{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:49:55Z","timestamp":1773089395890,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.mcn.2020.103586","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T08:13:52Z","timestamp":1610180032000},"page":"103586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Unexpected role of stress as a possible resilience mechanism upon mild traumatic brain injury (mTBI) in mice"],"prefix":"10.1016","volume":"111","author":[{"given":"Efrat","family":"Shavit-Stein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Gerasimov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shay","family":"Aharoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shany G.","family":"Gofrit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Pikus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaim G.","family":"Pick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Maggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2020.103586_bb0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S1474-4422(18)30444-7","article-title":"Global burden of traumatic brain and spinal cord injury","volume":"18","author":"Badhiwala","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mcn.2020.103586_bb0010","series-title":"The Rat: A Study in Behavior","author":"Barnett","year":"2007"},{"key":"10.1016\/j.mcn.2020.103586_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188524","article-title":"Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus","volume":"12","author":"Ben Shimon","year":"2017","journal-title":"PLOS ONE"},{"key":"10.1016\/j.mcn.2020.103586_bb0020","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2701526","article-title":"Role of NMDA receptor-mediated glutamatergic signaling in chronic and acute neuropathologies","author":"Carvajal","year":"2016","journal-title":"Neural Plast."},{"key":"10.1016\/j.mcn.2020.103586_bb0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.yfrne.2018.02.003","article-title":"Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation","volume":"49","author":"de Kloet","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mcn.2020.103586_bb0030","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1089\/neu.2016.4618","article-title":"Mild traumatic brain injury: longitudinal study of cognition, functional status, and post-traumatic symptoms","volume":"34","author":"Dikmen","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mcn.2020.103586_bb0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1113\/jphysiol.2004.080028","article-title":"Subunit-specific gating controls rat NR1\/NR2A and NR1\/NR2B NMDA channel kinetics and synaptic signalling profiles","volume":"563","author":"Erreger","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.mcn.2020.103586_bb0040","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroscience.2011.01.028","article-title":"Heightening of the stress response during the first weeks after a mild traumatic brain injury","volume":"178","author":"Griesbach","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2020.103586_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11910-015-0545-1","article-title":"Glutamate and GABA imbalance following traumatic brain injury","volume":"15","author":"Guerriero","year":"2015","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.mcn.2020.103586_bb0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/neu.1994.11.187","article-title":"The Rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury","volume":"11","author":"Hamm","year":"1994","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mcn.2020.103586_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep12559","article-title":"Calcitonin gene-related peptide pre-administration acts as a novel antidepressant in stressed mice","volume":"5","author":"Hashikawa-Hobara","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcn.2020.103586_bb0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJMoa072972","article-title":"Mild traumatic brain injury in U.S. soldiers returning from Iraq","volume":"358","author":"Hoge","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mcn.2020.103586_bb0065","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1089\/neu.2015.4146","article-title":"Minimal Traumatic Brain Injury in Mice: Protease-Activated Receptor 1 and Thrombin-Related Changes","volume":"33","author":"Itsekson-Hayosh","year":"2016","journal-title":"Journal of Neurotrauma"},{"key":"10.1016\/j.mcn.2020.103586_bb0070","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrn2632","article-title":"The neuro-symphony of stress","volume":"10","author":"Jo\u00ebls","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mcn.2020.103586_bb0075","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.neuropharm.2015.10.014","article-title":"Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)","volume":"101","author":"Lesniak","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mcn.2020.103586_bb0080","doi-asserted-by":"crossref","first-page":"8633","DOI":"10.1523\/JNEUROSCI.1901-09.2009","article-title":"Differential modulation of long-term depression by acute stress in the rat dorsal and ventral hippocampus","volume":"29","author":"Maggio","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2020.103586_bb0085","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1100\/tsw.2010.48","article-title":"Corticosteroid regulation of synaptic plasticity in the hippocampus","volume":"10","author":"Maggio","year":"2010","journal-title":"TheScientificWorldJournal"},{"key":"10.1016\/j.mcn.2020.103586_bb0090","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.biopsych.2010.11.026","article-title":"Persistent changes in ability to express long-term potentiation\/depression in the rat hippocampus after juvenile\/adult stress","volume":"69","author":"Maggio","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.mcn.2020.103586_bb0095","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fncel.2012.00012","article-title":"Steroid modulation of hippocampal plasticity: switching between cognitive and emotional memories","volume":"6","author":"Maggio","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2020.103586_bb0100","doi-asserted-by":"crossref","first-page":"14960","DOI":"10.1073\/pnas.1516016112","article-title":"Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity","volume":"112","author":"Nascaa","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2020.103586_bb0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5271\/sjweh.1131","article-title":"Cognitive function in outpatients with perceived chronic stress","volume":"33","author":"\u00d6hman","year":"2007","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.mcn.2020.103586_bb0110","series-title":"Stress Resilience","author":"O\u2019Leary","year":"2020"},{"key":"10.1016\/j.mcn.2020.103586_bb0115","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fnmol.2017.00244","article-title":"Chronic stress triggers expression of immediate early genes and differentially affects the expression of AMPA and NMDA subunits in dorsal and ventral hippocampus of rats","volume":"10","author":"Pacheco","year":"2017","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"10.1016\/j.mcn.2020.103586_bb0120","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00221-002-1355-7","article-title":"Increased hippocampal uptake of tumor necrosis factor \u03b1 and behavioral changes in mice","volume":"149","author":"Pan","year":"2003","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.mcn.2020.103586_bb0125","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/geroni\/igx004.1552","article-title":"Association of psychosocial work stress with cognitive decline and brain structure differences","volume":"1","author":"Pan","year":"2017","journal-title":"Innov. Aging"},{"key":"10.1016\/j.mcn.2020.103586_bb0130","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/arclin\/17.4.319","article-title":"Patient complaints within 1 month of mild traumatic brain injury: a controlled study","volume":"17","author":"Paniak","year":"2002","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.mcn.2020.103586_bb0135","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1212\/WNL.48.3.581","volume":"48","author":"Practice parameter: The management of concussion in sports (summary statement)","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.mcn.2020.103586_bb0140","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hipo.20751","article-title":"Stress-induced dynamic routing of hippocampal connectivity: a hypothesis","volume":"20","author":"Segal","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.mcn.2020.103586_bb0145","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1089\/089771501750357609","article-title":"Defining acute mild head injury in adults: a proposal based on prognostic factors, diagnosis, and management","volume":"18","author":"Servadei","year":"2001","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mcn.2020.103586_bb0150","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fncel.2017.00299","article-title":"Stress and corticosteroids modulate muscarinic long term potentiation (mLTP) in the hippocampus","volume":"11","author":"Shavit Stein","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2020.103586_bb0155","series-title":"MMWR. Surveillance Summaries","first-page":"1","article-title":"Traumatic brain injury\u2013related emergency department visits, hospitalizations, and deaths \u2014 United States, 2007 and 2013","volume":"66","author":"Taylor","year":"2017"},{"key":"10.1016\/j.mcn.2020.103586_bb0160","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1212\/WNL.0b013e3182553c38","article-title":"Treatment consent capacity in patients with traumatic brain injury across a range of injury severity","volume":"78","author":"Triebel","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.mcn.2020.103586_bb0165","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1037\/mil0000159","article-title":"Battlefield trauma training: A pilot study comparing the effects of live tissue vs. high-fidelity patient simulator on stress, cognitive function, and performance","volume":"29","author":"Vartanian","year":"2017","journal-title":"Military Psychology"},{"key":"10.1016\/j.mcn.2020.103586_bb0170","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1468-1331.2002.00407.x","article-title":"EFNS guideline on mild traumatic brain injury: report of an EFNS task force","volume":"9","author":"Vos","year":"2002","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.mcn.2020.103586_bb0175","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcn.2020.103586_bb0180","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jaut.2016.06.011","article-title":"Annexin A2, autoimmunity, anxiety and depression","volume":"73","author":"Weiss","year":"2016","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/j.mcn.2020.103586_bb0185","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0006-8993(99)01664-9","article-title":"Mouse strains differ in their sensitivity to alprazolam effect in the staircase test","volume":"839","author":"Weizman","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.mcn.2020.103586_bb0190","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0306-4522(03)00048-4","article-title":"Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice","volume":"118","author":"Zohar","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2020.103586_bb0195","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neulet.2005.10.099","article-title":"Morphine protects for head trauma induced cognitive deficits in mice","volume":"394","author":"Zohar","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mcn.2020.103586_bb0200","doi-asserted-by":"crossref","first-page":"36","DOI":"10.55782\/ane-2011-1821","article-title":"Behavioral consequences of minimal traumatic brain injury in mice","volume":"71","author":"Zohar","year":"2011","journal-title":"Acta Neurobiol. Exp."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743120302098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743120302098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T01:09:42Z","timestamp":1760922582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743120302098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":40,"alternative-id":["S1044743120302098"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2020.103586","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unexpected role of stress as a possible resilience mechanism upon mild traumatic brain injury (mTBI) in mice","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2020.103586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103586"}}