{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:20:45Z","timestamp":1777868445663,"version":"3.51.4"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"National Scientific and Technical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mce.2026.112772","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:43:35Z","timestamp":1771919015000},"page":"112772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fructose-induced prediabetes causes persistent DNA methylation changes in white adipose tissue despite metabolic normalization"],"prefix":"10.1016","volume":"616","author":[{"given":"B\u00e1rbara","family":"Dumrauf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Victoria","family":"Mencucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezequiel","family":"Lacunza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn Carlos","family":"Abba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-8748","authenticated-orcid":false,"given":"Luis Emilio","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-943X","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Maiztegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"Gagliardino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6197-7251","authenticated-orcid":false,"given":"Flavio","family":"Francini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1085-1609","authenticated-orcid":false,"given":"Carolina","family":"Lisi Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.mce.2026.112772_bib1","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","article-title":"methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles","volume":"13","author":"Akalin","year":"2012","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3945\/ajcn.112.051383","article-title":"Prospective associations between sugar-sweetened beverage intakes and cardiometabolic risk factors in adolescents","volume":"98","author":"Ambrosini","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib3","first-page":"681","article-title":"Fasting hyperglycemia in the goto-Kakizaki Rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes","volume":"5","author":"Beddow","year":"2012","journal-title":"Dis. Model. Mech."},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: global epidemiology and pathogenesis","volume":"15","author":"Bl\u00fcher","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"11","key":"10.1016\/j.mce.2026.112772_bib5","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1210\/en.2012-2255","article-title":"Maternal obesity enhances white adipose tissue differentiation and alters genome-scale DNA methylation in Male rat offspring","volume":"154","author":"Borengasser","year":"2013","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.mce.2026.112772_bib6","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jnutbio.2013.12.005","article-title":"High-fructose diet leads to visceral adiposity and hypothalamic leptin resistance in Male rats \u2014 do glucocorticoids play a role?","volume":"25","author":"Bursa\u0107","year":"2014","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.mce.2026.112772_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/medicina58010008","article-title":"Chronological appearance of endocrine and metabolic dysfunctions induced by an unhealthy diet in rats","volume":"58","author":"Castro","year":"2021","journal-title":"Medicina (Kaunas, Lithuania)"},{"issue":"17","key":"10.1016\/j.mce.2026.112772_bib8","first-page":"i884","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"4","key":"10.1016\/j.mce.2026.112772_bib9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s00125-006-0170-2","article-title":"Mitochondria are impaired in the adipocytes of type 2 diabetic mice","volume":"49","author":"Choo","year":"2006","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.mce.2026.112772_bib10","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.2337\/db05-1421","article-title":"Downregulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis Factor-\u03b1","volume":"55","author":"Dahlman","year":"2006","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1159\/000333445","article-title":"Combined gene and protein expression of hormone-sensitive lipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly Obese men","volume":"4","author":"De","year":"2011","journal-title":"Obes. Facts"},{"issue":"June","key":"10.1016\/j.mce.2026.112772_bib12","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1038\/ncomms5093","article-title":"LSD1 promotes oxidative metabolism of white adipose tissue","volume":"5","author":"Duteil","year":"2014","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/CS20120470","article-title":"Antioxidant treatment prevents the development of fructose-induced abdominal adipose tissue dysfunction","volume":"125","author":"Fari\u00f1a","year":"2013","journal-title":"Clinical Science (London, England: 1979)"},{"issue":"1","key":"10.1016\/j.mce.2026.112772_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.mce.2026.112772_bib15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00394-006-0608-9","article-title":"Effect of hyperglycemic condition on proteoglycan secretion in cultured human endothelial cells","volume":"45","author":"Gharagozlian","year":"2006","journal-title":"Eur. J. Nutr."},{"issue":"10","key":"10.1016\/j.mce.2026.112772_bib16","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.2337\/dc08-0909","article-title":"Serum xylosyltransferase activity in diabetic patients as a possible marker of reduced proteoglycan biosynthesis","volume":"31","author":"G\u00f6tting","year":"2008","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.mce.2026.112772_bib17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0026-0495(87)90019-9","article-title":"Long-term hypertriglyceridemia and glucose intolerance in rats fed chronically an isocaloric sucrose-rich diet","volume":"36","author":"Gutman","year":"1987","journal-title":"Metabolism"},{"issue":"February","key":"10.1016\/j.mce.2026.112772_bib18","article-title":"Diet and temperature interactively impact brown adipose tissue gene regulation controlled by DNA methylation","volume":"104","author":"Hagemann","year":"2026","journal-title":"Mol. Metabol."},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib19","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1172\/JCI96702","article-title":"Fructose metabolism and metabolic disease","volume":"128","author":"Hannou","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"40","key":"10.1016\/j.mce.2026.112772_bib20","doi-asserted-by":"crossref","first-page":"27646","DOI":"10.1074\/jbc.M109.034884","article-title":"The clavesin family, neuron-specific Lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology","volume":"284","author":"Katoh","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.mce.2026.112772_bib21","first-page":"1571","article-title":"Bismark: a flexible aligner and methylation caller for bisulfite-seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"8","key":"10.1016\/j.mce.2026.112772_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/cells8080859","article-title":"MicroRNAs in obesity and related metabolic disorders","volume":"8","author":"Landrier","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.mce.2026.112772_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2796.1992.tb00494.x","article-title":"Evidence for an independent relationship between insulin resistance and fasting plasma HDL-Cholesterol, triglyceride and insulin concentrations","volume":"231","author":"Laws","year":"1992","journal-title":"J. Intern. Med."},{"issue":"14","key":"10.1016\/j.mce.2026.112772_bib24","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1113\/jphysiol.2009.172601","article-title":"Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats","volume":"587","author":"Laye","year":"2009","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib25","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S2213-8587(19)30068-3","article-title":"Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial","volume":"7","author":"Lean","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"10120","key":"10.1016\/j.mce.2026.112772_bib26","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(17)33102-1","article-title":"Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial","volume":"391","author":"Lean","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bbrc.2012.03.005","article-title":"Identification of methylation-dependent regulatory elements for intergenic miRNAs in human H4 cells","volume":"420","author":"Lee","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/jpet.110.178046","article-title":"Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice","volume":"337","author":"Lijnen","year":"2011","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib29","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cmet.2019.03.009","article-title":"Epigenetics in human obesity and type 2 diabetes","volume":"29","author":"Ling","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2026.112772_bib30","unstructured":"Lizcano, Fernando, Carolina Romero, and Diana Vargas. n.d. Regulation of Adipogenesis by Nuclear Receptor Pparg is Modulated by the Histone Demethylase JMJD2C."},{"issue":"February","key":"10.1016\/j.mce.2026.112772_bib31","article-title":"Changes in mitochondrial epigenome in type 2 diabetes mellitus","volume":"80","author":"Low","year":"2023","journal-title":"Br. J. Biomed. Sci."},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.23938\/ASSN.0267","article-title":"[Alimentary and lifestyle changes as a strategy in the prevention of metabolic syndrome and diabetes mellitus type 2: milestones and perspectives]","volume":"39","author":"M Hern\u00e1ndez Ruiz de Eguilaz","year":"2016","journal-title":"An. del Sist. Sanit. Navar."},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib33","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2337\/dbi18-0057","article-title":"Functional implications of DNA methylation in adipose biology","volume":"68","author":"Ma","year":"2019","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.mce.2026.112772_bib34","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1042\/CS20171616","article-title":"Impaired endocrine-metabolic homeostasis: underlying mechanism of its induction by unbalanced diet","volume":"132","author":"Maiztegui","year":"2018","journal-title":"Clinical Science (London, England: 1979)"},{"issue":"18","key":"10.1016\/j.mce.2026.112772_bib35","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1161\/CIRCULATIONAHA.118.037401","article-title":"Long-term consumption of sugar-sweetened and artificially sweetened beverages and risk of mortality in US adults","volume":"139","author":"Malik","year":"2019","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib36","first-page":"435","article-title":"Chronic excessive fructose intake maximizes brown adipocyte whitening but causes similar white adipocyte hypertrophy than a high-fat diet in C57BL\/6 mice","volume":"42","author":"Miranda","year":"2023","journal-title":"J. Am. Nutr. Assoc."},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib37","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4103\/ijmr.IJMR_1910_18","article-title":"Subcutaneous adipose tissue & visceral adipose tissue","volume":"149","author":"Mittal","year":"2019","journal-title":"Indian J. Med. Res."},{"issue":"19","key":"10.1016\/j.mce.2026.112772_bib38","doi-asserted-by":"crossref","first-page":"16968","DOI":"10.1074\/jbc.M109316200","article-title":"UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis","volume":"277","author":"Moriarity","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.mce.2026.112772_bib39","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.2337\/db13-1459","article-title":"Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes","volume":"63","author":"Nilsson","year":"2014","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.mce.2026.112772_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084229","article-title":"Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice","volume":"8","author":"Okamatsu-Ogura","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.mce.2026.112772_bib41","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.2337\/db05-0585","article-title":"Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol","volume":"55","author":"Okazaki","year":"2006","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.mce.2026.112772_bib42","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/hmg\/ddy093","article-title":"Epigenome-wide association in adipose tissue from the METSIM cohort","volume":"27","author":"Orozco","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.mce.2026.112772_bib43","first-page":"445","article-title":"Diabetes: absence of hormone-sensitive lipase associated with risk of T2DM","volume":"10","author":"Os\u00f3rio","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BJ20100890","article-title":"The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein","volume":"431","author":"Ovens","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.mce.2026.112772_bib45","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3389\/fimmu.2020.00769","article-title":"Proteoglycans in obesity-associated metabolic dysfunction and meta-inflammation","volume":"11","author":"Pessentheiner","year":"2020","journal-title":"Front. Immunol."},{"issue":"51","key":"10.1016\/j.mce.2026.112772_bib46","doi-asserted-by":"crossref","first-page":"39691","DOI":"10.1074\/jbc.M110.180695","article-title":"C1q\/TNF-Related Protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output","volume":"285","author":"Peterson","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.mce.2026.112772_bib47","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.clinbiochem.2015.11.021","article-title":"Differential DNA methylation of microRNAs within promoters, intergenic and intragenic regions of type 2 diabetic, pre-diabetic and non-diabetic individuals","volume":"49","author":"Pheiffer","year":"2016","journal-title":"Clin. Biochem."},{"issue":"6","key":"10.1016\/j.mce.2026.112772_bib48","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/hep.25961","article-title":"Deficiency of carboxylesterase 1\/Esterase-x results in obesity, hepatic steatosis, and hyperlipidemia","volume":"56","author":"Quiroga","year":"2012","journal-title":"Hepatology"},{"issue":"21","key":"10.1016\/j.mce.2026.112772_bib49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/ijms222111652","article-title":"DNA methylation and type 2 diabetes: novel biomarkers for risk assessment?","volume":"22","author":"Raciti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00125-005-0097-z","article-title":"The Indian diabetes prevention programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1)","volume":"49","author":"Ramachandran","year":"2006","journal-title":"Diabetologia"},{"issue":"August","key":"10.1016\/j.mce.2026.112772_bib51","article-title":"Mini-review: Mitochondrial DNA methylation in type 2 diabetes and obesity","volume":"13","author":"Rautenberg","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"December","key":"10.1016\/j.mce.2026.112772_bib52","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1476-511X-8-58","article-title":"Depot-specific differences in perilipin and hormone-sensitive lipase expression in lean and Obese","volume":"8","author":"Ray","year":"2009","journal-title":"Lipids Health Dis."},{"issue":"12","key":"10.1016\/j.mce.2026.112772_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051302","article-title":"Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes","volume":"7","author":"Ribel-Madsen","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.mce.2026.112772_bib54","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.2337\/db06-1135","article-title":"Adipose mitochondrial biogenesis is suppressed in Db\/Db and high-fat diet\u2013fed mice and improved by rosiglitazone","volume":"56","author":"Rong","year":"2007","journal-title":"Diabetes"},{"issue":"19","key":"10.1016\/j.mce.2026.112772_bib55","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.3390\/ijms20194888","article-title":"Extracellular matrix remodeling of adipose tissue in obesity and metabolic diseases","volume":"20","author":"Ruiz-Ojeda","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"April","key":"10.1016\/j.mce.2026.112772_bib56","article-title":"Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments","volume":"14","author":"Ruze","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.mce.2026.112772_bib57","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.bbalip.2007.02.010","article-title":"The lipid-binding SEC14 domain","volume":"1771","author":"Saito","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib58","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tem.2010.10.003","article-title":"Fructose induced lipogenesis: from sugar to fat to insulin resistance","volume":"22","author":"Samuel","year":"2011","journal-title":"Trends Endocrinol. Metabol.: TEM (Trends Endocrinol. Metab.)"},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib59","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jhep.2016.01.025","article-title":"Metabolic interplay between white, beige, brown adipocytes and the liver","volume":"64","author":"Scheja","year":"2016","journal-title":"J. Hepatol."},{"issue":"7534","key":"10.1016\/j.mce.2026.112772_bib60","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature14192","article-title":"Function and information content of DNA methylation","volume":"517","author":"Sch\u00fcbeler","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mce.2026.112772_bib61","doi-asserted-by":"crossref","first-page":"E958","DOI":"10.1152\/ajpendo.00235.2007","article-title":"Adipocyte triglyceride lipase expression in human obesity","volume":"293","author":"Steinberg","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2026.112772_bib62","unstructured":"Swiss Academy of Medical Sciences (SAMS). n.d."},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib63","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0005-2728(98)00161-3","article-title":"The mitochondrial genome: structure, transcription, translation and replication","volume":"1410","author":"Taanman","year":"1999","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"issue":"9","key":"10.1016\/j.mce.2026.112772_bib64","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3390\/nu11091987","article-title":"Dietary fructose and the metabolic syndrome","volume":"11","author":"Taskinen","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.mce.2026.112772_bib65","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/21623945.2021.1886697","article-title":"Cafeteria diet induces global and Slc27a3-Specific hypomethylation in Male wistar rats","volume":"10","author":"Viraragavan","year":"2021","journal-title":"Adipocyte"},{"issue":"3","key":"10.1016\/j.mce.2026.112772_bib66","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"issue":"5","key":"10.1016\/j.mce.2026.112772_bib67","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/hep.26714","article-title":"Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis","volume":"59","author":"Xu","year":"2014","journal-title":"Hepatology (Baltimore, Md"},{"issue":"3","key":"10.1016\/j.mce.2026.112772_bib68","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.dsx.2019.04.047","article-title":"C1q\/TNF-Related Protein-3 and glucose homeostasis","volume":"13","author":"Yaribeygi","year":"2019","journal-title":"Diabetes Metabol. Syndr.: Clin. Res. Rev."},{"issue":"January","key":"10.1016\/j.mce.2026.112772_bib69","article-title":"How does adipose tissue contribute to inflammageing?","volume":"143","author":"Zamboni","year":"2021","journal-title":"Exp. Gerontol."},{"issue":"July","key":"10.1016\/j.mce.2026.112772_bib70","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.semcancer.2023.03.008","article-title":"Excess body weight: novel insights into its roles in obesity comorbidities","volume":"92","author":"Zhang","year":"2023","journal-title":"Semin. Cancer Biol."},{"issue":"2","key":"10.1016\/j.mce.2026.112772_bib71","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2337\/diabetes.50.2.361","article-title":"Expression and distribution of lactate\/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas","volume":"50","author":"Zhao","year":"2001","journal-title":"Diabetes"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726000493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726000493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:57:41Z","timestamp":1777550261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720726000493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":71,"alternative-id":["S0303720726000493"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2026.112772","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fructose-induced prediabetes causes persistent DNA methylation changes in white adipose tissue despite metabolic normalization","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2026.112772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112772"}}