{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:07:05Z","timestamp":1792624025020,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.mcn.2022.103784","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T21:35:07Z","timestamp":1665437707000},"page":"103784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation"],"prefix":"10.1016","volume":"123","author":[{"given":"Zhi","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2022.103784_bb0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tins.2010.11.001","article-title":"Repairing the Parkinsonian brain with neurotrophic factors","volume":"34","author":"Aron","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.mcn.2022.103784_bb0010","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6901286","article-title":"Umbilical cord as prospective source for mesenchymal stem cell-based therapy","volume":"2016","author":"Arutyunyan","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.mcn.2022.103784_bb0015","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/jcp.27182","article-title":"Stem cell-based therapy for Parkinson's disease with a focus on human endometrium-derived mesenchymal stem cells","volume":"234","author":"Bagheri-Mohammadi","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.mcn.2022.103784_bb0020","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","article-title":"Brain-derived neurotrophic factor and its clinical implications","volume":"11","author":"Bathina","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.mcn.2022.103784_bb0025","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.mcn.2022.103784_bb0030","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.4103\/1673-5374.211201","article-title":"Umbilical cord: an unlimited source of cells differentiable towards dopaminergic neurons","volume":"12","author":"Boroujeni","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.mcn.2022.103784_bb0035","first-page":"1771","article-title":"Effect of PI3K\/Akt\/mTOR signaling pathway on JNK3 in Parkinsonian rats","volume":"17","author":"Chen","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.mcn.2022.103784_bb0040","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.3892\/mmr.2014.2411","article-title":"HSP60 is involved in the neuroprotective effects of naloxone","volume":"10","author":"Cheng","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mcn.2022.103784_bb0045","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41467-020-15119-w","article-title":"Microglia clear neuron-released \u03b1-synuclein via selective autophagy and prevent neurodegeneration","volume":"11","author":"Choi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcn.2022.103784_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00024382-199901000-00001","article-title":"Heat shock proteins: facts, thoughts, and dreams","volume":"11","author":"De Maio","year":"1999","journal-title":"Shock"},{"key":"10.1016\/j.mcn.2022.103784_bb0055","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/brain\/awaa090","article-title":"Microglial exosomes facilitate \u03b1-synuclein transmission in Parkinson's disease","volume":"143","author":"Guo","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.mcn.2022.103784_bb0060","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.expneurol.2005.01.013","article-title":"Oxidative stress and inflammation in Parkinson's disease: is there a causal link?","volume":"193","author":"Hald","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mcn.2022.103784_bb0065","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41531-019-0105-5","article-title":"Emerging regenerative medicine and tissue engineering strategies for Parkinson's disease","volume":"6","author":"Harris","year":"2020","journal-title":"NPJ Parkinsons. Dis"},{"key":"10.1016\/j.mcn.2022.103784_bb0070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2018.12.034","article-title":"Brain-derived neurotrophic factor modified human umbilical cord mesenchymal stem cells-derived cholinergic-like neurons improve spatial learning and memory ability in Alzheimer's disease rats","volume":"1710","author":"Hu","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.mcn.2022.103784_bb0075","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev.biochem.72.121801.161629","article-title":"Trk receptors: roles in neuronal signal transduction","volume":"72","author":"Huang","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mcn.2022.103784_bb0080","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1007\/s12035-018-1419-8","article-title":"Cellular and molecular aspects of Parkinson treatment: future therapeutic perspectives","volume":"56","author":"Jamebozorgi","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mcn.2022.103784_bb0085","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pnpbp.2018.07.010","article-title":"Serum level of brain-derived neurotrophic factor in Parkinson's disease: a meta-analysis","volume":"88","author":"Jiang","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.mcn.2022.103784_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9010257","article-title":"Regulation of BDNF-TrkB signaling and potential therapeutic strategies for Parkinson's disease","volume":"9","author":"Jin","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mcn.2022.103784_bb0095","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5016768","article-title":"The effect of MSCs derived from the human umbilical cord transduced by fibroblast growth factor-20 on Parkinson's disease","volume":"2016","author":"Jinfeng","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.mcn.2022.103784_bb0100","article-title":"Parkinson's disease and mesenchymal stem cells: potential for cell-based therapy","volume":"2012","author":"Kitada","year":"2012","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.mcn.2022.103784_bb0105","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/stem.2827","article-title":"Neural stem cell grafts promote astroglia-driven neurorestoration in the aged Parkinsonian brain via Wnt\/\u03b2-catenin signaling","volume":"36","author":"L'Episcopo","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.mcn.2022.103784_bb0110","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1523\/JNEUROSCI.4760-07.2008","article-title":"A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS","volume":"28","author":"Lehnardt","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2022.103784_bb0115","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.expneurol.2016.02.003","article-title":"Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease","volume":"278","author":"Lelos","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mcn.2022.103784_bb0120","first-page":"855","article-title":"The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease","volume":"9","author":"Li","year":"2009","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.mcn.2022.103784_bb0125","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jconrel.2018.07.017","article-title":"Cell reprogramming approaches in gene- and cell-based therapies for Parkinson's disease","volume":"286","author":"Man","year":"2018","journal-title":"J. Control Release"},{"key":"10.1016\/j.mcn.2022.103784_bb0130","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/BF00689592","article-title":"Expression of the histocompatibility glycoprotein HLA-DR in neurological disease","volume":"76","author":"McGeer","year":"1988","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mcn.2022.103784_bb0135","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/02656730500041871","article-title":"Role of molecular chaperones in neurodegenerative disorders","volume":"21","author":"Meriin","year":"2005","journal-title":"Int. J. Hyperthermia"},{"key":"10.1016\/j.mcn.2022.103784_bb0140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00702-012-0828-5","article-title":"A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer","volume":"120","author":"Nakashima","year":"2013","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.mcn.2022.103784_bb0145","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3892\/ijo.2016.3449","article-title":"Tetramethylpyrazine induces differentiation of human umbilical cord-derived mesenchymal stem cells into neuron-like cells in vitro","volume":"48","author":"Nan","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.mcn.2022.103784_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031170","article-title":"BDNF as a promising therapeutic agent in Parkinson's disease","volume":"21","author":"Palasz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcn.2022.103784_bb0155","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1530\/JME-10-0125","article-title":"GDNF and protection of adult central catecholaminergic neurons","volume":"46","author":"Pascual","year":"2011","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mcn.2022.103784_bb0160","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41586-020-2388-4","article-title":"Reversing a model of Parkinson's disease with in situ converted nigral neurons","volume":"582","author":"Qian","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2022.103784_bb0165","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s40266-014-0160-x","article-title":"Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease","volume":"31","author":"Rodrigues","year":"2014","journal-title":"Drugs Aging"},{"key":"10.1016\/j.mcn.2022.103784_bb0170","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12640-015-9586-0","article-title":"Role of Nurr1 in the generation and differentiation of dopaminergic neurons from stem cells","volume":"30","author":"Rodr\u00edguez-Traver","year":"2016","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.mcn.2022.103784_bb0175","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1089\/scd.2008.0411","article-title":"Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease","volume":"18","author":"Sadan","year":"2009","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.mcn.2022.103784_bb0180","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/jnr.24488","article-title":"BDNF-overexpressing human mesenchymal stem cells mediate increased neuronal protection in vitro","volume":"97","author":"Scheper","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mcn.2022.103784_bb0185","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.yexcr.2017.05.018","article-title":"Engineered cartilage regeneration from adipose tissue derived-mesenchymal stem cells: a morphomolecular study on osteoblast, chondrocyte and apoptosis evaluation","volume":"357","author":"Szychlinska","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mcn.2022.103784_bb0190","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson's disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mcn.2022.103784_bb0195","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.4103\/1673-5374.270296","article-title":"Glial cells in intracerebral transplantation for Parkinson's disease","volume":"15","author":"Tomov","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.mcn.2022.103784_bb0200","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/stem.2651","article-title":"Concise review: mesenchymal stem cells in neurodegenerative diseases","volume":"35","author":"Volkman","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.mcn.2022.103784_bb0205","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/01616412.2020.1834775","article-title":"BDNF-overexpressing human umbilical cord mesenchymal stem cell-derived motor neurons improve motor function and prolong survival in amyotrophic lateral sclerosis mice","volume":"43","author":"Wang","year":"2021","journal-title":"Neurol. Res."},{"key":"10.1016\/j.mcn.2022.103784_bb0210","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4252\/wjsc.v12.i5.323","article-title":"Advances in treatment of neurodegenerative diseases: perspectives for combination of stem cells with neurotrophic factors","volume":"12","author":"Wang","year":"2020","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.mcn.2022.103784_bb0215","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/cbf.3204","article-title":"Study of differentiated human umbilical cord-derived mesenchymal stem cells transplantation on rat model of advanced parkinsonism","volume":"34","author":"Wang","year":"2016","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.mcn.2022.103784_bb0220","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1007\/s11064-015-1816-6","article-title":"Heat shock protein 60 affects behavioral improvement in a rat model of Parkinson's disease grafted with human umbilical cord mesenchymal stem cell-derived dopaminergic-like neurons","volume":"41","author":"Zhao","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mcn.2022.103784_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2017.03.029","article-title":"Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: recent developments","volume":"1665","author":"Zhao","year":"2017","journal-title":"Brain Res"},{"key":"10.1016\/j.mcn.2022.103784_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105094","article-title":"Activated microglia facilitate the transmission of \u03b1-synuclein in Parkinson's disease","volume":"148","author":"Zheng","year":"2021","journal-title":"Neurochem. Int."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743122000902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743122000902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T01:12:52Z","timestamp":1760922772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743122000902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":46,"alternative-id":["S1044743122000902"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2022.103784","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2022.103784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103784"}}