{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:22:34Z","timestamp":1791278554536,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY009357"],"award-info":[{"award-number":["EY009357"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY009769"],"award-info":[{"award-number":["EY009769"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM074244"],"award-info":[{"award-number":["GM074244"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01MH070306"],"award-info":[{"award-number":["P01MH070306"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01MH70056"],"award-info":[{"award-number":["P01MH70056"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.mcn.2007.08.016","type":"journal-article","created":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T08:42:58Z","timestamp":1188895378000},"page":"85-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["\u03b2A3\/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development"],"prefix":"10.1016","volume":"37","author":[{"given":"Debasish","family":"Sinha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Klise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Sergeev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Hose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran A.","family":"Bhutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Laszlo","family":"Hackler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Malpic-llanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Samtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda","family":"Grebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morton F.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Fielding","family":"Hejtmancik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avindra","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Zack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Fariss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Scott","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Sundin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl W.","family":"Broman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard A.","family":"Lutty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"J. Samuel","family":"Zigler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2007.08.016_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.preteyeres.2006.10.003","article-title":"Crystallins in the eye: function and pathology","volume":"26","author":"Andley","year":"2007","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.mcn.2007.08.016_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/oxfordjournals.bmb.a070758","article-title":"Retinal angiogenesis in the human embryo","volume":"26","author":"Ashton","year":"1970","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.mcn.2007.08.016_bib3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1017\/S0952523800012335","article-title":"The appearance and distribution of microglia in the developing retina of the rat","volume":"2","author":"Ashwell","year":"1989","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.mcn.2007.08.016_bib4","first-page":"3278","article-title":"A new betaA1-crystallin splice junction mutation in autosomal dominant cataract","volume":"41","author":"Bateman","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mcn.2007.08.016_bib5","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1167\/iovs.03-1169","article-title":"Astrocyte\u2013endothelial cell relationships during human retinal vascular development","volume":"45","author":"Chan-Ling","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mcn.2007.08.016_bib6","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1096\/fj.00-0868fje","article-title":"Differentiation and migration of astrocyte precursor cells and astrocytes in human fetal retina: relevance to optic nerve coloboma","volume":"15","author":"Chu","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.mcn.2007.08.016_bib7","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.222551899","article-title":"Drusen proteome analysis: an approach to the etiology of age-related macular degeneration","volume":"99","author":"Crabb","year":"2002","journal-title":"PNAS"},{"key":"10.1016\/j.mcn.2007.08.016_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/BF00187183","article-title":"Development of the retinal circulation in the pig","volume":"192","author":"De Schaepdrijver","year":"1995","journal-title":"Anat. Embryol. (Berl)"},{"key":"10.1016\/j.mcn.2007.08.016_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.preteyeres.2006.01.001","article-title":"Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina","volume":"25","author":"Dorrell","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.mcn.2007.08.016_bib10","first-page":"366","article-title":"Subfertility in mice harboring a mutation in \u03b2B2-crystallin","volume":"13","author":"DuPrey","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mcn.2007.08.016_bib11","doi-asserted-by":"crossref","first-page":"23996","DOI":"10.1074\/jbc.274.34.23996","article-title":"Intermediate filament protein partnership in astrocytes","volume":"274","author":"Eliasson","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2007.08.016_bib12","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1167\/iovs.03-0760","article-title":"CRYBA3\/A1 gene mutation associated with suture-sparing autosomal dominant congenital nuclear cataract: a novel phenotype","volume":"45","author":"Ferrini","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mcn.2007.08.016_bib13","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1083\/jcb.133.4.853","article-title":"Disrupted glial fibrillary acidic protein network in astrocytes from vimentin knockout mice","volume":"133","author":"Galou","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mcn.2007.08.016_bib14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuroscience.2005.08.084","article-title":"Developmental abnormalities in the Nuc1 rat retina: a spontaneous mutation that affects neuronal and vascular remodeling and retinal function","volume":"137","author":"Gehlbach","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2007.08.016_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/geno.1999.5974","article-title":"Mutation in the betaA3\/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse","volume":"62","author":"Graw","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.mcn.2007.08.016_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.imlet.2004.09.017","article-title":"A novel rat model to study the functions of macrophages during normal development and pathophysiology of the eye","volume":"96","author":"Hose","year":"2005","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.mcn.2007.08.016_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/glia.440150102","article-title":"Astrocytes modulate retinal vasculogenesis: effects on endothelial cell differentiation","volume":"15","author":"Jiang","year":"1995","journal-title":"Glia"},{"key":"10.1016\/j.mcn.2007.08.016_bib18","first-page":"21","article-title":"Autosomal dominant zonular cataract with sutural opacities is associated with a splice mutation in the betaA3\/A1-crystallin gene","volume":"4","author":"Kannabiran","year":"1998","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mcn.2007.08.016_bib19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1471-4159.2001.00595.x","article-title":"Intermediate filaments regulate astrocyte motility","volume":"79","author":"Lepekhin","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mcn.2007.08.016_bib20","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1074\/mcp.M600245-MCP200","article-title":"Elongation of axons during regeneration involves retinal crystallin \u03b2 b2 (crybb2)","volume":"6","author":"Liedtke","year":"2007","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcn.2007.08.016_bib21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cne.902860305","article-title":"Origin of retinal astrocytes in the rat: evidence of migration from the optic nerve","volume":"286","author":"Ling","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.mcn.2007.08.016_bib22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/hmg\/6.5.665","article-title":"Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2","volume":"6","author":"Litt","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2007.08.016_bib23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature03928","article-title":"WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature","volume":"437","author":"Lobov","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2007.08.016_bib24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/archopht.1992.01080140123039","article-title":"A new technique for visualization of the human retinal vasculature","volume":"110","author":"Lutty","year":"1992","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.mcn.2007.08.016_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0012-1606(85)90432-4","article-title":"A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: in vivo evidence for two distinct astrocyte lineages","volume":"111","author":"Miller","year":"1985","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mcn.2007.08.016_bib26","first-page":"pe53","article-title":"Intermediate filaments as signaling platforms","author":"Pallari","year":"2006","journal-title":"Sci. STKE"},{"key":"10.1016\/j.mcn.2007.08.016_bib27","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcn.2007.08.016_bib28","series-title":"Gene Sharing and Evolution: The Diversity of Protein Function","author":"Piatigorsky","year":"2007"},{"key":"10.1016\/j.mcn.2007.08.016_bib29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00439-003-1049-7","article-title":"A deletion mutation in the betaA1\/A3 crystallin gene (CRYBA1\/A3) is associated with autosomal dominant congenital nuclear cataract in a Chinese family","volume":"114","author":"Qi","year":"2004","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mcn.2007.08.016_bib30","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/hmg\/ddh110","article-title":"Characterization of the G91del CRYBA1\/3-crystallin protein: a cause of human inherited cataract","volume":"13","author":"Reddy","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2007.08.016_bib31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-4835(02)00249-X","article-title":"Intense light exposure changes the crystallin content in retina","volume":"76","author":"Sakaguchi","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mcn.2007.08.016_bib32","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/glia.440010109","article-title":"Astrocytes in the guinea pig, horse, and monkey retina: their occurrence coincides with the presence of blood vessels","volume":"1","author":"Schnitzer","year":"1988","journal-title":"Glia"},{"key":"10.1016\/j.mcn.2007.08.016_bib33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.exer.2004.09.014","article-title":"A spontaneous mutation affects programmed cell death during development of the rat eye","volume":"80","author":"Sinha","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mcn.2007.08.016_bib34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/328155a0","article-title":"Evidence for migration of oligodendrocyte-type-2 astrocyte progenitor cells into the developing rat optic nerve","volume":"328","author":"Small","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2007.08.016_bib35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/cne.902550104","article-title":"Relationship between astrocytes, ganglion cells and vasculature of the retina","volume":"255","author":"Stone","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.mcn.2007.08.016_bib36","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1167\/iovs.03-1047","article-title":"Temporal changes in gene expression after injury in the rat retina","volume":"45","author":"Vazquez-Chona","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mcn.2007.08.016_bib37","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/332834a0","article-title":"Retinal astrocytes are immigrants from the optic nerve","volume":"332","author":"Watanabe","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2007.08.016_bib38","series-title":"Molecular Biology and Evolution of Crystallins: Gene Recruitment and Multifunctional Proteins in the Eye Lens","author":"Wistow","year":"1995"},{"key":"10.1016\/j.mcn.2007.08.016_bib39","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/dvdy.20494","article-title":"A potential role for beta- and gamma-crystallins in the vascular remodeling of the eye","volume":"234","author":"Zhang","year":"2005","journal-title":"Dev. Dyn."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743107002011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743107002011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T01:03:56Z","timestamp":1760922236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743107002011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S1044743107002011"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2007.08.016","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2A3\/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2007.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}