{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T19:45:42Z","timestamp":1774640742068,"version":"3.50.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["MU 1017\/14-1"],"award-info":[{"award-number":["MU 1017\/14-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.mce.2024.112385","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T15:34:34Z","timestamp":1728833674000},"page":"112385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The impact of acyl-CoA:cholesterol transferase (ACAT) inhibitors on biophysical membrane properties depends on membrane lipid composition"],"prefix":"10.1016","volume":"594","author":[{"given":"Huong","family":"To","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2406-700X","authenticated-orcid":false,"given":"Peter","family":"Reinholdt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-8738","authenticated-orcid":false,"given":"Mohammad","family":"Bashawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike","family":"Luck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-571X","authenticated-orcid":false,"given":"Line","family":"Lauritsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5103-1240","authenticated-orcid":false,"given":"Vibeke","family":"Akkerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Kroiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-9709","authenticated-orcid":false,"given":"Daniel","family":"W\u00fcstner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-2164","authenticated-orcid":false,"given":"Jacob","family":"Kongsted","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-5043","authenticated-orcid":false,"given":"Peter","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9935-8229","authenticated-orcid":false,"given":"Holger A.","family":"Scheidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2024.112385_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.mce.2024.112385_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BFb0116295","article-title":"Preparation of giant vesicles by external AC electric fields. Kinetics and applications","volume":"89","author":"Angelova","year":"1992","journal-title":"Progr. Colloid Polym. Sci."},{"key":"10.1016\/j.mce.2024.112385_bib3","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/B978-0-12-391857-4.00003-3","article-title":"Chapter three - applications of fluorescence lifetime spectroscopy and imaging to lipid domains in vivo","author":"Bastos","year":"2012"},{"key":"10.1016\/j.mce.2024.112385_bib4","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1021\/j100142a004","article-title":"A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model","volume":"97","author":"Bayly","year":"1993","journal-title":"The Journal of Physical Chemistry"},{"key":"10.1016\/j.mce.2024.112385_bib5","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular dynamics with coupling to an external bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.mce.2024.112385_bib6","first-page":"489","article-title":"DGAT1 inhibitors as anti-obesity and anti-diabetic agents","volume":"13","author":"Birch","year":"2010","journal-title":"Curr Opin Drug Discov Devel"},{"key":"10.1016\/j.mce.2024.112385_bib7","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1152\/ajpendo.90926.2008","article-title":"Acyl-coenzyme A:cholesterol acyltransferases","volume":"297","author":"Chang","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2024.112385_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1021\/bi00375a006","article-title":"Parallax method for direct measurement of membrane penetration depth utilizing fluorescence quenching by spin-labeled phospholipids","volume":"26","author":"Chattopadhyay","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2024.112385_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101181","article-title":"Acyl-CoA:diacylglycerol acyltransferase: properties, physiological roles, metabolic engineering and intentional control","volume":"88","author":"Chen","year":"2022","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.mce.2024.112385_bib10","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle mesh Ewald: an N\u22c5log(N) method for Ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.mce.2024.112385_bib74","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0009-2614(76)80392-2","article-title":"Quadrupolar echo deuteron magnetic resonance spectroscopy in ordered hydrocarbon chains","volume":"42","author":"Davis","year":"1976","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.mce.2024.112385_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s11523-016-0460-7","article-title":"Ceritinib: a review in ALK-positive advanced NSCLC","volume":"11","author":"Deeks","year":"2016","journal-title":"Target Oncol"},{"key":"10.1016\/j.mce.2024.112385_bib12","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1021\/ct4010307","article-title":"Lipid14: the amber lipid force field","volume":"10","author":"Dickson","year":"2014","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.mce.2024.112385_bib13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/019262339302100107","article-title":"Morphogenesis of a zone-specific adrenocortical cytotoxicity in Guinea pigs administered PD 132301-2, an inhibitor of acyl-CoA:cholesterol acyltransferase","volume":"21","author":"Dominick","year":"1993","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.mce.2024.112385_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/faat.1993.1029","article-title":"Subacute toxicity of a novel inhibitor of acyl-CoA: cholesterol acyltransferase in beagle dogs","volume":"20","author":"Dominick","year":"1993","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.mce.2024.112385_bib75","series-title":"Methods in Molecular Biology. Biomembrane Protocols: II. Architecture and Function","first-page":"161","article-title":"Synthesis and use of spin-labeled lipids for studies of the transmembrane movement of phospholipids","author":"Fellmann","year":"1994"},{"key":"10.1016\/j.mce.2024.112385_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphyslip.2023.105351","article-title":"The small-molecule kinase inhibitor ceritinib, unlike imatinib, causes a significant disturbance of lipid membrane integrity: a combined experimental and MD study","volume":"257","author":"Fischer","year":"2023","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.mce.2024.112385_bib16","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1021\/acs.biochem.2c00042","article-title":"Drug\u2013membrane interactions: effects of virus-specific RNA-dependent RNA polymerase inhibitors remdesivir and favipiravir on the structure of lipid bilayers","volume":"61","author":"Fischer","year":"2022","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2024.112385_bib17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.bbamem.2018.12.013","article-title":"Interaction of statins with phospholipid bilayers studied by solid-state NMR spectroscopy","volume":"1861","author":"Galiullina","year":"2019","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes."},{"key":"10.1016\/j.mce.2024.112385_bib18","doi-asserted-by":"crossref","first-page":"8326","DOI":"10.1021\/bi010552+","article-title":"Influence of the bovine seminal plasma protein PDC-109 on the physical state of membranes","volume":"40","author":"Greube","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2024.112385_bib19","doi-asserted-by":"crossref","DOI":"10.1063\/5.0040021","article-title":"r(2)SCAN-3c: a \"Swiss army knife\" composite electronic-structure method","volume":"154","author":"Grimme","year":"2021","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.mce.2024.112385_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11080543","article-title":"Acyl-coenzyme A: cholesterol acyltransferase (ACAT) in cholesterol metabolism: from its discovery to clinical trials and the genomics era","volume":"11","author":"Hai","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.mce.2024.112385_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2020.183414","article-title":"Interaction of the small-molecule kinase inhibitors tofacitinib and lapatinib with membranes","volume":"1862","author":"Haralampiev","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes."},{"key":"10.1016\/j.mce.2024.112385_bib22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/anie.201408089","article-title":"Recruitment of SH-containing peptides to lipid and biological membranes through the use of a palmitic acid functionalized with a maleimide group","volume":"54","author":"Haralampiev","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.mce.2024.112385_bib23","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/j.bbamem.2016.08.014","article-title":"The interaction of sorafenib and regorafenib with membranes is modulated by their lipid composition","volume":"1858","author":"Haralampiev","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2024.112385_bib24","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","article-title":"LINCS: a linear constraint solver for molecular simulations","volume":"18","author":"Hess","year":"1997","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.mce.2024.112385_bib25","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0006-3495(01)76061-4","article-title":"Dynamics of membrane penetration of the fluorescent 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) group attached to an acyl chain of phosphatidylcholine","volume":"80","author":"Huster","year":"2001","journal-title":"Biophys. J."},{"key":"10.1016\/j.mce.2024.112385_bib26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neuron.2004.08.043","article-title":"The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease","volume":"44","author":"Hutter-Paier","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.mce.2024.112385_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12020473","article-title":"Extracellular vesicles, as drug-delivery vehicles, improve the biological activities of astaxanthin","volume":"12","author":"Jang","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.mce.2024.112385_bib28","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1063\/1.438208","article-title":"Investigation of exchange processes by two\u2010dimensional NMR spectroscopy","volume":"71","author":"Jeener","year":"1979","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.mce.2024.112385_bib29","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1021\/ja9621760","article-title":"Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids","volume":"118","author":"Jorgensen","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mce.2024.112385_bib30","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1021\/ja00449a004","article-title":"Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems","volume":"99","author":"Kalyanasundaram","year":"1977","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mce.2024.112385_bib31","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1161\/01.ATV.18.3.423","article-title":"Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death","volume":"18","author":"Kellner-Weibel","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mce.2024.112385_bib32","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0006-3495(89)82749-3","article-title":"Smoothed orientational order profile of lipid bilayers by 2H-nuclear magnetic resonance","volume":"56","author":"Lafleur","year":"1989","journal-title":"Biophys. J."},{"key":"10.1016\/j.mce.2024.112385_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0009-3084(93)90078-H","article-title":"Dithionite penetration through phospholipid bilayers as a measure of defects in lipid molecular packing","volume":"65","author":"Langner","year":"1993","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.mce.2024.112385_bib34","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1210\/en.2015-2052","article-title":"ATR-101, a selective and potent inhibitor of acyl-CoA acyltransferase 1, induces apoptosis in H295R adrenocortical cells and in the adrenal cortex of dogs","volume":"157","author":"LaPensee","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2024.112385_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mce.2024.112385_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073726","article-title":"SOAT1: a suitable target for therapy in high-grade astrocytic glioma?","volume":"23","author":"L\u00f6hr","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2024.112385_bib37","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.str.2021.07.009","article-title":"Molecular structures of human ACAT2 disclose mechanism for selective inhibition","volume":"29","author":"Long","year":"2021","journal-title":"Structure"},{"key":"10.1016\/j.mce.2024.112385_bib38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41586-020-2295-8","article-title":"Structure of nevanimibe-bound tetrameric human ACAT1","volume":"581","author":"Long","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mce.2024.112385_bib39","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/jcc.21224","article-title":"PACKMOL: a package for building initial configurations for molecular dynamics simulations","volume":"30","author":"Mart\u00ednez","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.mce.2024.112385_bib40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0005-2736(85)90084-7","article-title":"Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles","volume":"817","author":"Mayer","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2024.112385_bib41","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1016\/j.bmcl.2012.04.117","article-title":"Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes","volume":"22","author":"McCoull","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.mce.2024.112385_bib42","doi-asserted-by":"crossref","first-page":"11819","DOI":"10.1021\/bi00115a012","article-title":"Fluorescence assay for phospholipid membrane asymmetry","volume":"30","author":"McIntyre","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2024.112385_bib43","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/jcc.21787","article-title":"MDAnalysis: a toolkit for the analysis of molecular dynamics simulations","volume":"32","author":"Michaud-Agrawal","year":"2011","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.mce.2024.112385_bib44","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1002\/cmdc.201402069","article-title":"Therapeutic strategies for metabolic diseases: small-molecule diacylglycerol acyltransferase (DGAT) inhibitors","volume":"9","author":"Naik","year":"2014","journal-title":"ChemMedChem"},{"key":"10.1016\/j.mce.2024.112385_bib45","doi-asserted-by":"crossref","DOI":"10.1063\/5.0004608","article-title":"The ORCA quantum chemistry program package","volume":"152","author":"Neese","year":"2020","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.mce.2024.112385_bib46","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/00268978400101201","article-title":"A molecular dynamics method for simulations in the canonical ensemble","volume":"52","author":"Nos\u00e9","year":"1984","journal-title":"Mol. Phys."},{"key":"10.1016\/j.mce.2024.112385_bib47","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1063\/1.328693","article-title":"Polymorphic transitions in single crystals: a new molecular dynamics method","volume":"52","author":"Parrinello","year":"1981","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.mce.2024.112385_bib48","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2165\/00003088-200544090-00001","article-title":"Clinical pharmacokinetics of imatinib","volume":"44","author":"Peng","year":"2005","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.mce.2024.112385_bib49","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1016\/S0006-3495(00)76551-9","article-title":"Area per lipid and acyl length distributions in fluid phosphatidylcholines determined by (2)H NMR spectroscopy","volume":"79","author":"Petrache","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.mce.2024.112385_bib50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/09687689409161028","article-title":"Rapid determination of the transbilayer distribution of NBD-phospholipids in erythrocyte membranes with dithionite","volume":"11","author":"Pomorski","year":"1994","journal-title":"Molec. Membr. Biol."},{"key":"10.1016\/j.mce.2024.112385_bib51","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2008.10.008","article-title":"Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance","volume":"8","author":"Radhakrishnan","year":"2008","journal-title":"Cell Metabol."},{"key":"10.1016\/j.mce.2024.112385_bib52","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data","volume":"9","author":"Roe","year":"2013","journal-title":"J Chem Theory Comput"},{"key":"10.1016\/j.mce.2024.112385_bib53","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0021-9258(17)43530-7","article-title":"Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035","volume":"259","author":"Ross","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112385_bib54","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1021\/acs.jctc.1c00195","article-title":"Q-force: quantum mechanically augmented molecular force fields","volume":"17","author":"Sami","year":"2021","journal-title":"J Chem Theory Comput"},{"key":"10.1016\/j.mce.2024.112385_bib55","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0021-9150(94)05392-V","article-title":"Acyl-coenzyme A:cholesterol-acyltransferase (ACAT) inhibitors modulate monocyte adhesion to aortic endothelial cells","volume":"112","author":"Saxena","year":"1995","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mce.2024.112385_bib56","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1210\/en.2015-1367","article-title":"Mitotane inhibits sterol-O-acyl transferase 1 triggering lipid-mediated endoplasmic reticulum stress and apoptosis in adrenocortical carcinoma cells","volume":"156","author":"Sbiera","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2024.112385_bib57","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mce.2016.03.022","article-title":"The adrenal specific toxicant mitotane directly interacts with lipid membranes and alters membrane properties depending on lipid composition","volume":"428","author":"Scheidt","year":"2016","journal-title":"Molec. Cell. Endocrin."},{"key":"10.1016\/j.mce.2024.112385_bib58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1745-7254.2008.00726.x","article-title":"The Interaction of small molecules with phospholipid membranes studied by 1H NOESY NMR under Magic-Angle Spinning","volume":"29","author":"Scheidt","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.mce.2024.112385_bib59","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbamem.2004.02.004","article-title":"Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy","volume":"1663","author":"Scheidt","year":"2004","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes."},{"key":"10.1016\/j.mce.2024.112385_bib60","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s10637-020-00899-1","article-title":"A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma","volume":"38","author":"Smith","year":"2020","journal-title":"Invest New Drugs"},{"key":"10.1016\/j.mce.2024.112385_bib61","first-page":"274","article-title":"De-pake-ing of NMR spectra","volume":"55","author":"Sternin","year":"1983","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.mce.2024.112385_bib62","doi-asserted-by":"crossref","first-page":"11621","DOI":"10.1021\/bi7011299","article-title":"The lipid composition modulates the influence of the bovine seminal plasma protein PDC-109 on membrane stability","volume":"46","author":"Tannert","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2024.112385_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112027","article-title":"Intestine-targeted DGAT1 inhibition improves obesity and insulin resistance without skin aberrations in mice","volume":"9","author":"Tsuda","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2024.112385_bib64","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/S0006-3495(03)74599-8","article-title":"The distribution of lipid attached spin probes in bilayers: application to membrane protein topology","volume":"85","author":"Vogel","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.mce.2024.112385_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2016.05.001","article-title":"Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis","volume":"378","author":"Wang","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mce.2024.112385_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114731","article-title":"Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: a systematic review and meta-analysis of preclinical models","volume":"196","author":"Websdale","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mce.2024.112385_bib67","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1016\/j.bbamem.2012.07.014","article-title":"Interaction of local anesthetics with lipid bilayers investigated by 1H MAS NMR spectroscopy","volume":"1818","author":"Weizenmann","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2024.112385_bib68","doi-asserted-by":"crossref","first-page":"32395","DOI":"10.1074\/jbc.R100008200","article-title":"How membranes shape protein structure","volume":"276","author":"White","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112385_bib69","doi-asserted-by":"crossref","first-page":"19306","DOI":"10.1074\/jbc.RA119.011160","article-title":"Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function","volume":"294","author":"Xu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112385_bib70","doi-asserted-by":"crossref","first-page":"21324","DOI":"10.1074\/jbc.M002541200","article-title":"Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia","volume":"275","author":"Yagyu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112385_bib71","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.mce.2024.112385_bib72","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature17412","article-title":"Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism","volume":"531","author":"Yang","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mce.2024.112385_bib73","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pharmthera.2008.03.010","article-title":"Diacylglycerol acyltransferases: potential roles as pharmacological targets","volume":"118","author":"Zammit","year":"2008","journal-title":"Pharmacol. Ther."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724002417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724002417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T03:46:51Z","timestamp":1730432811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720724002417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":75,"alternative-id":["S0303720724002417"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2024.112385","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of acyl-CoA:cholesterol transferase (ACAT) inhibitors on biophysical membrane properties depends on membrane lipid composition","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2024.112385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112385"}}