{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:10:18Z","timestamp":1773198618589,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["306895\/2021-8"],"award-info":[{"award-number":["306895\/2021-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["141080\/2024-8"],"award-info":[{"award-number":["141080\/2024-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["312111\/2023-1"],"award-info":[{"award-number":["312111\/2023-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["140841\/2021-0"],"award-info":[{"award-number":["140841\/2021-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["403028\/2023-0"],"award-info":[{"award-number":["403028\/2023-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mce.2025.112664","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:40:58Z","timestamp":1758631258000},"page":"112664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Perinatal exposure to BPA leads to pronounced prostatic morphophysiological disorders in a rodent model of induced hyperplasia"],"prefix":"10.1016","volume":"610","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5198-0454","authenticated-orcid":false,"given":"Stella","family":"Bicalho-Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-4550","authenticated-orcid":false,"given":"Vitor","family":"Grigio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalles Fernando Rocha","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia","family":"de Freitas Calmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Rahal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e3o Roberto","family":"Taboga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Cristina Alc\u00e2ntara","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9559-5497","authenticated-orcid":false,"given":"Patr\u00edcia Simone Leite","family":"Vilamaior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2025.112664_bib1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.lfs.2015.01.023","article-title":"What do we know about phytotherapy of benign prostatic hyperplasia?","volume":"126","author":"Allkanjari","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2025.112664_bib2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/iep.12232","article-title":"Corticosterone influences gerbil (Meriones unguiculatus) prostatic morphophysiology and alters its proliferation and apoptosis rates","volume":"98","author":"Antoniassi","year":"2017","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.mce.2025.112664_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108828","article-title":"In vitro bisphenol A impairs testicular energy metabolism and spermatogenesis through nuclear estrogen receptors activation in zebrafish","volume":"132","author":"Batista-Silva","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.fct.2015.07.011","article-title":"Genistein reduces the noxious effects of in utero bisphenol A exposure on the rat prostate gland at weaning and in adulthood","volume":"84","author":"Bernardo","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/1008-682X.170436","article-title":"Prenatal and pubertal testosterone exposure imprint permanent modifications in the prostate that predispose to the development of lesions in old Mongolian gerbils","volume":"19","author":"Biancardi","year":"2017","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.mce.2025.112664_bib6","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00441-023-03746-w","article-title":"Effects of perinatal exposure to bisphenol A or S in EAE model of multiple sclerosis","volume":"392","author":"Bonaldo","year":"2023","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mce.2025.112664_bib7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.reprotox.2013.11.001","article-title":"Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of Male F1 rats","volume":"43","author":"Brandt","year":"2014","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.envint.2013.02.014","article-title":"Dietary and sociodemographic determinants of bisphenol A urine concentrations in pregnant women and children","volume":"56","author":"Casas","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.mce.2025.112664_bib9","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/pros.24177","article-title":"Therapeutic effects of \u03b2-caryophyllene on proliferative disorders and inflammation of the gerbil prostate","volume":"81","author":"Castro","year":"2021","journal-title":"Prostate"},{"key":"10.1016\/j.mce.2025.112664_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119918","article-title":"Endocrine disrupting chemicals in the environment: environmental sources, biological effects, remediation techniques, and perspective","volume":"310","author":"Chen","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.mce.2025.112664_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21165761","article-title":"Potential mechanisms of bisphenol a (BPA) contributing to human disease","volume":"21","author":"Cimmino","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112664_bib12","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.micron.2008.02.008","article-title":"Androgen receptor in the Mongolian gerbil ventral prostate: evaluation during different phases of postnatal development and following androgen blockage","volume":"39","author":"Cordeiro","year":"2008","journal-title":"Micron"},{"key":"10.1016\/j.mce.2025.112664_bib13","first-page":"231","article-title":"Proinflammatory cytokine interleukin-6 in prostate carcinogenesis","volume":"2","author":"Culig","year":"2014","journal-title":"Am. J. Clin. Exp. Urol."},{"key":"10.1016\/j.mce.2025.112664_bib14","article-title":"Scientific opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs","volume":"13","year":"2015","journal-title":"EFSA J."},{"key":"10.1016\/j.mce.2025.112664_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112700","article-title":"Protective effect of the association of curcumin with piperine on prostatic lesions: new perspectives on BPA-Induced carcinogenesis","volume":"158","author":"Facina","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113318","article-title":"Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells","volume":"255","author":"Fatma Karaman","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.mce.2025.112664_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-40465-1","article-title":"Prostate telocytes change their phenotype in response to castration or testosterone replacement","volume":"9","author":"Felisbino","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2025.112664_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118012","article-title":"Bisphenol-A exposure worsens hepatic steatosis in ovariectomized mice fed on a high-fat diet: role of endoplasmic reticulum stress and fibrogenic pathways","volume":"256","author":"Figueiredo","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2025.112664_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118552","article-title":"Angiotensin (1-7)-attenuated vasoconstriction is associated with the Interleukin-10 signaling pathway","volume":"262","author":"Freitas","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2025.112664_bib20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/pros.22669","article-title":"A new proposed rodent model of chemically induced prostate carcinogenesis: distinct time-course prostate cancer progression in the dorsolateral and ventral lobes","volume":"73","author":"Gon\u00e7alves","year":"2013","journal-title":"Prostate"},{"key":"10.1016\/j.mce.2025.112664_bib21","first-page":"395","article-title":"Coconut oil mitigates the effects of aging on the Mongolian gerbil prostate","author":"Guerra","year":"2024","journal-title":"Prostate"},{"key":"10.1016\/j.mce.2025.112664_bib22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.lfs.2014.11.007","article-title":"Leptin influences estrogen metabolism and accelerates prostate cell proliferation","volume":"121","author":"Habib","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2025.112664_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.reprotox.2016.11.011","article-title":"Review of developmental origins of health and disease publications in environmental epidemiology","volume":"68","author":"Heindel","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120980","article-title":"Decreased mitophagy aggravates benign prostatic hyperplasia in aged mice through DRP1 and estrogen receptor \u03b1","volume":"309","author":"Hong","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2025.112664_bib25","first-page":"357","article-title":"A histoquantitative study on the effects of castration on the rat ventral prostate lobe","volume":"132","author":"Huttunen","year":"1981","journal-title":"J. Anat."},{"key":"10.1016\/j.mce.2025.112664_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123104","article-title":"Tetra aniline-based polymers ameliorate BPA-Induced cardiotoxicity in sprague dawley rats, in silico and in vivo analysis","volume":"358","author":"Ishtiaq","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2025.112664_bib27","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1096\/fj.201500089R","article-title":"Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure","volume":"30","author":"Jorgensen","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.mce.2025.112664_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145771","article-title":"Pesticide-induced multigenerational effects on amphibian reproduction and metabolism","volume":"775","author":"Karlsson","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.mce.2025.112664_bib29","first-page":"253","article-title":"Cyclooxygenase-2 overexpression in chronic inflammation associated with benign prostatic hyperplasia: is it related to apoptosis and angiogenesis of prostate cancer? Korean","volume":"52","author":"Kim","year":"2011","journal-title":"J. Urol."},{"key":"10.1016\/j.mce.2025.112664_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112085","article-title":"Impacts of endocrine-disrupting chemicals on prostate function and cancer","volume":"204","author":"Lacouture","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.mce.2025.112664_bib31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.reprotox.2008.05.058","article-title":"Maternal and fetal exposure to bisphenol A in Korea","volume":"25","author":"Lee","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104374","article-title":"Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils","volume":"113","author":"Leonel","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.mce.2025.112664_bib33","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.reprotox.2015.10.016","article-title":"Bisphenol-A promotes antiproliferative effects during neonatal prostate development in Male and female gerbils","volume":"58","author":"Lima","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127880","article-title":"Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice","volume":"262","author":"Liu","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.mce.2025.112664_bib35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.reprotox.2017.09.013","article-title":"The effects of in utero bisphenol A exposure on ovarian follicle numbers and steroidogenesis in the F1 and F2 generations of mice","volume":"74","author":"Mahalingam","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112658","article-title":"An introduction to the sources, fate, occurrence and effects of endocrine disrupting chemicals released into the environment","volume":"207","author":"Metcalfe","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.mce.2025.112664_bib37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.taap.2013.05.015","article-title":"In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors","volume":"272","author":"Molina-Molina","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.mce.2025.112664_bib38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.reprotox.2022.02.005","article-title":"Transgenerational effects of bisphenol A on zebrafish reproductive tissues and sperm motility","volume":"109","author":"Mostari","year":"2022","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/and.13093","article-title":"Implications of prostate inflammation on male fertility","volume":"50","author":"Motrich","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.mce.2025.112664_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-04995-3","article-title":"Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3","volume":"13","author":"Park","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mce.2025.112664_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133935","article-title":"Deciphering the mechanisms and interactions of the endocrine disruptor bisphenol A and its analogs with the androgen receptor","volume":"469","author":"Pathak","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.mce.2025.112664_bib42","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1464-410X.2009.08853.x","article-title":"Serum testosterone is associated with aggressive prostate cancer in older men: results from the Baltimore Longitudinal study of aging","volume":"105","author":"Pierorazio","year":"2010","journal-title":"BJU Int."},{"key":"10.1016\/j.mce.2025.112664_bib43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1742-7843.2007.00166.x","article-title":"Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis","volume":"102","author":"Prins","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125791","article-title":"Multigenerational impacts of gestational bisphenol A exposure on the sperm function and fertility of Male mice","volume":"416","author":"Rahman","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.mce.2025.112664_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104473","article-title":"Developmental changes induced by exogenous testosterone during early phases of prostate organogenesis","volume":"115","author":"Ramos","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.mce.2025.112664_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells11193163","article-title":"Multi- and transgenerational effects of environmental toxicants on Mammalian reproduction","volume":"11","author":"Rebuzzini","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.mce.2025.112664_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147722","article-title":"Perfluorinated iodine alkanes induce tissue-specific expression of estrogen receptor and its phosphorylation","volume":"787","author":"Ren","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.mce.2025.112664_bib48","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/cbin.12007","article-title":"Bisphenol A disruption promotes mammary tumor microenvironment via phenotypic cell polarization and inflammatory response","volume":"47","author":"Ruiz","year":"2023","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.mce.2025.112664_bib49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.reprotox.2017.07.013","article-title":"Intrauterine exposure to 17\u03b2-oestradiol (E2) impairs postnatal development in both female and Male prostate in gerbil","volume":"73","author":"Sanches","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.mce.2025.112664_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113142","article-title":"Impact of chronic exposure of rats to bisphenol A from perinatal period to adulthood on intraprostatic levels of 5\u03b1-reductase isozymes, aromatase, and genes implicated in prostate cancer development","volume":"212","author":"S\u00e1nchez","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.mce.2025.112664_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113142","article-title":"Impact of chronic exposure of rats to bisphenol A from perinatal period to adulthood on intraprostatic levels of 5\u03b1-reductase isozymes, aromatase, and genes implicated in prostate cancer development","volume":"212","author":"S\u00e1nchez","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.mce.2025.112664_bib52","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.scitotenv.2019.06.029","article-title":"Transgenerational effects of BPA on female reproduction","volume":"685","author":"Santangeli","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.mce.2025.112664_bib53","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/toxsci\/kfz141","article-title":"Exposure to an environmentally relevant phthalate mixture during prostate development induces MicroRNA upregulation and transcriptome modulation in rats","volume":"171","author":"Scarano","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.mce.2025.112664_bib54","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1289\/ehp.021100703","article-title":"Parent bisphenol a accumulation in the human maternal-fetal-placental unit","volume":"110","author":"Sch\u00f6nfelder","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mce.2025.112664_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109960","article-title":"The chemical environmental pollutants BPA and BPS induce alterations of the proteomic profile of different phenotypes of human breast cancer cells: a proposed interactome","volume":"191","author":"Segovia-Mendoza","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.mce.2025.112664_bib56","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1158\/0008-5472.CAN-03-0946","article-title":"Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the bar Harbor meeting of the mouse models of human cancer consortium prostate pathology committee","volume":"64","author":"Shappell","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2025.112664_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143626","article-title":"Individual and combined effects of commercial glyphosate, atrazine and 2,4-D herbicides on the gerbil ventral prostate","volume":"367","author":"Silva","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.mce.2025.112664_bib58","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.envres.2017.07.005","article-title":"Bisphenol A induces COX-2 through the mitogen-activated protein kinase pathway and is associated with levels of inflammation-related markers in elderly populations","volume":"158","author":"Song","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.mce.2025.112664_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111389","article-title":"Differential methylation of genes in the human placenta associated with bisphenol A exposure","volume":"200","author":"Song","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.mce.2025.112664_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21113902","article-title":"Interactive effects of perinatal bpa or des and adult testosterone and estradiol exposure on adult urethral obstruction and bladder, kidney, and prostate pathology in male mice","volume":"21","author":"Taylor","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112664_bib61","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cbi.2013.03.013","article-title":"Bisphenol A affects androgen receptor function via multiple mechanisms","volume":"203","author":"Teng","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.mce.2025.112664_bib62","first-page":"1","article-title":"Update on the health effects of bisphenol A: overwhelming evidence of harm","volume":"162","author":"Vom Saal","year":"2021","journal-title":"Endocrinol. (United States)"},{"key":"10.1016\/j.mce.2025.112664_bib63","doi-asserted-by":"crossref","first-page":"18376","DOI":"10.1074\/jbc.M112.355164","article-title":"Increased infiltrated macrophages in benign prostatic hyperplasia (BPH): Role of stromal androgen receptor in macrophage-induced prostate stromal cell proliferation","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2025.112664_bib64","first-page":"131","article-title":"Principles and methods for the morphometric study of the lung and other organs","volume":"12","author":"Weibel","year":"1963","journal-title":"Lab. Invest."},{"key":"10.1016\/j.mce.2025.112664_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052894","article-title":"Does bisphenol A confer risk of neurodevelopmental disorders? What we have learned from developmental neurotoxicity studies in animal models","volume":"23","author":"Welch","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112664_bib66","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1177\/0748233711399310","article-title":"Oral exposure to low-dose bisphenol A aggravates testosterone-induced benign hyperplasia prostate in rats","volume":"27","author":"Wu","year":"2011","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.mce.2025.112664_bib67","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.semcdb.2015.05.008","article-title":"Multigenerational and transgenerational effects of endocrine disrupting chemicals: a role for altered epigenetic regulation?","volume":"43","author":"Xin","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.mce.2025.112664_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156136","article-title":"Laoxianghuang polysaccharide promotes the anti-inflammatory cytokine interleukin-10 in colitis via gut microbial linoleic acid","volume":"135","author":"Zhang","year":"2024","journal-title":"Phytomedicine"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725002151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725002151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T06:47:15Z","timestamp":1773125235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720725002151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":68,"alternative-id":["S0303720725002151"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2025.112664","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perinatal exposure to BPA leads to pronounced prostatic morphophysiological disorders in a rodent model of induced hyperplasia","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2025.112664","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112664"}}