{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:43:54Z","timestamp":1785887034625,"version":"3.56.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374499"],"award-info":[{"award-number":["82374499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["25ZR1401320"],"award-info":[{"award-number":["25ZR1401320"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018684","name":"National Health Commission of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mce.2026.112850","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:22:35Z","timestamp":1781911355000},"page":"112850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Patient-derived eutopic and ectopic endometrial stromal cells: characterization and development of immortalized lines"],"prefix":"10.1016","volume":"620","author":[{"given":"Xin-Yue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Chun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Ning","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-4756","authenticated-orcid":false,"given":"Wen-Wen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2026.112850_bib1","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.3390\/ijms25147624","article-title":"Pathogenesis of endometriosis and endometriosis-associated cancers","volume":"25","author":"Adilbayeva","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112850_bib2","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.1038\/sj.onc.1209046","article-title":"SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation","volume":"24","author":"Ahuja","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2026.112850_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jama.2025.2975","article-title":"Endometriosis: a review","volume":"334","author":"As-Sanie","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.mce.2026.112850_bib4","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1210\/endo.137.6.8641169","article-title":"Human endometrial fibroblasts immortalized by simian virus 40 large T antigen differentiate in response to a decidualization stimulus","volume":"137","author":"Brosens","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2026.112850_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.111790","article-title":"Spatial transcriptomic analysis identifies epithelium-macrophage crosstalk in endometriotic lesions","volume":"28","author":"Burns","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.mce.2026.112850_bib6","article-title":"Peritoneal immune microenvironment of endometriosis: role and therapeutic perspectives","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2026.112850_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13148-025-01828-w","article-title":"Systematic review on the DNA methylation role in endometriosis: current evidence and perspectives","volume":"17","author":"Ducreux","year":"2025","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.mce.2026.112850_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41588-022-01254-1","article-title":"Single-cell transcriptomic analysis of endometriosis","volume":"55","author":"Fonseca","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2026.112850_bib9","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.molmed.2024.06.008","article-title":"Endometriosis: recent advances that could accelerate diagnosis and improve care","volume":"30","author":"Griffiths","year":"2024","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mce.2026.112850_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/s12916-024-03571-0","article-title":"NLRC5 exerts anti-endometriosis effects through inhibiting ER\u03b2-mediated inflammatory response","volume":"22","author":"Guo","year":"2024","journal-title":"BMC Med."},{"key":"10.1016\/j.mce.2026.112850_bib10","article-title":"Role of the gut microbiota in the pathogenesis of endometriosis: a review","volume":"15","author":"Guo","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.mce.2026.112850_bib12","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00404-020-05472-y","article-title":"Localization of claudin-2 and claudin-3 in eutopic and ectopic endometrium is highly similar","volume":"301","author":"Hoerscher","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.mce.2026.112850_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12958-020-00669-x","article-title":"Establishment of an immortalized stromal cell line derived from human endometriotic lesion","volume":"18","author":"Huang","year":"2020","journal-title":"Reprod Biol Endocrinol RBE"},{"key":"10.1016\/j.mce.2026.112850_bib14","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/med.21802","article-title":"Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: a review","volume":"41","author":"Hung","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.mce.2026.112850_bib15","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1093\/biolre\/ioaf255","article-title":"Establishment and characterization of a new immortalized human adenomyosis epithelial-like cell line, tAEC21","volume":"114","author":"Klymenko","year":"2026","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2026.112850_bib16","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1210\/en.2003-1606","article-title":"A novel immortalized human endometrial stromal cell line with normal progestational response","volume":"145","author":"Krikun","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2026.112850_bib17","article-title":"Single-cell and spatial transcriptomic profiling revealed niche interactions sustaining growth of endometriotic lesions","volume":"5","author":"Liu","year":"2025","journal-title":"Cell Genom."},{"key":"10.1016\/j.mce.2026.112850_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaaf024","article-title":"WERF endometriosis phenome and biobanking harmonisation project for experimental models in endometriosis research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research","volume":"31","author":"Marr","year":"2025","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2026.112850_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.961599","article-title":"Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology","volume":"13","author":"McCallion","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2026.112850_bib21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tem.2018.05.006","article-title":"Progesterone resistance in endometriosis: an acquired property?","volume":"29","author":"McKinnon","year":"2018","journal-title":"Trends Endocrinol Metab TEM"},{"key":"10.1016\/j.mce.2026.112850_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0248-4900(96)89428-7","article-title":"Normal human endometrial cells in culture: characterization and immortalization of epithelial and stromal cells by SV 40 large T antigen","volume":"84","author":"Merviel","year":"1995","journal-title":"Biol. Cell"},{"key":"10.1016\/j.mce.2026.112850_bib23","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.3390\/ijms26157600","article-title":"Unraveling the core of endometriosis: the impact of endocrine disruptors","volume":"26","author":"Moustakli","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112850_bib24","article-title":"Emerging bacterial factors for understanding pathogenesis of endometriosis","volume":"27","author":"Muraoka","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.mce.2026.112850_bib25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3390\/cells13080703","article-title":"Establishment and characterization of SV40 T-Antigen immortalized porcine muscle satellite cell","volume":"13","author":"Ni","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.mce.2026.112850_bib26","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/aogs.13156","article-title":"Progesterone resistance in endometriosis: origins, consequences and interventions","volume":"96","author":"Patel","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.mce.2026.112850_bib27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/humupd\/dmaa009","article-title":"Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure","volume":"26","author":"Reis","year":"2020","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2026.112850_bib28","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/s41556-022-00961-5","article-title":"Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues","volume":"24","author":"Tan","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mce.2026.112850_bib29","series-title":"Endometriosis. StatPearls [Internet]","author":"Tsamantioti","year":"2025"},{"key":"10.1016\/j.mce.2026.112850_bib30","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3390\/biomedicines8110525","article-title":"Three-dimensional biofabrication models of endometriosis and the endometriotic microenvironment","volume":"8","author":"Wendel","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.mce.2026.112850_bib31","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/humrep\/dey119","article-title":"Increased AIF-1-mediated TNF-\u03b1 expression during implantation phase in IVF cycles with GnRH antagonist protocol","volume":"33","author":"Xu","year":"2018","journal-title":"Hum Reprod Oxf Engl"},{"key":"10.1016\/j.mce.2026.112850_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113716","article-title":"Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis","volume":"43","author":"Yan","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.mce.2026.112850_bib33","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/humupd\/dmz005","article-title":"Endometriosis and nuclear receptors","volume":"25","author":"Yilmaz","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2026.112850_bib34","article-title":"Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review","volume":"16","author":"Yu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mce.2026.112850_bib18","article-title":"Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli","volume":"9","author":"Yuhki","year":"2011","journal-title":"Reprod Biol Endocrinol RBE"},{"key":"10.1016\/j.mce.2026.112850_bib35","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/humrep\/deae116","article-title":"Overview of crosstalk between stromal and epithelial cells in the pathogenesis of adenomyosis and shared features with deep endometriotic nodules","volume":"39","author":"Zipponi","year":"2024","journal-title":"Hum Reprod Oxf Engl"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726001279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726001279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:45:29Z","timestamp":1785883529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720726001279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"alternative-id":["S0303720726001279"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2026.112850","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patient-derived eutopic and ectopic endometrial stromal cells: characterization and development of immortalized lines","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2026.112850","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112850"}}