{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:22:35Z","timestamp":1782530555726,"version":"3.54.5"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["PTDC\/NEU-NMC\/0248\/2012"],"award-info":[{"award-number":["PTDC\/NEU-NMC\/0248\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["UID\/DTP\/04138\/2013"],"award-info":[{"award-number":["UID\/DTP\/04138\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007038"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007038"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["SFRH\/BPD72891\/2010"],"award-info":[{"award-number":["SFRH\/BPD72891\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["SFRH\/BPD\/95855\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/95855\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["SFRH\/BPD\/98023\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/98023\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["SFRH\/BD\/102771\/2014"],"award-info":[{"award-number":["SFRH\/BD\/102771\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["UMINHO\/BI\/248\/2016"],"award-info":[{"award-number":["UMINHO\/BI\/248\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.mcn.2019.01.003","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T12:07:11Z","timestamp":1550059631000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy"],"prefix":"10.1016","volume":"96","author":[{"given":"Mariana Oliveira","family":"Mendes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Isabel","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia Neves","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jo\u00e3o","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Dion\u00edsio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Duarte-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cec\u00edlia Maria Pereira","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jo\u00e3o","family":"Gama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Castro-Caldas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2019.01.003_bb0005","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fnagi.2016.00263","article-title":"Bile acids in neurodegenerative disorders","volume":"8","author":"Ackerman","year":"2016","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.mcn.2019.01.003_bb0010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1432-1327.2001.01840.x","article-title":"CREB is involved in mouse annexin A1 regulation by cAMP and glucocorticoids","volume":"268","author":"Antonicelli","year":"2001","journal-title":"Eur. J. Biochem."},{"issue":"5","key":"10.1016\/j.mcn.2019.01.003_bb0015","first-page":"4240","article-title":"Effect of intrastriatal 6-OHDA lesions on extrastriatal brain structures in the mouse","volume":"55","author":"Becker","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mcn.2019.01.003_bb0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fnana.2015.00091","article-title":"Oxidative stress and Parkinson's disease","volume":"9","author":"Blesa","year":"2015","journal-title":"Front. Neuroanat."},{"issue":"1-2","key":"10.1016\/j.mcn.2019.01.003_bb0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3940(95)12192-7","article-title":"Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients","author":"Blum-Degen","year":"1995","journal-title":"Neurosci. Lett."},{"issue":"7","key":"10.1016\/j.mcn.2019.01.003_bb0030","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S1357-4310(97)88908-3","article-title":"Lipocortin 1: a second messenger of glucocorticoid action in the hypothalamo-pituitary-adrenocortical axis","volume":"3","author":"Buckingham","year":"1997","journal-title":"Mol. Med. Today"},{"issue":"10","key":"10.1016\/j.mcn.2019.01.003_bb0035","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/1873-3468.12177","article-title":"S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection","volume":"590","author":"Carvalho","year":"2016","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.mcn.2019.01.003_bb0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0925-4439(97)00070-7","article-title":"Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease","volume":"1362","author":"Cassarino","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0045","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1124\/jpet.104.070532","article-title":"The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons","volume":"311","author":"Castro","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.mcn.2019.01.003_bb0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/09629350310001633351","article-title":"Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expression in CCRF-CEM lymphoblastic cells: evidence for the involvement of cAMP and p38 MAPK","volume":"12","author":"Castro-Caldas","year":"2003","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0055","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12031-008-9141-z","article-title":"GSTpi expression in MPTP induced dopaminergic neurodegeneration of C57BL\/6 mouse midbrain and striatum","volume":"38","author":"Castro-Caldas","year":"2009","journal-title":"J. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0060","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12035-012-8295-4","article-title":"Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease","volume":"46","author":"Castro-Caldas","year":"2012","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.mcn.2019.01.003_bb0065","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0070","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/hep.510310217","article-title":"Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin III SV40 T large antigen transgenic mice","volume":"31","author":"de Coupade","year":"2000","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.mcn.2019.01.003_bb0075","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF03655585","article-title":"Effect of MPTP on brain mitochondrial H2O2 and ATP production and on dopamine and DOPAC in the striatum","volume":"55","author":"Fabre","year":"1999","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.mcn.2019.01.003_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb07458.x","article-title":"Description of Parkinson's disease as a clinical syndrome","volume":"991","author":"Fahn","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.mcn.2019.01.003_bb0085","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1091\/mbc.e03-09-0670","article-title":"Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes","volume":"15","author":"Fan","year":"2004","journal-title":"Mol. Biol. Cell"},{"issue":"4","key":"10.1016\/j.mcn.2019.01.003_bb0090","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/j.1476-5381.1988.tb11614.x","article-title":"Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids","volume":"94","author":"Flower","year":"1988","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.mcn.2019.01.003_bb0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/bpa.12474","article-title":"Mitochondrial activity in the frontal cortex area 8 and angular gyrus in Parkinson's disease and Parkinson's disease with dementia","volume":"28","author":"Garcia-Esparcia","year":"2018","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.mcn.2019.01.003_bb0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrneurol.2012.242","article-title":"100 years of Lewy pathology","volume":"9","author":"Goedert","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.mcn.2019.01.003_bb0105","first-page":"311","article-title":"FELASA guidelines and recommendations","volume":"51","author":"Guillen","year":"2012","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"issue":"8","key":"10.1016\/j.mcn.2019.01.003_bb0110","first-page":"4852","article-title":"Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A","volume":"13","author":"Hagiwara","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mcn.2019.01.003_bb0115","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11064-012-0907-x","article-title":"Alteration in glutathione content and associated enzyme activities in the synaptic terminals but not in the non-synaptic mitochondria from the frontal cortex of Parkinson's disease brains","volume":"38","author":"Harish","year":"2013","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/j.mcn.2019.01.003_bb0120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S1474-4422(09)70062-6","article-title":"Neuroinflammation in Parkinson's disease: a target for neuroprotection?","volume":"8","author":"Hirsch","year":"2009","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0125","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0014-4886(03)00273-5","article-title":"Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys","volume":"184","author":"Hurley","year":"2003","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.mcn.2019.01.003_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5607\/en.2013.22.1.11","article-title":"Role of oxidative stress in Parkinson's disease","volume":"22","author":"Hwang","year":"2013","journal-title":"Exp. Neurobiol."},{"issue":"1","key":"10.1016\/j.mcn.2019.01.003_bb0135","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nprot.2006.342","article-title":"Protocol for the MPTP mouse model of Parkinson's disease","volume":"2","author":"Jackson-Lewis","year":"2007","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.mcn.2019.01.003_bb0140","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/1055-8330(95)90015-2","article-title":"Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"4","author":"Jackson-Lewis","year":"1995","journal-title":"Neurodegeneration"},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0145","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/exnr.2001.7755","article-title":"A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease","volume":"171","author":"Keene","year":"2001","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.mcn.2019.01.003_bb0150","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuint.2013.01.029","article-title":"Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol","volume":"62","author":"Khan","year":"2013","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.mcn.2019.01.003_bb0155","doi-asserted-by":"crossref","first-page":"a008888","DOI":"10.1101\/cshperspect.a008888","article-title":"Genetics of Parkinson's disease","volume":"2","author":"Klein","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"12","key":"10.1016\/j.mcn.2019.01.003_bb0160","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/70978","article-title":"Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease","volume":"5","author":"Liberatore","year":"1999","journal-title":"Nat. Med."},{"issue":"7638","key":"10.1016\/j.mcn.2019.01.003_bb0165","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"33","key":"10.1016\/j.mcn.2019.01.003_bb0170","doi-asserted-by":"crossref","first-page":"13758","DOI":"10.1074\/jbc.M117.800391","article-title":"The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1","volume":"292","author":"Lima","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0175","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000320027","article-title":"MPTP-induced neuroinflammation increases the expression of pro-inflammatory cytokines and their receptors in mouse brain","volume":"18","author":"Lofrumento","year":"2011","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.mcn.2019.01.003_bb0180","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-genom-082410-101440","article-title":"Recent advances in the genetics of Parkinson's disease","volume":"12","author":"Martin","year":"2011","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"issue":"10","key":"10.1016\/j.mcn.2019.01.003_bb0185","doi-asserted-by":"crossref","first-page":"6317","DOI":"10.4049\/jimmunol.1001095","article-title":"Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia","volume":"185","author":"McArthur","year":"2010","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.mcn.2019.01.003_bb0190","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0195","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2005.10.034","article-title":"Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys","volume":"197","author":"Miklossy","year":"2006","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0200","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-3940(94)90508-8","article-title":"Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients","volume":"180","author":"Mogi","year":"1994","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0205","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5607\/en.2015.24.2.103","article-title":"Mitochondrial dysfunction in Parkinson's disease","volume":"24","author":"Moon","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.mcn.2019.01.003_bb0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.expneurol.2017.05.009","article-title":"Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease","volume":"295","author":"Moreira","year":"2017","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0215","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-0404.1998.tb01736.x","article-title":"Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease","volume":"98","author":"Muller","year":"1998","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.mcn.2019.01.003_bb0220","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s10863-009-9250-6","article-title":"Brain mitochondrial dysfunction and oxidative damage in Parkinson's disease","volume":"41","author":"Navarro","year":"2009","journal-title":"J. Bioenerg. Biomembr."},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0225","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1460-9568.2009.06806.x","article-title":"Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation","volume":"30","author":"Nayyar","year":"2009","journal-title":"Eur. J. Neurosci."},{"issue":"26","key":"10.1016\/j.mcn.2019.01.003_bb0230","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/0024-3205(85)90146-8","article-title":"Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine","volume":"36","author":"Nicklas","year":"1985","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.mcn.2019.01.003_bb0235","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1258\/0023677021911740","article-title":"Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units","volume":"36","author":"Nicklas","year":"2002","journal-title":"Lab. Anim."},{"issue":"1","key":"10.1016\/j.mcn.2019.01.003_bb0240","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12035-013-8483-x","article-title":"The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes","volume":"49","author":"Niranjan","year":"2014","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.mcn.2019.01.003_bb0245","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/dneu.20506","article-title":"PI3K\/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation","volume":"67","author":"Peltier","year":"2007","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.mcn.2019.01.003_bb0250","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"13","key":"10.1016\/j.mcn.2019.01.003_bb0255","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson's disease: a systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"issue":"Suppl. 1","key":"10.1016\/j.mcn.2019.01.003_bb0260","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.parkreldis.2004.10.012","article-title":"Pathogenesis of nigral cell death in Parkinson's disease","volume":"11","author":"Przedborski","year":"2005","journal-title":"Parkinsonism Relat. Disord."},{"issue":"4","key":"10.1016\/j.mcn.2019.01.003_bb0265","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00004647-200204000-00010","article-title":"Neuroprotection by a bile acid in an acute stroke model in the rat","volume":"22","author":"Rodrigues","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"9","key":"10.1016\/j.mcn.2019.01.003_bb0270","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.bbadis.2017.06.004","article-title":"Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson's disease","volume":"1863","author":"Rosa","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"10.1016\/j.mcn.2019.01.003_bb0275","doi-asserted-by":"crossref","first-page":"9139","DOI":"10.1007\/s12035-018-1062-4","article-title":"Tauroursodeoxycholic acid improves motor symptoms in a mouse model of Parkinson's disease","volume":"55","author":"Rosa","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.mcn.2019.01.003_bb0280","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1046\/j.1471-4159.2000.0751200.x","article-title":"MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo","volume":"75","author":"Saporito","year":"2000","journal-title":"J. Neurochem."},{"issue":"9\u201312","key":"10.1016\/j.mcn.2019.01.003_bb0285","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2119\/2003-00042.Rodrigues","article-title":"Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway","volume":"9","author":"Sol\u00e1","year":"2003","journal-title":"Mol. Med."},{"issue":"2","key":"10.1016\/j.mcn.2019.01.003_bb0290","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/sj.bjp.0704054","article-title":"Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation","volume":"133","author":"Solito","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.mcn.2019.01.003_bb5000","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tips.2007.12.003","article-title":"Annexin A1 in the brain--undiscovered roles?","volume":"29","author":"Solito","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"issue":"R2","key":"10.1016\/j.mcn.2019.01.003_bb0295","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/hmg\/ddm159","article-title":"Parkinson's disease","volume":"16","author":"Thomas","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2019.01.003_bb0300","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1742-2094-11-50","article-title":"Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation","volume":"11","author":"Yanguas-Casas","year":"2014","journal-title":"J. Neuroinflammation"},{"issue":"8","key":"10.1016\/j.mcn.2019.01.003_bb0305","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1002\/jcp.25742","article-title":"TUDCA: an agonist of the bile acid receptor GPBAR1\/TGR5 with anti-inflammatory effects in microglial cells","volume":"232","author":"Yanguas-Casas","year":"2017","journal-title":"J. Cell. Physiol."}],"updated-by":[{"DOI":"10.1016\/j.mcn.2021.103626","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000}}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743118303907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743118303907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T01:07:14Z","timestamp":1760922434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743118303907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":62,"alternative-id":["S1044743118303907"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2019.01.003","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2019.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}