{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:00:00Z","timestamp":1790409600895,"version":"4.1.0"},"reference-count":144,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010599","name":"Universidad de Talca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.mce.2026.112897","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:30:24Z","timestamp":1787787024000},"page":"112897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Role of liver connexins and pannexins in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) in the context of overnutrition: A narrative review"],"prefix":"10.1016","volume":"623","author":[{"given":"Juan Pablo","family":"Bravo-Novoa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Norambuena-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Qui\u00f1ones San Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-991X","authenticated-orcid":false,"given":"Jessica","family":"Z\u00fa\u00f1iga-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2026.112897_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051296","article-title":"Connexins: synthesis, post-translational modifications, and trafficking in health and disease","volume":"19","author":"Aasen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrc.2016.105","article-title":"Gap junctions and cancer: communicating for 50 years","volume":"16","author":"Aasen","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mce.2026.112897_bib3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.molmet.2015.06.009","article-title":"Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes","volume":"4","author":"Adamson","year":"2015","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.mce.2026.112897_bib4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/j.2040-4603.2013.tb00492.x","article-title":"Calcium signaling in the liver","volume":"3","author":"Amaya","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.mce.2026.112897_bib5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0165-0173(99)00099-5","article-title":"Gap junctions: the \u201ckiss of death\u201d and the \u201ckiss of life.\u201d","volume":"32","author":"Andrade-Rozental","year":"2000","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.mce.2026.112897_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/hep.20256","article-title":"Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals","volume":"40","author":"Asamoto","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2026.112897_bib7","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.yjmcc.2006.03.005","article-title":"Identification of ischemia-regulated phosphorylation sites in connexin43: a possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123)","volume":"40","author":"Axelsen","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.mce.2026.112897_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216160","article-title":"Intercellular communication in airway epithelial cell regeneration: potential roles of connexins and pannexins","volume":"24","author":"Badaoui","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib9","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1124\/jpet.106.112045","article-title":"Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB)","volume":"319","author":"Bai","year":"2006","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.mce.2026.112897_bib10","doi-asserted-by":"crossref","first-page":"20772","DOI":"10.1073\/pnas.1018262108","article-title":"Pannexins in ischemia-induced neurodegeneration","volume":"108","author":"Bargiotas","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mce.2026.112897_bib11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ceca.2014.02.007","article-title":"Calcium-dependent regulation of glucose homeostasis in the liver","volume":"55","author":"Bartlett","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mce.2026.112897_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3109\/15419060109080719","article-title":"Identification and functional expression of HCx31.9, a novel gap junction gene","volume":"8","author":"Belluardo","year":"2001","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.mce.2026.112897_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26062394","article-title":"A comprehensive review of metabolic dysfunction-associated steatotic liver disease: its mechanistic development focusing on Methylglyoxal and counterbalancing treatment strategies","volume":"26","author":"Berdowska","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1053\/jhep.2002.35274","article-title":"Expression and regulation of gap junctions in rat cholangiocytes","volume":"36","author":"Bode","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2026.112897_bib15","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1111\/bph.13804","article-title":"The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischaemia\/reperfusion independent from mitochondrial connexin 43","volume":"174","author":"Boengler","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2026.112897_bib16","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.2000.279.4.L623","article-title":"Connexin mimetic peptides reversibly inhibit Ca2+ signaling through gap junctions in airway cells","volume":"279","author":"Boitano","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.mce.2026.112897_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21186943","article-title":"Lens connexin channels show differential permeability to signaling molecules","volume":"21","author":"Brink","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib18","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1113\/JP283691","article-title":"Short-term high-fat diet feeding of mice suppresses catecholamine-stimulated Ca2+ signalling in hepatocytes and intact liver","volume":"601","author":"Brumer","year":"2023","journal-title":"J. Physiol."},{"key":"10.1016\/j.mce.2026.112897_bib19","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/bph.15329","article-title":"Carbenoxolone and 18\u03b2-glycyrrhetinic acid inhibit inositol 1,4,5-trisphosphate-mediated endothelial cell calcium signalling and depolarise mitochondria","volume":"178","author":"Buckley","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2026.112897_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cbin.12253","article-title":"Rotigaptide inhibits spontaneous contractions of gastric smooth muscle in diabetic rats via the PKC\u03b1-Cx43 pathway","volume":"49","author":"Changri","year":"2025","journal-title":"Cell Biol. Int."},{"issue":"3","key":"10.1016\/j.mce.2026.112897_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00232-016-9881-6","article-title":"Connexins, pannexins, and their channels in fibroproliferative diseases","volume":"249","author":"Cogliati","year":"2016","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.mce.2026.112897_bib22","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.3390\/ijms21186534","article-title":"Cholestasis differentially affects liver connexins","volume":"21","author":"Cooreman","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103139","article-title":"Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes","volume":"24","author":"Corr\u00eaa-Velloso","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.mce.2026.112897_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-015-1543-4","article-title":"Experimental models of liver fibrosis","author":"Crespo Yanguas","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.mce.2026.112897_bib25","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1007\/s00204-018-2255-3","article-title":"Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model","volume":"92","author":"Crespo Yanguas","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.mce.2026.112897_bib26","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0191","article-title":"ATP release through pannexon channels","volume":"370","author":"Dahl","year":"2015","journal-title":"Phil. Trans. Biol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib27","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1002\/ueg2.70072","article-title":"The rising global burden of MASLD and other metabolic diseases (2000\u20132021)","volume":"13","author":"Danpanichkul","year":"2025","journal-title":"United Eur. Gastroenterol. J."},{"key":"10.1016\/j.mce.2026.112897_bib28","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202112871","article-title":"Piezo1\u2013Pannexin1 complex couples force detection to ATP secretion in cholangiocytes","volume":"153","author":"Desplat","year":"2021","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.mce.2026.112897_bib29","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1152\/physrev.00042.2022","article-title":"Physiology of intracellular calcium buffering","volume":"103","author":"Eisner","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2026.112897_bib30","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1111\/bph.13568","article-title":"Effect of connexin 43 inhibition by the mimetic peptide Gap27 on corneal wound healing, inflammation and neovascularization","volume":"173","author":"Elbadawy","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2026.112897_bib31","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2026.112897_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cellimm.2007.08.001","article-title":"Inflammatory conditions induce gap junctional communication between rat kupffer cells both in vivo and in vitro","volume":"247","author":"Eugen\u00edn","year":"2007","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.mce.2026.112897_bib33","series-title":"EASL Annual Report 2024","year":"2024"},{"key":"10.1016\/j.mce.2026.112897_bib34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1053\/j.gastro.2004.11.065","article-title":"Intercellular communication via gap junctions in activated rat hepatic stellate cells","volume":"128","author":"Fischer","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2026.112897_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/path.4232","article-title":"Pathways mediating resolution of inflammation: when enough is too much","volume":"231","author":"Fullerton","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.mce.2026.112897_bib36","volume":"121","author":"Gaete","year":"2024"},{"key":"10.1016\/j.mce.2026.112897_bib37","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3892\/mmr.2014.2099","article-title":"\u03b2-catenin is overexpressed in hepatic fibrosis and blockage of Wnt\/\u03b2-catenin signaling inhibits hepatic stellate cell activation","volume":"9","author":"Ge","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mce.2026.112897_bib38","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00298.2001","article-title":"Regulation of hepatic connexins in cholestasis: possible involvement of kupffer cells and inflammatory mediators","volume":"282","author":"Gonz\u00e1lez","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.mce.2026.112897_bib39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12885-015-1229-6","article-title":"Targeting connexin 43 with \u03b1\u2013connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer: clinical implication for ACT1","volume":"15","author":"Grek","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mce.2026.112897_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2023.102753","article-title":"Interplay between calcium and endoplasmic reticulum stress","volume":"113","author":"Groenendyk","year":"2023","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mce.2026.112897_bib41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.107067","article-title":"ATP-Release pannexin channels are gated by lysophospholipids","volume":"14","author":"Henze","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.mce.2026.112897_bib42","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/liv.12446","article-title":"Role of gap junctions modulating hepatic vascular tone in cirrhosis","volume":"34","author":"Hern\u00e1ndez-Guerra","year":"2014","journal-title":"Liver Int."},{"key":"10.1016\/j.mce.2026.112897_bib43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40779-024-00543-6","article-title":"PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis","volume":"11","author":"Hu","year":"2024","journal-title":"Milit. Med. Res."},{"key":"10.1016\/j.mce.2026.112897_bib44","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.trsl.2023.07.008","article-title":"Dual-regulation by Cx32 in hepatocyte to trigger and worsen liver graft injury","volume":"262","author":"Huang","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.mce.2026.112897_bib45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.omtn.2016.12.003","article-title":"Preclinical and clinical advances of GalNAc-Decorated nucleic acid therapeutics","volume":"6","author":"Huang","year":"2017","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.mce.2026.112897_bib46","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1083\/jcb.201101050","article-title":"Pannexin 3 functions as an ER Ca2+ channel, hemichannel, and gap junction to promote osteoblast differentiation","volume":"193","author":"Ishikawa","year":"2011","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.mce.2026.112897_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.105","article-title":"Gap junctional communication promotes apoptosis in a connexin-type-dependent manner","volume":"4","author":"Kameritsch","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mce.2026.112897_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006843","article-title":"Connexin 43 plays an important role in the transformation of cholangiocytes with clonochis sinensis excretory-secretory protein and N-nitrosodimethylamine","volume":"13","author":"Kim","year":"2019","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"2","key":"10.1016\/j.mce.2026.112897_bib49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1134\/S1990747821020069","article-title":"Structure and functions of gap junctions and their constituent connexins in the mammalian CNS","volume":"15","author":"Kirichenko","year":"2021","journal-title":"Biochemistry (Moscow), Supplement Series A: Membr. Cell Biol."},{"key":"10.1016\/j.mce.2026.112897_bib50","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0003-9861(02)00488-5","article-title":"Positive regulation of connexin32 transcription by hepatocyte nuclear factor-1\u03b1","volume":"407","author":"Koffler","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mce.2026.112897_bib51","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.jacc.2006.04.093","article-title":"The effects of carbenoxolone on human myocardial conduction","volume":"48","author":"Kojodjojo","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mce.2026.112897_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2023.102359","article-title":"Pharmacology of pannexin channels","volume":"69","author":"Koval","year":"2023","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.mce.2026.112897_bib53","article-title":"Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis","volume":"3","author":"Kurosaki","year":"2021","journal-title":"JHEP Rep."},{"issue":"1","key":"10.1016\/j.mce.2026.112897_bib54","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1038\/s41467-024-50657-7","article-title":"Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry","volume":"15","author":"Kwok","year":"2024","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.mce.2026.112897_bib55","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nrd.2018.138","article-title":"Therapeutic strategies targeting connexins","volume":"17","author":"Laird","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mce.2026.112897_bib56","doi-asserted-by":"crossref","first-page":"13086","DOI":"10.1021\/acs.jmedchem.3c01116","article-title":"Structure-based design and synthesis of stapled 10Panx1 analogues for use in cardiovascular inflammatory diseases","volume":"66","author":"Lamouroux","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.mce.2026.112897_bib57","doi-asserted-by":"crossref","DOI":"10.12703\/r\/11-14","article-title":"Recent advances in connexin gap junction biology","volume":"11","author":"Lampe","year":"2022","journal-title":"Fac. Rev."},{"key":"10.1016\/j.mce.2026.112897_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0315510","article-title":"Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate","volume":"19","author":"Lavriha","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2026.112897_bib59","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.biocel.2003.08.004","article-title":"Differential effects of gadolinium chloride on kupffer cells in vivo and in vitro","volume":"36","author":"Lee","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mce.2026.112897_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111724","article-title":"Connexin-based channel activity is not specifically altered by hepatocarcinogenic chemicals","volume":"22","author":"Leroy","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib61","first-page":"1111","article-title":"Expression of connexins and pannexins in diseased human liver","volume":"21","author":"Leroy","year":"2022","journal-title":"EXCLI J."},{"key":"10.1016\/j.mce.2026.112897_bib62","article-title":"Advances in nanotechnology for the diagnosis and management of metabolic dysfunction-associated steatotic liver disease","volume":"20","author":"Li","year":"2025","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib63","first-page":"309","article-title":"Heterozygous GJA1 variants with ocular phenotype: missense in domain but truncation out of domain","volume":"27","author":"Li","year":"2021","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mce.2026.112897_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105263","article-title":"Diversity in connexin biology","volume":"299","author":"Lucaciu","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2026.112897_bib65","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/hep4.1179","article-title":"Hepatic connexin 32 associates with nonalcoholic fatty liver disease severity","volume":"2","author":"Luther","year":"2018","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.mce.2026.112897_bib66","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jconrel.2024.07.011","article-title":"Lipid nanoparticle-mediated hepatocyte delivery of siRNA and silibinin in metabolic dysfunction-associated steatotic liver disease","volume":"373","author":"Lyu","year":"2024","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.mce.2026.112897_bib67","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12974-018-1230-5","article-title":"Astrocytic gap junction inhibition by carbenoxolone enhances the protective effects of ischemic preconditioning following cerebral ischemia","volume":"15","author":"Ma","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mce.2026.112897_bib68","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.toxlet.2017.07.007","article-title":"Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice","volume":"278","author":"Maes","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.mce.2026.112897_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2013.00405","article-title":"Connexin and pannexin (hemi)channels in the liver","volume":"4","author":"Maes","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mce.2026.112897_bib70","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbadis.2016.02.007","article-title":"Involvement of connexin43 in acetaminophen-induced liver injury","volume":"1862","author":"Maes","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.mce.2026.112897_bib71","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1007\/s00204-016-1885-6","article-title":"Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity","volume":"91","author":"Maes","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"10","key":"10.1016\/j.mce.2026.112897_bib72","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1007\/s00221-017-5023-3","article-title":"Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats","volume":"235","author":"Mao","year":"2017","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.mce.2026.112897_bib73","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s13311-019-00786-5","article-title":"Connexin hemichannel block using orally delivered tonabersat improves outcomes in animal models of retinal disease","volume":"17","author":"Mat Nor","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.mce.2026.112897_bib74","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.3390\/biomedicines11071972","article-title":"Evaluation of Cx43 gap junction inhibitors using a quantitative structure-activity relationship model","volume":"11","author":"Matusevi\u010di\u016bt\u0117","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.mce.2026.112897_bib75","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-020-2121-3","article-title":"Metabolites released from apoptotic cells act as tissue messengers","volume":"580","author":"Medina","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mce.2026.112897_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105399","article-title":"The role of the gap junction protein connexin in adrenal gland tumorigenesis","volume":"25","author":"Mizdrak","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib77","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061778","article-title":"Connexin 43-Based therapeutics for dermal wound healing","volume":"19","author":"Montgomery","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib78","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11302-021-09822-6","article-title":"Mechanisms of ATP release in pain: role of pannexin and connexin channels","volume":"17","author":"Mu\u00f1oz","year":"2021","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.mce.2026.112897_bib79","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1007\/s00204-020-02873-5","article-title":"A novel model of non-alcoholic steatohepatitis with fibrosis and carcinogenesis in connexin 32 dominant-negative transgenic rats","volume":"94","author":"Naiki-Ito","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.mce.2026.112897_bib80","doi-asserted-by":"crossref","first-page":"9119","DOI":"10.3390\/ijms21239119","article-title":"Connexins\u2014therapeutic targets in cancers","volume":"21","author":"Nalewajska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.64787","article-title":"ATP and large signaling metabolites flux through caspase-activated pannexin 1 channels","volume":"10","author":"Narahari","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.mce.2026.112897_bib82","doi-asserted-by":"crossref","first-page":"9565","DOI":"10.1073\/pnas.93.18.9565","article-title":"Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice","volume":"93","author":"Nelles","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mce.2026.112897_bib83","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.3390\/ijms22041755","article-title":"Differential action of connexin hemichannel and pannexin channel therapeutics for potential treatment of retinal diseases","volume":"22","author":"Nor","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib84","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"\u00d6zcan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.mce.2026.112897_bib85","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0167-4781(00)00036-1","article-title":"Liver cell-specific transcriptional regulation of connexin32","volume":"1491","author":"Piechocki","year":"2000","journal-title":"Biochim. Biophys. Acta Gene Struct. Expr."},{"key":"10.1016\/j.mce.2026.112897_bib86","first-page":"210","article-title":"Assignment of the human connexin 32 gene (GJB1) to band Xq13. Cytogenet","volume":"60","author":"Raimondi","year":"1992","journal-title":"Cell Genet"},{"key":"10.1016\/j.mce.2026.112897_bib87","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2026.112897_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114377","article-title":"Antibody-activation of connexin hemichannels in bone osteocytes with ATP release suppresses breast cancer and osteosarcoma malignancy","volume":"43","author":"Riquelme","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.mce.2026.112897_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094413","article-title":"Connexins in the heart: regulation, function and involvement in cardiac disease","volume":"22","author":"Rodr\u00edguez-Sinovas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl. 2","key":"10.1016\/j.mce.2026.112897_bib90","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/dom.70659","article-title":"Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD): a literature review on pathophysiology and treatment","volume":"28","author":"Romanos","year":"2026","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.mce.2026.112897_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1020826","article-title":"Pannexin1 Channels\u2014a potential therapeutic target in inflammation","volume":"10","author":"Rusiecka","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mce.2026.112897_bib92","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/physrev.00007.2003","article-title":"Plasma membrane channels formed by connexins: their regulation and functions","volume":"83","author":"S\u00e1ez","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2026.112897_bib93","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/742734","article-title":"Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells","author":"S\u00e1ez","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.mce.2026.112897_bib94","doi-asserted-by":"crossref","DOI":"10.1093\/carcin\/bgv143","article-title":"Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats","author":"Sagawa","year":"2015","journal-title":"Carcinogenesis bgv143"},{"key":"10.1016\/j.mce.2026.112897_bib95","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00052","article-title":"The P2X7 receptor in inflammatory diseases: Angel or demon?","volume":"9","author":"Savio","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mce.2026.112897_bib96","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00004.2018","article-title":"Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury","volume":"315","author":"Sharma","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.mce.2026.112897_bib97","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00441-006-0165-9","article-title":"Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development","volume":"324","author":"Shiojiri","year":"2006","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mce.2026.112897_bib98","author":"Silverman"},{"key":"10.1016\/j.mce.2026.112897_bib99","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cardiores.2003.11.013","article-title":"Gap junctions and the connexin protein family","volume":"62","author":"S\u00f6hl","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mce.2026.112897_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/wmts.72","article-title":"Gap junctions and bystander effects: good samaritans and executioners","volume":"2","author":"Spray","year":"2012","journal-title":"Wiley Interdiscip. Rev. Membr. Transp. Signal."},{"key":"10.1016\/j.mce.2026.112897_bib101","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062809","article-title":"Danegaptide prevents TGF\u03b21-Induced damage in human proximal tubule epithelial cells of the kidney","volume":"22","author":"Squires","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib102","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1124\/mol.63.6.1389","article-title":"Closure of gap junction channels by arylaminobenzoates","volume":"63","author":"Srinivas","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2026.112897_bib103","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bbamem.2017.04.024","article-title":"Human diseases associated with connexin mutations","volume":"1860","author":"Srinivas","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.mce.2026.112897_bib104","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S2213-8587(24)00318-8","article-title":"Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment. thelancet.comN Stefan, H Yki-J\u00e4rvinen","volume":"13","author":"Stefan","year":"2025","journal-title":"BA Neuschwander-TetriThe Lancet Diabetes & Endocrinology"},{"key":"10.1016\/j.mce.2026.112897_bib105","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/hep.510280622","article-title":"Connexin 32 gap junctions enhance stimulation of glucose output by glucagon and noradrenaline in mouse liver","volume":"28","author":"St\u00fcmpel","year":"1998","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.mce.2026.112897_bib106","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41392-024-01888-z","article-title":"Cell\u2013cell communication: new insights and clinical implications","volume":"9","author":"Su","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.mce.2026.112897_bib107","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/s42003-023-05226-x","article-title":"Pannexin 1 targets mitophagy to mediate renal ischemia\/reperfusion injury","volume":"6","author":"Su","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mce.2026.112897_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153283","article-title":"Oxidative stress and Cx43-mediated apoptosis are involved in PFOS-induced nephrotoxicity","volume":"478","author":"Tang","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.mce.2026.112897_bib109","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1124\/mol.106.027508","article-title":"2-Aminoethoxydiphenyl borate directly inhibits channels composed of Connexin26 and\/or Connexin32","volume":"71","author":"Tao","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2026.112897_bib110","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/1440-1681.12701","article-title":"Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis","volume":"44","author":"Tiburcio","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.mce.2026.112897_bib111","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cmet.2020.11.009","article-title":"Intercellular transmission of hepatic ER stress in obesity disrupts systemic metabolism","volume":"33","author":"Tirosh","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2026.112897_bib112","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103736","article-title":"Connexin-mediated signaling at the immunological synapse","volume":"21","author":"Tittarelli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib113","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1093\/emboj\/16.17.5398","article-title":"Coordinated intercellular calcium waves induced by noradrenaline in rat hepatocytes: dual control by gap junction permeability and agonist","volume":"16","author":"Tordjmann","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2026.112897_bib114","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1093\/emboj\/17.16.4695","article-title":"Receptor-oriented intercellular calcium waves evoked by vasopressin in rat hepatocytes","volume":"17","author":"Tordjmann","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2026.112897_bib115","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.21873\/invivo.13940","article-title":"Connexin-43 protein expression pattern analysis in myocardial infarction tissues","volume":"39","author":"Tsantoulas","year":"2025","journal-title":"In Vivo (Brooklyn)"},{"key":"10.1016\/j.mce.2026.112897_bib116","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11302-024-10044-9","article-title":"Purinergic signaling in liver disease: calcium signaling and induction of inflammation","volume":"21","author":"Ulrich","year":"2025","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.mce.2026.112897_bib117","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1220405","article-title":"Pannexin1 channels in the liver: an open enemy","volume":"11","author":"Van Campenhout","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mce.2026.112897_bib118","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pbiomolbio.2020.03.002","article-title":"Non-canonical roles of connexins","volume":"153","author":"Van Campenhout","year":"2020","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.mce.2026.112897_bib119","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1007\/s10495-009-0400-4","article-title":"Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver?","volume":"14","author":"van der Kallen","year":"2009","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.mce.2026.112897_bib120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00395-012-0309-x","article-title":"Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia\/reperfusion injury","volume":"108","author":"Wang","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.mce.2026.112897_bib121","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1097\/CM9.0000000000003517","article-title":"Global burden of metabolic-associated fatty liver disease: a systematic analysis of global burden of disease study 2021","volume":"138","author":"Wang","year":"2025","journal-title":"Chin. Med. J. (Engl)."},{"issue":"1","key":"10.1016\/j.mce.2026.112897_bib122","doi-asserted-by":"crossref","first-page":"8268","DOI":"10.1038\/s41598-017-08583-w","article-title":"Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice","volume":"7","author":"Willebrords","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2026.112897_bib123","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pharmthera.2017.07.001","article-title":"Inhibitors of connexin and pannexin channels as potential therapeutics","volume":"180","author":"Willebrords","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.mce.2026.112897_bib124","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.bbadis.2017.12.013","article-title":"Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease","volume":"1864","author":"Willebrords","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.mce.2026.112897_bib125","series-title":"Noncommunicable Diseases Progress Monitor 2025","year":"2025"},{"key":"10.1016\/j.mce.2026.112897_bib127","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1128\/MCB.01844-08","article-title":"Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3\/beta-catenin signaling","volume":"30","author":"Xia","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mce.2026.112897_bib128","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11302-015-9456-5","article-title":"Lipoapoptosis induced by saturated free fatty acids stimulates monocyte migration: a novel role for Pannexin1 in liver cells","volume":"11","author":"Xiao","year":"2015","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.mce.2026.112897_bib129","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00175.2012","article-title":"Pannexin1 contributes to pathophysiological ATP release in lipoapoptosis induced by saturated free fatty acids in liver cells","volume":"303","author":"Xiao","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mce.2026.112897_bib130","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1650548","article-title":"Research progress of connexin 43 in cardiovascular diseases","volume":"12","author":"Xinxin","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.mce.2026.112897_bib131","first-page":"780","article-title":"Comprehensive pan-cancer analysis of connexin 43 as a potential biomarker and therapeutic target in human kidney renal clear cell carcinoma (KIRC)","volume":"60","author":"Xu","year":"2024","journal-title":"Medicina (Lithuania)"},{"key":"10.1016\/j.mce.2026.112897_bib132","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ejcb.2010.09.007","article-title":"S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes","volume":"90","author":"Yamaji","year":"2010","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.mce.2026.112897_bib133","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.immuni.2015.10.009","article-title":"Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock","volume":"43","author":"Yang","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.mce.2026.112897_bib134","article-title":"Gadolinium chloride restores the function of the gap junctional intercellular communication between hepatocytes in a liver injury","volume":"20","author":"Yang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib135","article-title":"Nano-drug delivery systems (NDDS) in metabolic dysfunction-associated steatotic liver disease (MASLD): current status, prospects and challenges","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mce.2026.112897_bib136","article-title":"TAT-Gap19 and carbenoxolone alleviate liver fibrosis in mice","volume":"19","author":"Yanguas","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2026.112897_bib137","first-page":"177","article-title":"Connexins and pannexins in liver damage","volume":"15","author":"Yanguas","year":"2016","journal-title":"EXCLI J."},{"key":"10.1016\/j.mce.2026.112897_bib138","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of metabolic dysfunction-associated steatotic liver disease","volume":"31","author":"Younossi","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.mce.2026.112897_bib139","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/s41467-023-36861-x","article-title":"Cryo-EM structure of human heptameric pannexin 2 channel","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2026.112897_bib140","article-title":"Connexin 43 phosphorylation: implications in multiple diseases","volume":"28","author":"Zhang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.mce.2026.112897_bib141","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/abt\/tbae024","article-title":"Connexin 43 hemichannels and related diseases","volume":"7","author":"Zhang","year":"2024","journal-title":"Antibody Ther."},{"issue":"2","key":"10.1016\/j.mce.2026.112897_bib142","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s12072-024-10660-y","article-title":"MAFLD as part of systemic metabolic dysregulation","volume":"18","author":"Zhao","year":"2024","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.mce.2026.112897_bib143","doi-asserted-by":"crossref","DOI":"10.1111\/liv.70155","article-title":"Global burden of chronic liver disease and temporal trends: a population-based analysis from 1990 to 2021 with projections to 2050","volume":"45","author":"Zhao","year":"2025","journal-title":"Liver Int."},{"key":"10.1016\/j.mce.2026.112897_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115741","article-title":"Trans-cinnamaldehyde alleviates IFN-\u03b1-induced depressive-like behaviors by restoring astrocytic Cx43 gap junction","volume":"167","author":"Zhou","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mce.2026.112897_bib145","first-page":"6357","article-title":"Kupffer cell depletion by gadolinium chloride aggravates liver injury after brain death in rats","volume":"17","author":"Zhu","year":"2018","journal-title":"Mol. Med. Rep."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726001747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726001747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:37:16Z","timestamp":1790408236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720726001747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":144,"alternative-id":["S0303720726001747"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2026.112897","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of liver connexins and pannexins in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) in the context of overnutrition: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2026.112897","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112897"}}