{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:39:50Z","timestamp":1790199590622,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH\/NIAID","award":["MH098891"],"award-info":[{"award-number":["MH098891"]}]},{"name":"NIH\/NIAID","award":["MH072567"],"award-info":[{"award-number":["MH072567"]}]},{"name":"NIH\/NIAID","award":["DA039576"],"award-info":[{"award-number":["DA039576"]}]},{"name":"NIH\/NIAID","award":["DA027569"],"award-info":[{"award-number":["DA027569"]}]},{"name":"NIH\/NIAID","award":["HL126559"],"award-info":[{"award-number":["HL126559"]}]},{"name":"Miami CFAR","award":["MH063022"],"award-info":[{"award-number":["MH063022"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.mcn.2016.12.006","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T23:04:50Z","timestamp":1482966290000},"page":"12-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology"],"prefix":"10.1016","volume":"79","author":[{"given":"Ibolya E.","family":"Andr\u00e1s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Leda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Garcia","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minseon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Skowronska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Toborek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mcn.2016.12.006_bb0005","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1469-7580.2002.00064.x","article-title":"Astrocyte-endothelial interactions and blood-brain barrier permeability","volume":"200","author":"Abbott","year":"2002","journal-title":"J. Anat."},{"issue":"Suppl. 6","key":"10.1016\/j.mcn.2016.12.006_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1167.2012.03696.x","article-title":"Overview and introduction: the blood-brain barrier in health and disease","volume":"53","author":"Abbott","year":"2012","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.mcn.2016.12.006_bb0015","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11481-009-9152-8","article-title":"Increased accumulation of intraneuronal amyloid beta in HIV-infected patients","volume":"4","author":"Achim","year":"2009","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.mcn.2016.12.006_bb0020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1756-6606-6-47","article-title":"Exosomes neutralize synaptic-plasticity-disrupting activity of Abeta assemblies in vivo","volume":"6","author":"An","year":"2013","journal-title":"Mol. Brain"},{"issue":"1","key":"10.1016\/j.mcn.2016.12.006_bb0025","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.yexcr.2014.01.027","article-title":"HIV-1 stimulates nuclear entry of amyloid beta via dynamin dependent EEA1 and TGF-beta\/Smad signaling","volume":"323","author":"Andras","year":"2014","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.mcn.2016.12.006_bb0030","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2015.1131804","article-title":"Extracellular vesicles of the blood-brain barrier","volume":"4","author":"Andras","year":"2016","journal-title":"Tissue Barriers"},{"issue":"2","key":"10.1016\/j.mcn.2016.12.006_bb0035","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.mcn.2009.11.004","article-title":"HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin","volume":"43","author":"Andras","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.mcn.2016.12.006_bb0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbrc.2012.03.128","article-title":"Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells","volume":"421","author":"Andras","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mcn.2016.12.006_bb0045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1074-7613(01)00111-X","article-title":"CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin","volume":"14","author":"Basu","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.mcn.2016.12.006_bb0050","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fphys.2012.00124","article-title":"Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?","volume":"3","author":"Bellingham","year":"2012","journal-title":"Front. Physiol."},{"issue":"6","key":"10.1016\/j.mcn.2016.12.006_bb0055","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1083\/jcb.200508014","article-title":"Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane","volume":"172","author":"Booth","year":"2006","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.mcn.2016.12.006_bb0060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11481-008-9143-1","article-title":"Neurodegeneration and ageing in the HAART era","volume":"4","author":"Brew","year":"2009","journal-title":"J. NeuroImmune Pharmacol."},{"issue":"7","key":"10.1016\/j.mcn.2016.12.006_bb0065","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1002\/jnr.21973","article-title":"Vessel microport technique for applications in cerebrovascular research","volume":"87","author":"Chen","year":"2009","journal-title":"J. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.mcn.2016.12.006_bb0070","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/cmi.12046","article-title":"Sequences within RNA coding for HIV-1 Gag p17 are efficiently targeted to exosomes","volume":"15","author":"Columba Cabezas","year":"2013","journal-title":"Cell. Microbiol."},{"issue":"2","key":"10.1016\/j.mcn.2016.12.006_bb0075","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2174\/156720507780362245","article-title":"Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease","volume":"4","author":"Deane","year":"2007","journal-title":"Curr. Alzheimer Res."},{"issue":"8","key":"10.1016\/j.mcn.2016.12.006_bb0080","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.neurobiolaging.2014.02.012","article-title":"Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease","volume":"35","author":"Dinkins","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mcn.2016.12.006_bb0085","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-150088","article-title":"The 5XFAD mouse model of Alzheimer's disease exhibits an age-dependent increase in anti-ceramide IgG and exogenous administration of ceramide further increases anti-ceramide titers and amyloid plaque burden","author":"Dinkins","year":"2015","journal-title":"J. Alzheimers Dis."},{"issue":"6","key":"10.1016\/j.mcn.2016.12.006_bb0090","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jalz.2014.06.008","article-title":"Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: a case-control study","volume":"11","author":"Fiandaca","year":"2015","journal-title":"Alzheimers Dement."},{"issue":"4","key":"10.1016\/j.mcn.2016.12.006_bb0095","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/01.aids.0000161770.06158.5c","article-title":"Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients","volume":"19","author":"Green","year":"2005","journal-title":"AIDS"},{"key":"10.1016\/j.mcn.2016.12.006_bb0100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1742-2094-11-68","article-title":"Exosomes as mediators of neuroinflammation","volume":"11","author":"Gupta","year":"2014","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.mcn.2016.12.006_bb0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2045-8118-10-4","article-title":"Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells","volume":"10","author":"Haqqani","year":"2013","journal-title":"Fluids Barriers CNS"},{"issue":"11","key":"10.1016\/j.mcn.2016.12.006_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.336","article-title":"Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications","volume":"7","author":"Hu","year":"2016","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.mcn.2016.12.006_bb0115","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/QAI.0000000000000756","article-title":"Elevated abundance, size, and MicroRNA content of plasma extracellular vesicles in viremic HIV-1+ patients: correlations with known markers of disease progression","volume":"70","author":"Hubert","year":"2015","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"2","key":"10.1016\/j.mcn.2016.12.006_bb0120","doi-asserted-by":"crossref","first-page":"744","DOI":"10.4049\/jimmunol.1102244","article-title":"Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages","volume":"189","author":"Kadiu","year":"2012","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.mcn.2016.12.006_bb0125","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s12035-013-8544-1","article-title":"Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics","volume":"49","author":"Kalani","year":"2014","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.mcn.2016.12.006_bb0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s13365-015-0383-6","article-title":"Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Abeta(1\u201342) secretion in SH-SY5Y neural cells","volume":"22","author":"Khan","year":"2016","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.mcn.2016.12.006_bb0135","first-page":"1525","article-title":"Exosome mimetics: a novel class of drug delivery systems","volume":"7","author":"Kooijmans","year":"2012","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.mcn.2016.12.006_bb0140","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1600-0854.2009.01006.x","article-title":"HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells","volume":"11","author":"Lenassi","year":"2010","journal-title":"Traffic"},{"issue":"4","key":"10.1016\/j.mcn.2016.12.006_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124436","article-title":"Exosomes are unlikely involved in intercellular Nef transfer","volume":"10","author":"Luo","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.mcn.2016.12.006_bb0150","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.3390\/v7072810","article-title":"Exosomes: implications in HIV-1 pathogenesis","volume":"7","author":"Madison","year":"2015","journal-title":"Viruses"},{"issue":"10","key":"10.1016\/j.mcn.2016.12.006_bb0155","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","article-title":"Exosomes: extracellular organelles important in intercellular communication","volume":"73","author":"Mathivanan","year":"2010","journal-title":"J. Proteome"},{"issue":"4","key":"10.1016\/j.mcn.2016.12.006_bb0160","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.neuroscience.2008.08.022","article-title":"Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades","volume":"156","author":"Matos","year":"2008","journal-title":"Neuroscience"},{"issue":"24","key":"10.1016\/j.mcn.2016.12.006_bb0165","doi-asserted-by":"crossref","first-page":"12844","DOI":"10.1128\/JVI.05853-11","article-title":"Microvesicles and viral infection","volume":"85","author":"Meckes","year":"2011","journal-title":"J. Virol."},{"issue":"1\u20132","key":"10.1016\/j.mcn.2016.12.006_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0090-6980(02)00111-9","article-title":"Pro-inflammatory effect of freshly solubilized beta-amyloid peptides in the brain","volume":"70","author":"Paris","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"46","key":"10.1016\/j.mcn.2016.12.006_bb0175","doi-asserted-by":"crossref","first-page":"33324","DOI":"10.1074\/jbc.M113.483487","article-title":"Methamphetamine-induced occludin endocytosis is mediated by the Arp2\/3 complex-regulated actin rearrangement","volume":"288","author":"Park","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"51","key":"10.1016\/j.mcn.2016.12.006_bb0180","doi-asserted-by":"crossref","first-page":"43108","DOI":"10.1074\/jbc.M112.404467","article-title":"The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space","volume":"287","author":"Perez-Gonzalez","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"15","key":"10.1016\/j.mcn.2016.12.006_bb0185","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1128\/JVI.00504-16","article-title":"HIV-1 Vpu antagonizes CD317\/tetherin by adaptor protein-1-mediated exclusion from virus assembly sites","volume":"90","author":"Pujol","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.mcn.2016.12.006_bb0190","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/978-1-62703-727-3_34","article-title":"Isolation of circulating microRNAs from microvesicles found in human plasma","volume":"1102","author":"Quackenbush","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mcn.2016.12.006_bb0195","doi-asserted-by":"crossref","DOI":"10.1007\/s13365-016-0451-6","article-title":"Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein","author":"Rahimian","year":"2016","journal-title":"J. Neurovirol."},{"issue":"30","key":"10.1016\/j.mcn.2016.12.006_bb0200","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1073\/pnas.0603838103","article-title":"Alzheimer's disease beta-amyloid peptides are released in association with exosomes","volume":"103","author":"Rajendran","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.mcn.2016.12.006_bb0205","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/cdd.2008.172","article-title":"Astroglia in dementia and Alzheimer's disease","volume":"16","author":"Rodriguez","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mcn.2016.12.006_bb0210","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuroscience.2015.01.007","article-title":"Astrocytes in physiological aging and Alzheimer's disease","volume":"323","author":"Rodriguez-Arellano","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2016.12.006_bb0215","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/ncomms3932","article-title":"Pericyte loss influences Alzheimer-like neurodegeneration in mice","volume":"4","author":"Sagare","year":"2013","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.mcn.2016.12.006_bb0220","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s13365-014-0238-6","article-title":"Exosomes and their role in CNS viral infections","volume":"20","author":"Sampey","year":"2014","journal-title":"J. Neurovirol."},{"issue":"3","key":"10.1016\/j.mcn.2016.12.006_bb0225","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1074\/jbc.M115.662171","article-title":"Exosomes from HIV-1-infected cells stimulate production of pro-inflammatory cytokines through trans-activating response (TAR) RNA","volume":"291","author":"Sampey","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mcn.2016.12.006_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/syn.890120102","article-title":"Fine structure of presynaptic axonal terminals in sympathetic autonomic ganglia of aging and diabetic human subjects","volume":"12","author":"Schroer","year":"1992","journal-title":"Synapse"},{"issue":"5","key":"10.1016\/j.mcn.2016.12.006_bb0235","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1096\/fj.07-9357com","article-title":"Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes","volume":"22","author":"Sharples","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.mcn.2016.12.006_bb0240","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.4049\/jimmunol.170.6.3037","article-title":"Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo","volume":"170","author":"Skokos","year":"2003","journal-title":"J. Immunol."},{"issue":"18","key":"10.1016\/j.mcn.2016.12.006_bb0245","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1097\/QAD.0b013e32835a117c","article-title":"Cerebral beta-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE epsilon4 carriers","volume":"26","author":"Soontornniyomkij","year":"2012","journal-title":"AIDS"},{"issue":"3","key":"10.1016\/j.mcn.2016.12.006_bb0250","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/ene.12006","article-title":"Cognitive impairment in HIV infection is associated with MRI and CSF pattern of neurodegeneration","volume":"20","author":"Steinbrink","year":"2013","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.mcn.2016.12.006_bb0255","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/978-1-61779-068-3_15","article-title":"Exosome isolation for proteomic analyses and RNA profiling","volume":"728","author":"Taylor","year":"2011","journal-title":"Methods Mol. Biol."},{"issue":"8","key":"10.1016\/j.mcn.2016.12.006_bb0260","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Thery","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.mcn.2016.12.006_bb0265","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jcb.22733","article-title":"Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy","volume":"111","author":"Tian","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mcn.2016.12.006_bb0270","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v3.24858","article-title":"The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling","volume":"3","author":"Van Deun","year":"2014","journal-title":"J. Extracell Vesicles"},{"issue":"28","key":"10.1016\/j.mcn.2016.12.006_bb0275","doi-asserted-by":"crossref","first-page":"19599","DOI":"10.1074\/jbc.M114.567644","article-title":"Astrocyte elevated gene-1 is a novel modulator of HIV-1-associated neuroinflammation via regulation of nuclear factor-kappaB signaling and excitatory amino acid transporter-2 repression","volume":"289","author":"Vartak-Sharma","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.mcn.2016.12.006_bb0280","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00249-007-0246-z","article-title":"The role of exosomes in the processing of proteins associated with neurodegenerative diseases","volume":"37","author":"Vella","year":"2008","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.mcn.2016.12.006_bb0285","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.coph.2015.09.011","article-title":"Astroglia dynamics in ageing and Alzheimer's disease","volume":"26","author":"Verkhratsky","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.mcn.2016.12.006_bb0290","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3389\/fphys.2012.00229","article-title":"Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease","volume":"3","author":"Vingtdeux","year":"2012","journal-title":"Front. Physiol."},{"issue":"7","key":"10.1016\/j.mcn.2016.12.006_bb0295","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbagen.2012.03.017","article-title":"Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials","volume":"1820","author":"Vlassov","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"13","key":"10.1016\/j.mcn.2016.12.006_bb0300","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1096\/fj.04-3458fje","article-title":"Blood-brain barrier-specific properties of a human adult brain endothelial cell line","volume":"19","author":"Weksler","year":"2005","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.mcn.2016.12.006_bb0305","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1073\/pnas.0507995103","article-title":"Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection","volume":"103","author":"Wiley","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.mcn.2016.12.006_bb0310","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/bpa.12152","article-title":"The pericyte: a forgotten cell type with important implications for Alzheimer's disease?","volume":"24","author":"Winkler","year":"2014","journal-title":"Brain Pathol."},{"issue":"2","key":"10.1016\/j.mcn.2016.12.006_bb0315","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s11481-008-9136-0","article-title":"The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era","volume":"4","author":"Xu","year":"2009","journal-title":"J. NeuroImmune Pharmacol."},{"issue":"50","key":"10.1016\/j.mcn.2016.12.006_bb0320","doi-asserted-by":"crossref","first-page":"34554","DOI":"10.1074\/jbc.M801487200","article-title":"The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells","volume":"283","author":"Yamada","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mcn.2016.12.006_bb9000","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1471-4159.2007.05128.x","article-title":"Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation","volume":"105","author":"Yuyama","year":"2008","journal-title":"J. Neurochem."},{"issue":"35","key":"10.1016\/j.mcn.2016.12.006_bb0325","doi-asserted-by":"crossref","first-page":"24488","DOI":"10.1074\/jbc.M114.577213","article-title":"Decreased amyloid-beta pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice","volume":"289","author":"Yuyama","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mcn.2016.12.006_bb0330","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.febslet.2014.11.027","article-title":"A potential function for neuronal exosomes: sequestering intracerebral amyloid-beta peptide","volume":"589","author":"Yuyama","year":"2015","journal-title":"FEBS Lett."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743116300999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743116300999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T21:36:56Z","timestamp":1568669816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743116300999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":67,"alternative-id":["S1044743116300999"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2016.12.006","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2016.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}