{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:34:51Z","timestamp":1792928091793,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012467","name":"Distinguished Professor of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012467","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.mce.2026.112907","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:35:30Z","timestamp":1788968130000},"page":"112907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bufalin targets CENPA-modulated glycolysis via PI3K\/AKT in hepatocellular carcinoma: A bioinformatics, In Vitro and preliminary In Vivo evidence"],"prefix":"10.1016","volume":"623","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-2476","authenticated-orcid":false,"given":"Muhammad Muddasar","family":"Saeed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Khalid","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Jabbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimsha","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mce.2026.112907_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib2","article-title":"Comprehensive pan-cancer analysis reveals ENC1 as a promising prognostic biomarker for tumor microenvironment and therapeutic responses","volume":"14","author":"Cao","year":"2024","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.mce.2026.112907_bib3","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/HEP.0000000000000599","article-title":"Hypoxia-driven tumor stromal remodeling and immunosuppressive microenvironment in scirrhous HCC","volume":"79","author":"Chen","year":"2024","journal-title":"Hepatology"},{"issue":"17","key":"10.1016\/j.mce.2026.112907_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713274","article-title":"Hepatocellular carcinoma: past and present challenges and progress in molecular classification and precision oncology","volume":"24","author":"Coffin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drudis.2021.09.007","article-title":"Machine-learning methods for ligand\u2013protein molecular docking","volume":"27","author":"Crampon","year":"2022","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.mce.2026.112907_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12876-016-0440-5","article-title":"Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of chronic hepatitis C","volume":"16","author":"El-Derany","year":"2016","journal-title":"BMC Gastroenterol."},{"issue":"2","key":"10.1016\/j.mce.2026.112907_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020460","article-title":"Natural compounds in prostate cancer prevention and treatment: mechanisms of action and molecular targets","volume":"9","author":"Fontana","year":"2020","journal-title":"Cells"},{"issue":"10127","key":"10.1016\/j.mce.2026.112907_bib8","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.mce.2026.112907_bib9","doi-asserted-by":"crossref","first-page":"14785","DOI":"10.1007\/s00210-025-04285-7","article-title":"LincRNA-miR interactions in hepatocellular carcinoma: comprehensive review and in silico analysis: a step toward ncRNA precision","volume":"398","author":"Hamdy","year":"2025","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib10","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1038\/s41598-023-30851-1","article-title":"Differentially expressed discriminative genes and significant meta-hub genes based key genes identification for hepatocellular carcinoma using statistical machine learning","volume":"13","author":"Hasan","year":"2023","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.mce.2026.112907_bib11","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1158\/0008-5472.CAN-21-2647","article-title":"Cancer signaling drives cancer metabolism: AKT and the warburg effect","volume":"81","author":"Hosios","year":"2021","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12943-023-01714-0","article-title":"Regulatory cells and the effect of cancer immunotherapy","volume":"22","author":"Iglesias-Escudero","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mce.2026.112907_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2147\/OTT.S333233","article-title":"The research progress of bufalin in the treatment of hepatocellular carcinoma","volume":"15","author":"Jiang","year":"2022","journal-title":"OncoTargets Ther."},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12885-022-09209-9","article-title":"Identification of a glycolysis-related gene signature for predicting prognosis in patients with hepatocellular carcinoma","volume":"22","author":"Kong","year":"2022","journal-title":"BMC Cancer"},{"issue":"16","key":"10.1016\/j.mce.2026.112907_bib15","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.7150\/ijbs.85656","article-title":"CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1","volume":"19","author":"Liao","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.mce.2026.112907_bib16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"3","key":"10.1016\/j.mce.2026.112907_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac129","article-title":"CAMOIP: a web server for comprehensive analysis on multi-omics of immunotherapy in pan-cancer","volume":"23","author":"Lin","year":"2022","journal-title":"Briefings Bioinf."},{"issue":"2","key":"10.1016\/j.mce.2026.112907_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.acvdsp.2019.02.092","article-title":"Pharmacological effects of cardiac glycosides on cell death and autophagy: impact on the mitochondrial network structure and function","volume":"11","author":"Liu","year":"2019","journal-title":"Archives of Cardiovascular Diseases Supplements"},{"key":"10.1016\/j.mce.2026.112907_bib19","article-title":"CDXC. RACGAP1 and MKI67 are potential prognostic biomarker in hepatocellular carcinoma caused by HBV\/HCV via lactylation","volume":"15","author":"Muhammad Muddasar","year":"2025","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.mce.2026.112907_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/biom15060885","article-title":"Cardiac glycosides: from natural defense molecules to emerging therapeutic agents","volume":"15","author":"Ponce","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.mce.2026.112907_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129584","article-title":"Molecular subtypes of disulfidptosis-regulated genes and prognosis models for predicting prognosis, tumor microenvironment infiltration, and therapeutic response in hepatocellular carcinoma","volume":"261","author":"Qu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mce.2026.112907_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115876","article-title":"Mechanism of sijunzi decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation","volume":"302","author":"Shang","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.mce.2026.112907_bib23","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/cas.16137","article-title":"YTHDC1-dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple-negative breast cancer","volume":"115","author":"Shen","year":"2024","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib24","first-page":"54","article-title":"Effect of PI3K\/AKT\/mTOR Signaling Pathway on Regulating and Controlling the Anti-Invasion and Metastasis of Hepatoma Cells by Bufalin","volume":"16","author":"Sheng","year":"2021","journal-title":"Recent Patents on Anti-Cancer Drug Discovery"},{"issue":"7","key":"10.1016\/j.mce.2026.112907_bib25","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1002\/ptr.7087","article-title":"Apoptotic effect of compound K in hepatocellular carcinoma cells via inhibition of glycolysis and Akt\/mTOR\/c-Myc signaling","volume":"35","author":"Shin","year":"2021","journal-title":"Phytother Res."},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib26","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.mce.2026.112907_bib27","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fgene.2020.00342","article-title":"Identification of crucial genes associated with immune cell infiltration in hepatocellular carcinoma by weighted gene Co-expression network analysis","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Genet."},{"issue":"17","key":"10.1016\/j.mce.2026.112907_bib28","doi-asserted-by":"crossref","first-page":"13783","DOI":"10.18632\/oncotarget.24475","article-title":"Cardiac glycoside bufalin blocks cancer cell growth by inhibition of Aurora A and Aurora B activation via PI3K-Akt pathway","volume":"9","author":"Xie","year":"2018","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.mce.2026.112907_bib29","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.35066","article-title":"Survival outcomes among patients with hepatocellular carcinoma in a large integrated US health system","volume":"7","author":"Yilma","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"15","key":"10.1016\/j.mce.2026.112907_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells13151245","article-title":"A comprehensive insight and in silico analysis of CircRNAs in hepatocellular carcinoma: a step toward ncRNA-Based precision medicine","volume":"13","author":"Youness","year":"2024","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib31","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1038\/s41598-018-22113-2","article-title":"Bufalin suppresses hepatocarcinogenesis by targeting \u03b2-catenin\/TCF signaling via cell cycle-related kinase","volume":"8","author":"Yu","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.mce.2026.112907_bib32","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004297","article-title":"Bufalin stimulates antitumor immune response by driving tumor-infiltrating macrophage toward M1 phenotype in hepatocellular carcinoma","volume":"10","author":"Yu","year":"2022","journal-title":"J. ImmunoTher. Cancer"},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib33","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1186\/s12967-023-04613-6","article-title":"Bufalin targeting CAMKK2 inhibits the occurrence and development of intrahepatic cholangiocarcinoma through Wnt\/beta-catenin signal pathway","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.mce.2026.112907_bib34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s40364-024-00646-1","article-title":"Metabolic reprogramming and immune evasion: the interplay in the tumor microenvironment","volume":"12","author":"Zhang","year":"2024","journal-title":"Biomarker Res."},{"issue":"Pt 2","key":"10.1016\/j.mce.2026.112907_bib35","article-title":"UBA protein family: an emerging set of E1 ubiquitin ligases in cancer-A review","volume":"308","author":"Zhang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mce.2026.112907_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118197","article-title":"Bufalin targeting METTL17 inhibits the occurrence and metastasis of oral cancer through JAK1\/STAT3 signaling pathway","volume":"301","author":"Zhang","year":"2026","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.mce.2026.112907_bib37","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3724\/abbs.2024014","article-title":"UBA3 promotes the occurrence and metastasis of intrahepatic cholangiocarcinoma through MAPK signaling pathway","volume":"56","author":"Zhang","year":"2024","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.mce.2026.112907_bib38","article-title":"The oncogenic role of CENPA in hepatocellular carcinoma development: evidence from bioinformatic analysis","volume":"2020","author":"Zhang","year":"2020","journal-title":"Biomed Res. Int."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372072600184X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372072600184X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:13:40Z","timestamp":1792926820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030372072600184X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":38,"alternative-id":["S030372072600184X"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2026.112907","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bufalin targets CENPA-modulated glycolysis via PI3K\/AKT in hepatocellular carcinoma: A bioinformatics, In Vitro and preliminary In Vivo evidence","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2026.112907","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112907"}}