{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:04:59Z","timestamp":1775466299792,"version":"3.50.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012478","name":"Universidad Nacional de C\u00f3rdoba Secretaria de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","award":["BID\/PICT2019-3898"],"award-info":[{"award-number":["BID\/PICT2019-3898"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","award":["PICT2019-3054"],"award-info":[{"award-number":["PICT2019-3054"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","award":["PICT2020-3270"],"award-info":[{"award-number":["PICT2020-3270"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010442","name":"Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010442","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.mce.2025.112608","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T02:26:26Z","timestamp":1750904786000},"page":"112608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ghrelin treatment and exercise improve sperm quality in rats fed an obesogenic diet:A potential link to LEAP2"],"prefix":"10.1016","volume":"607","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9726-9046","authenticated-orcid":false,"given":"E.M.","family":"Luque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-2678","authenticated-orcid":false,"given":"V.P.","family":"Carlini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Guantay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Machuca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2974-886X","authenticated-orcid":false,"given":"V.","family":"Cantarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ponzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-8509","authenticated-orcid":false,"given":"D.","family":"Castrogiovanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Perell\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-5640","authenticated-orcid":false,"given":"A.C.","family":"Martini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2025.112608_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpobgyn.2023.102393","article-title":"Obesity and Male infertility","volume":"90","author":"Ameratunga","year":"2023","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.mce.2025.112608_bib2","article-title":"Physiological effect of ghrelin on body systems","volume":"2020","author":"Akalu","year":"2020","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.mce.2025.112608_bib3","first-page":"551","article-title":"Exercise protects against obesity induced semen abnormalities via downregulating stem cell factor, upregulating Ghrelin and normalizing oxidative stress","volume":"13","author":"Alhashem","year":"2014","journal-title":"EXCLI J."},{"key":"10.1016\/j.mce.2025.112608_bib4","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.3390\/nu14234944","article-title":"Evaluation of the anti-obesity effect of zeaxanthin and exercise in HFD-induced obese rats","volume":"14","author":"Al-Thepyani","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112608_bib5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00394-023-03304-8","article-title":"Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner","volume":"63","author":"Andreoli","year":"2024","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.mce.2025.112608_bib6","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1111\/dom.15850","article-title":"LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans","volume":"26","author":"Andreoli","year":"2024","journal-title":"Diabetes Obes Metab."},{"key":"10.1016\/j.mce.2025.112608_bib7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/09513590.2019.1665646","article-title":"Decreased levels of liver-expressed antimicrobial peptide-2 and ghrelin are related to insulin resistance in women with polycystic ovary syndrome","volume":"36","author":"Aslanipour","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.mce.2025.112608_bib8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41366-020-00703-3","article-title":"Circulating LEAP-2 is associated with puberty in girls","volume":"45","author":"Barja-Fern\u00e1ndez","year":"2021","journal-title":"Int. J. Obes.(Lond)"},{"key":"10.1016\/j.mce.2025.112608_bib9","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1095\/biolreprod.102.008862","article-title":"Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis","volume":"68","author":"Barreiro","year":"2003","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.mce.2025.112608_bib10","first-page":"398","article-title":"Effect of cholesterol diet on reproductive function in Male albino rats","volume":"26","author":"Bataineh","year":"2005","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.mce.2025.112608_bib11","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1210\/en.2010-0556","article-title":"Diet-induced obesity causes ghrelin resistance in arcuate NPY\/AgRP neurons","volume":"151","author":"Briggs","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112608_bib12","doi-asserted-by":"crossref","first-page":"E244","DOI":"10.1152\/ajpendo.00023.2023","article-title":"LEAP2 is associated with cardiometabolic markers but is unchanged by antidiabetic treatment in people with prediabetes","volume":"325","author":"Byberg","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2025.112608_bib13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/aja.2010.38","article-title":"Obesity: modern man's fertility nemesis","volume":"12","author":"Cabler","year":"2010","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.mce.2025.112608_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031462","article-title":"Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents","volume":"7","author":"Cabral","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2025.112608_bib15","first-page":"1738","article-title":"Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines","volume":"86","author":"Cassoni","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2025.112608_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.plefa.2023.102582","article-title":"Effect of a pescetarian and vegan diet on fatty acid composition in blood and spermatozoa in young healthy men","volume":"196","author":"Chamorro","year":"2023","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.mce.2025.112608_bib17","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/lipd.12265","article-title":"Diet, plasma, erythrocytes, and spermatozoa fatty acid composition changes in young vegan men","volume":"55","author":"Chamorro","year":"2020","journal-title":"Lipids"},{"key":"10.1016\/j.mce.2025.112608_bib18","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.exger.2005.09.003","article-title":"Ghrelin and immunity: a young player in an old field","volume":"40","author":"Dixit","year":"2005","journal-title":"Exp. Gerontol."},{"issue":"3","key":"10.1016\/j.mce.2025.112608_bib81","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrurol.2010.6","article-title":"The effect of obesity on sperm disorders and male infertility","volume":"7","author":"Du Plessis","year":"2010","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.mce.2025.112608_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12349","article-title":"Des-Acyl ghrelin directly targets the arcuate nucleus in a ghrelin-receptor independent manner and impairs the orexigenic effect of ghrelin","volume":"28","author":"Fernandez","year":"2016","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2025.112608_bib20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00018-022-04302-5","article-title":"GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner","volume":"79","author":"Fernandez","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mce.2025.112608_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121305","article-title":"Ghrelin proteolysis increases in plasma of men, but not women, with obesity","volume":"313","author":"Fittipaldi","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2025.112608_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1530\/EJE-19-0684","article-title":"Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance","volume":"182","author":"Fittipaldi","year":"2020","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2025.112608_bib23","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/BF03349243","article-title":"Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome","volume":"30","author":"Fusco","year":"2007","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.mce.2025.112608_bib24","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1530\/REP-06-0249","article-title":"Role of ghrelin in reproduction","volume":"133","author":"Garc\u00eda","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2025.112608_bib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2017.10.016","article-title":"LEAP2 is an endogenous antagonist of the ghrelin receptor","volume":"27","author":"Ge","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2025.112608_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.2004.02160.x","article-title":"Ghrelin: more than a natural GH secretagogue and\/or an orexigenic factor","volume":"62","author":"Ghigo","year":"2005","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.mce.2025.112608_bib27","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s40519-018-0599-6","article-title":"Ghrelin forms in the modulation of energy balance and metabolism","volume":"24","author":"GortanCappellari","year":"2019","journal-title":"Eat. Weight Disord."},{"key":"10.1016\/j.mce.2025.112608_bib28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.fertnstert.2006.11.067","article-title":"Administration of exogenous ghrelin in obese patients with polycystic ovary syndrome: effects on plasma levels of growth hormone, glucose, and insulin","volume":"88","author":"Guido","year":"2007","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112608_bib29","first-page":"236","article-title":"Effect of dietary cholesterol on spermatogenesis","volume":"27","author":"Gupta","year":"1988","journal-title":"Zeitschriftf\u00fcrErn\u00e4hrungswissenschaft"},{"key":"10.1016\/j.mce.2025.112608_bib30","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41386-019-0334-7","article-title":"\u03b21-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress","volume":"44","author":"Gupta","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.mce.2025.112608_bib31","article-title":"LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men","volume":"3","author":"Hagemann","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.mce.2025.112608_bib32","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1017\/S0954422410000168","article-title":"High-fat diet-induced obesity in animal models","volume":"23","author":"Hariri","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.mce.2025.112608_bib33","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac038","article-title":"Beta-Hydroxybutyrate suppresses hepatic production of the Ghrelin receptor antagonist LEAP2","volume":"163","author":"Holm","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112608_bib34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/19390211.2018.1431753","article-title":"The effect of Omega-3 fatty acids, EPA, and\/or DHA on Male infertility: a systematic review and meta-analysis","volume":"16","author":"Hosseini","year":"2019","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.mce.2025.112608_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-74048-6","article-title":"Liver-expressed antimicrobial peptide 2 is a hepatokine regulated by ghrelin, nutrients, and body weight","volume":"14","author":"Islam","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2025.112608_bib36","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/oby.2003.98","article-title":"Sex hormones and sexual function in obese men losing weight","volume":"11","author":"Kaukua","year":"2003","journal-title":"Obes. Res."},{"key":"10.1016\/j.mce.2025.112608_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.appet.2013.04.018","article-title":"Exercise and ghrelin. A narrative overview of research","volume":"68","author":"King","year":"2013","journal-title":"Appetite"},{"key":"10.1016\/j.mce.2025.112608_bib38","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00012.2004","article-title":"Ghrelin: structure and function","volume":"85","author":"Kojima","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2025.112608_bib39","first-page":"184","article-title":"Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin","volume":"232","author":"Kraemer","year":"2007","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.mce.2025.112608_bib40","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3390\/nu15051180","article-title":"The influence of metabolic factors and diet on fertility","volume":"15","author":"\u0141akoma","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112608_bib41","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/cen.14290","article-title":"Increased lipolysis after infusion of acylated ghrelin: a randomized, double-blinded placebo-controlled trial in hypopituitary patients","volume":"93","author":"Lauritzen","year":"2020","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.mce.2025.112608_bib42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1055\/s-0030-1262790","article-title":"Effects of exercise on the levels of peptide YY and ghrelin","volume":"119","author":"Li","year":"2011","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.mce.2025.112608_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1288779","article-title":"Ghrelin misbalance affects mice embryo implantation and pregnancy success by uterine immune dysregulation and nitrosative stress","volume":"14","author":"Luque","year":"2023","journal-title":"Front. Endocrinol.(Lausanne)"},{"key":"10.1016\/j.mce.2025.112608_bib44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mce.2009.06.007","article-title":"Obesity and testicular function","volume":"316","author":"Mah","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2025.112608_bib45","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1172\/JCI125332","article-title":"LEAP2 changes with body mass and food intake in humans and mice","volume":"129","author":"Mani","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112608_bib46","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1210\/en.2005-1422","article-title":"Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in Male rats","volume":"147","author":"Martini","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112608_bib47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1586\/eem.13.8","article-title":"The impact of obesity on Male reproduction: its biological significance","volume":"8","author":"Martini","year":"2013","journal-title":"Expet Rev. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2025.112608_bib48","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.fertnstert.2009.11.017","article-title":"Overweight and seminal quality: a study of 794 patients","volume":"94","author":"Martini","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2025.112608_bib49","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11259-010-9420-3","article-title":"Expression of chicken LEAP-2 in the reproductive organs and embryos and in response to Salmonella enterica infection","volume":"34","author":"Michailidis","year":"2010","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.mce.2025.112608_bib50","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1021\/acs.jmedchem.8b01644","article-title":"N-Terminal liver-expressed antimicrobial peptide 2 (LEAP2) region exhibits inverse agonist activity toward the ghrelin receptor","volume":"62","author":"M'Kadmi","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.mce.2025.112608_bib51","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mce.2011.02.010","article-title":"The ghrelin axis in disease: potential therapeutic indications","volume":"340","author":"Nass","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2025.112608_bib52","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1462-8902.2004.00335.x","article-title":"Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome","volume":"6","author":"Niskanen","year":"2004","journal-title":"Diabetes Obes Metab."},{"key":"10.1016\/j.mce.2025.112608_bib53","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.3390\/nu12092493","article-title":"The effect of high-fat diet-induced obesity on the expression of nutrient chemosensors in the mouse stomach and the gastric Ghrelin cell","volume":"12","author":"Nunez-Salces","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112608_bib55","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40279-020-01364-y","article-title":"Which physical exercise interventions increase HDL-Cholesterol levels? A systematic review of meta-analyses of randomized controlled trials","volume":"51","author":"Palaz\u00f3n-Bru","year":"2021","journal-title":"Sports Med."},{"key":"10.1016\/j.mce.2025.112608_bib56","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.ajcnut.2023.10.007","article-title":"Nutrient sensing: LEAP2 concentration in response to fasting, glucose, lactate, and \u03b2-hydroxybutyrate in healthy young males","volume":"118","author":"Pedersen","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.mce.2025.112608_bib57","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaf011","article-title":"Critical insights into LEAP2 biology and physiological functions: potential roles beyond ghrelin antagonism","volume":"166","author":"Perell\u00f3","year":"2025","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2025.112608_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13081","article-title":"Diet-induced rodent models of obesity-related metabolic disorders-A guide to a translational perspective","volume":"21","author":"Pregui\u00e7a","year":"2020","journal-title":"Obes. Rev."},{"key":"10.1016\/j.mce.2025.112608_bib59","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1745-7262.2007.00268.x","article-title":"Do reproductive hormones explain the association between body mass index and semen quality?","volume":"9","author":"Qin","year":"2007","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.mce.2025.112608_bib60","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3390\/nu15030655","article-title":"Plasma LEAP-2 following a low-calorie diet with or without interval exercise in women with obesity","volume":"15","author":"Ragland","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112608_bib61","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1071\/RD19429","article-title":"Recategorisation of body mass index to achieve andrological predictive power: a study in more than 20 000 patients","volume":"32","author":"Ram\u00edrez","year":"2020","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.mce.2025.112608_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02886","article-title":"Modulatory effects of ghrelin on sperm quality alterations induced by a fructose-enriched diet","volume":"5","author":"Ram\u00edrez","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.mce.2025.112608_bib63","first-page":"608","article-title":"Mejora de calidad seminal y perfil hormonal en adultos obesos sedentarios mediante ejercicio","volume":"34","author":"Rosety","year":"2017","journal-title":"Nutr. Hosp."},{"key":"10.1016\/j.mce.2025.112608_bib64","article-title":"Semen quality and sperm function loss by hypercholesterolemic diet was recovered by addition of olive oil to diet in rabbit","volume":"8","author":"SaezLancellotti","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.mce.2025.112608_bib65","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.repbio.2019.07.005","article-title":"Diet and sperm quality: nutrients, foods and dietary patterns","volume":"19","author":"Salas-Huetos","year":"2019","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.mce.2025.112608_bib66","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13082","article-title":"Male adiposity, sperm parameters and reproductive hormones: an updated systematic review and collaborative meta-analysis","volume":"22","author":"Salas-Huetos","year":"2021","journal-title":"Obes. Rev."},{"key":"10.1016\/j.mce.2025.112608_bib67","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/humupd\/dms050","article-title":"BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis","volume":"19","author":"Sermondade","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2025.112608_bib68","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.rbmo.2011.10.014","article-title":"Sperm parameters and Male fertility after bariatric surgery: three case series","volume":"24","author":"Sermondade","year":"2012","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.mce.2025.112608_bib69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s40279-024-02115-z","article-title":"The effect of exercise training on blood lipids: a systematic review and meta-analysis","volume":"55","author":"Smart","year":"2025","journal-title":"Sports Med."},{"key":"10.1016\/j.mce.2025.112608_bib70","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/014850100262281","article-title":"Functional activity of mouse sperm was not affected by low doses of aspirin-like drugs","volume":"44","author":"Stutz","year":"2000","journal-title":"Arch. Androl."},{"key":"10.1016\/j.mce.2025.112608_bib71","first-page":"325","article-title":"Novel connections between the neuroendocrine and immune systems: the ghrelin immunoregulatory network","volume":"77","author":"Taub","year":"2008","journal-title":"VitamHorm"},{"key":"10.1016\/j.mce.2025.112608_bib72","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/humupd\/dmr017","article-title":"Functional relationship between obesity and Male reproduction: from humans to animal models","volume":"17","author":"Teerds","year":"2011","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2025.112608_bib73","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/oby.21019","article-title":"Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance","volume":"23","author":"Van Name","year":"2015","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.mce.2025.112608_bib74","first-page":"R43","article-title":"Ghrelin and lipid metabolism: key partners in energy balance","volume":"46","author":"Varela","year":"2011","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mce.2025.112608_bib75","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ijo.2013.150","article-title":"Exercise in obese female rats has beneficial effects on maternal and Male and female offspring metabolism","volume":"39","author":"Vega","year":"2015","journal-title":"Int. J. Obes. (Lond)."},{"key":"10.1016\/j.mce.2025.112608_bib76","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.2337\/db08-0025","article-title":"Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling","volume":"57","author":"Vestergaard","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2025.112608_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2020.102112","article-title":"Regulatory effects of ghrelin on endoplasmic reticulum stress, oxidative stress, and autophagy: therapeutic potential","volume":"85","author":"Wang","year":"2021","journal-title":"Neuropeptides"},{"key":"10.1016\/j.mce.2025.112608_bib84","year":"2025","journal-title":"Obesity and overweight"},{"key":"10.1016\/j.mce.2025.112608_bib78","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-23-0342","article-title":"Hormonal changes in PCOS","volume":"261","author":"Yang","year":"2024","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2025.112608_bib79","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3071658","article-title":"Effect of different exercise loads on testicular oxidative stress and reproductive function in obese Male mice","volume":"2020","author":"Yi","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mce.2025.112608_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2024.112629","article-title":"Modulation of \u03945- and \u03946-desaturases in the brain-liver axis","volume":"131","author":"Z\u00fa\u00f1iga-Hern\u00e1ndez","year":"2025","journal-title":"Nutrition"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725001595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725001595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T20:32:49Z","timestamp":1762288369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720725001595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":81,"alternative-id":["S0303720725001595"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2025.112608","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin treatment and exercise improve sperm quality in rats fed an obesogenic diet:A potential link to LEAP2","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2025.112608","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112608"}}