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Biol."},{"key":"10.1016\/j.mcn.2013.02.005_bb0975","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington's disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2013.02.005_bb0320","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb0945","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0306-4522(94)00494-P","article-title":"Quinolinic acid-induced increases in calbindin D28k immunoreactivity in rat striatal neurons in vivo and in vitro mimic the pattern seen in Huntington's disease","volume":"65","author":"Huang","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2013.02.005_bb0490","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF03401776","article-title":"Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers","volume":"6","author":"Itskovitz-Eldor","year":"2000","journal-title":"Mol. Med."},{"key":"10.1016\/j.mcn.2013.02.005_bb0710","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1093\/hmg\/ddr195","article-title":"HD CAG-correlated gene expression changes support a simple dominant gain of function","volume":"20","author":"Jacobsen","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2013.02.005_bb0280","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0361-9230(01)00555-X","article-title":"Cellular and molecular aspects of striatal development","volume":"55","author":"Jain","year":"2001","journal-title":"Brain Res. 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Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb0585","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nn1654","article-title":"FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains","volume":"9","author":"Lobo","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb1000","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/nn1987","article-title":"Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6","volume":"10","author":"Lobo","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb0420","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Annu. Rev. Cell Dev. 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Genet."},{"issue":"4","key":"10.1016\/j.mcn.2013.02.005_bb0400","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.stem.2012.01.021","article-title":"Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice","volume":"10","author":"Ma","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mcn.2013.02.005_bb0145","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1073\/pnas.0600549103","article-title":"Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease","volume":"103","author":"Mahley","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2013.02.005_bb0595","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2013.02.005_bb0740","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cell.2010.10.016","article-title":"A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells","volume":"143","author":"Marchetto","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2013.02.005_bb0290","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/35097509","article-title":"A long, remarkable journey: tangential migration in the telencephalon","volume":"2","author":"Marin","year":"2001","journal-title":"Nat. Rev. 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Reprod."},{"key":"10.1016\/j.mcn.2013.02.005_bb0970","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0893-133X(95)00150-C","article-title":"Dopamine receptor mRNA expression in human striatum and neocortex","volume":"15","author":"Meador-Woodruff","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.mcn.2013.02.005_bb0985","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/exnr.1999.7327","article-title":"Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease","volume":"162","author":"Menalled","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mcn.2013.02.005_bb0990","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/cne.903180302","article-title":"Comparative distribution of messenger RNAs encoding glutamic acid decarboxylases (Mr 65,000 and Mr 67,000) in the basal ganglia of the rat","volume":"318","author":"Mercugliano","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.mcn.2013.02.005_bb0175","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.mcn.2013.02.005_bb0050","first-page":"CD006455","article-title":"Therapeutic interventions for disease progression in Huntington's disease","author":"Mestre","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.mcn.2013.02.005_bb0085","doi-asserted-by":"crossref","first-page":"10541","DOI":"10.1523\/JNEUROSCI.0146-10.2010","article-title":"Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into Huntington\u2019s disease molecular pathogenesis","volume":"30","author":"Miller","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb1005","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1006\/geno.2000.6340","article-title":"A novel G-protein-coupled receptor gene expressed in striatum","volume":"69","author":"Mizushima","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.mcn.2013.02.005_bb0840","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1074\/jbc.M111.309849","article-title":"Early alterations of brain cellular energy homeostasis in Huntington disease models","volume":"287","author":"Mochel","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2013.02.005_bb0260","doi-asserted-by":"crossref","first-page":"21900","DOI":"10.1073\/pnas.0912171106","article-title":"Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease","volume":"106","author":"Molero","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2013.02.005_bb0135","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1073\/pnas.051611498","article-title":"Estimation of divergence times from multiprotein sequences for a few mammalian species and several distantly related organisms","volume":"98","author":"Nei","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2013.02.005_bb0680","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S1472-6483(10)60053-3","article-title":"Human embryonic stem cell models of Huntington disease","volume":"19","author":"Niclis","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.mcn.2013.02.005_bb9005","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1073\/pnas.96.9.5268","article-title":"A neuronal morphologic type unique to humans and great apes","volume":"96","author":"Nimchinsky","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2013.02.005_bb0210","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/brain\/awq280","article-title":"Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment","volume":"134","author":"Nopoulos","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.mcn.2013.02.005_bb0630","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S1355617700000278","article-title":"Sensory- and memory-mediated olfactory dysfunction in Huntington's disease","volume":"1","author":"Nordin","year":"1995","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.mcn.2013.02.005_bb0165","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.tins.2006.08.004","article-title":"Astrocytic complexity distinguishes the human brain","volume":"29","author":"Oberheim","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb0195","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ng2047","article-title":"Tissue-specific transcriptional regulation has diverged significantly between human and mouse","volume":"39","author":"Odom","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mcn.2013.02.005_bb0515","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0925-4773(96)00572-2","article-title":"Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro","volume":"59","author":"Okabe","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1016\/j.mcn.2013.02.005_bb0925","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.mcn.2011.12.001","article-title":"Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin","volume":"49","author":"Olson","year":"2012","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb0295","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0306-4522(97)00532-0","article-title":"Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence","volume":"84","author":"Olsson","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2013.02.005_bb0535","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1523\/JNEUROSCI.04-01-00111.1984","article-title":"DARPP-32, a dopamine- and adenosine 3\u2032:5\u2032-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization","volume":"4","author":"Ouimet","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb0540","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0006-8993(98)00724-0","article-title":"Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamen","volume":"808","author":"Ouimet","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.mcn.2013.02.005_bb0040","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.neuro.25.112701.142937","article-title":"Learning and memory functions of the basal ganglia","volume":"25","author":"Packard","year":"2002","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb0360","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1242\/dev.032656","article-title":"FGF signaling is strictly required to maintain early telencephalic precursor cell survival","volume":"136","author":"Paek","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.mcn.2013.02.005_bb0520","series-title":"Human Stem Cell Manual. 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A"},{"key":"10.1016\/j.mcn.2013.02.005_bb0695","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/hmg\/ddq456","article-title":"Huntington's and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiation","volume":"20","author":"Seriola","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2013.02.005_bb0470","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nn.3041","article-title":"Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses","volume":"15","author":"Shi","year":"2012","journal-title":"Nat. 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Lett."},{"key":"10.1016\/j.mcn.2013.02.005_bb0285","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.gde.2010.04.008","article-title":"Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain","volume":"20","author":"Sousa","year":"2010","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mcn.2013.02.005_bb0855","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000098976","article-title":"Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's chorea","volume":"58","author":"Sramka","year":"1992","journal-title":"Stereotact. Funct. 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Res."},{"key":"10.1016\/j.mcn.2013.02.005_bb0370","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/stem.498","article-title":"Neural induction intermediates exhibit distinct roles of Fgf signaling","volume":"28","author":"Sterneckert","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.mcn.2013.02.005_bb0500","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0925-4773(95)00446-8","article-title":"Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons","volume":"53","author":"Strubing","year":"1995","journal-title":"Mech. 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Dis."},{"key":"10.1016\/j.mcn.2013.02.005_bb9010","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/147342202320883551","article-title":"'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology","volume":"1","author":"Schwaller","year":"2002","journal-title":"Studies with knockout mice. Cerebellum"},{"key":"10.1016\/j.mcn.2013.02.005_bb0565","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jnr.10638","article-title":"Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum","volume":"73","author":"Takahashi","year":"2003","journal-title":"J. Neurosci. 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Neurosci."},{"key":"10.1016\/j.mcn.2013.02.005_bb1010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.baga.2011.04.001","article-title":"GPR88 \u2014 a putative signaling molecule predominantly expressed in the striatum: cellular localization and developmental regulation","volume":"1","author":"Van Waes","year":"2011","journal-title":"Basal Ganglia"},{"key":"10.1016\/j.mcn.2013.02.005_bb0150","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bbalip.2010.02.007","article-title":"Formation and function of apolipoprotein E-containing lipoproteins in the nervous system","volume":"1801","author":"Vance","year":"2010","journal-title":"Biochim. Biophys. 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