{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:41:17Z","timestamp":1790872877625,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":471,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Austrian Science Funds","award":["P19122-B05"],"award-info":[{"award-number":["P19122-B05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.mcn.2012.03.001","type":"journal-article","created":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T00:22:05Z","timestamp":1331252525000},"page":"456-463","source":"Crossref","is-referenced-by-count":20,"title":["Homocysteine has anti-inflammatory properties in a hypercholesterolemic rat model in vivo"],"prefix":"10.1016","volume":"49","author":[{"given":"Michael","family":"Pirchl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Ullrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sperner-Unterweger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Humpel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2012.03.001_bb0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000205317","article-title":"Mild methionine excess does not affect thymidylate synthesis or inflammation markers expression in human aortic endothelial cells","volume":"54","author":"Ach\u00f3n","year":"2009","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.mcn.2012.03.001_bb0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0049-3848(93)90153-F","article-title":"Elevated total plasma homocysteine, a risk factor for thrombosis. Relation to coagulation and fibrinolytic parameters","volume":"70","author":"Bienvenu","year":"1993","journal-title":"Thromb. Res."},{"key":"10.1016\/j.mcn.2012.03.001_bb0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000026175","article-title":"Gene-environment interaction in Alzheimer's disease: a potential role for cholesterol","volume":"17","author":"Chandra","year":"1998","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.mcn.2012.03.001_bb0020","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1055\/s-0037-1615841","article-title":"The plasminogen (fibrinolytic) system","volume":"82","author":"Collen","year":"1999","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.mcn.2012.03.001_bb0025","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00394-010-0102-2","article-title":"Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol","volume":"49","author":"Dugas","year":"2010","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.mcn.2012.03.001_bb0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuroscience.2011.12.054","article-title":"Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation and vascular impairment in rats","volume":"205","author":"Ehrlich","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2012.03.001_bb0035","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1001\/archneur.61.5.668","article-title":"Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study","volume":"61","author":"Engelhart","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.mcn.2012.03.001_bb0040","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0045","first-page":"897","article-title":"Homocysteine and cognitive function in elderly people","volume":"171","author":"Garcia","year":"2004","journal-title":"C.M.A.J."},{"key":"10.1016\/j.mcn.2012.03.001_bb0050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1749-6632.2010.05726.x","article-title":"Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials","volume":"1207","author":"Gorelick","year":"2010","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/JAD-2008-14202","article-title":"Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat","volume":"14","author":"Granholm","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mcn.2012.03.001_bb0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/glia.20115","article-title":"Tissue plasminogen activator and glial function","volume":"49","author":"Gravanis","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.mcn.2012.03.001_bb0065","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1172\/JCI116532","article-title":"Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor","volume":"91","author":"Hajjar","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mcn.2012.03.001_bb0070","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.1074\/jbc.273.16.9987","article-title":"Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine","volume":"273","author":"Hajjar","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2012.03.001_bb0075","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1172\/JCI10588","article-title":"Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model","volume":"107","author":"Hofmann","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mcn.2012.03.001_bb0080","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.exger.2010.11.032","article-title":"Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?","volume":"46","author":"Humpel","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mcn.2012.03.001_bb0085","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2174\/156720205774322610","article-title":"Cerebrovascular damage as a cause for Alzheimer's disease","volume":"2","author":"Humpel","year":"2005","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.mcn.2012.03.001_bb0090","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-3-7091-6139-5_23","article-title":"Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices. Implication in Alzheimer's disease?","volume":"62","author":"Humpel","year":"2002","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.mcn.2012.03.001_bb0095","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2174\/092986711795328445","article-title":"Oxysterol derivatives of cholesterol in neurodegenerative disorders","volume":"18","author":"Jeitner","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mcn.2012.03.001_bb0100","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/02713680601187951","article-title":"Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells","volume":"32","author":"Joffre","year":"2007","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.mcn.2012.03.001_bb0105","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1080\/14647270802336650","article-title":"Influence of hypercholesterolemia and hypertension on the integrity of the blood-brain barrier in rats","volume":"119","author":"Kalayci","year":"2009","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0110","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/ana.410420514","article-title":"Dietary fat intake and the risk of incident dementia in the Rotterdam Study","volume":"42","author":"Kalmijn","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mcn.2012.03.001_bb0115","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1136\/bmj.322.7300.1447","article-title":"Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study","volume":"322","author":"Kivipelto","year":"2001","journal-title":"B.M.J."},{"key":"10.1016\/j.mcn.2012.03.001_bb0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10565-005-0141-2","article-title":"Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols","volume":"21","author":"Lemaire-Ewing","year":"2005","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.mcn.2012.03.001_bb0125","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1152\/ajpheart.00376.2005","article-title":"Homocysteine causes cerebrovascular leakage in mice","volume":"290","author":"Lominadze","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mcn.2012.03.001_bb0130","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/sj.mp.4002072","article-title":"Beta-amyloid expression, release and extracellular deposition in aged rat brain slices","volume":"13","author":"Marksteiner","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.mcn.2012.03.001_bb0135","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.neurobiolaging.2009.03.011","article-title":"Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease","volume":"32","author":"Marksteiner","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mcn.2012.03.001_bb0140","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/bbrc.2000.2753","article-title":"Enhancement by homocysteine of plasminogen activator inhibitor-1 gene expression and secretion from vascular endothelial and smooth muscle cells","volume":"272","author":"Midorikawa","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mcn.2012.03.001_bb0145","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.atherosclerosis.2009.04.001","article-title":"LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms","volume":"207","author":"Morello","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mcn.2012.03.001_bb0150","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1474-4422(03)00438-1","article-title":"Homocysteine and Alzheimer's disease","volume":"2","author":"Morris","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mcn.2012.03.001_bb0155","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1515\/CCLM.2007.356","article-title":"The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases","volume":"45","author":"Obeid","year":"2007","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.mcn.2012.03.001_bb0160","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/ars.2007.1750","article-title":"Vascular oxidant stress and inflammation in hyperhomocysteinemia","volume":"9","author":"Papatheodorou","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mcn.2012.03.001_bb0165","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1179\/016164106X130371","article-title":"Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer's disease","volume":"28","author":"Pirchl","year":"2006","journal-title":"Neurol. Res."},{"key":"10.1016\/j.mcn.2012.03.001_bb0170","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/j.1460-9568.2010.07434.x","article-title":"Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats","volume":"32","author":"Pirchl","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0175","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/507524","article-title":"Female Sprague Dawley rats show impaired spatial memory in the 8-arm radial maze under dim blue and red light","author":"Pirchl","year":"2010","journal-title":"Int. J. Zool."},{"key":"10.1016\/j.mcn.2012.03.001_bb0180","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1161\/01.CIR.103.22.2717","article-title":"Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease","volume":"103","author":"Poddar","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.mcn.2012.03.001_bb0185","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/cyto.a.20272","article-title":"Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients","volume":"69","author":"Prunet","year":"2006","journal-title":"Cytometry A"},{"key":"10.1016\/j.mcn.2012.03.001_bb0190","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nn0403-345","article-title":"Alzheimer's disease: the cholesterol connection","volume":"6","author":"Puglielli","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0195","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1194\/jlr.R300007-JLR200","article-title":"Cholesterol: from heart attacks to Alzheimer's disease","volume":"44","author":"Raffai","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.mcn.2012.03.001_bb0200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jneuroim.2005.07.018","article-title":"High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice","volume":"169","author":"Rahman","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.mcn.2012.03.001_bb0205","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.4049\/jimmunol.181.5.3567","article-title":"Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier","volume":"181","author":"Reijerkerk","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.mcn.2012.03.001_bb0210","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1242\/jcs.112.22.4007","article-title":"Activation of microglia reveals a non-proteolytic cytokine function for tissue plasminogen activator in the central nervous system","volume":"112","author":"Rogove","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0215","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2362.2002.00931.x","article-title":"Oxysterols induce interleukin-1beta production in human macrophages","volume":"32","author":"Rosklint","year":"2002","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.mcn.2012.03.001_bb0220","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-8993(02)02896-2","article-title":"Down-regulation of complement receptor 3 and major histocompatibility complex I and II antigen-like immunoreactivity accompanies ramification in isolated rat microglia","volume":"946","author":"Salimi","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.mcn.2012.03.001_bb0225","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1523\/JNEUROSCI.22-06-02125.2002","article-title":"Localization and regulation of the tissue plasminogen activator-plasmin system in the hippocampus","volume":"22","author":"Salles","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0230","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-0270(93)90147-J","article-title":"A one-step immunohistochemical method for detection of blood-brain barrier disturbances for immunoglobulins in lesioned rat brain with special reference to false-positive labelling in immunohistochemistry","volume":"46","author":"Schmidt-Kastner","year":"1993","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.mcn.2012.03.001_bb0235","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1523\/JNEUROSCI.23-19-07368.2003","article-title":"Absence of tissue plasminogen activator gene or activity impairs mouse cerebellar motor learning","volume":"23","author":"Seeds","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0240","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer's disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mcn.2012.03.001_bb0245","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1523\/JNEUROSCI.22-09-03352.2002","article-title":"Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II","volume":"22","author":"Siao","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0250","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1212\/WNL.57.6.1089","article-title":"Cholesterol and Alzheimer's disease: is there a link?","volume":"57","author":"Simons","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.mcn.2012.03.001_bb0255","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2174\/092986709787458353","article-title":"Cholesterol oxidation products and disease: an emerging topic of interest in medicinal chemistry","volume":"16","author":"Sottero","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mcn.2012.03.001_bb1005","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.thromres.2006.02.011","article-title":"Mild hyperhomocysteinemia is associated with a decreased fibrinolytic activity in patients after ST-elevation myocardial infarction","volume":"119","author":"Speidl","year":"2007","journal-title":"Thromb. Res."},{"key":"10.1016\/j.mcn.2012.03.001_bb0260","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.plipres.2009.10.004","article-title":"Dietary fats, cerebrovasculature integrity and Alzheimer's disease risk","volume":"49","author":"Takechi","year":"2010","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.mcn.2012.03.001_bb1000","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/S0002-9440(10)63073-8","article-title":"Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice","volume":"159","author":"Teesalu","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mcn.2012.03.001_bb0265","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1471-4159.2008.05415.x","article-title":"High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice","volume":"106","author":"Thirumangalakudi","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mcn.2012.03.001_bb0270","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1471-4159.2009.06009.x","article-title":"25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR","volume":"109","author":"Trousson","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mcn.2012.03.001_bb0275","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.mcn.2010.08.001","article-title":"Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits","volume":"45","author":"Ullrich","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2012.03.001_bb0280","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000314333","article-title":"Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices","volume":"86","author":"Ullrich","year":"2010","journal-title":"Pharmacology"},{"key":"10.1016\/j.mcn.2012.03.001_bb0285","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1590\/S0100-879X2008000700001","article-title":"Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis","volume":"41","author":"Vejux","year":"2008","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.mcn.2012.03.001_bb0290","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0306-4522(00)00452-8","article-title":"Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic neuronal phenotype in organotypic brain slices of the basal nucleus of Meynert","volume":"102","author":"Weis","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2012.03.001_bb0295","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1742-2094-4-20","article-title":"Microglial activation in the hippocampus of hypercholesterolemic rabbits occurs independent of increased amyloid production","volume":"4","author":"Xue","year":"2007","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mcn.2012.03.001_bb0300","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1172\/JCI200319212","article-title":"Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein","volume":"112","author":"Yepes","year":"2003","journal-title":"J. Clin. Invest."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743112000413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743112000413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T05:39:50Z","timestamp":1641101990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743112000413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1044743112000413"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2012.03.001","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}