{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:34:47Z","timestamp":1792928087312,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["2026ZD008"],"award-info":[{"award-number":["2026ZD008"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB25446"],"award-info":[{"award-number":["20242BAB25446"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260315"],"award-info":[{"award-number":["82260315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271693"],"award-info":[{"award-number":["82271693"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.mce.2026.112913","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:02:40Z","timestamp":1788760960000},"page":"112913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nicotinamide N-methyltransferase deficiency disrupts endometrial decidualization partly through dysregulated H3K27 trimethylation in recurrent implantation failure"],"prefix":"10.1016","volume":"623","author":[{"given":"Bin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hancheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-3986","authenticated-orcid":false,"given":"Jialyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2026.112913_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117790","article-title":"Nicotinamide N-methyltransferase in cardiovascular diseases: mechanistic insights and therapeutic potential","volume":"295","author":"Bi","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.rbmo.2019.10.014","article-title":"How common is real repeated implantation failure? An indirect estimate of the prevalence","volume":"40","author":"Busnelli","year":"2020","journal-title":"Reprod. Biomed. Online"},{"issue":"12","key":"10.1016\/j.mce.2026.112913_bib3","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat. Med."},{"issue":"17","key":"10.1016\/j.mce.2026.112913_bib4","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.7150\/thno.32097","article-title":"MRP4 sustains Wnt\/\u03b2-catenin signaling for pregnancy, endometriosis and endometrial cancer","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.mce.2026.112913_bib5","article-title":"ESHRE good practice recommendations on recurrent implantation failure","volume":"2023","author":"Cimadomo","year":"2023","journal-title":"Hum. Reprod. Open"},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod. Biomed. Online"},{"issue":"2","key":"10.1016\/j.mce.2026.112913_bib7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/humupd\/dmy044","article-title":"Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis","volume":"25","author":"Craciunas","year":"2019","journal-title":"Hum. Reprod. Update"},{"issue":"7758","key":"10.1016\/j.mce.2026.112913_bib8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41586-019-1173-8","article-title":"Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts","volume":"569","author":"Eckert","year":"2019","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mce.2026.112913_bib9","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.fertnstert.2021.09.014","article-title":"A review of the pathophysiology of recurrent implantation failure","volume":"116","author":"Franasiak","year":"2021","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12958-022-01013-1","article-title":"TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-kappaB signaling pathway","volume":"20","author":"Fu","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"5","key":"10.1016\/j.mce.2026.112913_bib11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41419-023-05832-x","article-title":"The EZH2-PRC2-H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion","volume":"14","author":"Fukui","year":"2023","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.mce.2026.112913_bib12","doi-asserted-by":"crossref","first-page":"376 e1","DOI":"10.1016\/j.ajog.2019.11.1250","article-title":"Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2","volume":"222","author":"Garrido-Gomez","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.mce.2026.112913_bib14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"issue":"6","key":"10.1016\/j.mce.2026.112913_bib13","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"issue":"11","key":"10.1016\/j.mce.2026.112913_bib15","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1210\/me.2011-1139","article-title":"Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells","volume":"25","author":"Grimaldi","year":"2011","journal-title":"Mol. Endocrinol."},{"issue":"5","key":"10.1016\/j.mce.2026.112913_bib16","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/humrep\/dey022","article-title":"Decreased PECAM1-mediated TGF-beta1 expression in the mid-secretory endometrium in women with recurrent implantation failure","volume":"33","author":"Guo","year":"2018","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2026.112913_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-025-09303-5","article-title":"NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity","author":"Heide","year":"2025","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.mce.2026.112913_bib18","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.fertnstert.2021.06.028","article-title":"Podocalyxin inhibits human embryo implantation in vitro and luminal podocalyxin in putative receptive endometrium is associated with implantation failure in fertility treatment","volume":"116","author":"Heng","year":"2021","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41420-024-02229-3","article-title":"Overexpressed nicotinamide N-methyltransferase in endometrial stromal cells induced by macrophages and estradiol contributes to cell proliferation in endometriosis","volume":"10","author":"Hou","year":"2024","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib20","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgz019","article-title":"Uterine fluid proteins for minimally invasive assessment of endometrial receptivity","volume":"105","author":"Kasvandik","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.mce.2026.112913_bib21","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.2217\/epi-2018-0006","article-title":"Reciprocal changes of H3K27ac and H3K27me3 at the promoter regions of the critical genes for endometrial decidualization","volume":"10","author":"Katoh","year":"2018","journal-title":"Epigenomics"},{"issue":"7495","key":"10.1016\/j.mce.2026.112913_bib22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nature13198","article-title":"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity","volume":"508","author":"Kraus","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mce.2026.112913_bib23","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/path.2948","article-title":"Specific and extensive endometrial deregulation is present before conception in IVF\/ICSI repeated implantation failures (IF) or recurrent miscarriages","volume":"225","author":"L\u00e9d\u00e9e","year":"2011","journal-title":"J. Pathol."},{"issue":"4","key":"10.1016\/j.mce.2026.112913_bib24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.fertnstert.2019.02.009","article-title":"What exactly is endometrial receptivity?","volume":"111","author":"Lessey","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2026.112913_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115253","article-title":"Nicotinamide N-methyltransferase as a potential therapeutic target for neurodegenerative disorders: mechanisms, challenges, and future directions","volume":"389","author":"Liu","year":"2025","journal-title":"Exp. Neurol."},{"issue":"11","key":"10.1016\/j.mce.2026.112913_bib25","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1007\/s00018-019-03395-9","article-title":"Epigenetic modifications working in the decidualization and endometrial receptivity","volume":"77","author":"Liu","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41389-022-00415-5","article-title":"NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis","volume":"11","author":"Lu","year":"2022","journal-title":"Oncogenesis"},{"key":"10.1016\/j.mce.2026.112913_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40738-019-0059-7","article-title":"15 years of transcriptomic analysis on endometrial receptivity: what have we learnt?","volume":"5","author":"Messaoudi","year":"2019","journal-title":"Fertil. Res. Pract."},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1172\/JCI95937","article-title":"H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition","volume":"128","author":"Nancy","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12679","article-title":"Downregulation of genes related to immune and inflammatory response in IVF implantation failure cases under controlled ovarian stimulation","volume":"78","author":"Pathare","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib31","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41467-023-36483-3","article-title":"Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle","volume":"14","author":"Rajabian","year":"2023","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.mce.2026.112913_bib32","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nm.2771","article-title":"Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation","volume":"18","author":"Ruan","year":"2012","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.mce.2026.112913_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/14647273.2017.1324180","article-title":"Diverse endometrial mRNA signatures during the window of implantation in patients with repeated implantation failure","volume":"21","author":"Shi","year":"2018","journal-title":"Hum. Fertil."},{"issue":"1","key":"10.1016\/j.mce.2026.112913_bib34","article-title":"Overexpressed nicotinamide N-methyltransferase in endometrial stromal cells induced by macrophages and estradiol contributes to cell proliferation in endometriosis","volume":"10","author":"Shuhui","year":"2024","journal-title":"Cell Death Discov."},{"issue":"23","key":"10.1016\/j.mce.2026.112913_bib35","doi-asserted-by":"crossref","first-page":"8630","DOI":"10.1002\/cam4.4359","article-title":"Nicotinamide N-methyltransferase is related to MELF pattern invasion in endometrioid carcinoma","volume":"10","author":"Tahara","year":"2021","journal-title":"Cancer Med."},{"issue":"10","key":"10.1016\/j.mce.2026.112913_bib37","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41591-020-1040-z","article-title":"Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle","volume":"26","author":"Wang","year":"2020","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.mce.2026.112913_bib39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41419-022-04713-z","article-title":"Complex roles of nicotinamide N-methyltransferase in cancer progression","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.mce.2026.112913_bib36","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/biolre\/ioy018","article-title":"An update on the progress of transcriptomic profiles of human endometrial receptivity","volume":"98","author":"Wang","year":"2018","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.mce.2026.112913_bib38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41419-021-03679-8","article-title":"ATF3 deficiency impairs the proliferative-secretory phase transition and decidualization in RIF patients","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"21","key":"10.1016\/j.mce.2026.112913_bib40","doi-asserted-by":"crossref","first-page":"11860","DOI":"10.18632\/aging.205142","article-title":"Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression","volume":"15","author":"Wen","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"10.1016\/j.mce.2026.112913_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113716","article-title":"Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis","volume":"43","author":"Yan","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.mce.2026.112913_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2025.110558","article-title":"Nicotinamide N-methyltransferase in non-alcoholic fatty liver disease: mechanistic insights and emerging therapeutic strategies","volume":"772","author":"Zhang","year":"2025","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726001905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720726001905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:14:17Z","timestamp":1792926857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720726001905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":42,"alternative-id":["S0303720726001905"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2026.112913","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotinamide N-methyltransferase deficiency disrupts endometrial decidualization partly through dysregulated H3K27 trimethylation in recurrent implantation failure","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2026.112913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112913"}}