{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:21:37Z","timestamp":1792419697428,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.mce.2024.112444","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T13:00:50Z","timestamp":1735045250000},"page":"112444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Endocrine-disrupting chemical, methylparaben, in environmentally relevant exposure promotes hazardous effects on the hypothalamus-pituitary-thyroid axis"],"prefix":"10.1016","volume":"598","author":[{"given":"Dam\u00e1ris Barcelos Cunha","family":"Azeredo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2910-5768","authenticated-orcid":false,"given":"Denilson de","family":"Sousa Anselmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Clara","family":"Falc\u00e3o Ver\u00edssimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0737-3240","authenticated-orcid":false,"given":"Luana Lopes de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-4364","authenticated-orcid":false,"given":"Patricia Cristina","family":"Lisboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Santos-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9349-4369","authenticated-orcid":false,"given":"Jones Bernardes","family":"Graceli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Pires de","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-961X","authenticated-orcid":false,"given":"D'Angelo","family":"Magliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-8717","authenticated-orcid":false,"given":"Leandro","family":"Miranda-Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mce.2024.112444_bib1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2133\/dmpk.DMPK-10-RG-013","article-title":"Metabolism of parabens (4-hydroxybenzoic acid esters) by hepatic esterases and UDP-glucuronosyltransferases in man","volume":"25","author":"Abbas","year":"2010","journal-title":"Drug Metabol. Pharmacokinet."},{"key":"10.1016\/j.mce.2024.112444_bib2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.envres.2016.07.002","article-title":"Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women","volume":"151","author":"Aker","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.mce.2024.112444_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-019-0459-5","article-title":"A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort","volume":"18","author":"Aker","year":"2019","journal-title":"Environ. Health"},{"issue":"Suppl. 4","key":"10.1016\/j.mce.2024.112444_bib4","first-page":"1","article-title":"Final amended report on the safety assessment of methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben, and benzylparaben as used in cosmetic products","volume":"27","author":"Andersen","year":"2008","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.mce.2024.112444_bib5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.envpol.2018.06.006","article-title":"The environmental contaminant tributyltin leads to abnormalities in different levels of the hypothalamus-pituitary-thyroid axis in female rats","volume":"241","author":"Andrade","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.mce.2024.112444_bib6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.envres.2017.03.030","article-title":"Assumed non-persistent environmental chemicals in human adipose tissue; matrix stability and correlation with levels measured in urine and serum","volume":"156","author":"Artacho-Cord\u00f3n","year":"2017","journal-title":"Environ. Res."},{"issue":"20","key":"10.1016\/j.mce.2024.112444_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015246","article-title":"Environmental endocrinology: parabens hazardous effects on hypothalamic\u2013pituitary\u2013thyroid Axis","volume":"24","author":"Azeredo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2024.112444_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105716","article-title":"Methylparaben in meconium and risk of maternal thyroid dysfunction, adverse birth outcomes, and Attention-Deficit Hyperactivity Disorder (ADHD)","volume":"139","author":"Baker","year":"2020","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.mce.2024.112444_bib9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1210\/endo.141.1.7282","article-title":"Characterization of the 5\u2032-flanking and 5\u2032-untranslated regions of the cyclic adenosine 3\u2032, 5\u2032-monophosphate-responsive human type 2 iodothyronine deiodinase gene","volume":"141","author":"Bartha","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2024.112444_bib10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.envres.2018.05.005","article-title":"Associations of maternal exposure to triclosan, parabens, and other phenols with prenatal maternal and neonatal thyroid hormone levels","volume":"165","author":"Berger","year":"2018","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.mce.2024.112444_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1089\/thy.2013.0109","article-title":"American Thyroid Association guide to investigating thyroid hormone economy and action in rodent and cell models: report of the American Thyroid Association Task Force on Approaches and Strategies to investigate thyroid hormone economy and action","volume":"24","author":"Bianco","year":"2014","journal-title":"Thyroid"},{"issue":"2","key":"10.1016\/j.mce.2024.112444_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.reprotox.2010.03.011","article-title":"Possible endocrine disrupting effects of parabens and their metabolites","volume":"30","author":"Boberg","year":"2010","journal-title":"Reprod. Toxicol."},{"issue":"9","key":"10.1016\/j.mce.2024.112444_bib13","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/jat.3810","article-title":"Thyroid disruption properties of three indoor dust chemicals tested in Silurana tropicalis tadpoles","volume":"39","author":"Carlsson","year":"2019","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.mce.2024.112444_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.mce.2017.01.038","article-title":"Thyroid hormone biosynthesis and release","volume":"458","author":"Carvalho","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"issue":"6","key":"10.1016\/j.mce.2024.112444_bib15","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1067\/msy.1998.92008","article-title":"Overexpression of TTF-1 and PAX-8 restores thyroglobulin gene promoter activity in ARO and WRO cell lines","volume":"124","author":"Chun","year":"1998","journal-title":"Surgery"},{"key":"10.1016\/j.mce.2024.112444_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114778","article-title":"Adverse effects of in vitro GenX exposure on rat thyroid cell viability, DNA integrity and thyroid-related genes expression","volume":"264","author":"Coperchini","year":"2020","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.mce.2024.112444_bib17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.yrtph.2009.08.004","article-title":"Refining aggregate exposure: example using parabens","volume":"55","author":"Cowan-Ellsberry","year":"2009","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.mce.2024.112444_bib18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ecoenv.2017.02.048","article-title":"Developmental toxicity and induction of vitellogenin in embryo-larval stages of zebrafish (Danio rerio) exposed to methyl Paraben","volume":"141","author":"Dambal","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.mce.2024.112444_bib19","article-title":"Deiodinases in thyroid tumorigenesis","volume":"30","author":"de Stefano","year":"2023","journal-title":"Endocr. Relat. Cancer"},{"issue":"1","key":"10.1016\/j.mce.2024.112444_bib20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1210\/er.2001-0029","article-title":"The sodium\/iodide symporter (NIS): characterization, regulation, and medical significance","volume":"24","author":"Dohan","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2024.112444_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108445","article-title":"Methylparaben induces hepatic glycolipid metabolism disorder by activating the IRE1\u03b1-XBP1 signaling pathway in male mice","volume":"184","author":"du","year":"2024","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.mce.2024.112444_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2903\/j.efsa.2004.83","article-title":"Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to para hydroxybenzoates (E 214\u2013219)","volume":"2","year":"2004","journal-title":"EFSA J."},{"issue":"3","key":"10.1016\/j.mce.2024.112444_bib23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1042\/bj2470519","article-title":"Thyroid-stimulating hormone stimulates increases in inositol phosphates as well as cyclic AMP in the FRTL-5 rat thyroid cell line","volume":"247","author":"Field","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/j.mce.2024.112444_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152562","article-title":"Effects of butylparaben exposure on thyroid peroxidase (TPO) and type 1 iodothyronine deiodinase (D1) in female Wistar rats","volume":"443","author":"Gogoi","year":"2020","journal-title":"Toxicology"},{"issue":"S8","key":"10.1016\/j.mce.2024.112444_bib25","doi-asserted-by":"crossref","first-page":"216S","DOI":"10.1038\/oby.2006.312","article-title":"Distributed neural control of energy balance: contributions from hindbrain and hypothalamus","volume":"14","author":"Grill","year":"2006","journal-title":"Obesity"},{"issue":"24","key":"10.1016\/j.mce.2024.112444_bib26","doi-asserted-by":"crossref","first-page":"14442","DOI":"10.1021\/es4042034","article-title":"A survey of phthalates and parabens in personal care products from the United States and its implications for human exposure","volume":"47","author":"Guo","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.mce.2024.112444_bib27","series-title":"Guyton & Hall. Tratado de fisiolog\u00eda m\u00e9dica","year":"2021"},{"key":"10.1016\/j.mce.2024.112444_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.watres.2014.09.030","article-title":"Occurrence, fate and behavior of parabens in aquatic environments: a review","volume":"68","author":"Haman","year":"2015","journal-title":"Water Res."},{"issue":"6","key":"10.1016\/j.mce.2024.112444_bib29","doi-asserted-by":"crossref","first-page":"485","DOI":"10.5603\/EP.2014.0068","article-title":"Effect of tributyltin on the food intake and brain neuropeptide expression in rats","volume":"65","author":"He","year":"2014","journal-title":"Endokrynol. Pol."},{"issue":"6","key":"10.1016\/j.mce.2024.112444_bib30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nrendo.2017.40","article-title":"Chemical contaminants\u2014a toxic mixture for neurodevelopment","volume":"13","author":"Hernandez","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.mce.2024.112444_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/bdrb.20153","article-title":"Lack of effect of butylparaben and methylparaben on the reproductive system in male rats","volume":"83","author":"Hoberman","year":"2008","journal-title":"Birth Defects Res. Part B Dev. Reproductive Toxicol."},{"issue":"1","key":"10.1016\/j.mce.2024.112444_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/toxsci\/kfs262","article-title":"Effects of parabens on adipocyte differentiation","volume":"131","author":"Hu","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.mce.2024.112444_bib33","doi-asserted-by":"crossref","first-page":"21957","DOI":"10.1007\/s11356-016-7452-0","article-title":"Differential effects on adiposity and serum marker of bone formation by post-weaning exposure to methylparaben and butylparaben","volume":"23","author":"Hu","year":"2016","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.mce.2024.112444_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114502","article-title":"Maternal paraben exposure and intra-pair thyroid-stimulating hormone difference in twin neonates","volume":"250","author":"Hu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.mce.2024.112444_bib35","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2605.2007.00841.x","article-title":"Urinary excretion of phthalates and paraben after repeated whole\u2010body topical application in humans","volume":"31","author":"Janjua","year":"2008","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.mce.2024.112444_bib36","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.envres.2015.12.032","article-title":"Urinary concentrations of parabens and their association with demographic factors: a population-based cross-sectional study","volume":"146","author":"Kang","year":"2016","journal-title":"Environ. Res."},{"issue":"5","key":"10.1016\/j.mce.2024.112444_bib37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/10937404.2013.809252","article-title":"Potential impact of low-affinity estrogen receptor binding chemicals on human health","volume":"16","author":"Karpuzoglu","year":"2013","journal-title":"J. Toxicol. Environ. Health, Part A B"},{"issue":"2","key":"10.1016\/j.mce.2024.112444_bib38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.watres.2008.10.047","article-title":"The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters","volume":"43","author":"Kasprzyk-Hordern","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.mce.2024.112444_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109710","article-title":"Effects of prenatal exposure to five parabens on neonatal thyroid function and birth weight: evidence from SMBCS study","volume":"188","author":"Li","year":"2020","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.mce.2024.112444_bib40","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1021\/acs.est.1c06562","article-title":"Assessment of thyroid endocrine disruption effects of parabens using in vivo, in vitro, and in silico approaches","volume":"56","author":"Liang","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.mce.2024.112444_bib41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.envint.2013.04.001","article-title":"Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure","volume":"57","author":"Liao","year":"2013","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.mce.2024.112444_bib42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"5","key":"10.1016\/j.mce.2024.112444_bib43","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1210\/er.2003-0028","article-title":"Thyroid development and its disorders: genetics and molecular mechanisms","volume":"25","author":"de Felice","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2024.112444_bib44","series-title":"Fisiologia End\u00f3crina-5","author":"Molina","year":"2021"},{"key":"10.1016\/j.mce.2024.112444_bib45","series-title":"Resolution RDC No. 29, Dated June 1, 2012. Approves the Mercosur Technical Regulation on \"List of Preservative Action Substances Permitted for Personal Hygiene Products, Cosmetics, and Perfumes\" and Provides Other Provisions","first-page":"81","year":"2012"},{"key":"10.1016\/j.mce.2024.112444_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113893","article-title":"Investigation of estrogen-like effects of parabens on human neutrophils","volume":"214","author":"Nowak","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.mce.2024.112444_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113142","article-title":"Parabens in breast milk and possible sources of exposure among lactating women in Korea","volume":"255","author":"Park","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.mce.2024.112444_bib48","doi-asserted-by":"crossref","first-page":"45534","DOI":"10.1007\/s11356-021-12800-5","article-title":"CToxicity and sublethal effects of methylparaben on zebrafish (Danio rerio) larvae and adults","volume":"28","author":"Penha","year":"2021","journal-title":"Environ. Sci. Pollut. Control Ser."},{"issue":"10","key":"10.1016\/j.mce.2024.112444_bib49","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1289\/ehp.1206335","article-title":"Prenatal exposure to environmental phenols: concentrations in amniotic fluid and variability in urinary concentrations during pregnancy","volume":"121","author":"Philippat","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.mce.2024.112444_bib50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1039\/C2TX20005H","article-title":"Triclosan interferes with the thyroid axis in the zebrafish (Danio rerio)","volume":"2","author":"Pinto","year":"2013","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.mce.2024.112444_bib51","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1016\/j.toxlet.2011.05.768","article-title":"Study of oxidative stress induction after exposure to bisphenol a and methylparaben in rats","volume":"205","author":"Popa","year":"2011","journal-title":"Toxicol. Lett."},{"issue":"12","key":"10.1016\/j.mce.2024.112444_bib52","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.3390\/ijms17122086","article-title":"Estrogenic endocrine disrupting chemicals influencing NRF1 regulated gene networks in the development of complex human brain diseases","volume":"17","author":"Preciados","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.mce.2024.112444_bib53","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-physiol-022516-034125","article-title":"The sodium\/iodide symporter (NIS): molecular physiology and preclinical and clinical applications","volume":"79","author":"Ravera","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mce.2024.112444_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112376","article-title":"Personal care products: demographic characteristics and maternal hormones in pregnant women from Puerto Rico","volume":"206","author":"Rivera-N\u00fa\u00f1ez","year":"2022","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.mce.2024.112444_bib55","first-page":"1","article-title":"Influence of organotin on thyroid morphophysiological status","volume":"1","author":"Rodrigues-Pereira","year":"2015","journal-title":"J. Environ. Health Sci."},{"key":"10.1016\/j.mce.2024.112444_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110677","article-title":"Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats","volume":"502","author":"Rodrigues-Pereira","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2024.112444_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2022.109279","article-title":"Subacute and low-dose tributyltin exposure disturbs the mammalian hypothalamus-pituitary-thyroid axis in a sex-dependent manner","volume":"254","author":"Rodrigues-Pereira","year":"2022","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"issue":"7","key":"10.1016\/j.mce.2024.112444_bib60","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.fct.2005.01.020","article-title":"BURDOCK, GA15833376. Safety assessment of esters of p-hydroxybenzoic acid (parabens)","volume":"43","author":"Soni","year":"2005","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.mce.2024.112444_bib61","article-title":"The estrogenicity of methylparaben and ethylparaben at doses close to the acceptable daily intake in immature Sprague-Dawley rats","volume":"6","author":"Sun","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.mce.2024.112444_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22521","article-title":"Combined approaches for evaluation of xenoestrogen neural toxicity and thyroid dysfunction: screening of oxido\u2010nitrosative markers, DNA fragmentation, and biogenic amine degradation","volume":"34","author":"Taha","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.mce.2024.112444_bib63","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.seizure.2015.07.021","article-title":"Thyroid hormones: possible roles in epilepsy pathology","volume":"31","author":"Tamijani","year":"2015","journal-title":"Seizure"},{"issue":"2","key":"10.1016\/j.mce.2024.112444_bib64","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.beem.2017.03.006","article-title":"Iodide handling disorders (nis, tpo, tg, iyd)","volume":"31","author":"Targovnik","year":"2017","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.mce.2024.112444_bib65","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfn148","article-title":"Do parabens have the ability to interfere with steroidogenesis?","volume":"106","author":"Taxvig","year":"2008","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.mce.2024.112444_bib66","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqad007","article-title":"Chronic exposure to low levels of parabens increases mammary cancer growth and metastasis in mice","volume":"164","author":"Tong","year":"2023","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2024.112444_bib67","series-title":"Corpo Humano-: Fundamentos de Anatomia e Fisiologia","author":"Tortora","year":"2016"},{"issue":"S1","key":"10.1016\/j.mce.2024.112444_bib68","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1111\/j.1440-1746.1995.tb01798.x","article-title":"Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis","volume":"10","author":"Tsukamoto","year":"1995","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2024.112444_bib69","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.envint.2015.12.034","article-title":"Determination of parabens and benzophenone-type UV filters in human placenta. First description of the existence of benzyl paraben and benzophenone-4","volume":"88","author":"Valle-Sistac","year":"2016","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.mce.2024.112444_bib70","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.reprotox.2010.01.013","article-title":"Potential estrogenic effect (s) of parabens at the prepubertal stage of a postnatal female rat model","volume":"29","author":"Vo","year":"2010","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.mce.2024.112444_bib71","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/toxsci\/67.2.207","article-title":"Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium","volume":"67","author":"Wade","year":"2002","journal-title":"Toxicol. Sci."},{"issue":"21","key":"10.1016\/j.mce.2024.112444_bib72","doi-asserted-by":"crossref","first-page":"11584","DOI":"10.1021\/es303516u","article-title":"Occurrence and human exposure of p-hydroxybenzoic acid esters (parabens), bisphenol A diglycidyl ether (BADGE), and their hydrolysis products in indoor dust from the United States and three East Asian countries","volume":"46","author":"Wang","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"46","key":"10.1016\/j.mce.2024.112444_bib73","doi-asserted-by":"crossref","first-page":"70125","DOI":"10.1007\/s11356-022-20741-w","article-title":"Risk of thyroid cancer and benign nodules associated with exposure to parabens among Chinese adults in Wuhan, China","volume":"29","author":"Wu","year":"2022","journal-title":"Environ. Sci. Pollut. Control Ser."},{"issue":"12","key":"10.1016\/j.mce.2024.112444_bib74","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1289\/ehp.9413","article-title":"Parabens as urinary biomarkers of exposure in humans","volume":"114","author":"Ye","year":"2006","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"10.1016\/j.mce.2024.112444_bib75","first-page":"4230","article-title":"Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters","volume":"12","author":"Zannini","year":"1992","journal-title":"Mol. Cell Biol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724003009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724003009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T03:40:02Z","timestamp":1740368402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720724003009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":73,"alternative-id":["S0303720724003009"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2024.112444","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endocrine-disrupting chemical, methylparaben, in environmentally relevant exposure promotes hazardous effects on the hypothalamus-pituitary-thyroid axis","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2024.112444","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112444"}}