{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:47:03Z","timestamp":1788490023541,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.mce.2024.112406","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T12:39:52Z","timestamp":1730464792000},"page":"112406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["NLRP3 inhibitor alleviates glycemic variability-induced cognitive impairment in aged rats with type 2 diabetes mellitus"],"prefix":"10.1016","volume":"595","author":[{"given":"Wei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Cong","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2024.112406_bib1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.33012","article-title":"Assessment of advanced glycation end products and receptors and the risk of dementia","volume":"4","author":"Chen","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.mce.2024.112406_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2019.107911","article-title":"The relationship between glucose variability and insulin sensitivity and oxidative stress in subjects with prediabetes","volume":"158","author":"Dimova","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.mce.2024.112406_bib3","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16698","article-title":"Correlation between long-term glycemic variability and cognitive function in middle-aged and elderly patients with type 2 diabetes mellitus: a retrospective study","volume":"11","author":"Ding","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.mce.2024.112406_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1021351","article-title":"Neuropsychological decrements in midlife type-2 diabetes are not associated with peripheral NLRP3 inflammasome responsiveness","volume":"13","author":"Dyer","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2024.112406_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41386-021-01132-0","article-title":"The role of prefrontal cortex in cognitive control and executive function","volume":"47","author":"Friedman","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.mce.2024.112406_bib6","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.2337\/db15-0596","article-title":"Hippocampal insulin resistance impairs spatial learning and synaptic plasticity","volume":"64","author":"Grillo","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2024.112406_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/tri.13783","article-title":"Management of post-transplant diabetes: immunosuppression, early prevention, and novel antidiabetics","volume":"34","author":"Hecking","year":"2021","journal-title":"Transpl. Int."},{"key":"10.1016\/j.mce.2024.112406_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2012.02.018","article-title":"Advanced glycation end products and neurodegenerative diseases: mechanisms and perspective","volume":"317","author":"Li","year":"2012","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.mce.2024.112406_bib9","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s13300-022-01274-4","article-title":"Blood glucose fluctuation in older adults with diabetes mellitus and end-stage renal disease on maintenance hemodialysis: an observational study","volume":"13","author":"Li","year":"2022","journal-title":"Diabetes Ther"},{"key":"10.1016\/j.mce.2024.112406_bib10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fendo.2018.00174","article-title":"Cardiovascular autonomic neuropathy and glucose variability in patients with type 1 diabetes: is there an association?","volume":"9","author":"Nyiraty","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2024.112406_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8030319","article-title":"Association of glucose fluctuations with sarcopenia in older adults with type 2 diabetes mellitus","volume":"8","author":"Ogama","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mce.2024.112406_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1232629","article-title":"Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities","volume":"14","author":"Ortega","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2024.112406_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7489795","article-title":"Association of glycemic indices (hyperglycemia, glucose variability, and hypoglycemia) with oxidative stress and diabetic complications","volume":"2020","author":"Papachristoforou","year":"2020","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.mce.2024.112406_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4093\/dmj.2015.39.5.353","article-title":"Interaction between glucose and lipid metabolism: more than diabetic dyslipidemia","volume":"39","author":"Parhofer","year":"2015","journal-title":"Diabetes Metab. J"},{"key":"10.1016\/j.mce.2024.112406_bib15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2337\/db09-1495","article-title":"Recurrent moderate hypoglycemia ameliorates brain damage and cognitive dysfunction induced by severe hypoglycemia","volume":"59","author":"Puente","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2024.112406_bib16","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.18240\/ijo.2022.12.03","article-title":"Establishment of blood glucose control model in diabetic mice","volume":"15","author":"Rao","year":"2022","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.mce.2024.112406_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1219598","article-title":"Diabetic complications and prospective immunotherapy","volume":"14","author":"Reynolds","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2024.112406_bib18","doi-asserted-by":"crossref","first-page":"18381","DOI":"10.3390\/ijms151018381","article-title":"Glycemic variability and oxidative stress: a link between diabetes and cardiovascular disease?","volume":"15","author":"Saisho","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2024.112406_bib19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.4103\/2230-8210.113751","article-title":"Glycemic variability: clinical implications","volume":"17","author":"Satya Krishna","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"key":"10.1016\/j.mce.2024.112406_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94339-6","article-title":"Retrospective study of glycemic variability, BMI, and blood pressure in diabetes patients in the Digital Twin Precision Treatment Program","volume":"11","author":"Shamanna","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2024.112406_bib21","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1038\/s41467-017-02221-9","article-title":"Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a","volume":"8","author":"Spinelli","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2024.112406_bib22","doi-asserted-by":"crossref","DOI":"10.2174\/1573399816666200716201550","article-title":"Glycemic variability, oxidative stress, and impact on complications related to type 2 diabetes mellitus","volume":"17","author":"Valente","year":"2021","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.mce.2024.112406_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.phrs.2019.01.035","article-title":"NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia","volume":"142","author":"Ward","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mce.2024.112406_bib24","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jjcc.2016.07.001","article-title":"Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products","volume":"69","author":"Watanabe","year":"2017","journal-title":"J. Cardiol."},{"key":"10.1016\/j.mce.2024.112406_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/nu12123906","article-title":"Glycemic variability and CNS inflammation: reviewing the connection","volume":"12","author":"Watt","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2024.112406_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.7748\/ns2012.12.27.15.44.c9484","article-title":"Cognitive impairment in patients with diabetes","volume":"27","author":"Wilson","year":"2012","journal-title":"Nurs. Stand."},{"key":"10.1016\/j.mce.2024.112406_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.108968","article-title":"Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1)","volume":"709","author":"Wu","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mce.2024.112406_bib28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3233\/JAD-191217","article-title":"Glucose fluctuations are linked to disrupted brain functional architecture and cognitive impairment","volume":"74","author":"Xia","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.mce.2024.112406_bib29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mehy.2018.01.010","article-title":"Mismatch between GLUTs and glucose levels causes neuronal damage during glucose fluctuations","volume":"112","author":"Xie","year":"2018","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.mce.2024.112406_bib30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12902-021-00753-2","article-title":"Significant abnormal glycemic variability increased the risk for arrhythmias in elderly type 2 diabetic patients","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Endocr. Disord."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724002624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724002624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:51:41Z","timestamp":1778683901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720724002624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":30,"alternative-id":["S0303720724002624"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2024.112406","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NLRP3 inhibitor alleviates glycemic variability-induced cognitive impairment in aged rats with type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2024.112406","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112406"}}