{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:52:47Z","timestamp":1790679167958,"version":"4.1.0"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.mcn.2022.103705","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T11:39:16Z","timestamp":1644579556000},"page":"103705","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Differential expression of the neuronal CB1 cannabinoid receptor in the hippocampus of male Ts65Dn Down syndrome mouse model"],"prefix":"10.1016","volume":"119","author":[{"given":"Nadia","family":"Di Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Drutel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Roullot-Lacarri\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Julio-Kalajzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Lalanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Grel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Leste-Lasserre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Matias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Cannich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Cota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marsicano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Vincenzo","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Vall\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Revest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.mcn.2022.103705_bb0005","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1152\/physrev.00055.2003","article-title":"Adult neurogenesis: from precursors to network and physiology","volume":"85","author":"Abrous","year":"2005","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.mcn.2022.103705_bb0010","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1021\/pr2011582","article-title":"Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome","volume":"11","author":"Ahmed","year":"2012","journal-title":"J. Proteome Res."},{"issue":"7","key":"10.1016\/j.mcn.2022.103705_bb0015","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1101\/lm.866408","article-title":"c-Rel, an NF-\u03baB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation","volume":"15","author":"Ahn","year":"2008","journal-title":"Learn. Mem."},{"issue":"21","key":"10.1016\/j.mcn.2022.103705_bb0020","doi-asserted-by":"crossref","first-page":"11788","DOI":"10.1073\/pnas.1921314117","article-title":"Prefrontal\u2013hippocampal functional connectivity encodes recognition memory and is impaired in intellectual disability","volume":"117","author":"Alemany-Gonz\u00e1lez","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"18","key":"10.1016\/j.mcn.2022.103705_bb0025","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/hmg\/10.18.1915","article-title":"Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome","volume":"10","author":"Altafaj","year":"2001","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.mcn.2022.103705_bb0030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3233\/JAD-142349","article-title":"Elevation of plasma 2-arachidonoylglycerol levels in Alzheimer's disease patients as a potential protective mechanism against neurodegenerative decline","volume":"46","author":"Altamura","year":"2015","journal-title":"J. Alzheimers Dis."},{"issue":"3","key":"10.1016\/j.mcn.2022.103705_bb0035","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrg.2016.154","article-title":"Down syndrome and the complexity of genome dosage imbalance","volume":"18","author":"Antonarakis","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mcn.2022.103705_bb0040","first-page":"5","article-title":"MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia","author":"Aylward","year":"1999","journal-title":"Am. J. Psychiatry"},{"issue":"6","key":"10.1016\/j.mcn.2022.103705_bb5000","article-title":"Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1\/Yey mouse models of Down syndrome","volume":"11","author":"Aziz","year":"2018","journal-title":"Dis. Model. Mech."},{"issue":"3","key":"10.1016\/j.mcn.2022.103705_bb0045","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/092986607780090829","article-title":"Critical enzymes involved in endocannabinoid metabolism","volume":"14","author":"Basavarajappa","year":"2007","journal-title":"Protein Peptide Lett."},{"issue":"4","key":"10.1016\/j.mcn.2022.103705_bb0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cne.21433","article-title":"Synaptic and cognitive abnormalities in mouse models of down syndrome: exploring genotype-phenotype relationships","volume":"504","author":"Belichenko","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.mcn.2022.103705_bb0055","series-title":"PLOS ONE","article-title":"Down syndrome cognitive phenotypes modeled in mice trisomic for All HSA 21 homologues","volume":"10(7)","author":"Belichenko","year":"2015"},{"issue":"7","key":"10.1016\/j.mcn.2022.103705_bb0060","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1096\/fj.05-4743fje","article-title":"Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice","volume":"20","author":"Bilsland","year":"2006","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.mcn.2022.103705_bb5005","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1038\/s41380-021-01024-1","article-title":"PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory","volume":"26","author":"Bouarab","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"11","key":"10.1016\/j.mcn.2022.103705_bb0065","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/bies.201500046","article-title":"Dissecting the cannabinergic control of behavior: the where matters","volume":"37","author":"Busquets-Garcia","year":"2015","journal-title":"BioEssays"},{"issue":"11","key":"10.1016\/j.mcn.2022.103705_bb0070","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/mp.2017.4","article-title":"Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice","volume":"22","author":"Busquets-Garcia","year":"2017","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.mcn.2022.103705_bb0075","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/npp.2017.206","article-title":"CB1 receptor signaling in the brain: extracting specificity from ubiquity","volume":"43","author":"Busquets-Garcia","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.mcn.2022.103705_bb0080","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.mcn.2022.103705_bb0085","series-title":"Rosenberg\u2019s Molecular And Genetic Basis of Neurological And Psychiatric Disease","first-page":"163","article-title":"Chapter 15 - down syndrome","author":"Caban-Holt","year":"2015"},{"issue":"8","key":"10.1016\/j.mcn.2022.103705_bb0090","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nn.2600","article-title":"Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome","volume":"13","author":"Chakrabarti","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcn.2022.103705_bb0095","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neubiorev.2020.04.007","article-title":"The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: behavioral, anatomical and neurochemical properties","volume":"113","author":"Chao","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.mcn.2022.103705_bb0100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"issue":"9600","key":"10.1016\/j.mcn.2022.103705_bb0105","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/S0140-6736(07)61721-8","article-title":"Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials","volume":"370","author":"Christensen","year":"2007","journal-title":"Lancet (London, England)"},{"issue":"7","key":"10.1016\/j.mcn.2022.103705_bb0110","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/dmrr.764","article-title":"CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism, and cardiovascular health","volume":"23","author":"Cota","year":"2007","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.mcn.2022.103705_bb0115","first-page":"263","article-title":"Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome","volume":"360","author":"Davisson","year":"1990","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.mcn.2022.103705_bb0120","first-page":"117","article-title":"Segmental trisomy as a mouse model for Down syndrome","volume":"384","author":"Davisson","year":"1993","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.mcn.2022.103705_bb0125","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.drugalcdep.2010.05.019","article-title":"Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by \u0394(9)-tetrahydrocannabinol","volume":"112","author":"DeLong","year":"2010","journal-title":"Drug Alcohol Depend."},{"issue":"12","key":"10.1016\/j.mcn.2022.103705_bb0130","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nrn3314","article-title":"Down syndrome: the brain in trisomic mode","volume":"13","author":"Dierssen","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"11","key":"10.1016\/j.mcn.2022.103705_bb0135","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s00335-011-9356-0","article-title":"Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome","volume":"22","author":"Duchon","year":"2011","journal-title":"Mamm. Genome"},{"issue":"9","key":"10.1016\/j.mcn.2022.103705_bb0140","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/hmg\/ddab012","article-title":"Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models","volume":"30","author":"Duchon","year":"2021","journal-title":"Hum. Mol. Genet."},{"issue":"2\u20133","key":"10.1016\/j.mcn.2022.103705_bb0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3940(98)00317-6","article-title":"Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome","volume":"247","author":"Escorihuela","year":"1998","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.mcn.2022.103705_bb0150","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.mcn.2022.103705_bb0155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/hipo.1036","article-title":"Dorsal\/ventral hippocampus, fornix, and conditioned place preference","volume":"11","author":"Ferbinteanu","year":"2001","journal-title":"Hippocampus"},{"key":"10.1016\/j.mcn.2022.103705_bb0160","first-page":"121","article-title":"Constitutive activity in cannabinoid receptors","volume":"70","author":"Fong","year":"2014","journal-title":"Adv. Pharmacol. (San Diego, Calif.)"},{"key":"10.1016\/j.mcn.2022.103705_bb0165","first-page":"103","article-title":"Pharmacological approaches to improving cognitive function in down syndrome: current status and considerations","volume":"9","author":"Gardiner","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"issue":"45","key":"10.1016\/j.mcn.2022.103705_bb0170","doi-asserted-by":"crossref","first-page":"14943","DOI":"10.1523\/JNEUROSCI.3728-10.2010","article-title":"Down syndrome: from understanding the neurobiology to therapy","volume":"30","author":"Gardiner","year":"2010","journal-title":"J. Neurosci."},{"issue":"11\u201312","key":"10.1016\/j.mcn.2022.103705_bb0175","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s00335-016-9661-8","article-title":"Mouse models of down syndrome: gene content and consequences","volume":"27","author":"Gupta","year":"2016","journal-title":"Mamm. Genome"},{"issue":"5","key":"10.1016\/j.mcn.2022.103705_bb0180","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.cell.2012.01.037","article-title":"Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD","volume":"148","author":"Han","year":"2012","journal-title":"Cell"},{"issue":"7630","key":"10.1016\/j.mcn.2022.103705_bb0185","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nature20127","article-title":"A cannabinoid link between mitochondria and memory","volume":"539","author":"Hebert-Chatelain","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mcn.2022.103705_bb0190","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cmet.2012.12.005","article-title":"Adaptive downregulation of mitochondrial function in down syndrome","volume":"17","author":"Helguera","year":"2013","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.mcn.2022.103705_bb0195","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0361-9230(90)90044-Z","article-title":"Hippocampal pathway to the amygdala and stress ulcer development","volume":"25","author":"Henke","year":"1990","journal-title":"Brain Res. Bull."},{"issue":"10","key":"10.1016\/j.mcn.2022.103705_bb0200","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1242\/dmm.029728","article-title":"Rodent models in Down syndrome research: impact and future opportunities","volume":"10","author":"Herault","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.mcn.2022.103705_bb0205","article-title":"Altered distribution of hippocampal interneurons in the murine Down syndrome model Ts65Dn","volume":"40","author":"Hern\u00e1ndez-Gonz\u00e1lez","year":"2014","journal-title":"Neurochem. Res."},{"issue":"12","key":"10.1016\/j.mcn.2022.103705_bb0210","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1542\/pir.34.12.573","article-title":"Down syndrome","volume":"34","author":"Hobson-Rohrer","year":"2013","journal-title":"Pediatr. Rev."},{"issue":"5","key":"10.1016\/j.mcn.2022.103705_bb0215","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/hipo.450040503","article-title":"Localization of mRNAs encoding two forms of glutamic acid decarboxylase in the rat hippocampal formation","volume":"4","author":"Houser","year":"1994","journal-title":"Hippocampus"},{"issue":"5","key":"10.1016\/j.mcn.2022.103705_bb0220","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/ana.20250","article-title":"Minocycline prevents cholinergic loss in a mouse model of Down's syndrome","volume":"56","author":"Hunter","year":"2004","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.mcn.2022.103705_bb0225","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/1098-2302(2001)38:1<33::AID-DEV3>3.0.CO;2-0","article-title":"Motor learning in Ts65Dn mice, a model for Down syndrome","volume":"38","author":"Hyde","year":"2001","journal-title":"Dev. Psychobiol."},{"issue":"1","key":"10.1016\/j.mcn.2022.103705_bb0230","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/(SICI)1097-0029(19981001)43:1<8::AID-JEMT2>3.0.CO;2-4","article-title":"Human medial temporal lobe in aging: anatomical basis of memory preservation","volume":"43","author":"Insausti","year":"1998","journal-title":"Microsc. Res. Tech."},{"issue":"1","key":"10.1016\/j.mcn.2022.103705_bb0235","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nlm.2012.04.008","article-title":"Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo","volume":"98","author":"Jacob","year":"2012","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.mcn.2022.103705_bb0240","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neubiorev.2018.12.026","article-title":"Progress in brain cannabinoid CB2 receptor research: from genes to behavior","volume":"98","author":"Jordan","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.mcn.2022.103705_bb0245","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1152\/physrev.00019.2008","article-title":"Endocannabinoid-mediated control of synaptic transmission","volume":"89","author":"Kano","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mcn.2022.103705_bb0250","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1146\/annurev-neuro-062111-150420","article-title":"Multiple functions of endocannabinoid signaling in the brain","volume":"35","author":"Katona","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"issue":"11","key":"10.1016\/j.mcn.2022.103705_bb0255","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1523\/JNEUROSCI.4872-05.2006","article-title":"The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum","volume":"26","author":"Kawamura","year":"2006","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.mcn.2022.103705_bb0260","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1523\/JNEUROSCI.4166-04.2005","article-title":"Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro","volume":"25","author":"Kim","year":"2005","journal-title":"J. Neurosci."},{"issue":"16","key":"10.1016\/j.mcn.2022.103705_bb0265","doi-asserted-by":"crossref","first-page":"10825","DOI":"10.1073\/pnas.152112399","article-title":"Reduced fear expression after lesions of the ventral hippocampus","volume":"99","author":"Kjelstrup","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"37","key":"10.1016\/j.mcn.2022.103705_bb0270","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1523\/JNEUROSCI.1766-04.2004","article-title":"Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome","volume":"24","author":"Kleschevnikov","year":"2004","journal-title":"J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.mcn.2022.103705_bb0275","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2004.06.075","article-title":"Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome","volume":"1022","author":"Kurt","year":"2004","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.mcn.2022.103705_bb0280","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1242\/dmm.008078","article-title":"Down syndrome: searching for the genetic culprits","volume":"4","author":"Lana-Elola","year":"2011","journal-title":"Dis. Model. Mech."},{"issue":"8","key":"10.1016\/j.mcn.2022.103705_bb0285","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1111\/j.1476-5381.2012.02175.x","article-title":"The dynamic nature of type 1 cannabinoid receptor (CB(1)) gene transcription","volume":"167","author":"Laprairie","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.mcn.2022.103705_bb0290","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/hmg\/ddm086","article-title":"Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities","volume":"16","author":"Li","year":"2007","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.mcn.2022.103705_bb5010","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.mcn.2022.103705_bb0295","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainres.2006.05.022","article-title":"Hippocampal hypocellularity in the Ts65Dn mouse originates early in development","volume":"1104","author":"Lorenzi","year":"2006","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.mcn.2022.103705_bb0300","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.bbadis.2011.12.010","article-title":"Antioxidants in Down syndrome","volume":"1822","author":"Lott","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.mcn.2022.103705_bb0305","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","article-title":"An introduction to the endogenous cannabinoid system","volume":"79","author":"Lu","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.mcn.2022.103705_bb0310","series-title":"PLoS ONE","article-title":"Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of Down syndrome","volume":"9(12)","author":"Lysenko","year":"2014"},{"issue":"5\u20136","key":"10.1016\/j.mcn.2022.103705_bb0315","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.pneurobio.2006.11.006","article-title":"The endocannabinoid pathway in Huntington's disease: a comparison with other neurodegenerative diseases","volume":"81","author":"Maccarrone","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.mcn.2022.103705_bb0320","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-3-540-88955-7_8","article-title":"Roles of the endocannabinoid system in learning and memory","volume":"1","author":"Marsicano","year":"2009","journal-title":"Curr. Top. Behav. Neurosci."},{"issue":"12","key":"10.1016\/j.mcn.2022.103705_bb0325","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1046\/j.1460-9568.1999.00847.x","article-title":"Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain: CB1 expression in murine forebrain","volume":"11","author":"Marsicano","year":"1999","journal-title":"Eur. J. Neurosci."},{"issue":"6897","key":"10.1016\/j.mcn.2022.103705_bb0330","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature00839","article-title":"The endogenous cannabinoid system controls extinction of aversive memories","volume":"418","author":"Marsicano","year":"2002","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mcn.2022.103705_bb0335","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00018-007-6336-3","article-title":"The rodent hippocampus and spatial memory: from synapses to systems","volume":"64","author":"Martin","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"issue":"1\u20132","key":"10.1016\/j.mcn.2022.103705_bb0340","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0166-4328(02)00026-8","article-title":"Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for down syndrome","volume":"134","author":"Mart\u00ednez-Cu\u00e9","year":"2002","journal-title":"Behav. Brain Res."},{"issue":"7","key":"10.1016\/j.mcn.2022.103705_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042399","article-title":"Endocannabinoids measurement in human saliva as potential biomarker of obesity","volume":"7","author":"Matias","year":"2012","journal-title":"PloS One"},{"issue":"12","key":"10.1016\/j.mcn.2022.103705_bb0350","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/hipo.22664","article-title":"GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of Down syndrome: exploring the role of app: GABAergic interneurons in down syndrome","volume":"26","author":"Mojabi","year":"2016","journal-title":"Hippocampus"},{"issue":"6","key":"10.1016\/j.mcn.2022.103705_bb0355","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/(SICI)1098-1063(1998)8:6<608::AID-HIPO3>3.0.CO;2-7","article-title":"Functional differentiation in the hippocampus","volume":"8","author":"Moser","year":"1998","journal-title":"Hippocampus"},{"issue":"21","key":"10.1016\/j.mcn.2022.103705_bb0360","doi-asserted-by":"crossref","first-page":"9697","DOI":"10.1073\/pnas.92.21.9697","article-title":"Spatial learning with a minislab in the dorsal hippocampus","volume":"92","author":"Moser","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mcn.2022.103705_bb0365","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.nbd.2019.01.014","article-title":"Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome","volume":"125","author":"Navarro-Romero","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2022.103705_bb0370","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/724904","article-title":"Oxidative stress and Down syndrome: a route toward Alzheimer-like dementia","volume":"2012","author":"Perluigi","year":"2012","journal-title":"Curr. Gerontol. Geriatr. Res."},{"issue":"3","key":"10.1016\/j.mcn.2022.103705_bb0375","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.0953-816X.2004.03170.x","article-title":"Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within-subject, within-task comparison of reference and working spatial memory","volume":"19","author":"Pothuizen","year":"2004","journal-title":"Eur. J. Neurosci."},{"issue":"17","key":"10.1016\/j.mcn.2022.103705_bb0380","doi-asserted-by":"crossref","first-page":"R764","DOI":"10.1016\/j.cub.2013.05.041","article-title":"Interplay of hippocampus and prefrontal cortex in memory","volume":"23","author":"Preston","year":"2013","journal-title":"Curr. Biol."},{"issue":"1607","key":"10.1016\/j.mcn.2022.103705_bb0385","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1098\/rstb.2011.0384","article-title":"Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids","volume":"367","author":"Puighermanal","year":"2012","journal-title":"Philos. Trans. R. Soc. B: Biol. Sci."},{"issue":"8","key":"10.1016\/j.mcn.2022.103705_bb0390","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1523\/JNEUROSCI.4540-04.2005","article-title":"Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation","volume":"25","author":"Ramirez","year":"2005","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.mcn.2022.103705_bb0395","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1095-177","article-title":"A mouse model for Down syndrome exhibits learning and behaviour deficits","volume":"11","author":"Reeves","year":"1995","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.mcn.2022.103705_bb0400","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s11910-018-0859-x","article-title":"Cannabinoids for treatment of MS symptoms: state of the evidence","volume":"18","author":"Rice","year":"2018","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.mcn.2022.103705_bb0405","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/3-540-26573-2_15","article-title":"Cannabinoid function in learning,memory and plasticity","author":"Riedel","year":"2005","journal-title":"Cannabinoids"},{"issue":"Pt 1","key":"10.1016\/j.mcn.2022.103705_bb0410","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1348\/014466505X29594","article-title":"Cognitive executive function in Down's syndrome","volume":"45","author":"Rowe","year":"2006","journal-title":"Br. J. Clin. Psychol."},{"issue":"5","key":"10.1016\/j.mcn.2022.103705_bb0415","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuropharm.2012.06.046","article-title":"AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid\/cannabinoid interaction studies","volume":"63","author":"Seely","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mcn.2022.103705_bb0420","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00921","article-title":"Dual influence of endocannabinoids on long-term potentiation of synaptic transmission","volume":"8","author":"Silva-Cruz","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mcn.2022.103705_bb0425","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2015.00267","article-title":"Pharmacological correction of excitation\/inhibition imbalance in Down syndrome mouse models","volume":"9","author":"Souchet","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.mcn.2022.103705_bb0430","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/B978-0-444-54299-1.00005-4","article-title":"Pathways to cognitive deficits in Down syndrome","volume":"197","author":"Sturgeon","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.mcn.2022.103705_bb0435","series-title":"Cannabinoids And the Brain","first-page":"15","article-title":"Biosynthesis of anandamide and 2-arachidonoylglycerol","author":"Sugiura","year":"2008"},{"issue":"10","key":"10.1016\/j.mcn.2022.103705_bb0440","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1176\/appi.ajp.160.10.1870","article-title":"Relation of corpus callosum and hippocampal size to age in nondemented adults with Down's syndrome","volume":"160","author":"Teipel","year":"2003","journal-title":"Am. J. Psychiatry"},{"issue":"15","key":"10.1016\/j.mcn.2022.103705_bb0445","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.cub.2019.06.041","article-title":"CB1 receptors in the anterior piriform cortex control odor preference memory","volume":"29","author":"Terral","year":"2019","journal-title":"Curr. Biol."},{"issue":"9","key":"10.1016\/j.mcn.2022.103705_bb0450","article-title":"Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome","volume":"17","author":"Toma","year":"2021","journal-title":"PLoS Comput. Biol."},{"issue":"6166","key":"10.1016\/j.mcn.2022.103705_bb0455","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.1243985","article-title":"Pregnenolone can protect the brain from cannabis intoxication","volume":"343","author":"Vall\u00e9e","year":"2014","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.mcn.2022.103705_bb0460","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcn.2022.103705_bb0465","article-title":"Long-term decreased cannabinoid type-1 receptor activity restores specific neurological phenotypes in the Ts65Dn mouse model of Down syndrome","author":"V\u00e1zquez-Oliver","year":"2021","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.mcn.2022.103705_bb0470","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2788.2009.01158.x","article-title":"Down syndrome: a cardiovascular perspective","volume":"53","author":"Vis","year":"2009","journal-title":"J. Intellect. Disab. Res."},{"key":"10.1016\/j.mcn.2022.103705_bb0475","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainres.2010.09.107","article-title":"Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice","volume":"1366","author":"Yu","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.mcn.2022.103705_bb0480","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2011.00057","article-title":"Effects of endocannabinoid system modulation on cognitive and emotional behavior","volume":"5","author":"Zanettini","year":"2011","journal-title":"Front. Behav. Neurosci."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743122000112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743122000112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T01:10:42Z","timestamp":1760922642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743122000112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":99,"alternative-id":["S1044743122000112"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2022.103705","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential expression of the neuronal CB1 cannabinoid receptor in the hippocampus of male Ts65Dn Down syndrome mouse model","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2022.103705","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103705"}}