{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:56:02Z","timestamp":1772801762543,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073748"],"award-info":[{"award-number":["82073748"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373773"],"award-info":[{"award-number":["82373773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010993"],"award-info":[{"award-number":["2021A1515010993"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012921"],"award-info":[{"award-number":["2024A1515012921"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.mce.2025.112633","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T21:12:38Z","timestamp":1754428358000},"page":"112633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1\/ROS pathway"],"prefix":"10.1016","volume":"608","author":[{"given":"Jixiang","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runquan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2243-2248","authenticated-orcid":false,"given":"Yi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.mce.2025.112633_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/nu11091979","article-title":"Augmentation of glucotoxicity, oxidative stress, apoptosis and mitochondrial dysfunction in HepG2 cells by palmitic acid","volume":"11","author":"Alnahdi","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112633_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110795","article-title":"IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis","volume":"123","author":"An","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.mce.2025.112633_bib3","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41419-020-02985-x","article-title":"NLRP3 inflammasome in endothelial dysfunction","volume":"11","author":"Bai","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mce.2025.112633_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/srep27236","article-title":"Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation","volume":"6","author":"Batumalaie","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.mce.2025.112633_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3892\/br.2017.917","article-title":"Pituitary adenylate cyclase-activating polypeptide attenuates tumor necrosis factor-\u03b1-induced apoptosis in endothelial colony-forming cells","volume":"7","author":"Bian","year":"2017","journal-title":"Biomed. Rep."},{"issue":"7","key":"10.1016\/j.mce.2025.112633_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mce.2025.112633_bib7","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.crfs.2022.10.018","article-title":"Synergistic protection of quercetin and lycopene against oxidative stress via SIRT1-Nox4-ROS axis in HUVEC cells","volume":"5","author":"Chen","year":"2022","journal-title":"Curr. Res. Food Sci."},{"issue":"8","key":"10.1016\/j.mce.2025.112633_bib8","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/jamainternmed.2018.2310","article-title":"Association of obesity or weight change with coronary heart disease among young adults in South Korea","volume":"178","author":"Choi","year":"2018","journal-title":"JAMA Intern. Med."},{"issue":"8","key":"10.1016\/j.mce.2025.112633_bib9","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2022.04.003","article-title":"NLRP3 and pyroptosis blockers for treating inflammatory diseases","volume":"43","author":"Coll","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"issue":"27","key":"10.1016\/j.mce.2025.112633_bib10","doi-asserted-by":"crossref","first-page":"10042","DOI":"10.1073\/pnas.0400593101","article-title":"Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity","volume":"101","author":"Daitoku","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"50","key":"10.1016\/j.mce.2025.112633_bib11","doi-asserted-by":"crossref","first-page":"28093","DOI":"10.1021\/acs.jafc.4c05876","article-title":"Aflatoxin B1 promotes pyroptosis in IPEC-J2 cells by disrupting mitochondrial dynamics through the AMPK\/NLRP3 pathway","volume":"72","author":"Ding","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.mce.2025.112633_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172392","article-title":"SIRT1 alleviates Cd nephrotoxicity through NF-\u03baB\/p65 deacetylation-mediated pyroptosis in rat renal tubular epithelial cells","volume":"929","author":"Dong","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.mce.2025.112633_bib13","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/jnc.13614","article-title":"Involvement of endogenous antioxidant systems in the protective activity of pituitary adenylate cyclase-activating polypeptide against hydrogen peroxide-induced oxidative damages in cultured rat astrocytes","volume":"137","author":"Douiri","year":"2016","journal-title":"J. Neurochem."},{"issue":"8016","key":"10.1016\/j.mce.2025.112633_bib14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-024-07373-5","article-title":"ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D","volume":"630","author":"Du","year":"2024","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mce.2025.112633_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jmb.2017.11.013","article-title":"The NLRP3 inflammasome renders cell death pro-inflammatory","volume":"430","author":"Gaidt","year":"2018","journal-title":"J. Mol. Biol."},{"issue":"10","key":"10.1016\/j.mce.2025.112633_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003351","article-title":"Metabolically healthy obesity, transition to unhealthy metabolic status, and vascular disease in Chinese adults: a cohort study","volume":"17","author":"Gao","year":"2020","journal-title":"PLoS Med."},{"issue":"7","key":"10.1016\/j.mce.2025.112633_bib17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1042\/CS20243438","article-title":"Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis","volume":"139","author":"Gao","year":"2025","journal-title":"Clin. Sci."},{"key":"10.1016\/j.mce.2025.112633_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154766","article-title":"Insulin resistance, cardiovascular stiffening and cardiovascular disease","volume":"119","author":"Hill","year":"2021","journal-title":"Metab. Clin. Exp."},{"issue":"4a","key":"10.1016\/j.mce.2025.112633_bib19","doi-asserted-by":"crossref","first-page":"3j","DOI":"10.1016\/S0002-9149(03)00610-6","article-title":"The central role of fat and effect of peroxisome proliferator-activated receptor-gamma on progression of insulin resistance and cardiovascular disease","volume":"92","author":"Hsueh","year":"2003","journal-title":"Am. J. Cardiol."},{"issue":"9","key":"10.1016\/j.mce.2025.112633_bib20","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"10","key":"10.1016\/j.mce.2025.112633_bib21","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.7150\/ijbs.93465","article-title":"Antirheumatic drug leflunomide attenuates atherosclerosis by regulating lipid metabolism and endothelial dysfunction via DHODH\/AMPK signaling pathway","volume":"20","author":"Jiang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.mce.2025.112633_bib22","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/jamacardio.2018.0022","article-title":"Association of body mass index with lifetime risk of cardiovascular disease and compression of morbidity","volume":"3","author":"Khan","year":"2018","journal-title":"JAMA cardiol."},{"issue":"9","key":"10.1016\/j.mce.2025.112633_bib23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","article-title":"Gasdermins: effectors of pyroptosis","volume":"27","author":"Kovacs","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mce.2025.112633_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117008","article-title":"Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by astragaloside IV activation of the SIRT1\/PGC1\u03b1\/Nrf1 signaling pathway","volume":"177","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.mce.2025.112633_bib25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s11658-023-00482-5","article-title":"MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4","volume":"28","author":"Martino","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"3","key":"10.1016\/j.mce.2025.112633_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12031-010-9350-0","article-title":"Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor","volume":"42","author":"Ohtaki","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.mce.2025.112633_bib27","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-024-02041-2","article-title":"Gypenoside XLIX activates the Sirt1\/Nrf2 signaling pathway to inhibit NLRP3 inflammasome activation to alleviate septic acute lung injury","author":"Ping","year":"2024","journal-title":"Inflammation"},{"issue":"1\u20133","key":"10.1016\/j.mce.2025.112633_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ygcen.2006.12.006","article-title":"Protective effects of pituitary adenylate cyclase activating polypeptide in endothelial cells against oxidative stress-induced apoptosis","volume":"153","author":"R\u00e1cz","year":"2007","journal-title":"Gen. Comp. Endocrinol."},{"issue":"6","key":"10.1016\/j.mce.2025.112633_bib29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.mce.2025.112633_bib30","first-page":"2237","article-title":"Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease","volume":"371","author":"Shulman","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"9793","key":"10.1016\/j.mce.2025.112633_bib31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(11)60813-1","article-title":"The global obesity pandemic: shaped by global drivers and local environments","volume":"378","author":"Swinburn","year":"2011","journal-title":"Lancet (London, England)"},{"issue":"5","key":"10.1016\/j.mce.2025.112633_bib32","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1007\/s10753-021-01457-4","article-title":"Correction to: role of silent information regulator 1 (SIRT1) in regulating oxidative stress and inflammation","volume":"44","author":"Ubaid","year":"2021","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.mce.2025.112633_bib33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0031-6997(24)01449-2","article-title":"Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions","volume":"52","author":"Vaudry","year":"2000","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.mce.2025.112633_bib34","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.molmed.2017.02.005","article-title":"Mitochondrial sirtuins and molecular mechanisms of aging","volume":"23","author":"van de Ven","year":"2017","journal-title":"Trends Mol. Med."},{"issue":"12","key":"10.1016\/j.mce.2025.112633_bib35","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.1002\/fsn3.3696","article-title":"Notoginsenoside-R1 ameliorates palmitic acid-induced insulin resistance and oxidative stress in HUVEC via Nrf2\/ARE pathway","volume":"11","author":"Wang","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.mce.2025.112633_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175554","article-title":"Physcion prevents high-fat diet-induced endothelial dysfunction by inhibiting oxidative stress and endoplasmic reticulum stress pathways","volume":"943","author":"Wang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.mce.2025.112633_bib37","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1111\/jcmm.14453","article-title":"PACAP ameliorates hepatic metabolism and inflammation through up-regulating FAIM in obesity","volume":"23","author":"Xiao","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mce.2025.112633_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171177","article-title":"PM(2.5)-induced premature senescence in HUVECs through the SIRT1\/PGC-1\u03b1\/SIRT3 pathway","volume":"921","author":"Yan","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.mce.2025.112633_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12986-020-0434-8","article-title":"Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis","volume":"17","author":"Zeng","year":"2020","journal-title":"Nutr. Metabol."},{"key":"10.1016\/j.mce.2025.112633_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117085","article-title":"1,8-cineole ameliorates experimental diabetic angiopathy by inhibiting NLRP3 inflammasome-mediated pyroptosis in HUVECs via SIRT2","volume":"177","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mce.2025.112633_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1039241","article-title":"ROS-Triggered endothelial cell death mechanisms: focus on pyroptosis, parthanatos, and ferroptosis","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2025.112633_bib42","article-title":"Multifunctional copper-phenolic nanopills achieve comprehensive polyamines depletion to provoke enhanced pyroptosis and cuproptosis for cancer immunotherapy","author":"Zhu","year":"2024","journal-title":"Adv. Mater."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725001844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725001844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T09:46:28Z","timestamp":1772790388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720725001844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":42,"alternative-id":["S0303720725001844"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2025.112633","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1\/ROS pathway","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2025.112633","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112633"}}