{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:14:17Z","timestamp":1783494857567,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571408"],"award-info":[{"award-number":["81571408"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mce.2026.112836","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:16:09Z","timestamp":1780676169000},"page":"112836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Altered sulfite oxidase expression contributes to AMP-activated protein kinase-dependent mitochondrial dysfunction and metabolic dysregulation in polycystic ovary syndrome"],"prefix":"10.1016","volume":"620","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4516-4389","authenticated-orcid":false,"given":"Xiaomeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.mce.2026.112836_bib1","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1210\/jc.2005-0628","article-title":"Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span","volume":"90","author":"Azziz","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.mce.2026.112836_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JPD-201981","article-title":"Mitochondria and Parkinson's Disease: clinical, molecular, and translational aspects","volume":"11","author":"Borsche","year":"2021","journal-title":"J. Parkinsons Dis."},{"issue":"7","key":"10.1016\/j.mce.2026.112836_bib3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1515\/hsz-2012-0119","article-title":"Mitophagy: mechanisms, pathophysiological roles, and analysis","volume":"393","author":"Ding","year":"2012","journal-title":"Biol. Chem."},{"issue":"2","key":"10.1016\/j.mce.2026.112836_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/er.2018-00075","article-title":"Ovulation: parallels with inflammatory processes","volume":"40","author":"Duffy","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2026.112836_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112563","article-title":"AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation","volume":"146","author":"Entezari","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"6046","key":"10.1016\/j.mce.2026.112836_bib6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.1201940","article-title":"Mitochondria and the autophagy-inflammation-cell death axis in organismal aging","volume":"333","author":"Green","year":"2011","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.mce.2026.112836_bib7","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.bbadis.2014.04.022","article-title":"Sulfite disrupts brain mitochondrial energy homeostasis and induces mitochondrial permeability transition pore opening via thiol group modification","volume":"1842","author":"Grings","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.mce.2026.112836_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/B:REMD.0000021433.63915.bb","article-title":"AMP-activated protein kinase: a master switch in glucose and lipid metabolism","volume":"5","author":"Hardie","year":"2004","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"3","key":"10.1016\/j.mce.2026.112836_bib9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jhep.2013.04.028","article-title":"SUOX is a promising diagnostic and prognostic biomarker for hepatocellular carcinoma","volume":"59","author":"Jin","year":"2013","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.mce.2026.112836_bib10","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1080\/15548627.2021.1938914","article-title":"Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective","volume":"17","author":"Kumariya","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.mce.2026.112836_bib11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/s13023-022-02544-x","article-title":"Mutation analysis of SUOX in isolated sulfite oxidase deficiency with ectopia lentis as the presenting feature: insights into genotype-phenotype correlation","volume":"17","author":"Li","year":"2022","journal-title":"Orphanet J. Rare Dis."},{"issue":"6","key":"10.1016\/j.mce.2026.112836_bib13","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mce.2026.112836_bib12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.imlet.2005.03.019","article-title":"Origin and anti-tumor effects of anti-dsDNA autoantibodies in cancer patients and tumor-bearing mice","volume":"99","author":"Lv","year":"2005","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.mce.2026.112836_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101800","article-title":"The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H(2)S metabolism","volume":"38","author":"Mellis","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.mce.2026.112836_bib15","article-title":"Sulfite alters the mitochondrial network in Molybdenum cofactor deficiency","volume":"11","author":"Mellis","year":"2020","journal-title":"Front. Genet."},{"issue":"6","key":"10.1016\/j.mce.2026.112836_bib16","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mce.2026.112836_bib17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mce.2012.06.019","article-title":"AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity","volume":"366","author":"O'Neill","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2026.112836_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101191","article-title":"Defective mitophagy in Alzheimer's disease","volume":"64","author":"Pradeepkiran","year":"2020","journal-title":"Ageing Res. Rev."},{"issue":"6","key":"10.1016\/j.mce.2026.112836_bib19","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1007\/s10571-023-01328-6","article-title":"Sulfite impairs bioenergetics and redox status in neonatal Rat brain: insights into the early neuropathophysiology of isolated sulfite oxidase and molybdenum cofactor deficiencies","volume":"43","author":"Pramio","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.mce.2026.112836_bib20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1210\/clinem\/dgab613","article-title":"Health care-related economic burden of polycystic ovary syndrome in the United States: pregnancy-related and long-term health consequences","volume":"107","author":"Riestenberg","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.mce.2026.112836_bib21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.mce.2026.112836_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.mce.2026.112836_bib23","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41598-020-57672-w","article-title":"Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome","volume":"10","author":"Salehi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2026.112836_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.103097","article-title":"NLRP3 inflammasome activation in PCOS: a novel target for managing insulin resistance and metabolic dysregulation","volume":"97","author":"Samadi Nasab","year":"2025","journal-title":"Tissue Cell"},{"key":"10.1016\/j.mce.2026.112836_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-physiol-021317-121427","article-title":"The role of autophagy in the heart","volume":"80","author":"Sciarretta","year":"2018","journal-title":"Annu. Rev. Physiol."},{"issue":"9","key":"10.1016\/j.mce.2026.112836_bib26","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ng.2384","article-title":"Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome","volume":"44","author":"Shi","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2026.112836_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1273542","article-title":"Androgen excess: a hallmark of polycystic ovary syndrome","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.mce.2026.112836_bib28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/biolre\/ioab078","article-title":"NAD+ deficiency and mitochondrial dysfunction in granulosa cells of women with polycystic ovary syndrome","volume":"105","author":"Wang","year":"2021","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.mce.2026.112836_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2024.2377870","article-title":"CISD2 regulates oxidative stress and mitophagy to maintain the balance of the follicular microenvironment in PCOS","volume":"29","author":"Wu","year":"2024","journal-title":"Redox Rep."},{"issue":"2","key":"10.1016\/j.mce.2026.112836_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3892\/mmr.2023.13150","article-title":"Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome","volume":"29","author":"Xie","year":"2024","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mce.2026.112836_bib31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2147\/IJWH.S344542","article-title":"Effect of sex hormone-binding globulin on polycystic ovary syndrome: mechanisms, manifestations, genetics, and treatment","volume":"14","author":"Xing","year":"2022","journal-title":"Int J Womens Health"},{"key":"10.1016\/j.mce.2026.112836_bib32","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85338","article-title":"Direct economic burden of mental health disorders associated with polycystic ovary syndrome: systematic review and meta-analysis","volume":"12","author":"Yadav","year":"2023","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.mce.2026.112836_bib33","doi-asserted-by":"crossref","first-page":"E91","DOI":"10.1152\/ajpendo.00006.2020","article-title":"Melatonin ameliorates excessive PINK1\/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS","volume":"319","author":"Yi","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.mce.2026.112836_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13669","article-title":"Premature aging is associated with higher levels of 8-oxoguanine and increased DNA damage in the Polg mutator mouse","volume":"21","author":"Yu","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.mce.2026.112836_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.05.010","article-title":"Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3","volume":"187","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.mce.2026.112836_bib36","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.cmet.2025.08.002","article-title":"Polycystic ovary syndrome: a metabolic disorder with therapeutic opportunities","volume":"37","author":"Zhang","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2026.112836_bib37","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.freeradbiomed.2015.05.013","article-title":"Metabolism alteration in follicular niche: the nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome","volume":"86","author":"Zhao","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.mce.2026.112836_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2024.100889","article-title":"Mitophagy in mammalian follicle development and health","volume":"24","author":"Zhou","year":"2024","journal-title":"Reprod. Biol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726001139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726001139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:31:55Z","timestamp":1783492315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720726001139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":38,"alternative-id":["S0303720726001139"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2026.112836","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered sulfite oxidase expression contributes to AMP-activated protein kinase-dependent mitochondrial dysfunction and metabolic dysregulation in polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2026.112836","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112836"}}