{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:41:03Z","timestamp":1781188863109,"version":"3.54.1"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008484","name":"BioMarin Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.mcn.2019.103451","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T07:42:15Z","timestamp":1575272535000},"page":"103451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Cerebrospinal fluid and serum glycosphingolipid biomarkers in canine globoid cell leukodystrophy (Krabbe Disease)"],"prefix":"10.1016","volume":"102","author":[{"given":"Carley R.","family":"Corado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Pinkstaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuntian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn M.","family":"Galban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriane","family":"Scholler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica H.","family":"Bagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"ODonnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Ory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Vite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"Bradbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2019.103451_bb0005","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0014-4886(70)90075-0","article-title":"Ultrastructure of experimentally produced globoid cells in the rat","volume":"29","author":"Andrews","year":"1970","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mcn.2019.103451_bb0010","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/jnr.23838","article-title":"Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe\u2019s disease)","volume":"94","author":"Bradbury","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mcn.2019.103451_bb0015","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/1971400916665378","article-title":"Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease","volume":"29","author":"Bradbury","year":"2016","journal-title":"Neuroradiol. J."},{"key":"10.1016\/j.mcn.2019.103451_bb0020","doi-asserted-by":"crossref","DOI":"10.1089\/hum.2017.151","article-title":"AAVrh10 gene therapy ameliorates central and peripheral nervous system disease in canine globoid cellleukodystrophy(Krabbe disease)","author":"Bradbury","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.mcn.2019.103451_bb0025","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1748-5827.1998.tb03741.x","article-title":"MRI and electrophysiological abnormalities in a case of canine globoid cell leucodystrophy","volume":"39","author":"Cozzi","year":"1998","journal-title":"J. Small Anim. Pract."},{"issue":"3","key":"10.1016\/j.mcn.2019.103451_bb0030","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ymgme.2017.05.015","article-title":"Psychosine, a marker of Krabbe phenotype and treatment effect","volume":"121","author":"Escolar","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.mcn.2019.103451_bb0035","first-page":"165","article-title":"Globoid cell leukodystrophy (Krabbe type) in the dog","volume":"149","author":"Fletcher","year":"1966","journal-title":"American Journal of Veterinary Medicine"},{"key":"10.1016\/j.mcn.2019.103451_bb0040","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1748-5827.1967.tb04499.x","article-title":"A familial canine globoid cell leukodystrophy (\u201cKrabbe type\u201d)","volume":"8","author":"Hirth","year":"1966","journal-title":"J. Small Anim. Pract."},{"key":"10.1016\/j.mcn.2019.103451_bb0045","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1126\/science.6719111","article-title":"Progressive accumulation of toxic metabolite in a genetic leukodystrophy","volume":"18","author":"Igisu","year":"1984","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.mcn.2019.103451_bb0050","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.pediatrneurol.2014.08.003","article-title":"Experimental therapies in the murine model of globoid cell leukodsytrophy","volume":"51","author":"Li","year":"2014","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.mcn.2019.103451_bb0055","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/1971400917733431","article-title":"Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages","volume":"31","author":"Li","year":"2018","journal-title":"Neuroradiol. J."},{"key":"10.1016\/j.mcn.2019.103451_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.25259\/JCIS-18-2019","article-title":"Revisiting magnetic resonance imaging pattern of Krabbe disease- lessons from an Indian cohort","volume":"9","author":"Muthusamy","year":"2019","journal-title":"J Clin Imaging Sci"},{"issue":"8","key":"10.1016\/j.mcn.2019.103451_bb0065","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1194\/jlr.D800051-JLR200","article-title":"Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers","volume":"50","author":"Shaner","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.mcn.2019.103451_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4235","article-title":"A HILIC-MS\/MS method for simultaneous quantification of the lysosomal disease markers galactosylsphingosine and glucosylsphingosine in mouse serum","author":"Sidhu","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.mcn.2019.103451_bb0075","first-page":"612","article-title":"Ultrastructural study of experimental globoid cells","volume":"23","author":"Suzuki","year":"1970","journal-title":"Lab. Investig."},{"issue":"9","key":"10.1016\/j.mcn.2019.103451_bb0080","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/08830738030180090201","article-title":"Globoid cell leukodystrophy (Krabbe\u2019s disease): update","volume":"18","author":"Suzuki","year":"2003","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.mcn.2019.103451_bb0085","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0022-2275(20)39839-4","article-title":"Krabbe disease: a galactosylsphingosine (psychosine) 1ipidosis","volume":"21","author":"Svennerholm","year":"1980","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.mcn.2019.103451_bb0090","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4684-7735-1_8","article-title":"Chemical pathology of Krabbe disease: the occurrence of psychosine and other neutrual sphingolipids","volume":"68","author":"Vanier","year":"1976","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mcn.2019.103451_bb0095","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/geno.1996.0220","article-title":"Cloning of the canine GALC cDNA and identification of the mutation causing globoid cell leukodystrophy in West Highland white and cairn terriers","volume":"33","author":"Victoria","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.mcn.2019.103451_bb0100","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/jhered\/90.1.138","article-title":"Globoid cell leukodystrophy in cairn and West Highland white terriers","volume":"90","author":"Wenger","year":"1999","journal-title":"J Hered"},{"key":"10.1016\/j.mcn.2019.103451_bb0105","first-page":"138","article-title":"Globoid cell leukodystrophy in cairn and West Highland white terriers","volume":"90","author":"Wenger","year":"1999","journal-title":"The American Genetic Association"}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743119302003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743119302003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T01:08:37Z","timestamp":1760922517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743119302003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":21,"alternative-id":["S1044743119302003"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2019.103451","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebrospinal fluid and serum glycosphingolipid biomarkers in canine globoid cell leukodystrophy (Krabbe Disease)","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2019.103451","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103451"}}