{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:02:32Z","timestamp":1760954552813,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.mcn.2003.11.005","type":"journal-article","created":{"date-parts":[[2004,1,20]],"date-time":"2004-01-20T05:19:34Z","timestamp":1074575974000},"page":"422-432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Activation of cyclin-dependent kinase 5 is involved in axonal regeneration"],"prefix":"10.1016","volume":"25","author":[{"given":"Uk","family":"Namgung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Hwa","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Uek","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung-Suk","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Chang","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong-Tai","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2003.11.005_BIB1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0092-8674(95)90168-X","article-title":"Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice","volume":"83","author":"Aigner","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2003.11.005_BIB2","doi-asserted-by":"crossref","first-page":"34131","DOI":"10.1074\/jbc.M104271200","article-title":"Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery","volume":"276","author":"Araki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2003.11.005_BIB3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/35066591","article-title":"Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5","volume":"410","author":"Bibb","year":"2001","journal-title":"Nature (London)"},{"key":"10.1016\/j.mcn.2003.11.005_BIB4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/82881","article-title":"Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons","volume":"4","author":"Bomze","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0896-6273(01)80044-1","article-title":"Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality","volume":"18","author":"Chae","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2003.11.005_BIB6","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1523\/JNEUROSCI.20-24-08965.2000","article-title":"Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of \u03b4-FosB","volume":"20","author":"Chen","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-3806(89)90279-4","article-title":"GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system","volume":"46","author":"De la Monte","year":"1989","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.mcn.2003.11.005_BIB8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/ncb916","article-title":"Fas engagement induces neurite growth through ERK activation and p35 upregulation","volume":"5","author":"Desbarats","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mcn.2003.11.005_BIB9","first-page":"43","article-title":"The role of Schwann cells in the regeneration of peripheral nerve axons through muscle basal lamina grafts","volume":"13","author":"Fawcett","year":"1990","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00001756-200202110-00014","article-title":"Induction of Cdk5 activity in rat skeletal muscle after nerve injury","volume":"13","author":"Fu","year":"2002","journal-title":"NeuroReport"},{"key":"10.1016\/j.mcn.2003.11.005_BIB11","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1046\/j.1432-1327.2001.02025.x","article-title":"Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism","volume":"268","author":"Grant","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.mcn.2003.11.005_BIB12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0306-4522(00)00072-5","article-title":"Reducing transmitter release from nerve terminals influences motoneuron survival in developing rats","volume":"97","author":"Greensmith","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2003.11.005_BIB13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/35074516","article-title":"The stellate ganglion of the squid Loligo pealeii as a model for neuronal development: expression of a POU Class VI homeodomain gene, Rpf-1","volume":"3","author":"Harada","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mcn.2003.11.005_BIB14","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1083\/jcb.104.6.1623","article-title":"Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection","volume":"104","author":"Heumann","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mcn.2003.11.005_BIB15","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1046\/j.1471-4159.1996.67062478.x","article-title":"Developmental alteration of the expression and kinase activity of cyclin-dependent kinase 5 (Cdk5)\/p35nck5a in the rat retina","volume":"67","author":"Hirooka","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mcn.2003.11.005_BIB16","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1242\/jcs.113.6.975","article-title":"p39 activates cdk5 in neurons, and associated with the actin cytoskeleton","volume":"113","author":"Humbert","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0168-0102(96)01042-5","article-title":"Peripheral nerve regeneration","volume":"25","author":"Ide","year":"1996","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.mcn.2003.11.005_BIB18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/371423a0","article-title":"A brain-specific activator of cyclin-dependent kinase 5","volume":"371","author":"Lew","year":"1994","journal-title":"Nature (London)"},{"key":"10.1016\/j.mcn.2003.11.005_BIB19","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/37615","article-title":"A Schwann cell mitogen accompanying regeneration of motor neurons","volume":"390","author":"Livesey","year":"1997","journal-title":"Nature (London)"},{"key":"10.1016\/j.mcn.2003.11.005_BIB20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0169-328X(93)90014-G","article-title":"Induction of F1\/GAP-43 gene expression in hippocampal granule cells after seizures","volume":"17","author":"Meberg","year":"1993","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.mcn.2003.11.005_BIB21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1432-1033.1997.t01-2-00527.x","article-title":"Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5","volume":"243","author":"Meijer","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.mcn.2003.11.005_BIB22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1083\/jcb.119.1.45","article-title":"Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA","volume":"119","author":"Meyer","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mcn.2003.11.005_BIB23","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1002\/j.1460-2075.1992.tb05360.x","article-title":"A family of human cdc2-related protein kinases","volume":"11","author":"Meyerson","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.mcn.2003.11.005_BIB24","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1006\/bbrc.1999.0145","article-title":"Identification of ribosomal protein L34 as a novel Cdk5 inhibitor","volume":"255","author":"Moorthamer","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mcn.2003.11.005_BIB25","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1046\/j.1460-9568.2000.00196.x","article-title":"Transcriptional and post-transcriptional regulation of a brain growth protein: regional differentiation and regeneration induction of GAP-43","volume":"12","author":"Namgung","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB26","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1523\/JNEUROSCI.20-17-06442.2000","article-title":"Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase","volume":"20","author":"Namgung","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0896-6273(01)00268-9","article-title":"Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions","volume":"30","author":"Nguyen","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2003.11.005_BIB29","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1101\/gad.10.7.816","article-title":"The cdk5\/p35 kinase is essential for neurite outgrowth during neuronal differentiation","volume":"10","author":"Nikolic","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.mcn.2003.11.005_BIB28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/26034","article-title":"The p35\/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity","volume":"395","author":"Nikolic","year":"1998","journal-title":"Nature (London)"},{"key":"10.1016\/j.mcn.2003.11.005_BIB30","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/35046558","article-title":"Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway","volume":"2","author":"Nishimune","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mcn.2003.11.005_BIB31","doi-asserted-by":"crossref","first-page":"11173","DOI":"10.1073\/pnas.93.20.11173","article-title":"Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death","volume":"93","author":"Ohshima","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2003.11.005_BIB32","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1523\/JNEUROSCI.18-03-01009.1998","article-title":"Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons","volume":"18","author":"Parsadanian","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB33","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/45159","article-title":"Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration","volume":"402","author":"Patrick","year":"1999","journal-title":"Nature (London)"},{"key":"10.1016\/j.mcn.2003.11.005_BIB34","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0959-4388(93)90139-P","article-title":"Reciprocal Schwann cell-axon interactions","volume":"3","author":"Reynolds","year":"1993","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.mcn.2003.11.005_BIB35","doi-asserted-by":"crossref","first-page":"11156","DOI":"10.1073\/pnas.96.20.11156","article-title":"Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation","volume":"96","author":"Sharma","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2003.11.005_BIB36","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1523\/JNEUROSCI.08-09-03181.1988","article-title":"Changes in cytoskeletal proteins in the rat facial nucleus following axotomy","volume":"8","author":"Tetzlaff","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB37","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1523\/JNEUROSCI.11-08-02528.1991","article-title":"Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43","volume":"11","author":"Tetzlaff","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB38","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1242\/jcs.113.6.1059","article-title":"Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons","volume":"113","author":"Tokuoka","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB39","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1242\/dev.119.4.1029","article-title":"Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system","volume":"119","author":"Tsai","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.mcn.2003.11.005_BIB40","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/371419a0","article-title":"p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5","volume":"371","author":"Tsai","year":"1994","journal-title":"Nature (London)"},{"key":"10.1016\/j.mcn.2003.11.005_BIB41","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1523\/JNEUROSCI.09-10-03505.1989","article-title":"Expression of growth-associated protein B-50 (GAP43) in dorsal root ganglia and sciatic nerve during regenerative sprouting","volume":"9","author":"van der Zee","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2003.11.005_BIB42","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0306-4522(92)90300-Q","article-title":"Redistribution of B-50\/growth-associated protein 43 during differentiation and maturation of rat hippocampal neurons in vitro","volume":"51","author":"van Lookeren Campagne","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2003.11.005_BIB43","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0896-6273(00)81200-3","article-title":"Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth","volume":"26","author":"Zukerberg","year":"2000","journal-title":"Neuron"}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743103003592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743103003592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:58:28Z","timestamp":1760921908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743103003592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S1044743103003592"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2003.11.005","relation":{},"ISSN":["1044-7431"],"issn-type":[{"type":"print","value":"1044-7431"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of cyclin-dependent kinase 5 is involved in axonal regeneration","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2003.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}