{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:30:06Z","timestamp":1791383406191,"version":"4.3.3"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201068"],"award-info":[{"award-number":["31201068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.mcn.2016.06.004","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T01:24:09Z","timestamp":1466731449000},"page":"27-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"special_numbering":"C","title":["Valproic acid exposure sequentially activates Wnt and mTOR pathways in rats"],"prefix":"10.1016","volume":"75","author":[{"given":"Liyan","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhou","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2016.06.004_bb0005","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.celrep.2015.01.061","article-title":"Wnt signaling regulates multipolar-to-bipolar transition of migrating neurons in the cerebral cortex","volume":"10","author":"Boitard","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcn.2016.06.004_bb0010","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neuroscience.2013.03.030","article-title":"Rearrangement of the dendritic morphology in limbic regions and altered exploratory behavior in a rat model of autism spectrum disorder","volume":"241","author":"Bringas","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2016.06.004_bb0015","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1136\/jnnp-2012-304270","article-title":"The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs","volume":"84","author":"Bromley","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.mcn.2016.06.004_bb0020","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.brainresbull.2013.11.005","article-title":"Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)\/J mouse model of autism spectrum disorders","volume":"100","author":"Burket","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mcn.2016.06.004_bb0025","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/1742-2094-9-223","article-title":"Alteration of astrocytes and Wnt\/beta-catenin signaling in the frontal cortex of autistic subjects","volume":"9","author":"Cao","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mcn.2016.06.004_bb0030","doi-asserted-by":"publisher","first-page":"11910","DOI":"10.1074\/jbc.M511920200","article-title":"Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation","volume":"281","author":"Chen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2016.06.004_bb0035","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ijdevneu.2014.03.006","article-title":"Dysregulation of the IGF-I\/PI3K\/AKT\/mTOR signaling pathway in autism spectrum disorders","volume":"35","author":"Chen","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.mcn.2016.06.004_bb0040","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1126\/science.1074192","article-title":"Regulation of cerebral cortical size by control of cell cycle exit in neural precursors","volume":"297","author":"Chenn","year":"2002","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.mcn.2016.06.004_bb0045","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/712758","article-title":"What we have learned about autism spectrum disorder from valproic acid","volume":"2013","author":"Chomiak","year":"2013","journal-title":"Pathol. Res. Int."},{"key":"10.1016\/j.mcn.2016.06.004_bb0050","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/nrn1665","article-title":"WNTs in the vertebrate nervous system: from patterning to neuronal connectivity","volume":"6","author":"Ciani","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mcn.2016.06.004_bb0055","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.neubiorev.2010.12.013","article-title":"Fetal exposure to teratogens: evidence of genes involved in autism","volume":"35","author":"Dufour-Rainfray","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.mcn.2016.06.004_bb0060","doi-asserted-by":"publisher","first-page":"49","DOI":"10.4161\/auto.2156","article-title":"Neurodegeneration induces upregulation of Beclin 1","volume":"2","author":"Erlich","year":"2006","journal-title":"Autophagy"},{"key":"10.1016\/j.mcn.2016.06.004_bb0065","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037313","article-title":"Gestational valproate alters BOLD activation in response to complex social and primary sensory stimuli","volume":"7","author":"Felix-Ortiz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mcn.2016.06.004_bb0070","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ejphar.2014.01.050","article-title":"Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders","volume":"727","author":"Foley","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mcn.2016.06.004_bb0075","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1086\/303034","article-title":"Chromosome 7q: where autism meets language disorder?","volume":"67","author":"Folstein","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mcn.2016.06.004_bb0080","doi-asserted-by":"publisher","first-page":"e1642","DOI":"10.1542\/peds.2013-1868","article-title":"Neurofibromatosis type 1 and autism spectrum disorder","volume":"132","author":"Garg","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.mcn.2016.06.004_bb0085","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature11628","article-title":"Autism-related deficits via dysregulated eIF4E-dependent translational control","volume":"493","author":"Gkogkas","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2016.06.004_bb0090","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.neuropharm.2012.07.028","article-title":"Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3beta\/beta-catenin pathway","volume":"63","author":"Go","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mcn.2016.06.004_bb0095","article-title":"Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury","volume":"8","author":"Guo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mcn.2016.06.004_bb0100","doi-asserted-by":"publisher","first-page":"999","DOI":"10.2353\/ajpath.2009.080537","article-title":"Valproic acid activates the PI3K\/Akt\/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy","volume":"174","author":"Gurpur","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mcn.2016.06.004_bb0105","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s12264-013-1355-6","article-title":"Valproic acid reduces autophagy and promotes functional recovery after spinal cord injury in rats","volume":"29","author":"Hao","year":"2013","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.mcn.2016.06.004_bb0110","article-title":"Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism","author":"Hara","year":"2015","journal-title":"Autism Res."},{"key":"10.1016\/j.mcn.2016.06.004_bb0115","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1101\/gr.178855.114","article-title":"The discovery of integrated gene networks for autism and related disorders","volume":"25","author":"Hormozdiari","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.mcn.2016.06.004_bb0120","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1038\/nm.2984","article-title":"Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways","volume":"18","author":"Huang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcn.2016.06.004_bb0125","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.cell.2006.06.055","article-title":"TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth","volume":"126","author":"Inoki","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2016.06.004_bb0130","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.stemcr.2015.10.012","article-title":"Reduced adult hippocampal neurogenesis and cognitive impairments following prenatal treatment of the antiepileptic drug valproic acid","volume":"5","author":"Juliandi","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.mcn.2016.06.004_bb0135","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/wcs.1206","article-title":"The evolution of brains from early mammals to humans","volume":"4","author":"Kaas","year":"2013","journal-title":"Wiley Interdiscip. Rev. Cogn. Sci."},{"key":"10.1016\/j.mcn.2016.06.004_bb0140","doi-asserted-by":"publisher","first-page":"849186","DOI":"10.1155\/2013\/849186","article-title":"mTOR inhibition: from aging to autism and beyond","volume":"2013","author":"Kaeberlein","year":"2013","journal-title":"Scientifica"},{"key":"10.1016\/j.mcn.2016.06.004_bb0145","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/2040-2392-3-10","article-title":"A review of the evidence for the canonical Wnt pathway in autism spectrum disorders","volume":"3","author":"Kalkman","year":"2012","journal-title":"Mol. Autism"},{"key":"10.1016\/j.mcn.2016.06.004_bb0150","article-title":"Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mcn.2016.06.004_bb0155","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/jhg.2013.49","article-title":"Epigenomic strategies at the interface of genetic and environmental risk factors for autism","volume":"58","author":"LaSalle","year":"2013","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.mcn.2016.06.004_bb0160","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1158\/1535-7163.MCT-11-0559","article-title":"Sorafenib sensitizes (\u2212)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation","volume":"11","author":"Lian","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.mcn.2016.06.004_bb0165","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fnmol.2014.00027","article-title":"Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins","volume":"7","author":"Lugo","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mcn.2016.06.004_bb0170","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/ANC.0b013e31828d02a1","article-title":"Autism spectrum disorders and prematurity: a review across gestational age subgroups","volume":"13","author":"Mahoney","year":"2013","journal-title":"Adv. Neonatal Care"},{"key":"10.1016\/j.mcn.2016.06.004_bb0175","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.mcn.2016.06.004_bb0180","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1136\/jmg.2009.066852","article-title":"Deregulation of EIF4E: a novel mechanism for autism","volume":"46","author":"Neves-Pereira","year":"2009","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mcn.2016.06.004_bb0185","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40478-015-0184-4","article-title":"Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid","volume":"3","author":"Nicolini","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.mcn.2016.06.004_bb0190","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.bbr.2011.02.004","article-title":"An analysis of nicotine conditioned place conditioning in early postweanling and adolescent rats neonatally treated with quinpirole","volume":"220","author":"Perna","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.mcn.2016.06.004_bb0195","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.nbd.2007.08.005","article-title":"Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death","volume":"29","author":"Rami","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2016.06.004_bb0200","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nn1374","article-title":"Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development","volume":"8","author":"Rosso","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcn.2016.06.004_bb0205","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.neuroscience.2010.06.069","article-title":"Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid","volume":"170","author":"Roullet","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2016.06.004_bb0210","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ntt.2013.01.004","article-title":"In utero exposure to valproic acid and autism\u2014a current review of clinical and animal studies","volume":"36","author":"Roullet","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.mcn.2016.06.004_bb0215","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1523\/JNEUROSCI.2279-05.2006","article-title":"Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans","volume":"26","author":"Rowland","year":"2006","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.mcn.2016.06.004_bb0220","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bbr.2005.12.001","article-title":"Factor analysis of forced swimming test, sucrose preference test and open field test on enriched, social and isolated reared rats","volume":"169","author":"Saenz","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.mcn.2016.06.004_bb0225","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacol."},{"key":"10.1016\/j.mcn.2016.06.004_bb0230","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1001\/archpsyc.57.4.331","article-title":"Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome","volume":"57","author":"Schultz","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.mcn.2016.06.004_bb0235","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1083\/jcb.200907109","article-title":"Autophagy promotes synapse development in Drosophila","volume":"187","author":"Shen","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mcn.2016.06.004_bb0240","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/mp.2013.143","article-title":"Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction","volume":"19","author":"Sowers","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.mcn.2016.06.004_bb0245","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fnmol.2014.00028","article-title":"mTOR signaling and its roles in normal and abnormal brain development","volume":"7","author":"Takei","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mcn.2016.06.004_bb0250","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.neuron.2014.07.040","article-title":"Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits","volume":"83","author":"Tang","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2016.06.004_bb0255","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nature11310","article-title":"Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice","volume":"488","author":"Tsai","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2016.06.004_bb0260","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fncel.2013.00028","article-title":"Reversing autism by targeting downstream mTOR signaling","volume":"7","author":"Wang","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2016.06.004_bb0265","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1007\/s11064-012-0724-2","article-title":"Downregulating the canonical Wnt\/beta-catenin signaling pathway attenuates the susceptibility to autism-like phenotypes by decreasing oxidative stress","volume":"37","author":"Zhang","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mcn.2016.06.004_bb0270","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1172\/JCI65364","article-title":"WNT signaling underlies the pathogenesis of neuropathic pain in rodents","volume":"123","author":"Zhang","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mcn.2016.06.004_bb0275","doi-asserted-by":"publisher","first-page":"765","DOI":"10.2174\/1871527312666131223114149","article-title":"The canonical Wnt signaling pathway in autism","volume":"13","author":"Zhang","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.mcn.2016.06.004_bb0280","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3892\/ijmm.2014.1996","article-title":"Sulindac attenuates valproic acid-induced oxidative stress levels in primary cultured cortical neurons and ameliorates repetitive\/stereotypic-like movement disorders in Wistar rats prenatally exposed to valproic acid","volume":"35","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Med."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743116300549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743116300549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:24:25Z","timestamp":1568075065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743116300549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":56,"alternative-id":["S1044743116300549"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2016.06.004","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproic acid exposure sequentially activates Wnt and mTOR pathways in rats","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2016.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}