{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:24:35Z","timestamp":1789140275629,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Province Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.mce.2025.112639","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T08:09:42Z","timestamp":1754467782000},"page":"112639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The role of IGFBP7 in the immune regulation of PCOS-like symptoms based on spleen transcriptome and TCR \u03b2 CDR3 repertoire analysis"],"prefix":"10.1016","volume":"608","author":[{"given":"Li","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhu","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5777-2659","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2025.112639_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0165-0378(98)00026-6","article-title":"The igf family and folliculogenesis","volume":"39","author":"Adashi","year":"1998","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.mce.2025.112639_bib2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10549-011-1816-4","article-title":"Igfbp7 reduces breast tumor growth by induction of senescence and apoptosis pathways","volume":"133","author":"Benatar","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.mce.2025.112639_bib3","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.4049\/jimmunol.154.10.5165","article-title":"T cell development in tcr-alpha beta transgenic mice. Analysis using v(d)j recombination substrates","volume":"154","author":"Capone","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.mce.2025.112639_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1420862","article-title":"The multifaceted role of insulin-like growth factor binding protein 7","volume":"12","author":"Chen","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mce.2025.112639_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167743","article-title":"Elevated igfbp7 expression in follicular granulosa cells promotes pcos pathogenesis","volume":"1871","author":"Chen","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.mce.2025.112639_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083923","article-title":"Mitochondrial dysfunction and chronic inflammation in polycystic ovary syndrome","volume":"22","author":"Dabravolski","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112639_bib7","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1172\/JCI44752","article-title":"Paired analysis of tcralpha and tcrbeta chains at the single-cell level in mice","volume":"121","author":"Dash","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112639_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2025.112639_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2003184","article-title":"Igfbp7 binds to the igf-1 receptor and blocks its activation by insulin-like growth factors","volume":"5","author":"Evdokimova","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.mce.2025.112639_bib10","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3389\/fonc.2020.00727","article-title":"Insulin growth factor binding protein 7 (igfbp7)-related cancer and igfbp3 and igfbp7 crosstalk","volume":"10","author":"Jin","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mce.2025.112639_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1600-065X.1998.tb01236.x","article-title":"Developmental regulation of v(d)j recombination at the tcr alpha\/delta locus","volume":"165","author":"Krangel","year":"1998","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.mce.2025.112639_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41420-023-01336-x","article-title":"Cancer-associated fibroblast-secreted igfbp7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via fgf2\/fgfr1\/pi3k\/akt axis","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mce.2025.112639_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/JCI160451","article-title":"An igfbp7hi endothelial cell subset drives t cell extravasation in psoriasis via endothelial glycocalyx degradation","volume":"133","author":"Li","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112639_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112529","article-title":"When igf-1 meets metabolic inflammation and polycystic ovary syndrome","volume":"138","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mce.2025.112639_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3109\/19396360903247922","article-title":"Response of igf and il-6 to ovarian stimulation in pcos and normal women","volume":"55","author":"Liang","year":"2009","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.mce.2025.112639_bib16","doi-asserted-by":"crossref","first-page":"8875","DOI":"10.1007\/s13277-014-2160-1","article-title":"Decreased expression of igfbp7 was a poor prognosis predictor for gastric cancer patients","volume":"35","author":"Liu","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1016\/j.mce.2025.112639_bib17","article-title":"A novel role of igfbp7 in mouse uterus: regulating uterine receptivity through th1\/th2 lymphocyte balance and decidualization","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2025.112639_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jsbmb.2010.02.015","article-title":"Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome","volume":"119","author":"Motta","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2025.112639_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1324429","article-title":"Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging","volume":"14","author":"Orisaka","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2025.112639_bib20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1530\/REP-22-0449","article-title":"Emodin improves glucose metabolism and ovarian function in pcos mice via the hmgb1\/tlr4\/nf-kappab molecular pathway","volume":"166","author":"Otoo","year":"2023","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2025.112639_bib21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2018.04.008","article-title":"Polycystic ovary syndrome (Pcos), an inflammatory, systemic, lifestyle endocrinopathy","volume":"182","author":"Patel","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2025.112639_bib22","article-title":"Insulin-like growth factor (Igf) performance in ovarian function and applications in reproductive biotechnologies","volume":"72\u201373","author":"Piau","year":"2023","journal-title":"Growth Hormone IGF Res."},{"key":"10.1016\/j.mce.2025.112639_bib23","doi-asserted-by":"crossref","first-page":"13139","DOI":"10.1073\/pnas.1409155111","article-title":"Diversity and clonal selection in the human t-cell repertoire","volume":"111","author":"Qi","year":"2014","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.mce.2025.112639_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.985187","article-title":"Single-cell sequencing reveals effects of chemotherapy on the immune landscape and tcr\/bcr clonal expansion in a relapsed ovarian cancer patient","volume":"13","author":"Ren","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2025.112639_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073789","article-title":"Chronic low grade inflammation in pathogenesis of pcos","volume":"22","author":"Rudnicka","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112639_bib26","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/onc.2014.18","article-title":"Igfbp7, a novel tumor stroma marker, with growth-promoting effects in Colon cancer through a paracrine tumor-stroma interaction","volume":"34","author":"Rupp","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2025.112639_bib27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12967-023-04116-4","article-title":"The interplay between androgens and the immune response in polycystic ovary syndrome","volume":"21","author":"Shabbir","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mce.2025.112639_bib28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.smim.2010.07.002","article-title":"Epigenetic control of tcrb gene rearrangement","volume":"22","author":"Spicuglia","year":"2010","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.mce.2025.112639_bib29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.immuni.2019.05.014","article-title":"Single-cell rna sequencing of the t helper cell response to house dust mites defines a distinct gene expression signature in airway th2 cells","volume":"51","author":"Tibbitt","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.mce.2025.112639_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141049","article-title":"Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the nlrp3 inflammasome in mice","volume":"745","author":"Wang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.mce.2025.112639_bib31","article-title":"Dysregulation of immune response in pcos organ system","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2025.112639_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.898493","article-title":"Igfbp7 and the tumor immune landscape: a novel target for immunotherapy in bladder cancer","volume":"13","author":"Yi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2025.112639_bib33","doi-asserted-by":"crossref","first-page":"24432","DOI":"10.18632\/aging.203695","article-title":"Immune cell and tcr\/bcr repertoire profiling in systemic lupus erythematosus patients by single-cell sequencing","volume":"13","author":"Zheng","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mce.2025.112639_bib34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12958-021-00861-7","article-title":"Involvement of impaired cd8(+) mucosal-associated invariant t cells and myeloid-derived suppressor cells in polycystic ovary syndrome","volume":"19","author":"Zhu","year":"2021","journal-title":"Reprod. Biol. Endocrinol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372072500190X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372072500190X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T15:43:38Z","timestamp":1756655018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030372072500190X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":34,"alternative-id":["S030372072500190X"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2025.112639","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of IGFBP7 in the immune regulation of PCOS-like symptoms based on spleen transcriptome and TCR \u03b2 CDR3 repertoire analysis","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2025.112639","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112639"}}