the anti-amnesic but not anti-diabetic activity of metformin in experimentally induced type-2 diabetic encephalopathic rats","volume":"37","author":"Pandey","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.mce.2024.112346_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.114527","article-title":"Advanced glycation end-products and advanced oxidation protein products in schizophrenia","volume":"311","author":"Pandolfo","year":"2022","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.mce.2024.112346_bib133","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1006\/jmcc.2000.1334","article-title":"Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart","volume":"33","author":"Paolocci","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.mce.2024.112346_bib134","first-page":"471","article-title":"Involvement of nitric oxide in learning & memory processes","volume":"133","author":"Paul","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.mce.2024.112346_bib135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.expneurol.2017.08.013","article-title":"AMPK activation: role in the signaling pathways of neuroinflammation and neurodegeneration","volume":"298","author":"Peixoto","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mce.2024.112346_bib136","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/dc16-2042","article-title":"Diabetic neuropathy: a position statement by the American diabetes association","volume":"40","author":"Pop-Busui","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2024.112346_bib137","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3886710","article-title":"The amelioration of detrimental biochemical anomalies by supplementing B, C, and E vitamins in subjects with type 2 diabetes mellitus may reduce the rate of development of diabetic retinopathy","volume":"2022","author":"Pramanik","year":"2022","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.mce.2024.112346_bib138","doi-asserted-by":"crossref","first-page":"26464","DOI":"10.1074\/jbc.R113.472936","article-title":"Peroxynitrite, a stealthy biological oxidant","volume":"288","author":"Radi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112346_bib139","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev.ph.57.030195.003303","article-title":"Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission","volume":"57","author":"Rand","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mce.2024.112346_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbior.2019.100657","article-title":"Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease","volume":"75","author":"Rathinaswamy","year":"2020","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.mce.2024.112346_bib141","doi-asserted-by":"crossref","first-page":"10636","DOI":"10.1523\/JNEUROSCI.2143-06.2006","article-title":"Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies","volume":"26","author":"Reynolds","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2024.112346_bib142","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"CANTOS trial group, antiinflammatory therapy with Canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2024.112346_bib143","article-title":"Cerebrovascular disease lesions are additive and tied to vascular risk factors and cognitive impairment","volume":"3","author":"Robinson","year":"2022","journal-title":"Free Neuropathol."},{"key":"10.1016\/j.mce.2024.112346_bib144","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.mce.2024.112346_bib145","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1093\/ndt\/gfad009","article-title":"The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease","volume":"38","author":"Rossing","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.mce.2024.112346_bib146","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.niox.2005.04.008","article-title":"New aspects of the location of neuronal nitric oxide synthase in the skeletal muscle: a light and electron microscopic study","volume":"13","author":"Rothe","year":"2005","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.mce.2024.112346_bib147","doi-asserted-by":"crossref","first-page":"81","DOI":"10.9758\/cpn.2020.18.1.81","article-title":"Protective effects of citicoline and benfotiamine each alone and in combination on streptozotocin-induced memory impairment in mice","volume":"18","author":"Safavi","year":"2020","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.mce.2024.112346_bib148","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejphar.2007.04.016","article-title":"Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy","volume":"568","author":"Saini","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib149","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142241","article-title":"Insulin signaling in health and disease","volume":"131","author":"Saltiel","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2024.112346_bib150","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/bph.14459","article-title":"Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract","volume":"176","author":"Sanders","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib151","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1038\/s41598-022-07077-8","article-title":"Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK-eNOS-NO pathway","volume":"12","author":"Sanz-G\u00f3mez","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2024.112346_bib152","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.diabet.2011.11.001","article-title":"DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials","volume":"38","author":"Scheen","year":"2012","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.mce.2024.112346_bib153","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41574-021-00498-x","article-title":"Brain insulin signalling in metabolic homeostasis and disease","volume":"17","author":"Scherer","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2024.112346_bib154","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1111\/jcmm.14293","article-title":"Aucubin inhibited lipid accumulation and oxidative stress via Nrf2\/HO-1 and AMPK signalling pathways","volume":"23","author":"Shen","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mce.2024.112346_bib155","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/cns.13201","article-title":"Studies of pathology and pharmacology of diabetic encephalopathy with KK-Ay mouse model","volume":"26","author":"Shi","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.mce.2024.112346_bib156","doi-asserted-by":"crossref","first-page":"378","DOI":"10.5114\/fn.2021.112007","article-title":"Risk factors for ischemic stroke: differences between cerebral small vessel and large artery atherosclerosis aetiologies","volume":"59","author":"Shi","year":"2021","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.mce.2024.112346_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154993","article-title":"Dendrobine rescues cognitive dysfunction in diabetic encephalopathy by inhibiting ferroptosis via activating Nrf2\/GPX4 axis","volume":"119","author":"Shi","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.mce.2024.112346_bib158","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/exnr.2000.7448","article-title":"nNOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease","volume":"165","author":"Simic","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mce.2024.112346_bib159","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s001250051591","article-title":"Advanced glycation end-products: a review","volume":"44","author":"Singh","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2024.112346_bib160","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00432-012-1366-0","article-title":"Expression of vascular endothelial growth factor and transcription factors HIF-1, NF-kB expression in squamous cell carcinoma of head and neck; association with proteasome and calpain activities","volume":"139","author":"Spirina","year":"2013","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.mce.2024.112346_bib161","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0092-8674(01)00495-0","article-title":"Nitrosylation. the prototypic redox-based signaling mechanism","volume":"106","author":"Stamler","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.mce.2024.112346_bib162","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1161\/CIRCRESAHA.110.230698","article-title":"cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes","volume":"108","author":"Stangherlin","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2024.112346_bib163","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl8809","article-title":"Alzheimer's disease: ablating single master site abolishes tau hyperphosphorylation","volume":"8","author":"Stefanoska","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mce.2024.112346_bib164","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","article-title":"New insights into activation and function of the AMPK","volume":"24","author":"Steinberg","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2024.112346_bib165","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/1073858403261226","article-title":"Nitric oxide and memory","volume":"10","author":"Susswein","year":"2004","journal-title":"Neuroscientist"},{"key":"10.1016\/j.mce.2024.112346_bib166","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-25722-0","article-title":"Ocular surface microbiome in diabetes mellitus","volume":"12","author":"Suwajanakorn","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2024.112346_bib167","first-page":"114","article-title":"Co-administration of vitamin E and atorvastatin improves insulin sensitivity and peroxisome proliferator-activated receptor-\u03b3 expression in type 2 diabetic patients: a randomized double-blind clinical trial","volume":"47","author":"Tabaei","year":"2022","journal-title":"Iran. J. Med. Sci."},{"key":"10.1016\/j.mce.2024.112346_bib168","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/1073858420916696","article-title":"The accumulation of tau in postsynaptic structures: a common feature in multiple neurodegenerative diseases?","volume":"26","author":"Teravskis","year":"2020","journal-title":"Neuroscientist"},{"key":"10.1016\/j.mce.2024.112346_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115196","article-title":"Huang-Lian-Jie-Du decoction attenuates cognitive dysfunction of rats with type 2 diabetes by regulating autophagy and NLRP3 inflammasome activation","volume":"292","author":"Tian","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib170","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2006.09.020","article-title":"Elevated endogenous nitric oxide increases Ca2+ flux via L-type Ca2+ channels by S-nitrosylation in rat hippocampal neurons during severe hypoxia and in vitro ischemia","volume":"42","author":"Tjong","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mce.2024.112346_bib171","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.preteyeres.2007.01.004","article-title":"Nitric oxide: ocular blood flow, glaucoma, and diabetic retinopathy","volume":"26","author":"Toda","year":"2007","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.mce.2024.112346_bib172","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.672519","article-title":"Insulin signaling in arthritis","volume":"12","author":"Tripolino","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2024.112346_bib173","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10753-020-01344-4","article-title":"GLP-1R agonist liraglutide attenuates inflammatory reaction and neuronal apoptosis and reduces early brain injury after subarachnoid hemorrhage in rats","volume":"44","author":"Tu","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.mce.2024.112346_bib174","first-page":"1","article-title":"Dapagliflozin attenuates high glucose-and hypoxia\/reoxygenation-induced injury via activating AMPK\/mTOR-OPA1-mediated mitochondrial autophagy in H9c2 cardiomyocytes","author":"Tu","year":"2023","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.mce.2024.112346_bib175","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/313756a0","article-title":"Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes","volume":"313","author":"Ullrich","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.mce.2024.112346_bib176","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0167-5273(95)02380-F","article-title":"Anatomic distribution of nitric oxide synthase in the heart","volume":"50","author":"Ursell","year":"1995","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.mce.2024.112346_bib177","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1016\/j.dsx.2018.07.003","article-title":"The potential of transdermal nitric oxide treatment for diabetic peripheral neuropathy and diabetic foot ulcers","volume":"13","author":"Walton","year":"2019","journal-title":"Diabetes Metabol. Syndr."},{"key":"10.1016\/j.mce.2024.112346_bib178","article-title":"Aerobic exercise protects against pressure overload-induced cardiac dysfunction and hypertrophy via \u03b23-AR-nNOS-NO activation","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2024.112346_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113807","article-title":"A RNA-seq approach for exploring the protective effect of ginkgolide B on glutamate-induced astrocytes injury","volume":"270","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109716","article-title":"Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R\/SIRT1\/GLUT4 pathway","volume":"240","author":"Wang","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mce.2024.112346_bib181","article-title":"Hypoglycemic medicines in the treatment of Alzheimer's disease: pathophysiological links between AD and glucose metabolism","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib182","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s00213-023-06373-z","article-title":"Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K\/Akt\/GSK-3\u03b2 signaling pathway","volume":"240","author":"Wang","year":"2023","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.mce.2024.112346_bib183","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbr.2018.08.006","article-title":"Neural correlates of liraglutide effects in persons at risk for Alzheimer's disease","volume":"356","author":"Watson","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.mce.2024.112346_bib184","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.conb.2021.03.003","article-title":"A current view on Tau protein phosphorylation in Alzheimer's disease","volume":"69","author":"Wegmann","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.mce.2024.112346_bib185","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1161\/ATVBAHA.112.301068","article-title":"Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis","volume":"33","author":"Wood","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mce.2024.112346_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174974","article-title":"Propionate ameliorates diabetes-induced neurological dysfunction through regulating the PI3K\/Akt\/eNOS signaling pathway","volume":"925","author":"Wu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib187","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12967-022-03337-3","article-title":"Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4\/NF-kB signaling pathway","volume":"20","author":"Wu","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mce.2024.112346_bib188","first-page":"783","article-title":"PI3K\/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia","volume":"19","author":"Xie","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mce.2024.112346_bib189","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1007\/s12035-021-02390-1","article-title":"The mTOR\/NF-\u03baB pathway mediates neuroinflammation and synaptic plasticity in diabetic encephalopathy","volume":"58","author":"Xu","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mce.2024.112346_bib190","article-title":"Advances in the relationship between pyroptosis and diabetic neuropathy","volume":"9","author":"Xu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mce.2024.112346_bib191","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3892\/mmr.2021.12214","article-title":"Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK\/MLCK signaling","volume":"24","author":"Xu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mce.2024.112346_bib192","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.628950","article-title":"Dl-3-n-Butylphthalide ameliorates diabetic nephropathy by ameliorating excessive fibrosis and podocyte apoptosis","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib193","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4196\/kjpp.2022.26.4.255","article-title":"Oxytocin-induced endothelial nitric oxide dependent vasorelaxation and ERK1\/2-mediated vasoconstriction in the rat aorta","volume":"26","author":"Xu","year":"2022","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"key":"10.1016\/j.mce.2024.112346_bib194","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/cns.13839","article-title":"Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial\/macrophage polarization","volume":"28","author":"Xue","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.mce.2024.112346_bib195","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2174\/138920111794480534","article-title":"Advanced glycation end products (AGEs), oxidative stress and diabetic retinopathy","volume":"12","author":"Yamagishi","year":"2011","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/j.mce.2024.112346_bib196","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.3390\/ijms19113534","article-title":"Structure and physiological regulation of AMPK","volume":"19","author":"Yan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2024.112346_bib197","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8609213","article-title":"Molecular mechanisms linking oxidative stress and diabetes mellitus","volume":"2020","author":"Yaribeygi","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mce.2024.112346_bib198","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5551\/jat.9.276","article-title":"Insulin sensitizers and atherosclerosis","volume":"9","author":"Yatoh","year":"2002","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.mce.2024.112346_bib199","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.2169\/internalmedicine.0858-22","article-title":"Tocilizumab attenuates anti-neutrophil cytoplasmic antibody-associated nephritis occurring during abatacept and adalimumab therapy for rheumatoid arthritis","volume":"62","author":"Yoshimura","year":"2023","journal-title":"Intern. Med."},{"key":"10.1016\/j.mce.2024.112346_bib200","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1173402","article-title":"Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension","volume":"14","author":"Yousef","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2024.112346_bib201","first-page":"764","article-title":"Diabetoporosis: role of nitric oxide","volume":"20","author":"Yousefzadeh","year":"2021","journal-title":"Excli. J."},{"key":"10.1016\/j.mce.2024.112346_bib202","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/0269881115622239","article-title":"The role of CA3 GABAA receptors on anxiolytic-like behaviors and avoidance memory deficit induced by NMDA receptor antagonists","volume":"30","author":"Zarrabian","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib203","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1073\/pnas.88.24.11172","article-title":"Nitric oxide and another potent vasodilator are formed from NG-hydroxy-L-arginine by cultured endothelial cells","volume":"88","author":"Zembowicz","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2024.112346_bib204","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.18632\/oncotarget.24295","article-title":"Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation","volume":"9","author":"Zhai","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.mce.2024.112346_bib205","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12754","article-title":"nNOS-CAPON interaction mediates amyloid-\u03b2-induced neurotoxicity, especially in the early stages","volume":"17","author":"Zhang","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.mce.2024.112346_bib206","article-title":"Overnutrition induced cognitive impairment: insulin resistance, gut-brain Axis, and neuroinflammation","volume":"16","author":"Zhang","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mce.2024.112346_bib207","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1080\/15548627.2021.2016231","article-title":"Negative pressure wound therapy improves bone regeneration by promoting osteogenic differentiation via the AMPK-ULK1-autophagy axis","volume":"18","author":"Zhang","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.mce.2024.112346_bib208","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1007\/s12035-023-03304-z","article-title":"The aldose reductase inhibitor Epalrestat maintains blood-brain barrier integrity by enhancing endothelial cell function during cerebral ischemia","volume":"60","author":"Zhang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mce.2024.112346_bib209","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12943-017-0648-1","article-title":"ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway","volume":"16","author":"Zhao","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mce.2024.112346_bib210","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1007\/s11418-023-01741-7","article-title":"Rhein alleviates advanced glycation end products (AGEs)-induced inflammatory injury of diabetic cardiomyopathy in vitro and in vivo models","volume":"77","author":"Zhao","year":"2023","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.mce.2024.112346_bib211","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.7150\/ijbs.82015","article-title":"Phosphorylation by IKK\u03b2 promotes the degradation of HMGCL via NEDD4 in lung cancer","volume":"19","author":"Zhong","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mce.2024.112346_bib212","doi-asserted-by":"crossref","DOI":"10.1177\/03946320221111117","article-title":"Formononetin regulates endothelial nitric oxide synthase to protect vascular endothelium in deep vein thrombosis rats","volume":"36","author":"Zhou","year":"2022","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib213","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115763","article-title":"Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4\/MyD88\/NF-\u03baB pathway","volume":"301","author":"Zhu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.mce.2024.112346_bib214","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102612","article-title":"Red blood cells from endothelial nitric oxide synthase-deficient mice induce vascular dysfunction involving oxidative stress and endothelial arginase I","volume":"60","author":"Zhuge","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.mce.2024.112346_bib215","first-page":"255","article-title":"Nitric oxide in damage, disease and repair of the peripheral nervous system","volume":"51","author":"Zochodne","year":"2005","journal-title":"Cell. Mol. Biol. (Noisy-Le-Grand)"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724002028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724002028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:56:35Z","timestamp":1777550195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720724002028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":215,"alternative-id":["S0303720724002028"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2024.112346","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u201cNO\u201d controversy?: A controversial role in insulin signaling of diabetic encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2024.112346","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112346"}}