{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:50:54Z","timestamp":1792403454190,"version":"4.4.0"},"reference-count":210,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1221098"],"award-info":[{"award-number":["1221098"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Regular1221098"],"award-info":[{"award-number":["Regular1221098"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.mce.2025.112676","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:58:19Z","timestamp":1760101099000},"page":"112676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Interrelationship between alcohol consumption, overnutrition, and pharmacotherapy for liver steatosis: Considerations and proposals"],"prefix":"10.1016","volume":"611","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-6142","authenticated-orcid":false,"given":"Rodrigo","family":"Valenzuela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Far\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasna","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Z\u00fa\u00f1iga-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Videla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2025.112676_bib1","doi-asserted-by":"crossref","DOI":"10.1177\/1756284820974917","article-title":"The efficacy of vitamin E in reducing non-alcoholic fatty liver disease: a systematic review, me, MMta-analysis, and meta-regression","volume":"13","author":"Abdel-Maboud","year":"2020","journal-title":"Therap. Adv. Gastroenterol"},{"key":"10.1016\/j.mce.2025.112676_bib2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/acer.14271","article-title":"Interaction between alcohol use and metabolic risk factors for liver disease: a critical review of epidemiological studies","volume":"44","author":"\u00c5berg","year":"2020","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.mce.2025.112676_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jhep.2022.08.030","article-title":"Alcohol consumption and metabolic syndrome: clinical and epidemiological impact on liver disease","volume":"78","author":"\u00c5berg","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2025.112676_bib4","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2147\/DMSO.S447855","article-title":"Missed diagnosis of g.;stational diabetes mellitus due to selective screening: evidence from a cross-sectional study in the West Nile Sub-Region, Uganda","volume":"17","author":"Abindu","year":"2024","journal-title":"Diabetes. Metab. Syndr. Obes"},{"key":"10.1016\/j.mce.2025.112676_bib5","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.foodres.2016.11.009","volume":"99","author":"Agreg\u00e1n","year":"2017","journal-title":"Food Res. Int."},{"key":"10.1016\/j.mce.2025.112676_bib6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1177\/0748233711427050","article-title":"Fatal methanol poisoning: features of liver histopathology","volume":"29","author":"Akhgari","year":"2013","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.mce.2025.112676_bib7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1079\/PNS2006496","article-title":"Alcohol, oxidative stress and free radical damage","volume":"65","author":"Albano","year":"2006","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.mce.2025.112676_bib8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/abbi.1996.9855","article-title":"Localization of multiple forms of inducible cytochromes P450 in rat liver mitochondria: immunological characteristics and patterns of xenobiotic substrate metabolism","volume":"339","author":"Anandatheerthavarada","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mce.2025.112676_bib9","first-page":"309","article-title":"Alcohol biomarkers in clinical and forensic contexts","volume":"115","author":"Andresen-Streichert","year":"2018","journal-title":"Deutsch. Arztebl. Int"},{"key":"10.1016\/j.mce.2025.112676_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/acer.14503","article-title":"Comparison of the diagnostic value of phosphatidylethanol and carbohydrate-deficient transferrin as biomarkers of alcohol consumption","volume":"45","author":"\u00c5rving","year":"2021","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.mce.2025.112676_bib11","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.clinre.2011.04.015","article-title":"Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role","volume":"35","author":"Aubert","year":"2011","journal-title":"Clin. Res. Hepatol. Gastroenterol"},{"key":"10.1016\/j.mce.2025.112676_bib12","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10654-023-00970-0","article-title":"Diabetes mellitus, prediabetes and the risk of Parkinson's disease: a systematic review and meta-analysis of 15 cohort studies with 29.9 million participants and 86,345 cases","volume":"38","author":"Aune","year":"2023","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.mce.2025.112676_bib14","doi-asserted-by":"crossref","first-page":"24609","DOI":"10.1074\/jbc.M110.121822","article-title":"Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress","volume":"285","author":"Bansal","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2025.112676_bib15","doi-asserted-by":"crossref","first-page":"15284","DOI":"10.1074\/jbc.M111.314062","article-title":"Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes","volume":"287","author":"Bansal","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2025.112676_bib16","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.3390\/ijms26062394","article-title":"A comprehensive review of Metabolic dysfunction-associated steatotic liver disease: its mechanistic development focusing on Methylglyoxal and counterbalancing treatment strategies","volume":"26","author":"Berdowska","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112676_bib17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2020.04.019","article-title":"Disulfiram treatment normalizes body weight in obese mice","volume":"32","author":"Bernier","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2025.112676_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0300-2977(00)00064-4","article-title":"Hepatic steatosis and lactic acidosis caused by stavudine in an HIV-infected patient","volume":"57","author":"Bleeker-Rovers","year":"2000","journal-title":"Neth. J. Med."},{"key":"10.1016\/j.mce.2025.112676_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2147\/DMSO.S286334","article-title":"The impact of vitamin D in non-alcoholic fatty liver disease: a cross-sectional study in patients with morbid obesity","volume":"14","author":"Borges-Canha","year":"2021","journal-title":"Diabetes. Metab. Syndr. Obes"},{"key":"10.1016\/j.mce.2025.112676_bib20","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1249\/MSS.0000000000001901","article-title":"Physical activity and sedentary time: association with Metabolic Health and liver fat","volume":"51","author":"Bowden","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.mce.2025.112676_bib21","series-title":"Zakim and Boyer's Hepatology: a Textbook of Liver Disease","author":"Boyer","year":"2012"},{"key":"10.1016\/j.mce.2025.112676_bib22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jand.2017.09.030","article-title":"Associations of alcoholic beverage consumption with dietary intake, waist circumference, and body mass index in us adults: national health and nutrition examination survey 2003-2012","volume":"118","author":"Butler","year":"2018","journal-title":"J. Acad. Nutr. Diet."},{"key":"10.1016\/j.mce.2025.112676_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0281954","article-title":"Concomitant western diet and chronic-binge alcohol dysregulate hepatic metabolism","volume":"18","author":"Buyco","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2025.112676_bib24","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s00018-016-2145-x","article-title":"The epigenetic role of vitamin C in health and disease","volume":"73","author":"Camarena","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mce.2025.112676_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12916-024-03315-0","article-title":"Zhao, systematic review and meta-analysis","volume":"22","author":"Cao","year":"2024","journal-title":"BMC Med."},{"key":"10.1016\/j.mce.2025.112676_bib26","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00018-022-04319-w","article-title":"Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2\/EP4 pathway","volume":"79","author":"Cao","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mce.2025.112676_bib27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1515\/dmdi-2012-0014","article-title":"CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment","volume":"27","author":"Cederbaum","year":"2012","journal-title":"Drug Metabol. Drug Interact."},{"key":"10.1016\/j.mce.2025.112676_bib28","doi-asserted-by":"crossref","first-page":"17756","DOI":"10.3748\/wjg.v20.i47.17756","article-title":"Pathogenesis of alcoholic liver disease: role of oxidative metabolism","volume":"20","author":"Ceni","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.mce.2025.112676_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2024.111128","article-title":"Comparative analysis between CDT in serum and Ethyl glucuronide in hair to define the best reliable tool for the diagnosis of alcohol abuse","volume":"257","author":"Cerioni","year":"2024","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.mce.2025.112676_bib30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature14232","article-title":"Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome","volume":"519","author":"Chassaing","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.mce.2025.112676_bib31","article-title":"Meta-analysis: overweight, obesity, and parkinson's disease","volume":"2014","author":"Chen","year":"2014","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.mce.2025.112676_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.imbio.2017.10.005","article-title":"The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2","volume":"223","author":"Chistiakov","year":"2018","journal-title":"Immnobiology"},{"key":"10.1016\/j.mce.2025.112676_bib33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4291\/wjgp.v5.i3.147","article-title":"Molecular mechanisms of alcohol associated pancreatitis","volume":"5","author":"Clemens","year":"2014","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.mce.2025.112676_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3390\/livers2040023","article-title":"Role of oxidative stress in liver disorders","volume":"2","author":"Conde de la Rosa","year":"2022","journal-title":"Liver"},{"key":"10.1016\/j.mce.2025.112676_bib35","first-page":"252","article-title":"The combined Pioglitazone and Topiramate therapy for management of pediatric patients with severe MASLD","volume":"30","author":"Conroy","year":"2024","journal-title":"Saudi J. Gastroenterol."},{"key":"10.1016\/j.mce.2025.112676_bib36","article-title":"Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study","volume":"35","author":"Cordova","year":"2023","journal-title":"The Lancet. Reg. Health. Europe"},{"key":"10.1016\/j.mce.2025.112676_bib37","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.rce.2023.04.003","article-title":"Prevalence of nonalcoholic fatty liver disease in a Spanish town: a population-based study","volume":"223","author":"Cusacovich","year":"2023","journal-title":"Rev. Clin. Esp."},{"key":"10.1016\/j.mce.2025.112676_bib38","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2174\/1381612826666200122152417","article-title":"Nonalcoholic fatty liver disease versus alcohol-related liver disease: is it really so different?","volume":"26","author":"Craciun","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mce.2025.112676_bib39","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pcad.2019.01.005","article-title":"Non-alcoholic fatty liver disease: prevalence and all-cause mortality according to sedentary behaviour and cardiorespiratory fitness. The HUNT Study","volume":"62","author":"Croci","year":"2019","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.mce.2025.112676_bib40","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cld.2016.02.010","article-title":"Nutrition and alcoholic liver disease: effects of alcoholism on nutrition, effects of nutrition on alcoholic liver disease, and nutritional therapies for alcoholic liver disease","volume":"20","author":"Dasarathy","year":"2016","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.mce.2025.112676_bib41","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.1111\/liv.12312","article-title":"Hypovitaminosis D is associated with increased whole body fat mass and greater severity of non-alcoholic fatty liver disease","volume":"34","author":"Dasarathy","year":"2014","journal-title":"Liver Int."},{"key":"10.1016\/j.mce.2025.112676_bib42","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.2174\/0929867330666221209093343","article-title":"Cellular functional, protective or damaging responses associated with different redox imbalance intensities: a comprehensive review","volume":"30","author":"Del Campo","year":"2023","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mce.2025.112676_bib43","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1002\/hep.20957","article-title":"Alcohol and oxidative liver injury","volume":"43","author":"Dey","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2025.112676_bib44","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.injury.2016.03.007","article-title":"Alcohol consumption decreases lactate clearance in acutely injured patients","volume":"47","author":"Dezman","year":"2016","journal-title":"Injury"},{"key":"10.1016\/j.mce.2025.112676_bib45","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.3390\/ijms23052636","article-title":"Synergistic and detrimental effects of alcohol intake on progression of liver steatosis","volume":"23","author":"Di Ciaula","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112676_bib46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/nu14010023","article-title":"The role of diet quality in mediating the association between ultra-processed food intake, obesity and health-related outcomes: a review of prospective cohort studies","volume":"14","author":"Dicken","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/gast.2001.25540","article-title":"Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese","volume":"121","author":"Dixon","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2025.112676_bib48","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jnutbio.2014.04.011","article-title":"Reversal of high-fat diet-induced hepatic steatosis by n-3 LCPUFA: role of PPAR-\u03b1 and SREBP-1c","volume":"25","author":"Dossi","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.mce.2025.112676_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1138078","article-title":"Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and \u03b2-oxidation","volume":"14","author":"Du","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2025.112676_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/nutd.2015.4","article-title":"Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity","volume":"5","author":"Duly","year":"2015","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.mce.2025.112676_bib51","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/2047-783X-16-2-76","article-title":"Plasma levels of vitamin E and carotenoids are decreased in patients with Nonalcoholic Steatohepatitis (NASH)","volume":"16","author":"Erhardt","year":"2011","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.mce.2025.112676_bib52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3746\/pnf.2024.29.1.18","article-title":"Strategies for healthier meat foods: an overview","volume":"29","author":"Espinales","year":"2024","journal-title":"Prev. Nutr. Food. Sci"},{"key":"10.1016\/j.mce.2025.112676_bib53","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3390\/ijms12053117","article-title":"Inflammation, oxidative stress, and obesity","volume":"12","author":"Fern\u00e1ndez-S\u00e1nchez","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112676_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.774718","article-title":"Intake of ultra-processed food and ectopic-, visceral- and other fat depots: a cross-sectional study","volume":"9","author":"Frid\u00e9n","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib55","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12876-020-01369-x","article-title":"Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study","volume":"20","author":"Fujii","year":"2020","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.mce.2025.112676_bib56","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jhep.2021.02.027","article-title":"Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: a randomized controlled trial","volume":"5","author":"Geidl-Flueck","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2025.112676_bib57","first-page":"101","article-title":"Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1","volume":"569","author":"Gonz\u00e1lez","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mce.2025.112676_bib58","article-title":"Meat consumption: which are the current global risks? A review of recent (2010-2020) evidences","volume":"137","author":"Gonz\u00e1lez","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.mce.2025.112676_bib59","first-page":"273","article-title":"Alcohol promotes liver fibrosis in high fat diet induced diabetic rats","volume":"35","author":"Gopinath","year":"2024","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.mce.2025.112676_bib60","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/HEP.0000000000000570","article-title":"Medications for alcohol use disorder promote abstinence in alcohol-associated cirrhosis: results from a systematic review and meta-analysis","volume":"79","author":"Gratac\u00f3s-Gin\u00e8s","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2025.112676_bib61","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1124\/mi.3.4.194","article-title":"Cytochromes P450, drugs, and diseases","volume":"3","author":"Guengerich","year":"2003","journal-title":"Mol. Interv."},{"key":"10.1016\/j.mce.2025.112676_bib62","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.1038\/s41598-025-91312-5","article-title":"Global burden of MAFLD, MAFLD related cirrhosis and MASH related liver cancer from 1990 to 2021","volume":"15","author":"Guo","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2025.112676_bib63","first-page":"119","article-title":"Reflections on technological progress in the agri-food industry: past, present, and future","volume":"71","author":"Hailu","year":"2023","journal-title":"Canadian. J. Agricult. Agronom"},{"key":"10.1016\/j.mce.2025.112676_bib64","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-2004-832941","article-title":"Nutrition and alcoholic liver disease","volume":"24","author":"Halsted","year":"2004","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.mce.2025.112676_bib65","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cld.2018.09.010","article-title":"Chronic neurologic effects of alcohol","volume":"23","author":"Hammoud","year":"2019","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.mce.2025.112676_bib66","article-title":"Quantification of alcohol intake in patients with steatotic liver disease and excessive alcohol intake","volume":"7","author":"Hansen","year":"2025","journal-title":"JHEP. Rep"},{"key":"10.1016\/j.mce.2025.112676_bib67","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s40429-021-00402-7","article-title":"Blood biomarkers of alcohol use: a scoping review","volume":"8","author":"Harris","year":"2021","journal-title":"Curr. Addict. Rep"},{"key":"10.1016\/j.mce.2025.112676_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2023.100105","article-title":"Assessing the sensitivity and specificity of phosphatidylethanol (PEth) cutoffs to identify alcohol exposed pregnancies","volume":"4","author":"Hasken","year":"2023","journal-title":"Curr. Res. Toxicol"},{"key":"10.1016\/j.mce.2025.112676_bib69","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.plipres.2004.05.001","article-title":"Fatty acid-binding proteins--Insights from genetic manipulations","volume":"43","author":"Haunerland","year":"2004","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.mce.2025.112676_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.745609","article-title":"Effects of oral vitamin C supplementation on liver health and associated parameters in patients with non-alcoholic fatty liver disease: a randomized clinical trial","volume":"8","author":"He","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib71","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.3390\/nu15102266","article-title":"Ultra-processed food intake is associated with non-alcoholic fatty liver disease in adults: a systematic review and meta-analysis","volume":"15","author":"Henney","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib72","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.cmet.2021.09.010","article-title":"Molecular aspects of fructose metabolism and metabolic disease","volume":"33","author":"Herman","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2025.112676_bib73","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1172\/JCI89444","article-title":"Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance","volume":"127","author":"Hern\u00e1ndez","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112676_bib74","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.cgh.2022.11.033","article-title":"Alcohol abstinence improves prognosis across all stages of portal hypertension in alcohol-related cirrhosis","volume":"21","author":"Hofer","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2025.112676_bib75","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112676_bib76","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.dsx.2015.09.005","article-title":"Gamma glutamyl transferase is an independent determinant for the association of insulin resistance with nonalcoholic fatty liver disease in Bangladeshi adults: Association of GGT and HOMA-IR with NAFLD","volume":"10","author":"Hossain","year":"2016","journal-title":"Diabetes Metabol. Syndr."},{"key":"10.1016\/j.mce.2025.112676_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.716783","article-title":"Dietary interventions in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"8","author":"Houttu","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib78","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2147\/RMHP.S285880","article-title":"MAFLD criteria guide the subtyping of patients with fatty liver disease","volume":"14","author":"Huang","year":"2021","journal-title":"Risk Manag. Healthc. Policy"},{"key":"10.1016\/j.mce.2025.112676_bib79","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41380-023-02352-0","article-title":"Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup","volume":"29","author":"Huggins","year":"2024","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.mce.2025.112676_bib80","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/MEG.0b013e32830a4f4c","article-title":"The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption","volume":"21","author":"Imbert-Bismut","year":"2009","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2025.112676_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109224","article-title":"Fructose impairs fat oxidation: implications for the mechanism of western diet-induced NAFLD","volume":"114","author":"Inci","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.mce.2025.112676_bib82","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fnbeh.2013.00080","article-title":"Gene specific modifications unravel ethanol and acetaldehyde actions","volume":"7","author":"Israel","year":"2013","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.mce.2025.112676_bib83","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1111\/liv.14996","article-title":"Ultra-processed food is associated with features of metabolic syndrome and non-alcoholic fatty liver disease","volume":"41","author":"Ivancovsky-Wajcman","year":"2021","journal-title":"Liver Int."},{"key":"10.1016\/j.mce.2025.112676_bib84","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3390\/nu12082435","article-title":"Effects of resveratrol supplementation in patients with non-alcoholic fatty liver disease\u2014A meta-analysis","volume":"12","author":"Jakubczyk","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib85","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1039\/C1FO10111K","article-title":"Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBP1c with no effect on body weight or liver fat","volume":"3","author":"Janevski","year":"2012","journal-title":"Food Funct."},{"key":"10.1016\/j.mce.2025.112676_bib86","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.3748\/wjg.v20.i9.2143","article-title":"Therapy for alcoholic liver disease","volume":"20","author":"Jaurigue","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.mce.2025.112676_bib87","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.3390\/ijms21093066","article-title":"The molecular and mechanistic insights based on gut\u2013liver axis: nutritional target for non-alcoholic fatty liver disease (NAFLD) improvement","volume":"21","author":"Ji","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112676_bib88","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/biomedicines8030050","article-title":"Alcohol metabolizing enzymes, microsomal ethanol oxidizing system, cytochrome P450 2E1, catalase, and aldehyde dehydrogenase in alcohol-associated liver disease","volume":"8","author":"Jiang","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.mce.2025.112676_bib89","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2014.03.035","article-title":"Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy","volume":"72","author":"Jiang","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mce.2025.112676_bib90","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1161\/STROKEAHA.120.029630","article-title":"Phosphatidylethanol levels, as a marker of alcohol consumption, are associated with risk of intracerebral hemorrhage","volume":"51","author":"Johansson","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.mce.2025.112676_bib91","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.2174\/138161210791516404","article-title":"Topiramate in the new generation of drugs: efficacy in the treatment of alcoholic patients","volume":"16","author":"Johnson","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mce.2025.112676_bib92","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1001\/archinte.168.11.1188","article-title":"Improvement of physical health and quality of life of alcohol-dependent individuals with Topiramate treatment: US multisite randomized controlled trial","volume":"168","author":"Johnson","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.mce.2025.112676_bib93","doi-asserted-by":"crossref","DOI":"10.1002\/wfs2.1353","article-title":"Alcohol, its analysis in blood and breath for forensic purposes, impairment effects, and acute toxicity","volume":"1","author":"Jones","year":"2019","journal-title":"WIREs. Forensic. Sci"},{"key":"10.1016\/j.mce.2025.112676_bib94","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1093\/jn\/nxaa409","article-title":"Associations of serum fatty acid proportions with obesity, insulin resistance, blood pressure, and fatty liver: the cardiovascular risk in young finns study","volume":"151","author":"Kaikkonen","year":"2021","journal-title":"J. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib95","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/0972-6748.132914","article-title":"Clinical management of alcohol withdrawal: a systematic review","volume":"22","author":"Kattimani","year":"2013","journal-title":"Ind. Psychiatry J."},{"key":"10.1016\/j.mce.2025.112676_bib96","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.bbalip.2011.09.010","article-title":"Fatty acid transport proteins, implications in physiology and dsease","volume":"1821","author":"Kazantzis","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2025.112676_bib97","first-page":"E290","article-title":"Ketone metabolites in metabolic dysfunction-associated steatotic liver disease progression: optimizing keto-therapeutic strategies","volume":"329","author":"Kelty","year":"2025","journal-title":"Am. Jails"},{"key":"10.1016\/j.mce.2025.112676_bib98","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biochi.2016.12.019","article-title":"The role and regulation of the peroxisome proliferator activated receptor alpha in human liver","volume":"136","author":"Kersten","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.mce.2025.112676_bib99","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-020167","article-title":"Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women","volume":"8","author":"Khaw","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.mce.2025.112676_bib100","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/hep.31158","article-title":"Inadequate physical activity and sedentary behavior are independent predictors of nonalcoholic Fatty liver disease","volume":"72","author":"Kim","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2025.112676_bib101","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1172\/JCI81993","article-title":"ChREBP regulates fructose-induced glucose production independently of insulin signaling","volume":"126","author":"Kim","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112676_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117073","article-title":"Novel insights into regulators and functional modulators of adipogenesis","volume":"177","author":"Kim","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mce.2025.112676_bib103","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1111\/j.1742-4658.2011.08357.x","article-title":"Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity","volume":"278","author":"Knockaert","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.mce.2025.112676_bib104","doi-asserted-by":"crossref","DOI":"10.1097\/PG9.0000000000000126","article-title":"Utilization of topiramate as an adjunct to lifestyle intervention for weight loss in pediatric nonalcoholic fatty liver disease","volume":"2","author":"Kohut","year":"2021","journal-title":"JPGN. Rep"},{"key":"10.1016\/j.mce.2025.112676_bib105","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/jpen.2722","article-title":"Topiramate treatment of pediatric metabolic dysfunction-associated steatotic liver disease: a descriptive cohort study","volume":"49","author":"Kohut","year":"2025","journal-title":"JPEN - J. Parenter. Enter. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib106","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3390\/ijms20112712","article-title":"Pathogenesis, early diagnosis, and therapeutic management of alcoholic liver disease","volume":"20","author":"Kong","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112676_bib107","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.3390\/nu14194142","article-title":"Does consumption of ultra-processed foods matter for liver health? Prospective analysis among older adults with metabolic syndrome","volume":"14","author":"Konieczna","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib108","doi-asserted-by":"crossref","first-page":"387","DOI":"10.4082\/kjfm.19.0061","article-title":"Borderline-high mean corpuscular volume levels are associated with arterial stiffness among the apparently healthy korean individuals","volume":"41","author":"Kwon","year":"2020","journal-title":"Korean. J. Fam. Med"},{"key":"10.1016\/j.mce.2025.112676_bib109","doi-asserted-by":"crossref","first-page":"40732","DOI":"10.1074\/jbc.M112.399899","article-title":"Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress. Potential role in fructose-dependent and -independent fatty liver","volume":"287","author":"Lanaspa","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2025.112676_bib110","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.3390\/nu14142846","article-title":"Important food sources of fructose-containing sugars and non-alcoholic fatty liver disease: a systematic review and meta-analysis of controlled trials","volume":"14","author":"Lee","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib111","article-title":"Novel insights into regulators and functional modulators of adipogenesis","volume":"177","author":"Lee","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mce.2025.112676_bib112","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI27989","article-title":"Sorting out the roles of PPAR aIlpha in energy metabolism and vaszcular homeostasis","volume":"116","author":"Lefebvre","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112676_bib113","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1038\/s41467-022-34671-1","article-title":"Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism","volume":"13","author":"Lei","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2025.112676_bib114","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00018-022-04239-9","article-title":"Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets","volume":"79","author":"Li","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mce.2025.112676_bib115","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.3390\/nu16234008","article-title":"Trends in consumption of ultra-processed foods among adults in southern China: analysis of serial cross-sectional health survey data 2002-2022","volume":"16","author":"Li","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib116","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/07315724.1991.10718182","article-title":"Alcohol, liver, and nutrition","volume":"10","author":"Lieber","year":"1991","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib117","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0950-3528(93)90003-B","article-title":"Aetiology and pathogenesis of alcoholic liver disease","volume":"7","author":"Lieber","year":"1993","journal-title":"Bailliere. Clin. Gastroenterol"},{"key":"10.1016\/j.mce.2025.112676_bib118","first-page":"220","article-title":"Relationships between nutrition, alcohol use, and liver disease","volume":"27","author":"Lieber","year":"2003","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.mce.2025.112676_bib119","first-page":"972","article-title":"Epidemiology and clinical outcomes of Metabolic (Dysfunction)-associated Fatty liver disease","volume":"9","author":"Lin","year":"2021","journal-title":"J. Clin. Transl. Hepatol"},{"key":"10.1016\/j.mce.2025.112676_bib120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.phrs.2015.07.023","article-title":"Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPK\u03b1-SREBP-1 and PPAR\u03b1-dependent pathways","volume":"100","author":"Liu","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mce.2025.112676_bib121","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1111\/bph.14503","article-title":"Diethyldithiocarbamate, an anti-abuse drug, alleviates steatohepatitis and fibrosis in rodents through modulating lipid metabolism and oxidative stress","volume":"175","author":"Liu","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2025.112676_bib122","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1017\/S0007114522003956","article-title":"Association between ultra-processed foods consumption and risk of non-alcoholic fatty liver disease: a population-based analysis of NHANES 2011-2018","volume":"130","author":"Liu","year":"2023","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib123","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1093\/jnci\/djab078","article-title":"Novel biomarkers of habitual alcohol intake and associations with risk of pancreatic and liver cancers and liver disease mortality","volume":"113","author":"Loftfield","year":"2021","journal-title":"J. Nati. Cancer. Inst"},{"key":"10.1016\/j.mce.2025.112676_bib124","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1459790","article-title":"Effects of omega-3 fatty acid in nonalcoholic fatty liver disease: a meta-analysis","volume":"2016","author":"Lu","year":"2016","journal-title":"Gastroenterol. Res. Pract"},{"key":"10.1016\/j.mce.2025.112676_bib125","article-title":"Dietary vitamin C intake is associated with improved liver function and glucose metabolism in chinese adults","volume":"8","author":"Luo","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib126","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jhep.2015.03.032","article-title":"Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts","volume":"63","author":"Ma","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2025.112676_bib127","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41574-021-00627-6","article-title":"The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases","volume":"18","author":"Malik","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2025.112676_bib128","article-title":"Gelatinases as markers of chronic alcohol consumption: a pilot study in Uruguay","volume":"7","author":"Marco","year":"2020","journal-title":"An. Facultad. Med. (Univ Rep\u00fab Urug)"},{"key":"10.1016\/j.mce.2025.112676_bib129","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/iub.2550","article-title":"The redox signal: a physiological perspective","volume":"74","author":"Margaritelis","year":"2022","journal-title":"IUBMB Life"},{"key":"10.1016\/j.mce.2025.112676_bib130","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-98788-0_14","article-title":"Engineered animal models designed for investigating ethanol metabolism, toxicity and cancer","volume":"1032","author":"Marshal","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mce.2025.112676_bib131","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.3390\/nu13103390","article-title":"Ultra-processed foods and nutritional dietary profile: a meta-analysis of nationally representative samples","volume":"13","author":"Martini","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib132","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1530-0277.2010.01405.x","article-title":"Alcoholic liver disease and malnutrition","volume":"35","author":"McClain","year":"2011","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.mce.2025.112676_bib133","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/jama.2023.19761","article-title":"Pharmacotherapy for alcohol disorder: a systematic review and meta-analysis","volume":"330","author":"McPheeters","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.mce.2025.112676_bib134","doi-asserted-by":"crossref","first-page":"490","DOI":"10.2119\/molmed.2014.00048","article-title":"Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis","volume":"20","author":"Minato","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.mce.2025.112676_bib135","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev.nu.06.070186.002325","article-title":"Alcohol and nutrition: caloric value, bioenergetics, and relationship to liver damage","volume":"6","author":"Mitchell","year":"1986","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib136","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.946474","article-title":"Emerging role of hepatic ketogenesis in fatty liver disease","volume":"13","author":"Mooli","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mce.2025.112676_bib138","first-page":"63","article-title":"Open-label study with Nalmefene as needed use in alcohol-dependent patients with evidence of elevated liver stiffness and\/or hepatic steatosis","volume":"55","author":"Mueller","year":"2020","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.mce.2025.112676_bib139","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/nutrit\/nuy022","article-title":"Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease","volume":"76","author":"Musa-Veloso","year":"2018","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.mce.2025.112676_bib140","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jceh.2017.09.004","article-title":"Matrix metalloproteinases (MMPs) in liver diseases","volume":"7","author":"Naim","year":"2017","journal-title":"J. Clin. Exp. Hepatol"},{"key":"10.1016\/j.mce.2025.112676_bib141","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1089\/ars.2015.6407","article-title":"The roles of mitochondrial damage-associated molecular patterns in diseases","volume":"23","author":"Nakahira","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mce.2025.112676_bib142","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/ijerph13020166","article-title":"Biomarker-based approaches for assessing alcohol use disorders","volume":"13","author":"Niemel\u00e4","year":"2016","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.mce.2025.112676_bib143","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/bs.acc.2023.05.002","article-title":"Predictive risk markers in alcoholism","volume":"116","author":"Niemel\u00e4","year":"2023","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.mce.2025.112676_bib144","series-title":"Peroxisome Proliferator Activator Receptors (Ppars). Structure, Mecanisms of Action and Role in Health and Disease","first-page":"221","article-title":"Modulation of PPARs in health an disease: role of fatty acids","author":"Ortiz","year":"2019"},{"key":"10.1016\/j.mce.2025.112676_bib145","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1055\/s-0043-100019","article-title":"Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial","volume":"67","author":"Panahi","year":"2017","journal-title":"Drug Res."},{"key":"10.1016\/j.mce.2025.112676_bib146","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1080\/10826084.2021.1963984","article-title":"The contribution of alcohol beverage types to consumption, heavy drinking, and alcohol-related harms: a comparison across five countries","volume":"56","author":"Paschall","year":"2021","journal-title":"Subst. Use Misuse"},{"key":"10.1016\/j.mce.2025.112676_bib147","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/8821610","article-title":"Regulatory mechanism of M1\/M2 macrophage polarization in the development of autoimmune diseases","volume":"2023","author":"Peng","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.mce.2025.112676_bib148","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.bbadis.2009.08.015","article-title":"Enhancement in liver SREBP-1c\/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion","volume":"1792","author":"Pettinelli","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2025.112676_bib149","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/jc.2010-2129","article-title":"Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction","volume":"96","author":"Pettinelli","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2025.112676_bib150","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ajpath.2020.09.011","article-title":"High-fat diet-induced adipose tissue and liver inflammation and steatosis in mice are reduced by inhibiting sialidases","volume":"191","author":"Pilling","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mce.2025.112676_bib151","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1093\/ajcn\/83.6.1351","article-title":"Additive effects of moderate drinking and obesity on serum gamma-glutamyl transferase activity","volume":"83","author":"Puukka","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib152","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1038\/s41598-024-52482-w","article-title":"Vitamin E intake is inversely associated with NAFLD measured by liver ultrasound transient elastography","volume":"14","author":"Qi","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2025.112676_bib153","article-title":"Efficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis of clinical trials","volume":"42","author":"Rafiee","year":"2021","journal-title":"Compl. Ther. Clin. Pract."},{"key":"10.1016\/j.mce.2025.112676_bib154","doi-asserted-by":"crossref","first-page":"42","DOI":"10.7762\/cnr.2022.11.1.42","article-title":"Red and processed meat intake in relation to non-alcoholic fatty liver disease risk: results from a case-control satudy","volume":"11","author":"Rahimi-Sakak","year":"2022","journal-title":"Clin. Nutr. Res"},{"key":"10.1016\/j.mce.2025.112676_bib155","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/ptr.5659","article-title":"Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial","volume":"30","author":"Rahmani","year":"2016","journal-title":"Phytother Res."},{"key":"10.1016\/j.mce.2025.112676_bib156","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4103\/0253-7613.96297","article-title":"Molecular mechanism of alcoholic fatty liver","volume":"44","author":"Rasineni","year":"2012","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.mce.2025.112676_bib157","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jep.2018.12.034","article-title":"Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha","volume":"232","author":"Ren","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.mce.2025.112676_bib158","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1210\/jc.2019-00160","article-title":"Overeating saturated fat promotes fatty liver and ceramides compared with polyunsaturated fat: a randomized trial","volume":"104","author":"Rosqvist","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2025.112676_bib159","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.dld.2015.05.021","article-title":"Diagnosis and treatment of nutritional deficiencies in alcoholic liver disease: overview of available evidence and open issues","volume":"47","author":"Rossi","year":"2015","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.mce.2025.112676_bib160","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1002\/fsn3.2278","article-title":"The effect of anthocyanins supplementation on liver enzymes: a systematic review and meta-analysis of randomized clinical trials","volume":"9","author":"Sangsefidi","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib161","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1742-4658.2008.06807.x","article-title":"SREBPs: protein interaction and SREBPs","volume":"276","author":"Sato","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.mce.2025.112676_bib162","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.3390\/ijms25084537","article-title":"NLRP3 inflammasome in acute and chronic liver diseases","volume":"25","author":"Sayaf","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112676_bib163","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1152\/ajpendo.00513.2004","article-title":"PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes","volume":"288","author":"Schadinger","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2025.112676_bib164","series-title":"Encyclopedia of Forensic Sciences","first-page":"156","article-title":"Drug facilitated crimes","author":"Scott","year":"2023"},{"key":"10.1016\/j.mce.2025.112676_bib165","first-page":"147","article-title":"Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD)","volume":"4","author":"Seitz","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib166","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/npr2.12028","article-title":"Anticraving therapy for alcohol use disorder: a clinical review","volume":"383","author":"Shen","year":"2018","journal-title":"Neuropsychopharmacol. Rep"},{"key":"10.1016\/j.mce.2025.112676_bib167","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodpol.2018.04.013","article-title":"Review: Meta-analysis of the association between production diversity, diets, and nutrition in smallholder farm households","volume":"77","author":"Sibhatu","year":"2018","journal-title":"Food Policy"},{"key":"10.1016\/j.mce.2025.112676_bib168","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mce.2025.112676_bib169","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/jn\/135.5.969","article-title":"Nutritional, dietary and postprandial oxidative stress","volume":"135","author":"Sies","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib170","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/ajcn\/70.5.928","article-title":"De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption","volume":"70","author":"Siler","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib171","first-page":"1039","article-title":"Sialic acid: new potential marker of alcohol abuse","volume":"23","author":"Sillanaukee","year":"1999","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.mce.2025.112676_bib172","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-3-030-64872-5_18","article-title":"Beneficial effects of plant-derived natural products on non-alcoholic fatty liver disease","volume":"1308","author":"Simental-Mend\u00eda","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mce.2025.112676_bib173","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.clnu.2024.05.017","article-title":"A unified framework for prediction of liver steatosis dynamics in response to different diet and drug interventions","volume":"43","author":"Simonsson","year":"2024","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib174","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jhep.2022.04.040","article-title":"Ethyl glucuronide in hair detects a high rate of harmful alcohol consumption in presumed non-alcoholic fatty liver disease","volume":"77","author":"Staufer","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2025.112676_bib175","first-page":"306","article-title":"Intestinal immune barrier integrity in rats with nonalcoholic hepatic steatosis and steatohepatitis","volume":"125","author":"Su","year":"2012","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.mce.2025.112676_bib176","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1194\/jlr.M600276-JLR200","article-title":"The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317","volume":"47","author":"Talukdar","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.mce.2025.112676_bib177","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9719584","article-title":"Nutrients and oxidative stress: friend or foe?","volume":"2018","author":"Tan","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mce.2025.112676_bib178","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3390\/nu10081126","article-title":"Evaluation of a high concentrate omega-3 for correcting the omega-3 fatty acid nutritional deficiency in non-.se (CONDIN)","volume":"10","author":"Tobin","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib179","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.3390\/nu16162699","article-title":"Efficacy of the Mediterranean diet containing different macronutrients on non-alcoholic fatty liver disease","volume":"16","author":"Ulu\u00e7ay","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib180","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3390\/nu13051442","article-title":"Overview of non-alcoholic fatty liver disease (NAFLD) and the role of sugary food consumption and other dietary components in its development","volume":"13","author":"Vancells Lujan","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib181","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4067\/S0716-97602008000100010","article-title":"Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women","volume":"41","author":"Varela","year":"2008","journal-title":"Biol. Res."},{"key":"10.1016\/j.mce.2025.112676_bib182","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115528","article-title":"Omega-3 lipid mediators: modulation of the M1\/M2 macrophage phenotype and its protective role in chronic liver diseases","volume":"24","author":"Videla","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2025.112676_bib183","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202400062","article-title":"Relevant aspects of combined protocols for prevention of N(M)AFLD and other non-communicable diseases","volume":"68","author":"Videla","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.mce.2025.112676_bib184","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.3390\/nu15173733","article-title":"The effect of vitamin E supplementation on serum aminotransferases in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis","volume":"15","author":"Vogli","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib185","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.nut.2014.04.003","article-title":"Fructose content in popular beverages made with and without high-fructose corn syrup","volume":"30","author":"Walker","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.mce.2025.112676_bib186","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/eci.12161","article-title":"New insights into the molecular mechanism of intestinal fatty acid absorption","volume":"43","author":"Wang","year":"2013","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.mce.2025.112676_bib187","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm4074","article-title":"Transcriptional regulation of hepatic lipogenesis","volume":"16","author":"Wang","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2025.112676_bib188","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1038\/s41598-022-06636-3","article-title":"Circulating acyl and des-acyl ghrelin levels in obese adults: a systematic review and meta-analysis","volume":"12","author":"Wang","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2025.112676_bib189","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.2147\/JIR.S466469","article-title":"Association of hematological biomarkers of inflammation with 10-year major adverse cardiovascular events and all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease: the ARIC study","volume":"17","author":"Wang","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.mce.2025.112676_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.105816","article-title":"Alcohol aggravates metabolic fatty liver in high-fat diet mice via gut microbiota and metabolite-mediated TLR4\/NF-\u03baB and MCT1\/GPR pathways","volume":"63","author":"Wang","year":"2025","journal-title":"Food Biosci."},{"key":"10.1016\/j.mce.2025.112676_bib191","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12992-021-00767-4","article-title":"The future of human malnutrition: rebalancing agency for better nutritional health","volume":"17","author":"Wells","year":"2021","journal-title":"Glob. Health"},{"key":"10.1016\/j.mce.2025.112676_bib192","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s13679-023-00495-3","article-title":"Obesity stigma: causes, consequences, and potential solutions","volume":"12","author":"Westbury","year":"2023","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.mce.2025.112676_bib193","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.3390\/nu14142940","article-title":"A high-sugar diet consumption, metabolism and health impacts with a focus on the development of substance use disorder: a narrative review","volume":"14","author":"Witek","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.mce.2025.112676_bib194","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.4254\/wjh.v7.i16.2041","article-title":"Physical activity as a treatment of non-alcoholic fatty liver disease: a systematic review","volume":"7","author":"Whitsett","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.mce.2025.112676_bib195","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1162031","article-title":"Serum vitamin C levels and risk of non-alcoholic fatty liver disease: results from a cross-sectional study and Mendelian randomization analysis","volume":"10","author":"Wu","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib196","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1369-1600.2009.00185.x","article-title":"Normalization during detoxification, gender aspects and correlation with other biomarkers and self-reports","volume":"15","author":"Wurst","year":"2010","journal-title":"Addict. Biol."},{"key":"10.1016\/j.mce.2025.112676_bib197","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mce.2025.112676_bib198","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109609","article-title":"Role of farnesoid X receptor in hepatic steatosis in nonalcoholic fatty liver disease","volume":"121","author":"Xi","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mce.2025.112676_bib199","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12986-019-0420-1","article-title":"Insoluble dietary fibre intake is associated with lower prevalence of newly-diagnosed non-alcoholic fatty liver disease in Chinese men: a large population-based cross-sectional study","volume":"17","author":"Xia","year":"2020","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.mce.2025.112676_bib200","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1265507","article-title":"Higher anthocyanin intake is associated with a lower risk of non-alcoholic fatty liver disease in the United States adult population","volume":"10","author":"Xiang","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib201","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jhep.2010.12.034","article-title":"Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK","volume":"55","author":"Xu","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2025.112676_bib202","article-title":"Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2025.112676_bib203","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6572499","article-title":"Effects of Naltrexone on expression of lipid metabolism-related proteins in liver steatosis induced by endoplasmic reticulum stress in mice","volume":"2022","author":"Yang","year":"2022","journal-title":"Contrast Media Mol. Imaging"},{"key":"10.1016\/j.mce.2025.112676_bib204","doi-asserted-by":"crossref","first-page":"29342","DOI":"10.1074\/jbc.M202411200","article-title":"Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)","volume":"277","author":"You","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2025.112676_bib205","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.00056.2004","article-title":"Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver","volume":"287","author":"You","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.mce.2025.112676_bib206","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jhep.2018.01.015","article-title":"High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance","volume":"68","author":"Zelber-Sagi","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2025.112676_bib207","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.156028","article-title":"The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: an international multidisciplinary expert consensus","volume":"161","author":"Zeng","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2025.112676_bib208","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/ije\/dyab174","article-title":"Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease in the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study","volume":"51","author":"Zhang","year":"2022","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.mce.2025.112676_bib209","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/jamapediatrics.2024.1576","article-title":"Global prevalence of overweight and obesity in children and adolescents: a systematic review and meta-analysis","volume":"178","author":"Zhang","year":"2024","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.mce.2025.112676_bib210","article-title":"Efficacy of fish oil supplementation on metabolic dysfunction-associated steatotic liver disease: a meta-analysis","volume":"12","author":"Zhou","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.mce.2025.112676_bib211","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.2337\/db18-0474","article-title":"CETP inhibition improves HDL function but leads to fatty liver and insulin resistance in CETP-expressing transgenic mice on a high-fat diet","volume":"67","author":"Zhu","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2025.112676_bib212","doi-asserted-by":"crossref","first-page":"E532","DOI":"10.1152\/ajpendo.00258.2011","article-title":"Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance","volume":"302","author":"Zong","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725002278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720725002278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:38:11Z","timestamp":1773279491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720725002278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":210,"alternative-id":["S0303720725002278"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2025.112676","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interrelationship between alcohol consumption, overnutrition, and pharmacotherapy for liver steatosis: Considerations and proposals","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2025.112676","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112676"}}