{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:10:41Z","timestamp":1789834241758,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"am","delay-in-days":309,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA028761"],"award-info":[{"award-number":["R01AA028761"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK107583"],"award-info":[{"award-number":["R01DK107583"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.mce.2024.112407","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T08:15:24Z","timestamp":1730708124000},"page":"112407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["PRDM16 in thermogenic adipocytes mediates an inter-organ protective signaling against alcohol-associated liver disease"],"prefix":"10.1016","volume":"595","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-5196","authenticated-orcid":false,"given":"Shanshan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhou","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilai","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-5820","authenticated-orcid":false,"given":"Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2024.112407_bib1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/gutjnl-2011-301146","article-title":"Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis","volume":"62","author":"Affo","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.mce.2024.112407_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arcmed.2024.102986","article-title":"Role of angiotensin II in non-alcoholic steatosis development","volume":"55","author":"Alvarado-Ojeda","year":"2024","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.mce.2024.112407_bib3","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1038\/s41467-019-11004-3","article-title":"Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis","volume":"10","author":"Argemi","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2024.112407_bib4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mce.2024.112407_bib5","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.18713","article-title":"Trends in liver transplantation for acute alcohol-associated hepatitis during the COVID-19 pandemic in the US","volume":"4","author":"Bittermann","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.mce.2024.112407_bib6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.alcohol.2012.08.004","article-title":"Rodent models of alcoholic liver disease: of mice and men","volume":"46","author":"Brandon-Warner","year":"2012","journal-title":"Alcohol"},{"key":"10.1016\/j.mce.2024.112407_bib7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/HEP.0000000000000373","article-title":"Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis","volume":"78","author":"Chao","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2024.112407_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbalip.2018.05.014","article-title":"Brown and beige fat: from molecules to physiology","volume":"1864","author":"Chondronikola","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.mce.2024.112407_bib9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41580-021-00350-0","article-title":"The cellular and functional complexity of thermogenic fat","volume":"22","author":"Cohen","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2024.112407_bib10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.cell.2013.12.021","article-title":"Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch","volume":"156","author":"Cohen","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mce.2024.112407_bib11","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2024.112407_bib12","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jcmgh.2021.12.001","article-title":"Bile acid-mediated activation of Brown fat protects from alcohol-induced steatosis and liver injury in mice","volume":"13","author":"Fan","year":"2022","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2024.112407_bib13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112407_bib14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jhep.2018.10.023","article-title":"Inflammatory pathways in alcoholic steatohepatitis","volume":"70","author":"Gao","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2024.112407_bib15","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.jcmgh.2021.07.002","article-title":"Fatty acids inhibit LAMP2-mediated autophagy flux via activating ER stress pathway in alcohol-related liver disease","volume":"12","author":"Guo","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2024.112407_bib16","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/nm.4429","article-title":"UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis","volume":"23","author":"Ikeda","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.mce.2024.112407_bib17","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1042\/cs0660643","article-title":"Acute effects of moderate alcohol consumption on blood pressure and plasma catecholamines","volume":"66","author":"Ireland","year":"1984","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.mce.2024.112407_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/513787","article-title":"New insights into the pathogenesis of alcohol-induced ER stress and liver diseases","volume":"2014","author":"Ji","year":"2014","journal-title":"Int. J. Hepatol."},{"key":"10.1016\/j.mce.2024.112407_bib19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.devcel.2020.05.017","article-title":"Adrenergic-independent signaling via CHRNA2 regulates beige fat activation","volume":"54","author":"Jun","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mce.2024.112407_bib20","doi-asserted-by":"crossref","first-page":"28465","DOI":"10.1074\/jbc.M705503200","article-title":"Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation","volume":"282","author":"Kang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112407_bib21","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cell.2015.09.035","article-title":"A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat","volume":"163","author":"Kazak","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.mce.2024.112407_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/21623945.2015.1017170","article-title":"Effect of alcohol on adipose tissue: a review on ethanol mediated adipose tissue injury","volume":"4","author":"Kema","year":"2015","journal-title":"Adipocyte"},{"key":"10.1016\/j.mce.2024.112407_bib23","article-title":"Alcohol, white adipose tissue, and Brown adipose tissue: mechanistic links to lipogenesis and lipolysis","volume":"15","author":"Li","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2024.112407_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156727","article-title":"Growth differentiation factor 15: emerging role in liver diseases","volume":"182","author":"Li","year":"2024","journal-title":"Cytokine"},{"key":"10.1016\/j.mce.2024.112407_bib25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2024.112407_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/JCI176345","article-title":"Alcohol-associated liver disease","volume":"134","author":"Mackowiak","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2024.112407_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yexmp.2016.07.002","article-title":"Upregulation of autophagy components in alcoholic hepatitis and nonalcoholic steatohepatitis","volume":"101","author":"Masouminia","year":"2016","journal-title":"Exp. Mol. Pathol."},{"issue":"5","key":"10.1016\/j.mce.2024.112407_bib28","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/hep.32675","article-title":"Adipose lipolysis is important for ethanol to induce fatty liver in the National Institute on Alcohol Abuse and Alcoholism murine model of chronic and binge ethanol feeding","volume":"77","author":"Mathur","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2024.112407_bib29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrgastro.2017.116","article-title":"Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations","volume":"15","author":"Parker","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2024.112407_bib30","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1111\/acer.12558","article-title":"Stratification of risk of death in severe acute alcoholic hepatitis using a panel of adipokines and cytokines","volume":"38","author":"Rachakonda","year":"2014","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.mce.2024.112407_bib31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What we talk about when we talk about fat","volume":"156","author":"Rosen","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mce.2024.112407_bib32","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature07182","article-title":"PRDM16 controls a brown fat\/skeletal muscle switch","volume":"454","author":"Seale","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mce.2024.112407_bib33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1172\/JCI44271","article-title":"Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice","volume":"121","author":"Seale","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2024.112407_bib34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.mce.2024.112407_bib35","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1172\/JCI124376","article-title":"Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice","volume":"129","author":"Shen","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2024.112407_bib36","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1097\/MCG.0000000000001627","article-title":"The pandemic within the pandemic: unprecedented rise in alcohol-related hepatitis during the COVID-19 pandemic","volume":"56","author":"Sohal","year":"2022","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.mce.2024.112407_bib37","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000059","article-title":"mTORC1 inhibition uncouples lipolysis and thermogenesis in white adipose tissue to contribute to alcoholic liver disease","volume":"7","author":"Song","year":"2023","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.mce.2024.112407_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/biom7010016","article-title":"Alcohol, adipose tissue and lipid dysregulation","volume":"7","author":"Steiner","year":"2017","journal-title":"Biomolecules"},{"key":"10.1016\/j.mce.2024.112407_bib39","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1055\/s-0029-1214373","article-title":"\"Second hit\" models of alcoholic liver disease","volume":"29","author":"Tsukamoto","year":"2009","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.mce.2024.112407_bib40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4291\/wjgp.v7.i1.17","article-title":"Adipose tissue-liver axis in alcoholic liver disease","volume":"7","author":"Wang","year":"2016","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.mce.2024.112407_bib41","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.mce.2024.112407_bib42","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tig.2015.03.003","article-title":"Formation and activation of thermogenic fat","volume":"31","author":"Wu","year":"2015","journal-title":"Trends Genet."},{"key":"10.1016\/j.mce.2024.112407_bib43","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/hep.32612","article-title":"Macrophage-derived MLKL in alcohol-associated liver disease: regulation of phagocytosis","volume":"77","author":"Wu","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2024.112407_bib44","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","volume":"18","author":"Wu","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.mce.2024.112407_bib45","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1053\/j.gastro.2015.06.009","article-title":"Fat-specific protein 27\/CIDEC promotes development of alcoholic steatohepatitis in mice and humans","volume":"149","author":"Xu","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2024.112407_bib46","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000174","article-title":"Single ethanol binge causes severe liver injury in mice fed Western diet","volume":"7","author":"Yeh","year":"2023","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.mce.2024.112407_bib47","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1194\/jlr.M058610","article-title":"FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice","volume":"56","author":"Zhao","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.mce.2024.112407_bib48","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.ajpath.2011.11.017","article-title":"Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis","volume":"180","author":"Zhong","year":"2012","journal-title":"Am. J. Pathol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724002636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724002636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T08:59:16Z","timestamp":1732611556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720724002636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":48,"alternative-id":["S0303720724002636"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2024.112407","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PRDM16 in thermogenic adipocytes mediates an inter-organ protective signaling against alcohol-associated liver disease","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2024.112407","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112407"}}