{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:42:07Z","timestamp":1792525327837,"version":"4.5.0"},"reference-count":162,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mce.2026.112806","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:46:25Z","timestamp":1777045585000},"page":"112806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["3D bioprinted connections in Liver\u2012Pancreas crosstalk: Lessons learned and future directions"],"prefix":"10.1016","volume":"618","author":[{"given":"Marjorie Dardis","family":"Murucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-3301","authenticated-orcid":false,"given":"Sunday Amos","family":"Onikanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana","family":"da Cunha Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope","family":"Aribigbola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"da Costa Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatosin Stella","family":"Olayinka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo Sperduto","family":"Dezonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"da Cunha Boldrini Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Cabral","family":"Bonfim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Miranda-Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Gemini","family":"Piperni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mce.2026.112806_bib1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1108\/RPJ-06-2023-0207","article-title":"Extrusion-based bioprinting: considerations toward gelatin-alginate bioink","volume":"30","author":"Abedi","year":"2024","journal-title":"Rapid Prototyp. J."},{"key":"10.1016\/j.mce.2026.112806_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.reth.2021.09.007","article-title":"Prospect of 3D bioprinting over cardiac cell therapy and conventional tissue engineering in the treatment of COVID-19 patients with myocardial injury","volume":"18","author":"Akter","year":"2021","journal-title":"Regen. Ther."},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.111882","article-title":"Harnessing native blueprints for designing bioinks to bioprint functional cardiac tissue","volume":"28","author":"Akter","year":"2025","journal-title":"iScience"},{"issue":"10","key":"10.1016\/j.mce.2026.112806_bib4","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/jfb16100356","article-title":"Organ-specific strategies in bioprinting: addressing translational challenges in the heart, liver, kidney, and pancreas","volume":"16","author":"Al Qassab","year":"2025","journal-title":"J. Funct. Biomater."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/biomedicines9020226","article-title":"\u03b2-Cell dysfunction, hepatic lipid metabolism, and cardiovascular health in type 2 diabetes: new directions of research and novel therapeutic strategies","volume":"9","author":"Al-Mrabeh","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.mce.2026.112806_bib6","series-title":"Emerging Concepts in Endocrine Structure and Functions","first-page":"247","article-title":"Endocrine pancreas and glucose metabolism","author":"Al-Suhaimi","year":"2022"},{"key":"10.1016\/j.mce.2026.112806_bib7","article-title":"3D bioprinting of liver models: a systematic scoping review of methods, bioinks, and reporting quality","volume":"26","author":"Ali","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"7","key":"10.1016\/j.mce.2026.112806_bib8","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1089\/ars.2013.5697","article-title":"Extracellular matrix and liver disease","volume":"21","author":"Arriazu","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mce.2026.112806_bib9","first-page":"10","article-title":"Bioinspired NeuroPods: AI-Enhanced 4D composite bioprinting revolutionizing brain-on-chip and neural regeneration","author":"Ayad","year":"2025","journal-title":"Preprint"},{"issue":"11","key":"10.1016\/j.mce.2026.112806_bib10","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1161\/CIRCRESAHA.125.325515","article-title":"Emerging technologies and future directions in interorgan crosstalk Cardiometabolic research","volume":"136","author":"Bae","year":"2025","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2026.112806_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2025.01.006","article-title":"3D bioprinting approaches for enhancing stem cell-based neural tissue regeneration","author":"Bektas","year":"2025","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/bioengineering8020027","article-title":"Natural biomaterials and their use as bioinks for printing tissues","volume":"8","author":"Benwood","year":"2021","journal-title":"Bioengineering"},{"issue":"4","key":"10.1016\/j.mce.2026.112806_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.gendis.2017.10.002","article-title":"3-D bioprinting technologies in tissue engineering and regenerative medicine: current and future trends","volume":"4","author":"Bishop","year":"2017","journal-title":"Genes Dis."},{"key":"10.1016\/j.mce.2026.112806_bib14","first-page":"1","article-title":"A review on 4D tissue bioprinting: new dawn for tissue engineering","author":"Bose","year":"2025","journal-title":"Regener. Eng. Transl. Med."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s44164-024-00072-5","article-title":"Advancing diagnostics and disease modeling: current concepts in biofabrication of soft microfluidic systems","volume":"3","author":"Casanova","year":"2024","journal-title":"In vitro mod."},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1039\/C5LC01046B","article-title":"Microfluidic perfusion systems for secretion fingerprint analysis of pancreatic islets: applications, challenges and opportunities","volume":"16","author":"Castiello","year":"2016","journal-title":"Lab Chip"},{"issue":"6","key":"10.1016\/j.mce.2026.112806_bib17","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.3390\/biomedicines12061356","article-title":"Cardiovascular and metabolic disease: new treatments and future directions 2.0","volume":"12","author":"Caturano","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.mce.2026.112806_bib18","article-title":"3D bioprinting of vascularized tissues for in vitro and in vivo applications","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mce.2026.112806_bib19","first-page":"511","article-title":"Biomaterials\/bioinks and extrusion bioprinting","volume":"28","author":"Chen","year":"2023","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201902026","article-title":"Hydrogel bioink reinforcement for additive manufacturing: a focused review of emerging strategies","volume":"32","author":"Chimene","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mce.2026.112806_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.733868","article-title":"Hepatectomy-induced alterations in hepatic perfusion and function-toward multiscale computational modeling for a better prediction of posthepatectomy liver function","volume":"12","author":"Christ","year":"2021","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib22","first-page":"1","article-title":"Role of in vitro two-dimensional (2D) and three-dimensional (3D) cell culture systems for ADME-Tox screening in drug discovery and development: a comprehensive review","volume":"11","author":"Chunduri","year":"2023","journal-title":"ADMET and DMPK"},{"issue":"13","key":"10.1016\/j.mce.2026.112806_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310672","article-title":"New insights and potential therapeutic interventions in metabolic diseases","volume":"24","author":"Clemente-Su\u00e1rez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.mce.2026.112806_bib24","article-title":"ECM-enriched alginate hydrogels for bioartificial pancreas: an ideal niche to improve insulin secretion and diabetic glucose profile","volume":"17","author":"Cris\u00f3stomo","year":"2019","journal-title":"J. Appl. Biomater. Funct. Mater."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.xphs.2019.08.010","article-title":"Shifting paradigms revisited: biotechnology and the pharmaceutical sciences","volume":"109","author":"Crommelin","year":"2020","journal-title":"J. Pharmaceut. Sci."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/TP.0000000000004668","article-title":"The long road to develop custom-built livers: current status of 3D liver bioprinting","volume":"108","author":"Cross-Najafi","year":"2024","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1042\/BST20221008","article-title":"Toward using 3D cellular cultures to model the activation and diverse functions of macrophages","volume":"51","author":"Cutter","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mce.2026.112806_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120611","article-title":"3D culture of HepaRG cells in GelMa and its application to bioprinting of a multicellular hepatic model","volume":"269","author":"Cuvellier","year":"2021","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cell.2020.12.002","article-title":"Bioprinting for the biologist","volume":"184","author":"Daly","year":"2021","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.mce.2026.112806_bib30","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3390\/bioengineering11070664","article-title":"Bridging the gap: integrating 3D bioprinting and microfluidics for advanced multiorgan models in biomedical research","volume":"11","author":"De Spirito","year":"2024","journal-title":"Bioengineering"},{"key":"10.1016\/j.mce.2026.112806_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jmbbm.2015.10.016","article-title":"Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology","volume":"55","author":"Deegan","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.mce.2026.112806_bib32","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3389\/fphys.2015.00350","article-title":"Neuron-glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: a new hypothesis","volume":"6","author":"Del Rio","year":"2015","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib33","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/aa780f","article-title":"Correlating rheological properties and printability of collagen bioinks: the effects of riboflavin photocrosslinking and pH","volume":"9","author":"Diamantides","year":"2017","journal-title":"Biofabrication"},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib34","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cmet.2013.06.004","article-title":"MicroRNAs and metabolism crosstalk in energy homeostasis","volume":"18","author":"Dumortier","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2026.112806_bib35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cmpb.2017.12.009","article-title":"Integrated model of insulin and glucose kinetics describing both hepatic glucose and pancreatic insulin regulation","volume":"156","author":"Erlandsen","year":"2018","journal-title":"Comput. Methods Progr. Biomed."},{"key":"10.1016\/j.mce.2026.112806_bib36","series-title":"Biomaterials and Materials for Medicine","first-page":"49","article-title":"Biomaterials for fabricating vascularized scaffolds in tissue engineering","author":"Fan","year":"2021"},{"key":"10.1016\/j.mce.2026.112806_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1494560","article-title":"Interorgan metabolic interaction networks in nonalcoholic fatty liver disease","volume":"15","author":"Fan","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/gels8030179","article-title":"Natural hydrogel-based bioinks for 3D bioprinting in tissue engineering: a review","volume":"8","author":"Fatimi","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.mce.2026.112806_bib39","author":"Ferracci"},{"issue":"9","key":"10.1016\/j.mce.2026.112806_bib40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/bios10090110","article-title":"Integrating biosensors in organs-on-chip devices: a perspective on current strategies to monitor microphysiological systems","volume":"10","author":"Ferrari","year":"2020","journal-title":"Biosensors"},{"issue":"4","key":"10.1016\/j.mce.2026.112806_bib41","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3390\/pharmaceutics15041300","article-title":"Microfluidic liver-on-a-chip for preclinical drug discovery","volume":"15","author":"Fu","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mce.2026.112806_bib42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41392-024-02072-z","article-title":"Liver diseases: epidemiology, causes, trends and predictions","volume":"10","author":"Gan","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mce.2026.112806_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1554226","article-title":"3D bioprinting for bile duct tissue engineering: current status and prospects","volume":"13","author":"Gao","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mce.2026.112806_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.662084","article-title":"An overview of engineered hydrogel-based biomaterials for improved \u03b2-cell survival and insulin secretion","volume":"9","author":"Ghasemi","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"4","key":"10.1016\/j.mce.2026.112806_bib45","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41575-020-00386-1","article-title":"Human biomimetic liver microphysiology systems in drug development and precision medicine","volume":"18","author":"Gough","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2026.112806_bib46","first-page":"181","article-title":"A review of stem cell technology targeting hepatocyte growth as an alternative to organ transplantation","author":"Goulart","year":"2022","journal-title":"Gene Drug. Tiss. Eng."},{"issue":"12","key":"10.1016\/j.mce.2026.112806_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202200264","article-title":"Toward 3D\u2010Bioprinted models of the liver to boost drug development","volume":"22","author":"Guagliano","year":"2022","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.mce.2026.112806_bib48","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.coph.2020.10.016","article-title":"The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes","volume":"55","author":"Guerra","year":"2020","journal-title":"Curr. Opin. Pharmacol."},{"issue":"5","key":"10.1016\/j.mce.2026.112806_bib49","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1039\/C7BM00765E","article-title":"Bioinks for 3D bioprinting: an overview","volume":"6","author":"Gungor-Ozkerim","year":"2018","journal-title":"Biomater. Sci."},{"issue":"16","key":"10.1016\/j.mce.2026.112806_bib50","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.3390\/nu17162708","article-title":"Type 2 diabetes and the multifaceted Gut-X Axes","volume":"17","author":"Guo","year":"2025","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.mce.2026.112806_bib51","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.2337\/dbi22-0002","article-title":"Cross talk between insulin and glucagon receptor signaling in the hepatocyte","volume":"71","author":"Habegger","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2026.112806_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111707","article-title":"3D bioprinting of a stem cell-laden, multimaterial tubular composite: an approach for spinal cord repair","volume":"120","author":"Hamid","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.mce.2026.112806_bib53","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0070-2153(05)72004-4","article-title":"Regulation of hepatocyte cell cycle progression and differentiation by type I collagen structure","volume":"72","author":"Hansen","year":"2005","journal-title":"Curr. Top. Dev. Biol."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib54","doi-asserted-by":"crossref","first-page":"G305","DOI":"10.1152\/ajpgi.90229.2008","article-title":"Interaction of CD44 and hyaluronic acid enhances biliary epithelial proliferation in cholestatic livers","volume":"295","author":"He","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib55","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.biotechadv.2016.12.006","article-title":"The bioink: a comprehensive review on bioprintable materials","volume":"35","author":"Hospodiuk","year":"2017","journal-title":"Biotechnol. Adv."},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202403762","article-title":"Integrating 3D bioprinting and organoids to better recapitulate the complexity of cellular microenvironments for tissue engineering","volume":"14","author":"Hu","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mce.2026.112806_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1465816","article-title":"The role of vascular and lymphatic networks in bone and joint homeostasis and pathology","volume":"15","author":"Huang","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"5986","key":"10.1016\/j.mce.2026.112806_bib58","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1188302","article-title":"Reconstituting organ-level lung functions on a chip","volume":"328","author":"Huh","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.mce.2026.112806_bib59","series-title":"TMS Annual Meeting & Exhibition","first-page":"877","article-title":"Challenges and future perspectives of biomimetic materials for biomedical applications: bridging the gap between nature and medicine","author":"Ighodaro","year":"2024"},{"key":"10.1016\/j.mce.2026.112806_bib60","author":"Irene"},{"key":"10.1016\/j.mce.2026.112806_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1716166","article-title":"Collagen supplementation and regenerative health: advances in biomarker detection and smart material integration","volume":"12","author":"Ivaskiene","year":"2025","journal-title":"Front. Nutr."},{"issue":"11","key":"10.1016\/j.mce.2026.112806_bib62","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.3390\/ma11112199","article-title":"An introduction to 3D bioprinting: possibilities, challenges and future aspects","volume":"11","author":"Ka\u010darevi\u0107","year":"2018","journal-title":"Materials"},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib63","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1152\/physrev.00028.2023","article-title":"Hepatic glucagon action: beyond glucose mobilization","volume":"104","author":"Kajani","year":"2024","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s41205-020-00069-2","article-title":"DICOM segmentation and STL creation for 3D printing: a process and software package comparison for osseous anatomy","volume":"6","author":"Kamio","year":"2020","journal-title":"3D Print. Med."},{"issue":"10","key":"10.1016\/j.mce.2026.112806_bib65","doi-asserted-by":"crossref","first-page":"G807","DOI":"10.1152\/ajpgi.00447.2014","article-title":"Novel insights into the function and dynamics of extracellular matrix in liver fibrosis","volume":"308","author":"Karsdal","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib66","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s41232-023-00306-1","article-title":"Interorgan communication involved in metabolic regulation at the whole-body level","volume":"43","author":"Katagiri","year":"2023","journal-title":"Inflamm. Regen."},{"issue":"4","key":"10.1016\/j.mce.2026.112806_bib67","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3390\/pharmaceutics16040469","article-title":"Recent advances in alginate-based hydrogels for cell transplantation applications","volume":"16","author":"Kavand","year":"2024","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.mce.2026.112806_bib68","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000083","article-title":"Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets","volume":"7","author":"Kim","year":"2023","journal-title":"Hepatol. Commun."},{"issue":"19","key":"10.1016\/j.mce.2026.112806_bib69","doi-asserted-by":"crossref","first-page":"10608","DOI":"10.1021\/acs.chemrev.9b00808","article-title":"Decellularized extracellular matrix-based bioinks for engineering tissue-and organ-specific microenvironments","volume":"120","author":"Kim","year":"2020","journal-title":"Chem. Rev."},{"key":"10.1016\/j.mce.2026.112806_bib70","article-title":"Review on multicomponent hydrogel bioinks based on natural biomaterials for bioprinting 3D liver tissues","volume":"10","author":"Kim","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"10S","key":"10.1016\/j.mce.2026.112806_bib71","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1097\/01.tp.0001170344.34555.47","article-title":"PS4. 2: 3D bioprinted pancreatic organoids: a functional platform for cell therapy and regenerative applications","volume":"109","author":"Klak","year":"2025","journal-title":"Transplantation"},{"issue":"12","key":"10.1016\/j.mce.2026.112806_bib72","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1073\/pnas.1521342113","article-title":"Three-dimensional bioprinting of thick vascularized tissues","volume":"113","author":"Kolesky","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib73","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3390\/ijms24010891","article-title":"Bioprinting technologies and bioinks for vascular model establishment","volume":"24","author":"Kong","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112806_bib74","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.actbio.2018.12.039","article-title":"Directing the growth and alignment of biliary epithelium within extracellular matrix hydrogels","volume":"85","author":"Lewis","year":"2019","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.mce.2026.112806_bib75","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3390\/polym17070948","article-title":"Advances and challenges in 3D bioprinted cancer models: opportunities for personalized medicine and tissue engineering","volume":"17","author":"Liu","year":"2025","journal-title":"Polymers"},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib76","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/jfb17020072","article-title":"4D printing in regenerative medicine: bio-Inspired applications for dynamic tissue repair","volume":"17","author":"Liu","year":"2026","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.mce.2026.112806_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.892672","article-title":"Contribution of liver and pancreatic islet crosstalk to \u03b2-cell function\/dysfunction in the presence of fatty liver","volume":"13","author":"L\u00f3pez-Bermudo","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2026.112806_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1442854","article-title":"Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis","volume":"15","author":"Luo","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"346","key":"10.1016\/j.mce.2026.112806_bib79","doi-asserted-by":"crossref","first-page":"re7","DOI":"10.1126\/stke.3462006re7","article-title":"Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer","volume":"2006","author":"Marshall","year":"2006","journal-title":"Sci. STKE"},{"key":"10.1016\/j.mce.2026.112806_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119536","article-title":"Progress in 3D bioprinting technology for tissue\/organ regenerative engineering","volume":"226","author":"Matai","year":"2020","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.mce.2026.112806_bib81","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.3390\/molecules28093683","article-title":"Advancements in research on constructing physiological and pathological liver models and their applications utilizing bioprinting technology","volume":"28","author":"Ming","year":"2023","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.mce.2026.112806_bib82","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/bioengineering10050606","article-title":"3D bioprinting for vascularization","volume":"10","author":"Mir","year":"2023","journal-title":"Bioengineering"},{"issue":"8","key":"10.1016\/j.mce.2026.112806_bib83","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3390\/bioengineering11080777","article-title":"Three-dimensional bioprinting: a comprehensive review for applications in tissue engineering and regenerative medicine","volume":"11","author":"Mirsky","year":"2024","journal-title":"Bioengineering"},{"issue":"38","key":"10.1016\/j.mce.2026.112806_bib84","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.3748\/wjg.v29.i38.5361","article-title":"Intraductal papillary neoplasm of the bile duct: the new frontier of biliary pathology","volume":"29","author":"Mocchegiani","year":"2023","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib85","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3390\/pr9030447","article-title":"Digital twins for tissue culture techniques\u2014concepts, expectations, and state of the art","volume":"9","author":"M\u00f6ller","year":"2021","journal-title":"Processes"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib86","first-page":"81","article-title":"Newly developed 3D in vitro models to study tumor\u2013immune interaction","volume":"42","author":"Mu","year":"2023","journal-title":"J. Exp."},{"issue":"4","key":"10.1016\/j.mce.2026.112806_bib87","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41551-019-0471-7","article-title":"Opportunities and challenges of translational 3D bioprinting","volume":"4","author":"Murphy","year":"2020","journal-title":"Nat. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib88","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1074\/jbc.RA117.000148","article-title":"Hyaluronan content governs tissue stiffness in pancreatic islet inflammation","volume":"293","author":"Nagy","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2026.112806_bib89","first-page":"204","article-title":"Diffusion coefficient of alginate microcapsules used in pancreatic islet transplantation, a method to cure type 1 diabetes","volume":"10506","author":"Najdahmadi","year":"2018","journal-title":"Nanosc. Imag. Sens. Actuat. Biomed. Appl. XV"},{"issue":"4","key":"10.1016\/j.mce.2026.112806_bib90","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s005340170002","article-title":"Pathology and pathogenesis of intrahepatic bile duct loss","volume":"8","author":"Nakanuma","year":"2001","journal-title":"J. Hepato-Biliary-Pancreatic Surg."},{"issue":"12","key":"10.1016\/j.mce.2026.112806_bib91","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41568-022-00514-w","article-title":"3D bioprinted cancer models: from basic biology to drug development","volume":"22","author":"Neufeld","year":"2022","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib92","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12967-025-06381-x","article-title":"Advances in humanoid organoid-based research on interorgan communications during cardiac organogenesis and cardiovascular diseases","volume":"23","author":"Ni","year":"2025","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib93","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41540-024-00450-5","article-title":"Immune digital twins for complex human pathologies: applications, limitations, and challenges","volume":"10","author":"Niarakis","year":"2024","journal-title":"npj Syst. Biol. Appl."},{"issue":"41","key":"10.1016\/j.mce.2026.112806_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202104123","article-title":"Advanced bioresponsive multitasking hydrogels in the new era of biomedicine","volume":"31","author":"Niazi","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"11","key":"10.1016\/j.mce.2026.112806_bib95","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.mpaic.2020.08.002","article-title":"Hormonal control of metabolism: regulation of plasma glucose","volume":"21","author":"Nirmalan","year":"2020","journal-title":"Anesthesia & Intens. Care Med."},{"issue":"6","key":"10.1016\/j.mce.2026.112806_bib96","article-title":"Bioengineering methods for vascularizing organoids","volume":"4","author":"Nwokoye","year":"2024","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.mce.2026.112806_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmpk.2024.101049","article-title":"Development and application of 3D cardiac tissues derived from human pluripotent stem cells","author":"Ohno","year":"2025","journal-title":"Drug Metabol. Pharmacokinet."},{"key":"10.1016\/j.mce.2026.112806_bib98","doi-asserted-by":"crossref","DOI":"10.1177\/15330338221119743","article-title":"Cancer of the liver and its relationship with diabetes mellitus","volume":"21","author":"Onikanni","year":"2022","journal-title":"Technol. Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib99","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/cei\/uxae004","article-title":"Revolutionizing immune research with organoid-based coculture and chip systems","volume":"218","author":"Papp","year":"2024","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib100","doi-asserted-by":"crossref","first-page":"665","DOI":"10.18063\/ijb.v9i2.665","article-title":"Three-dimensional bioprinting of functional \u03b2-islet-like constructs","volume":"9","author":"Parvaneh","year":"2023","journal-title":"Int. J. Bioprint."},{"key":"10.1016\/j.mce.2026.112806_bib101","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.881525","article-title":"The foundation for engineering a pancreatic islet niche","volume":"13","author":"Patel","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib102","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jcmgh.2020.09.016","article-title":"Controversies surrounding the origin of hepatocytes in adult livers and the in vitro generation or propagation of hepatocytes","volume":"11","author":"Pek","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib103","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/jpm15030118","article-title":"Protocol for converting DICOM files to STL models using 3D slicer and ultimaker cura","volume":"15","author":"P\u00e9rez-Sevilla","year":"2025","journal-title":"J. Personalized Med."},{"issue":"36","key":"10.1016\/j.mce.2026.112806_bib104","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1039\/D0TB01005G","article-title":"Multicomponent polysaccharide alginate-based bioinks","volume":"8","author":"Piras","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mce.2026.112806_bib105","series-title":"Development of a 3D Microfluidic in Vitro Model of Pancreatic Beta Cells to Mimic Endocrine Pancreatic Function and Study Type 2 Diabetes Progression","author":"Pliner","year":"2024"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib106","article-title":"Recent advances in liver\u2010on\u2010chips: design, fabrication, and applications","volume":"2","author":"Qiu","year":"2023","journal-title":"Smart Med."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib107","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1677\/JOE-08-0290","article-title":"Physiology of the pancreatic \u03b1-cell and glucagon secretion: role in glucose homeostasis and diabetes","volume":"199","author":"Quesada","year":"2008","journal-title":"J. Endocrinol."},{"issue":"7","key":"10.1016\/j.mce.2026.112806_bib108","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nbt0708-743","article-title":"(Re) defining biopharmaceutical","volume":"26","author":"Rader","year":"2008","journal-title":"Nat. Biotechnol."},{"issue":"11\u201312","key":"10.1016\/j.mce.2026.112806_bib109","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1089\/ten.tea.2020.0350","article-title":"Recent advances on bioprinted gelatin methacrylate-based hydrogels for tissue repair","volume":"27","author":"Rajabi","year":"2021","journal-title":"Tissue Eng."},{"key":"10.1016\/j.mce.2026.112806_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibtech.2025.03.005","article-title":"Bioprinting and synthetic biology approaches to engineer functional endocrine pancreatic constructs","author":"Ribezzi","year":"2025","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.mce.2026.112806_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibtech.2025.03.005","article-title":"Bioprinting and synthetic biology approaches to engineer functional endocrine pancreatic constructs","author":"Ribezzi","year":"2025","journal-title":"Trends Biotechnol."},{"issue":"11","key":"10.1016\/j.mce.2026.112806_bib112","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.3390\/ijms19113308","article-title":"Additive manufacturing for guided bone regeneration: a perspective for alveolar ridge augmentation","volume":"19","author":"Rider","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.mce.2026.112806_bib113","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3390\/bioengineering10060705","article-title":"Bioinks of natural biomaterials for printing tissues","volume":"10","author":"Rijal","year":"2023","journal-title":"Bioengineering"},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib114","doi-asserted-by":"crossref","DOI":"10.4155\/fsoa-2016-0092","article-title":"Integration concepts for multi-organ chips: how to maintain flexibility?","volume":"3","author":"Rogal","year":"2017","journal-title":"Future Sci. OA"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib115","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.mce.2026.112806_bib116","doi-asserted-by":"crossref","DOI":"10.1177\/20417314221091033","article-title":"Toward 3D-bioprinting of an endocrine pancreas: a building-block concept for bioartificial insulin-secreting tissue","volume":"13","author":"Salg","year":"2022","journal-title":"J. Tissue Eng."},{"issue":"10","key":"10.1016\/j.mce.2026.112806_bib117","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3390\/biomimetics9100598","article-title":"The role of the pancreatic extracellular matrix as a tissue engineering support for the bioartificial pancreas","volume":"9","author":"Santos da Silva","year":"2024","journal-title":"Biomimetics"},{"key":"10.1016\/j.mce.2026.112806_bib118","article-title":"3D bioprinting strategies for recapitulation of hepatic structure and function in bioengineered liver: a state-of-the-art review","volume":"30","author":"Sanyal","year":"2024","journal-title":"Curr. Opin. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib119","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41536-021-00193-5","article-title":"3D in vitro M2 macrophage model to mimic modulation of tissue repair","volume":"6","author":"Sapudom","year":"2021","journal-title":"npj Regen. Med."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib120","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/nano11020275","article-title":"A perfusion bioreactor for longitudinal monitoring of bioengineered liver constructs","volume":"11","author":"Sassi","year":"2021","journal-title":"Nanomaterials"},{"issue":"19","key":"10.1016\/j.mce.2026.112806_bib121","doi-asserted-by":"crossref","first-page":"11028","DOI":"10.1021\/acs.chemrev.0c00084","article-title":"Printability and shape fidelity of bioinks in 3D bioprinting","volume":"120","author":"Schwab","year":"2020","journal-title":"Chem. Rev."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib122","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1089\/ten.teb.2021.0026","article-title":"Triblock copolymer bioinks in hydrogel three-dimensional printing for regenerative medicine: a focus on pluronic F127","volume":"28","author":"Shamma","year":"2022","journal-title":"Tissue Eng. B Rev."},{"issue":"8","key":"10.1016\/j.mce.2026.112806_bib123","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3390\/biom14081019","article-title":"The prospect of hepatic decellularized extracellular matrix as a bioink for liver 3D bioprinting","volume":"14","author":"Shi","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.mce.2026.112806_bib124","first-page":"1273","article-title":"Studying metabolism with multiorgan chips: new tools for disease modeling, pharmacokinetics and pharmacodynamics. Advances in Medical Imaging","author":"Shroff","year":"2023","journal-title":"Detect. Diagn."},{"issue":"5","key":"10.1016\/j.mce.2026.112806_bib125","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2174\/0118715303311209240709115156","article-title":"Bioengineered cell therapies for endocrine dysfunction: advancements and clinical prospects","volume":"25","author":"Singh","year":"2025","journal-title":"Endocr. Metab. Immune Disord. - Drug Targets"},{"key":"10.1016\/j.mce.2026.112806_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111694","article-title":"Synthesis and characterization of site selective photocrosslinkable glycidyl methacrylate functionalized gelatin-based 3D hydrogel scaffold for liver tissue engineering","volume":"123","author":"Sk","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.mce.2026.112806_bib127","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biomaterials.2018.04.034","article-title":"Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks","volume":"171","author":"Sorkio","year":"2018","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib128","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2012.258","article-title":"The role of hepatokines in metabolism","volume":"9","author":"Stefan","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"10.1016\/j.mce.2026.112806_bib129","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cmet.2016.04.011","article-title":"Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk","volume":"23","author":"Stern","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2026.112806_bib130","first-page":"1","article-title":"A review of advances in 3D and 4D bioprinting: toward mass individualization paradigm","author":"Tamir","year":"2024","journal-title":"J. Intell. Manuf."},{"issue":"4","key":"10.1016\/j.mce.2026.112806_bib131","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12195-018-0530-2","article-title":"3D bioprinting stem cell derived tissues","volume":"11","author":"Tasnim","year":"2018","journal-title":"Cell. Mol. Bioeng."},{"issue":"3","key":"10.1016\/j.mce.2026.112806_bib132","first-page":"91","article-title":"Bioprinting of organ-on-chip systems: a literature review from a manufacturing perspective","volume":"5","author":"Thakare","year":"2021","journal-title":"J. Manuf. Mater. Process."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib133","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.194","article-title":"3D bioprinting and its innovative approach for biomedical applications","volume":"4","author":"Tripathi","year":"2023","journal-title":"MedComm"},{"key":"10.1016\/j.mce.2026.112806_bib134","doi-asserted-by":"crossref","DOI":"10.1002\/mame.202500251","article-title":"From bioinks to functional tissues and organs: advances, challenges, and the promise of 3D bioprinting","author":"Ullah","year":"2025","journal-title":"Macromol. Mater. Eng."},{"key":"10.1016\/j.mce.2026.112806_bib135","article-title":"Hydrogel-based 3D bioprinting: a comprehensive review on cell-laden hydrogels, bioink formulations, and future perspectives","volume":"18","author":"Unagolla","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.mce.2026.112806_bib136","article-title":"Hydrogel-based 3D bioprinting: a comprehensive review on cell-laden hydrogels, bioink formulations, and future perspectives","volume":"18","author":"Unagolla","year":"2020","journal-title":"Appl. Mater. Today"},{"issue":"15","key":"10.1016\/j.mce.2026.112806_bib137","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512046","article-title":"Three-dimensional cell cultures: the bridge between in vitro and in vivo models","volume":"24","author":"Urz\u00ec","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.mce.2026.112806_bib138","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/biomedicines9060589","article-title":"Microvascular tissue engineering\u2014A review","volume":"9","author":"Vajda","year":"2021","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib139","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3390\/biomedicines11020468","article-title":"Nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and nonviral hepatocarcinoma: pathophysiological mechanisms and new therapeutic strategies","volume":"11","author":"Vetrano","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/apt.15773","article-title":"The signaling and functional role of the extracellular matrix in the development of liver fibrosis","volume":"52","author":"Villesen","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.iliver.2024.100080","article-title":"Innovations in 3D bioprinting and biomaterials for liver tissue engineering: paving the way for tissue-engineered liver","volume":"3","author":"Wang","year":"2024","journal-title":"iLIVER"},{"issue":"18","key":"10.1016\/j.mce.2026.112806_bib142","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3390\/polym16182668","article-title":"Collagen and its derivatives serving biomedical purposes: a review","volume":"16","author":"Wosicka-Fr\u0105ckowiak","year":"2024","journal-title":"Polymers"},{"issue":"10S","key":"10.1016\/j.mce.2026.112806_bib143","doi-asserted-by":"crossref","DOI":"10.1097\/01.tp.0001170304.67564.b1","article-title":"PS2. 2: 3D-bioprinted bionic pancreas\u2013ATMP: a disruptive innovation in transplantology","volume":"109","author":"Wszola","year":"2025","journal-title":"Transplantation"},{"issue":"43","key":"10.1016\/j.mce.2026.112806_bib145","doi-asserted-by":"crossref","first-page":"10263","DOI":"10.1039\/D3TB01630G","article-title":"Organ bioprinting: progress, challenges and outlook","volume":"11","author":"Wu","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib146","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.36922\/ijb.1256","article-title":"Research progress of 3D-bioprinted functional pancreas and in vitro tumor models","volume":"10","author":"Wu","year":"2024","journal-title":"Int. J. Bioprint."},{"key":"10.1016\/j.mce.2026.112806_bib147","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3389\/fbioe.2020.00971","article-title":"Production and characterization of an integrated multilayer 3D printed PLGA\/GelMA scaffold aimed for bile duct restoration and detection","volume":"8","author":"Xiang","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"5","key":"10.1016\/j.mce.2026.112806_bib148","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s12015-019-09893-4","article-title":"Gelatin methacrylate (GelMA)-based hydrogels for cell transplantation: an effective strategy for tissue engineering","volume":"15","author":"Xiao","year":"2019","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.mce.2026.112806_bib149","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202506259","article-title":"Pioneering 3D and 4D bioprinting strategies for advanced wound management: from design to healing","author":"Yadav","year":"2025","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib150","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41536-020-00099-8","article-title":"Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine","volume":"5","author":"Yao","year":"2020","journal-title":"npj Regen. Med."},{"issue":"34","key":"10.1016\/j.mce.2026.112806_bib151","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202203368","article-title":"Bioengineered pancreas\u2013liver crosstalk in a microfluidic coculture chip identifies human metabolic response signatures in prediabetic hyperglycemia","volume":"9","author":"Zandi Shafagh","year":"2022","journal-title":"Adv. Sci."},{"issue":"13\u201314","key":"10.1016\/j.mce.2026.112806_bib152","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1089\/ten.tea.2020.0250","article-title":"Collagen and endothelial cell coculture improves \u03b2-cell functionality and rescues pancreatic extracellular matrix","volume":"27","author":"Zbinden","year":"2021","journal-title":"Tissue Eng."},{"issue":"13\u201314","key":"10.1016\/j.mce.2026.112806_bib153","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1089\/ten.tea.2020.0250","article-title":"Collagen and endothelial cell coculture improves \u03b2-cell functionality and rescues pancreatic extracellular matrix","volume":"27","author":"Zbinden","year":"2021","journal-title":"Tissue Eng."},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib154","doi-asserted-by":"crossref","first-page":"322","DOI":"10.21037\/hbsn-2025-154","article-title":"Innovations in liver organoids: the role of 3D bioprinting in creating functional organoids","volume":"14","author":"Zhang","year":"2025","journal-title":"Hepatobiliary Surg. Nutr."},{"issue":"8","key":"10.1016\/j.mce.2026.112806_bib155","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3390\/ijms20081885","article-title":"Glucagon-induced acetylation of energy-sensing factors in control of hepatic metabolism","volume":"20","author":"Zhang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.mce.2026.112806_bib156","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/s41467-017-01627-9","article-title":"A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance","volume":"8","author":"Zhao","year":"2017","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.mce.2026.112806_bib157","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/biomedicines8090307","article-title":"Integrin-targeting peptides for the design of functional cell-responsive biomaterials","volume":"8","author":"Zhao","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.mce.2026.112806_bib158","first-page":"201","article-title":"In vivo bioprinting: broadening the therapeutic horizon for tissue injuries","volume":"25","author":"Zhao","year":"2023","journal-title":"Bioact. Mater."},{"issue":"8","key":"10.1016\/j.mce.2026.112806_bib159","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.3390\/ma16083197","article-title":"Recent advances in decellularized extracellular matrix-based bioinks for 3D bioprinting in tissue engineering","volume":"16","author":"Zhe","year":"2023","journal-title":"Materials"},{"issue":"2","key":"10.1016\/j.mce.2026.112806_bib160","doi-asserted-by":"crossref","first-page":"387","DOI":"10.62347\/KMSA5983","article-title":"Non-alcoholic fatty liver disease: pathogenesis and models","volume":"16","author":"Zhong","year":"2024","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.mce.2026.112806_bib161","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.copbio.2016.03.014","article-title":"3D printing of functional biomaterials for tissue engineering","volume":"40","author":"Zhu","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.mce.2026.112806_bib162","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1343177","article-title":"Advancements and application prospects of three-dimensional models for primary liver cancer: a comprehensive review","volume":"11","author":"Zhu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mce.2026.112806_bib163","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1143600","article-title":"Recent advaTasnimnces of three-dimensional bioprinting technology in hepato-pancreato-biliary cancer models","volume":"13","author":"Zhuang","year":"2023","journal-title":"Front. Oncol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726000833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726000833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:15:05Z","timestamp":1778742905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720726000833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":162,"alternative-id":["S0303720726000833"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2026.112806","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3D bioprinted connections in Liver\u2012Pancreas crosstalk: Lessons learned and future directions","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2026.112806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112806"}}