{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:39:44Z","timestamp":1792766384857,"version":"4.5.0"},"reference-count":133,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.mce.2025.112524","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T13:13:46Z","timestamp":1742994826000},"page":"112524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["An endocrinological perspective on polycystic ovarian syndrome"],"prefix":"10.1016","volume":"602","author":[{"given":"Smarto","family":"Basak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9544-4058","authenticated-orcid":false,"given":"Amit Kumar","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit Kumar","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalrin","family":"Puia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manajit","family":"Bora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar Y.R.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajji","family":"Babu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2025.112524_bib1","doi-asserted-by":"crossref","first-page":"e4275","DOI":"10.1210\/clinem\/dgab422","article-title":"Targeting elevated GnRH pulsatility to treat polycystic ovary syndrome","volume":"106","author":"Abbara","year":"2021","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib2","series-title":"StatPearls","article-title":"Physiology, prolactin","author":"Al-Chalabi","year":"2024"},{"key":"10.1016\/j.mce.2025.112524_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbrc.2019.04.126","article-title":"Biochemical and histological evidence of thyroid gland dysfunction in estradiol valerate model of the polycystic ovary in Wistar rats","volume":"514","author":"Alzahrani","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2025.112524_bib4","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1210\/jc.2006-1066","article-title":"Estradiol and regulation of anti-m\u00fcllerian hormone, inhibin-A, and inhibin-B secretion: analysis of small antral and preovulatory human follicles' fluid","volume":"91","author":"Andersen","year":"2006","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib5","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.1096\/fj.201802653RR","article-title":"Dysregulation of hypothalamic\u2010pituitary estrogen receptor \u03b1\u2013mediated signaling causes episodic LH secretion and cystic ovary","volume":"33","author":"Arao","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.mce.2025.112524_bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mce.2016.03.039","article-title":"The spatiotemporal hormonal orchestration of human folliculogenesis, early embryogenesis and blastocyst implantation","volume":"430","author":"Atwood","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib7","first-page":"18","article-title":"The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS","volume":"6","author":"Baculescu","year":"2013","journal-title":"J Med Life"},{"key":"10.1016\/j.mce.2025.112524_bib8","series-title":"Polycystic Ovary Syndrome","year":"2005"},{"key":"10.1016\/j.mce.2025.112524_bib9","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.1471-0528.1993.tb15170.x","article-title":"Hypersecretion of luteinising hormone: a significant cause of infertility and miscarriage","volume":"100","author":"Balen","year":"1993","journal-title":"BJOG"},{"key":"10.1016\/j.mce.2025.112524_bib10","first-page":"328","article-title":"Depression, anxiety, and anger in patients with polycystic ovary syndrome","volume":"51","author":"Balikci","year":"2014","journal-title":"Noro Psikiyatr Ars"},{"key":"10.1016\/j.mce.2025.112524_bib11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jsbmb.2009.12.010","article-title":"Insulin and hyperandrogenism in women with polycystic ovary syndrome","volume":"122","author":"Baptiste","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2025.112524_bib12","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/humupd\/dmu012","article-title":"Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"20","author":"Barry","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2025.112524_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2024.109489","article-title":"Rodent models in polycystic ovarian syndrome: dissecting reproductive and metabolic phenotypes for therapeutic advancements","volume":"211","author":"Basak","year":"2024","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2025.112524_bib14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12905-018-0658-1","article-title":"Polycystic ovary syndrome and its impact on Iranian women's quality of life: a population-based study","volume":"18","author":"Behboodi Moghadam","year":"2018","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.mce.2025.112524_bib15","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.jaad.2018.08.062","article-title":"Androgens in women","volume":"80","author":"Bienenfeld","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.mce.2025.112524_bib16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1055\/s-2007-984741","article-title":"Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female puberty","volume":"25","author":"Blank","year":"2007","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.mce.2025.112524_bib17","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1210\/en.2019-00038","article-title":"Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus","volume":"160","author":"Brown","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112524_bib18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s12020-018-1692-3","article-title":"Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"62","author":"Brutocao","year":"2018","journal-title":"Endocrine"},{"key":"10.1016\/j.mce.2025.112524_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13048-022-01072-3","article-title":"Past and present: a bibliometric study on polycystic ovary syndrome","volume":"16","author":"Cai","year":"2023","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.mce.2025.112524_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13115","article-title":"Highlights of neuroanatomical discoveries of the mammalian gonadotropin\u2010releasing hormone system","volume":"34","author":"Campbell","year":"2022","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib21","series-title":"StatPearls","article-title":"Physiology, gonadotropin-releasing hormone","author":"Casteel","year":"2024"},{"key":"10.1016\/j.mce.2025.112524_bib22","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.fertnstert.2005.01.096","article-title":"Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups","volume":"83","author":"Chang","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112524_bib23","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.12659\/MSM.910743","article-title":"A retrospective study of letrozole treatment prior to human chorionic gonadotropin in women with polycystic ovary syndrome undergoing in vitro fertilization at risk of ovarian hyperstimulation syndrome","volume":"24","author":"Chen","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.mce.2025.112524_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1291856","article-title":"Receptor modulators associated with the hypothalamus -pituitary-thyroid axis","volume":"14","author":"Cheng","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mce.2025.112524_bib25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.peptides.2018.07.008","article-title":"Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin","volume":"107","author":"Christen","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.mce.2025.112524_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1210\/jc.2008-1492","article-title":"Polycystic ovary syndrome is associated with tissue-specific differences in insulin resistance","volume":"94","author":"Ciaraldi","year":"2009","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10055","article-title":"Novel role for anti-M\u00fcllerian hormone in the regulation of GnRH neuron excitability and hormone secretion","volume":"7","author":"Cimino","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2025.112524_bib28","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/humrep\/dex044","article-title":"High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"32","author":"Cooney","year":"2017","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2025.112524_bib29","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1210\/en.2005-0213","article-title":"Estrogen receptor-\u03b2 is critical to granulosa cell differentiation and the ovulatory response to gonadotropins","volume":"146","author":"Couse","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112524_bib30","first-page":"84","article-title":"The role of the brain in the pathogenesis and physiology of polycystic ovary syndrome (PCOS)","volume":"7","author":"Coutinho","year":"2019","journal-title":"Med. Sci."},{"key":"10.1016\/j.mce.2025.112524_bib31","first-page":"4179","article-title":"Resistance of gonadotropin releasing hormone drive to sex steroid-induced suppression in hyperandrogenic Anovulation1","volume":"82","author":"Daniels","year":"1997","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s13679-017-0240-4","article-title":"Endocrine disruptors and obesity","volume":"6","author":"Darbre","year":"2017","journal-title":"Curr Obes Rep"},{"key":"10.1016\/j.mce.2025.112524_bib33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12958-017-0313-y","article-title":"Risks, benefits size and clinical implications of combined oral contraceptive use in women with polycystic ovary syndrome","volume":"15","author":"De Medeiros","year":"2017","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib34","doi-asserted-by":"crossref","DOI":"10.1177\/1179558119871921","article-title":"PCOS and Hyperprolactinemia: what do we know in 2019?","volume":"13","author":"Delcour","year":"2019","journal-title":"Clin Med Insights Reprod Health"},{"key":"10.1016\/j.mce.2025.112524_bib35","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.fertnstert.2009.03.004","article-title":"Increased anti-M\u00fcllerian hormone and decreased FSH levels in follicular fluid obtained in women with polycystic ovaries at the time of follicle puncture for in vitro fertilization","volume":"94","author":"Desforges-Bullet","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112524_bib36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/humupd\/dmw027","article-title":"Interactions between androgens, FSH, anti-M\u00fcllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary","volume":"22","author":"Dewailly","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2025.112524_bib37","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ejogrb.2004.06.024","article-title":"PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic\u2013pituitary\u2013adrenal axis?","volume":"118","author":"Doi","year":"2005","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.mce.2025.112524_bib38","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1590\/2359-3997000000230","article-title":"Interactions between prolactin and kisspeptin to control reproduction","volume":"60","author":"Donato","year":"2016","journal-title":"Arch. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2025.112524_bib39","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2025.112524_bib40","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1210\/endo.143.3.8691","article-title":"Anti-m\u00fcllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary","volume":"143","author":"Durlinger","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112524_bib41","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1210\/endo.142.11.8486","article-title":"Anti-m\u00fcllerian hormone attenuates the effects of FSH on follicle development in the mouse ovary","volume":"142","author":"Durlinger","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112524_bib42","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1530\/eje.0.1450619","article-title":"Receiver operating characteristic analysis of the performance of basal serum hormone profiles for the diagnosis of polycystic ovary syndrome in epidemiological studies","author":"Escobar-Morreale","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/410348","article-title":"A two-pathway mathematical model of the LH response to GnRH that predicts self-priming","author":"Evans","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib44","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1210\/jcem-73-4-811","article-title":"Serum bioactive and immunoreactive luteinizing hormone and follicle-stimulating hormone levels in women with cycle abnormalities, with or without polycystic ovarian disease","volume":"73","author":"Fauser","year":"1991","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib45","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group","volume":"97","author":"Fauser","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112524_bib46","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1210\/en.2004-1326","article-title":"Progesterone increases dynorphin A concentrations in cerebrospinal fluid and preprodynorphin messenger ribonucleic acid levels in a subset of dynorphin neurons in the sheep","volume":"146","author":"Foradori","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112524_bib47","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/09513590.2016.1276555","article-title":"Daytime decrease of prolactin levels is associated with PCOS regardless to nutritional status and other hormones levels","volume":"33","author":"Franik","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120086","article-title":"Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor \u03b1 improve ovarian functions in letrozole-induced rat polycystic ovary syndrome","volume":"295","author":"Ghosh","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2025.112524_bib49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1365-2265.1997.2321049.x","article-title":"Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome","volume":"47","author":"Gilling\u2010Smith","year":"1997","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib50","first-page":"1158","article-title":"Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries","volume":"79","author":"Gilling-Smith","year":"1994","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13094","article-title":"Neuroendocrine control of gonadotropin\u2010releasing hormone: pulsatile and surge modes of secretion","volume":"34","author":"Goodman","year":"2022","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/09513590.2017.1379499","article-title":"Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?","volume":"34","author":"Gorkem","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib53","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1365-2826.2008.01736.x","article-title":"Prolactin: a pleiotropic neuroendocrine hormone","volume":"20","author":"Grattan","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib54","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.fertnstert.2022.03.009","article-title":"Polycystic ovary syndrome: a \u201crisk-enhancing\u201d factor for cardiovascular disease","volume":"117","author":"Guan","year":"2022","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112524_bib55","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1210\/jcem-51-2-242","article-title":"Correlation of hyperprolactinemia with altered plasma insulin and glucagon: similarity to effects of late human pregnancy","volume":"51","author":"Gustafson","year":"1980","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib56","series-title":"Comprehensive Physiology","first-page":"603","article-title":"Regulation of the hypothalamic\u2010pituitary\u2010adrenocortical stress response","author":"Herman","year":"2016"},{"key":"10.1016\/j.mce.2025.112524_bib57","first-page":"723","volume":"vol. 61","author":"Himelein","year":"2006"},{"key":"10.1016\/j.mce.2025.112524_bib58","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/bmj.297.6655.1024","article-title":"Influence of serum luteinising hormone concentrations on ovulation, conception, and early pregnancy loss in polycystic ovary syndrome","volume":"297","author":"Homburg","year":"1988","journal-title":"Br. Med. J."},{"key":"10.1016\/j.mce.2025.112524_bib59","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/humrep\/deu076","article-title":"The role of AMH in anovulation associated with PCOS: a hypothesis","volume":"29","author":"Homburg","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2025.112524_bib60","first-page":"1318","article-title":"Luteinizing hormone receptor, steroidogenesis acute regulatory protein, and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic Ovaries1","volume":"86","author":"Jakimiuk","year":"2001","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib61","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/09513590.2017.1395841","article-title":"Treatment strategies for women with polycystic ovary syndrome","volume":"34","author":"Jin","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib62","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S2213-8587(22)00163-2","article-title":"Polycystic ovary syndrome","volume":"10","author":"Joham","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib63","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.2169\/internalmedicine.50.5475","article-title":"A 27-year-old woman diagnosed as polycystic ovary syndrome associated with graves' disease","volume":"50","author":"Jung","year":"2011","journal-title":"Intern. Med."},{"key":"10.1016\/j.mce.2025.112524_bib64","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1172\/JCI64455","article-title":"Hyperprolactinemia and infertility: new insights","volume":"122","author":"Kaiser","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112524_bib65","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.ph.49.030187.002053","article-title":"Central actions of ovarian steroids in the feedback regulation of pulsatile secretion of luteinizing hormone","volume":"49","author":"Karsch","year":"1987","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mce.2025.112524_bib66","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13643-019-0962-3","article-title":"Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"8","author":"Kite","year":"2019","journal-title":"Syst. Rev."},{"key":"10.1016\/j.mce.2025.112524_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/8427150","article-title":"The influence of treated and untreated subclinical hypothyroidism on metabolic profile in women with polycystic ovary syndrome","author":"Kowalczyk","year":"2021","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib68","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1365-2265.2005.02256.x","article-title":"Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS)","volume":"62","author":"Kumar","year":"2005","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib69","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0974-1208.82351","article-title":"Luteinizing hormone and its dilemma in ovulation induction","volume":"4","author":"Kumar","year":"2011","journal-title":"J. Hum. Reprod. Sci."},{"key":"10.1016\/j.mce.2025.112524_bib70","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1210\/jc.2003-030932","article-title":"Anti-m\u00fcllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age","volume":"89","author":"Laven","year":"2004","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/GRF.0000000000000563","article-title":"Clinical presentation and diagnosis of polycystic ovarian syndrome","volume":"64","author":"Lentscher","year":"2021","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2025.112524_bib72","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1467-789X.2012.01053.x","article-title":"The effect of obesity on polycystic ovary syndrome: a systematic review and meta\u2010analysis","volume":"14","author":"Lim","year":"2013","journal-title":"Obes. Rev."},{"key":"10.1016\/j.mce.2025.112524_bib73","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","article-title":"Criteria, prevalence, and phenotypes of polycystic ovary syndrome","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112524_bib74","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0300-595X(86)80021-4","article-title":"1 Adrenal and gonadal androgen secretion in normal females","volume":"15","author":"Longcope","year":"1986","journal-title":"Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib75","series-title":"Adverse Effects of Engineered Nanomaterials","first-page":"339","article-title":"Endocrine system","author":"Lu","year":"2017"},{"key":"10.1016\/j.mce.2025.112524_bib76","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.coemr.2020.04.005","article-title":"Abnormal GnRH pulsatility in polycystic ovary syndrome: recent insights","volume":"12","author":"McCartney","year":"2020","journal-title":"Curr. Opin. Endocr. Metabol. Res."},{"key":"10.1016\/j.mce.2025.112524_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13093","article-title":"The role of gonadotropin\u2010releasing hormone neurons in polycystic ovary syndrome","volume":"34","author":"McCartney","year":"2022","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib78","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/humrep\/deaa144","article-title":"Associations between polycystic ovary syndrome and adverse obstetric and neonatal outcomes: a population study of 9.1 million births","volume":"35","author":"Mills","year":"2020","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2025.112524_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yfrne.2017.05.002","article-title":"Polycystic ovary syndrome: understanding the role of the brain","volume":"46","author":"Moore","year":"2017","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib80","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jsbmb.2015.10.002","article-title":"The neuroendocrine genesis of polycystic ovary syndrome: a role for arcuate nucleus GABA neurons","volume":"160","author":"Moore","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2025.112524_bib81","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1210\/mend.13.6.0311","article-title":"Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries","volume":"13","author":"Nelson","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib82","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1210\/jcem.86.12.8088","article-title":"The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome","volume":"86","author":"Nelson","year":"2001","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib83","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.psym.2019.11.002","article-title":"Neuroendocrine disturbances in neurodegenerative disorders: a scoping review","volume":"61","author":"Newhouse","year":"2020","journal-title":"Psychosomatics"},{"key":"10.1016\/j.mce.2025.112524_bib84","series-title":"StatPearls","article-title":"Physiology, follicle stimulating hormone","author":"Orlowski","year":"2024"},{"key":"10.1016\/j.mce.2025.112524_bib85","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0015-0282(02)03111-4","article-title":"Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus","volume":"77","author":"Ovalle","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112524_bib86","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/10253890.2017.1369523","article-title":"Hypothalamic\u2013pituitary\u2013adrenal and hypothalamic\u2013pituitary\u2013gonadal axes: sex differences in regulation of stress responsivity","volume":"20","author":"Oyola","year":"2017","journal-title":"Stress"},{"key":"10.1016\/j.mce.2025.112524_bib87","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1093\/humrep\/deab181","article-title":"Is fertility reduced in ovulatory women with polycystic ovary syndrome? An opinion paper","volume":"36","author":"Palomba","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2025.112524_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1251866","article-title":"Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature","volume":"14","author":"Palomba","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib89","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tem.2016.11.008","article-title":"Oocyte competence in women with polycystic ovary syndrome","volume":"28","author":"Palomba","year":"2017","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib90","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/humupd\/dmaa051","article-title":"Endometrial function in women with polycystic ovary syndrome: a comprehensive review","volume":"27","author":"Palomba","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2025.112524_bib91","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1093\/humrep\/del267","article-title":"Uterine effects of clomiphene citrate in women with polycystic ovary syndrome: a prospective controlled study","volume":"21","author":"Palomba","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2025.112524_bib92","first-page":"582","article-title":"Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and Progesterone1","volume":"83","author":"Pastor","year":"1998","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib93","article-title":"The contribution of hyperinsulinemia to the hyperandrogenism of polycystic ovary syndrome","volume":"4","author":"Pateguana","year":"2019","journal-title":"JMH"},{"key":"10.1016\/j.mce.2025.112524_bib94","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1186\/s12889-021-12280-9","article-title":"Effectiveness of exercise interventions on mental health and health-related quality of life in women with polycystic ovary syndrome: a systematic review","volume":"21","author":"Patten","year":"2021","journal-title":"BMC Public Health"},{"key":"10.1016\/j.mce.2025.112524_bib95","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.fertnstert.2011.08.015","article-title":"Anti-M\u00fcllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells","volume":"96","author":"Pellatt","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112524_bib96","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1530\/REP-09-0415","article-title":"Anti-M\u00fcllerian hormone and polycystic ovary syndrome: a mountain too high?","volume":"139","author":"Pellatt","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2025.112524_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146574","article-title":"Leptin actions through the nitrergic system to modulate the hypothalamic expression of the kiss1 mRNA in the female rat","volume":"1728","author":"Petrine","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2025.112524_bib98","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1210\/en.2005-1029","article-title":"Androgens increase gonadotropin-releasing hormone neuron firing activity in females and interfere with progesterone negative feedback","volume":"147","author":"Pielecka","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112524_bib99","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1038\/s41598-024-58064-0","article-title":"Mechanism of elevated LH\/FSH ratio in lean PCOS revisited: a path analysis","volume":"14","author":"Pratama","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2025.112524_bib100","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1210\/er.2012-1003","article-title":"Cardiometabolic aspects of the polycystic ovary syndrome","volume":"33","author":"Randeva","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2025.112524_bib101","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1056\/NEJM199602083340607","article-title":"Hypertension and associated metabolic abnormalities \u2014 the role of insulin resistance and the sympathoadrenal system","volume":"334","author":"Reaven","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2025.112524_bib102","series-title":"Encyclopedia of Analytical Science","first-page":"495","article-title":"Endocrine disrupting chemicals","author":"Regan","year":"2005"},{"key":"10.1016\/j.mce.2025.112524_bib103","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0140-6736(90)92765-A","article-title":"Hypersecretion of luteinising hormone, infertility, and miscarriage","volume":"336","author":"Regan","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.mce.2025.112524_bib104","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1073\/pnas.92.5.1322","article-title":"Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors","volume":"92","author":"Risma","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.mce.2025.112524_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031305","article-title":"Prolactin secretion in healthy adults is determined by gender, age and body mass index","volume":"7","author":"Roelfsema","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2025.112524_bib106","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2025.112524_bib107","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1210\/en.2019-00428","article-title":"Neuroendocrine impairments of polycystic ovary syndrome","volume":"160","author":"Ruddenklau","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112524_bib108","article-title":"Metabolic profiling reveals reprogramming of lipid metabolic pathways in treatment of polycystic ovary syndrome with 3-iodothyronamine","volume":"5","author":"Selen Alpergin","year":"2017","journal-title":"Phys. Rep."},{"key":"10.1016\/j.mce.2025.112524_bib109","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1677\/JME-09-0025","article-title":"Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4\u03b1","volume":"43","author":"Selva","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib110","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1365-2265.2006.02469.x","article-title":"The influences of hyperprolactinemia and obesity on cardiovascular risk markers: effects of cabergoline therapy","volume":"64","author":"Serri","year":"2006","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib111","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/humupd\/dmu009","article-title":"The kisspeptin-GnRH pathway in human reproductive health and disease","volume":"20","author":"Skorupskaite","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2025.112524_bib112","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1172\/JCI63937","article-title":"Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration","volume":"122","author":"Sonigo","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112524_bib113","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/jcem-58-2-378","article-title":"Progesterone modulation of pulsatile luteinizing hormone secretion in normal women","volume":"58","author":"Soules","year":"1984","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib114","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/humrep\/des463","article-title":"Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp","volume":"28","author":"Stepto","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2025.112524_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120276","article-title":"Evidence-based hormonal, mutational, and endocrine-disrupting chemical-induced zebrafish as an alternative model to study PCOS condition similar to mammalian PCOS model","volume":"291","author":"Sudhakaran","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2025.112524_bib116","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1095\/biolreprod.104.033126","article-title":"GABAergic integration of progesterone and androgen feedback to gonadotropin-releasing hormone Neurons1","volume":"72","author":"Sullivan","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2025.112524_bib117","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/0006-291X(71)90644-9","article-title":"Thyrotropin releasing hormone: direct evidence for stimulation of prolactin production by pituitary cells in culture","volume":"43","author":"Tashjian","year":"1971","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2025.112524_bib118","first-page":"2248","article-title":"Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary Syndrome1","volume":"82","author":"Taylor","year":"1997","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib119","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.fertnstert.2023.07.025","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"120","author":"Teede","year":"2023","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112524_bib120","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1210\/jc.2009-0837","article-title":"Increased 5\u03b1-reductase activity and adrenocortical drive in women with polycystic ovary syndrome","volume":"94","author":"Vassiliadi","year":"2009","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib121","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/rp.56.1.295","article-title":"Insulin resistance in polycystic ovary syndrome: progress and paradoxes","volume":"56","author":"Venkatesan","year":"2001","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.mce.2025.112524_bib122","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1210\/jcem-66-1-165","article-title":"Hyperfunction of the hypothalamic-pituitary Axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization","volume":"66","author":"Waldstreicher","year":"1988","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112524_bib123","doi-asserted-by":"crossref","first-page":"R193","DOI":"10.1530\/REP-14-0517","article-title":"Role of androgens in normal and pathological ovarian function","volume":"149","author":"Walters","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2025.112524_bib124","series-title":"Polycystic Ovary Syndrome - Functional Investigation and Clinical Application","year":"2022"},{"key":"10.1016\/j.mce.2025.112524_bib125","series-title":"Encyclopedia of Infant and Early Childhood Development","first-page":"450","article-title":"Endocrine system","author":"Watamura","year":"2008"},{"key":"10.1016\/j.mce.2025.112524_bib126","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2337\/diabetes.48.4.821","article-title":"Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity","volume":"48","author":"Westerbacka","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2025.112524_bib127","first-page":"19","article-title":"Insulin and insulin resistance","volume":"26","author":"Wilcox","year":"2005","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.mce.2025.112524_bib128","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1159\/000526722","article-title":"History of polycystic ovary syndrome, premature adrenarche, and hyperandrogenism in pediatric endocrinology","volume":"95","author":"Witchel","year":"2022","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.mce.2025.112524_bib129","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41390-019-0615-1","article-title":"Curtailing PCOS","volume":"87","author":"Witchel","year":"2020","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.mce.2025.112524_bib130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fendo.2020.00263","article-title":"The association between prolactin and metabolic parameters in PCOS women: a retrospective analysis","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2025.112524_bib131","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11154-007-9054-0","article-title":"The adrenal and polycystic ovary syndrome","volume":"8","author":"Yildiz","year":"2007","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.mce.2025.112524_bib132","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0889-8545(05)70190-X","article-title":"Polycystic ovary syndrome, androgen excess, and the impact on bone","volume":"28","author":"Zborowski","year":"2001","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"10.1016\/j.mce.2025.112524_bib133","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13048-022-01091-0","article-title":"Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment","volume":"16","author":"Zhao","year":"2023","journal-title":"J. Ovarian Res."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725000759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725000759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T20:31:45Z","timestamp":1762288305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720725000759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":133,"alternative-id":["S0303720725000759"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2025.112524","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An endocrinological perspective on polycystic ovarian syndrome","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2025.112524","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112524"}}