{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T09:58:12Z","timestamp":1792835892713,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT120100039"],"award-info":[{"award-number":["FT120100039"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1049458"],"award-info":[{"award-number":["APP1049458"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1049459"],"award-info":[{"award-number":["APP1049459"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1102059"],"award-info":[{"award-number":["APP1102059"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001671","name":"Hereditary Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.mcn.2017.07.004","type":"journal-article","created":{"date-parts":[[2017,7,23]],"date-time":"2017-07-23T02:03:36Z","timestamp":1500775416000},"page":"103-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways"],"prefix":"10.1016","volume":"83","author":[{"given":"Nagaraj S.","family":"Moily","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelique R.","family":"Ormsby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Stojilovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin M.","family":"Ramdzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannine","family":"Diesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Zajac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Oshlack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny M.","family":"Hatters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2017.07.004_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2011.12.013","article-title":"Protein aggregates in Huntington's disease","volume":"238","author":"Arrasate","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0010","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2017.07.004_bb0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2005.06.005","article-title":"p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease","volume":"47","author":"Bae","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2017.07.004_bb0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jacl.2009.11.003","article-title":"Altered cholesterol and fatty acid metabolism in Huntington disease","volume":"4","author":"Block","year":"2010","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0025","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcn.2017.07.004_bb0030","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/bioinformatics\/btq431","article-title":"A framework for oligonucleotide microarray preprocessing","volume":"26","author":"Carvalho","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcn.2017.07.004_bb0035","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.2559","article-title":"Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1 and CREB transcriptional pathway","volume":"18","author":"Cohen","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcn.2017.07.004_bb0040","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.mcn.2005.05.003","article-title":"Mutant huntingtin represses CBP, but not p300, by binding and protein degradation","volume":"30","author":"Cong","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2017.07.004_bb0045","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2017.07.004_bb0050","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/1947601911409737","article-title":"The ribosomal protein-Mdm2-p53 pathway and energy metabolism: bridging the gap between feast and famine","volume":"2","author":"Deisenroth","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.mcn.2017.07.004_bb0055","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nsmb.3228","article-title":"BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin","volume":"23","author":"Devaiah","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0060","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.mcn.2017.07.004_bb0065","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1126\/science.1072613","article-title":"Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease","volume":"296","author":"Dunah","year":"2002","journal-title":"Science"},{"issue":"48\u201357","key":"10.1016\/j.mcn.2017.07.004_bb0070","article-title":"Polyglutamine-expanded huntingtin exacerbates age-related disruption of nuclear integrity and nucleocytoplasmic transport","volume":"94","author":"Gasset-Rosa","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2017.07.004_bb0075","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"Affy\u2013analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcn.2017.07.004_bb0080","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cell.2015.07.003","article-title":"Identification of genetic factors that modify clinical onset of Huntington's disease","volume":"162","author":"Genetic Modifiers of Huntington's Disease, Consortium","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2017.07.004_bb0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cytogfr.2009.11.005","article-title":"Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer","volume":"21","author":"Grivennikov","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.mcn.2017.07.004_bb0090","doi-asserted-by":"crossref","first-page":"15467","DOI":"10.1073\/pnas.1000462107","article-title":"PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy","volume":"107","author":"Ha","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2017.07.004_bb0095","doi-asserted-by":"crossref","first-page":"10768","DOI":"10.1073\/pnas.1501956112","article-title":"CBP30, a selective CBP\/p300 bromodomain inhibitor, suppresses human Th17 responses","volume":"112","author":"Hammitzsch","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2017.07.004_bb0100","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.2174\/1568026611212220013","article-title":"Putting huntingtin \u201caggregation\u201d in view with windows into the cellular milieu","volume":"12","author":"Hatters","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.mcn.2017.07.004_bb0105","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington's disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2017.07.004_bb0110","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/hmg\/ddg075","article-title":"Transgenic rat model of Huntington's disease","volume":"12","author":"von Horsten","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2017.07.004_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcn.2017.07.004_bb0120","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcn.2017.07.004_bb0125","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1023684503883","article-title":"Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling","volume":"23","author":"Insel","year":"2003","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0130","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.nbd.2006.04.011","article-title":"Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin","volume":"23","author":"Jiang","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2017.07.004_bb0135","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nature07195","article-title":"Misfolded proteins partition between two distinct quality control compartments","volume":"454","author":"Kaganovich","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2017.07.004_bb0140","doi-asserted-by":"crossref","first-page":"11404","DOI":"10.1073\/pnas.96.20.11404","article-title":"Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells","volume":"96","author":"Kazantsev","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2017.07.004_bb0145","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0150","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI200318182","article-title":"Oxidative stress, cell cycle, and neurodegeneration","volume":"111","author":"Klein","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mcn.2017.07.004_bb0155","doi-asserted-by":"crossref","first-page":"D1113","DOI":"10.1093\/nar\/gku1057","article-title":"ArrayExpress update\u2013simplifying data submissions","volume":"43","author":"Kolesnikov","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcn.2017.07.004_bb0160","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0962-8924(00)01852-3","article-title":"Aggresomes, inclusion bodies and protein aggregation","volume":"10","author":"Kopito","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0165","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"Voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0170","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkt214","article-title":"The subread aligner: fast, accurate and scalable read mapping by seed-and-vote","volume":"41","author":"Liao","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcn.2017.07.004_bb0175","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1750-1326-5-24","article-title":"Heat shock protein 90 in neurodegenerative diseases","volume":"5","author":"Luo","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcn.2017.07.004_bb0180","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","article-title":"Decreased expression of striatal signaling genes in a mouse model of Huntington's disease","volume":"9","author":"Luthi-Carter","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2017.07.004_bb0185","author":"MacDonald"},{"key":"10.1016\/j.mcn.2017.07.004_bb0190","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2017.07.004_bb0195","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2017.07.004_bb0200","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng882","article-title":"Disruption of CREB function in brain leads to neurodegeneration","volume":"31","author":"Mantamadiotis","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mcn.2017.07.004_bb0205","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1111\/j.1742-4658.2008.06612.x","article-title":"Increased glucose metabolism and ATP level in brain tissue of Huntington's disease transgenic mice","volume":"275","author":"Olah","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.mcn.2017.07.004_bb0210","doi-asserted-by":"crossref","first-page":"21807","DOI":"10.1074\/jbc.M109.084434","article-title":"Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool","volume":"285","author":"Olshina","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2017.07.004_bb0215","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1158\/0008-5472.CAN-15-0236","article-title":"Generation of a selective small molecule inhibitor of the CBP\/p300 bromodomain for leukemia therapy","volume":"75","author":"Picaud","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.mcn.2017.07.004_bb0220","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1074\/jbc.M113.520189","article-title":"Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell","volume":"289","author":"Polling","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2017.07.004_bb0225","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/nsmb.3127","article-title":"Polyalanine expansions drive a shift into alpha-helical clusters without amyloid-fibril formation","volume":"22","author":"Polling","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0230","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.chembiol.2010.03.011","article-title":"Conformation sensors that distinguish monomeric proteins from oligomers in live cells","volume":"17","author":"Ramdzan","year":"2010","journal-title":"Chem. Biol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0235","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nmeth.1930","article-title":"Tracking protein aggregation and mislocalization in cells with flow cytometry","volume":"9","author":"Ramdzan","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcn.2017.07.004_bb2017","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.celrep.2017.04.029","article-title":"Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis","volume":"19","author":"Ramdzan","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcn.2017.07.004_bb0240","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrc2819","article-title":"MYC as a regulator of ribosome biogenesis and protein synthesis","volume":"10","author":"Riggelen","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mcn.2017.07.004_bb0245","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcn.2017.07.004_bb0250","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molcel.2004.06.029","article-title":"Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation","volume":"15","author":"Schaffar","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mcn.2017.07.004_bb0255","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1073\/pnas.96.8.4604","article-title":"Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology","volume":"96","author":"Scherzinger","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2017.07.004_bb0260","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcn.2017.07.004_bb0265","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/79139","article-title":"Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription","volume":"26","author":"Shimohata","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mcn.2017.07.004_bb0270","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/13506129.2016.1257986","article-title":"Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines","volume":"23","author":"Sipe","year":"2016","journal-title":"Amyloid"},{"key":"10.1016\/j.mcn.2017.07.004_bb0275","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1073\/pnas.100110097","article-title":"The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription","volume":"97","author":"Steffan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2017.07.004_bb0280","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/35099568","article-title":"Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila","volume":"413","author":"Steffan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2017.07.004_bb0285","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1092194","article-title":"SUMO modification of Huntingtin and Huntington's disease pathology","volume":"304","author":"Steffan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.mcn.2017.07.004_bb0290","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein-protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcn.2017.07.004_bb0295","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/brain\/awt355","article-title":"HTT-lowering reverses Huntington's disease immune dysfunction caused by NFkappaB pathway dysregulation","volume":"137","author":"Trager","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.mcn.2017.07.004_bb0300","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.cell.2013.01.032","article-title":"Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer","volume":"152","author":"Tropberger","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2017.07.004_bb0305","doi-asserted-by":"crossref","first-page":"16982","DOI":"10.1073\/pnas.1004498107","article-title":"A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model","volume":"107","author":"Tsvetkov","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2017.07.004_bb0310","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molcel.2009.03.006","article-title":"How common are extra-ribosomal functions of ribosomal proteins?","volume":"34","author":"Warner","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mcn.2017.07.004_bb0315","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1093\/bioinformatics\/btq401","article-title":"ROAST: rotation gene set tests for complex microarray experiments","volume":"26","author":"Wu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcn.2017.07.004_bb0320","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/hmg\/10.17.1829","article-title":"Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease","volume":"10","author":"Wyttenbach","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2017.07.004_bb0325","doi-asserted-by":"crossref","first-page":"W167","DOI":"10.1093\/nar\/gku443","article-title":"NetworkAnalyst\u2013integrative approaches for protein-protein interaction network analysis and visual exploration","volume":"42","author":"Xia","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcn.2017.07.004_bb0330","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nprot.2015.052","article-title":"NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data","volume":"10","author":"Xia","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcn.2017.07.004_bb0335","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nature06975","article-title":"Towards a transgenic model of Huntington's disease in a non-human primate","volume":"453","author":"Yang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2017.07.004_bb0340","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1385\/JMN:15:1:31","article-title":"Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease","volume":"15","author":"Yu","year":"2000","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.mcn.2017.07.004_bb0345","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/brain\/awv002","article-title":"Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment","volume":"138","author":"Zhou","year":"2015","journal-title":"Brain"}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743117301306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743117301306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T08:18:33Z","timestamp":1569917913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743117301306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":70,"alternative-id":["S1044743117301306"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2017.07.004","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2017.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}