{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:40:09Z","timestamp":1790728809785,"version":"4.1.0"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.mcn.2023.103853","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T06:08:47Z","timestamp":1682316527000},"page":"103853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The Translocase of the Outer Mitochondrial Membrane (TOM40) is required for mitochondrial dynamics and neuronal integrity in Dorsal Root Ganglion Neurons"],"prefix":"10.1016","volume":"125","author":[{"given":"Caitlin","family":"Overmeyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupinder P.S.","family":"Vohra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2023.103853_bb0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mito.2017.12.005","article-title":"Metabolic defects in multiple sclerosis","volume":"44","author":"Adiele","year":"2019","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mcn.2023.103853_bb0010","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1046\/j.1471-4159.2002.01047.x","article-title":"Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan","volume":"82","author":"Akao","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mcn.2023.103853_bb0015","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuint.2013.08.013","article-title":"Axon degeneration is key component of neuronal death in amyloid-\u03b2 toxicity","volume":"63","author":"Alobuia","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.mcn.2023.103853_bb0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.expneurol.2008.01.010","article-title":"Mitochondrial fusion and function in charcot-Marie-tooth type 2A patient fibroblasts with mitofusin 2 mutations","volume":"211","author":"Amiott","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mcn.2023.103853_bb0025","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41586-019-1680-7","article-title":"Structure of the mitochondrial import gate reveals distinct preprotein paths","volume":"575","author":"Araiso","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2023.103853_bb0030","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1038\/s41598-021-85510-0","article-title":"The TOMM40 \u201c523\u201d polymorphism in disease risk and age of symptom onset in two independent cohorts of Parkinson\u2019s disease","volume":"11","author":"Bakeberg","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcn.2023.103853_bb0035","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3390\/ijms18081812","article-title":"Regulation of mitochondrial structure and dynamics by the cytoskeleton and mechanical factors","volume":"18","author":"Bartol\u00e1k-Suki","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcn.2023.103853_bb0040","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.tins.2016.01.007","article-title":"Calpain-1 and Calpain-2: the yin and Yang of synaptic plasticity and neurodegeneration","volume":"39","author":"Baudry","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.mcn.2023.103853_bb0045","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/CIRCRESAHA.119.316306","article-title":"Role of mitochondrial calcium and the permeability transition pore in regulating cell death","volume":"126","author":"Bauer","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.mcn.2023.103853_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062277","article-title":"TOM40 mediates mitochondrial dysfunction induced by \u03b1-synuclein accumulation in Parkinson\u2019s disease","volume":"8","author":"Bender","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.mcn.2023.103853_bb0055","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3389\/fncel.2016.00179","article-title":"Mitochondrial dynamics decrease prior to axon degeneration induced by vincristine and are partially rescued by overexpressed cytNmnat1","volume":"10","author":"Berbusse","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2023.103853_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.23-01-00002.2003","article-title":"Actin-ATP hydrolysis is a major energy drain for neurons","volume":"23","author":"Bernstein","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2023.103853_bb0065","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.4161\/auto.25884","article-title":"The TOMM machinery is a molecular switch in PINK1 and PARK2\/PARKIN-dependent mitochondrial clearance","volume":"9","author":"Bertolin","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.mcn.2023.103853_bb0070","doi-asserted-by":"crossref","first-page":"13653","DOI":"10.3390\/ijms232113653","article-title":"Mitochondrial effects of common cardiovascular medications: the good, the bad and the mixed","volume":"23","author":"Be\u021biu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcn.2023.103853_bb0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2165\/11532140-000000000-00000","article-title":"Mitochondrial dynamics in Alzheimer\u2019s disease: opportunities for future treatment strategies","volume":"27","author":"Bonda","year":"2010","journal-title":"Drugs Aging"},{"key":"10.1016\/j.mcn.2023.103853_bb0080","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molmed.2019.10.007","article-title":"Regulation of mitochondrial ATP production: Ca2+ signaling and quality control","volume":"26","author":"Boyman","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mcn.2023.103853_bb0085","doi-asserted-by":"crossref","first-page":"C817","DOI":"10.1152\/ajpcell.00139.2004","article-title":"Calcium, ATP, and ROS: a mitochondrial love-hate triangle","volume":"287","author":"Brookes","year":"2004","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.mcn.2023.103853_bb0090","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1074\/jbc.273.6.3320","article-title":"Hibernation during hypoxia in cardiomyocytes. Role of mitochondria as the O2 sensor","volume":"273","author":"Budinger","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2023.103853_bb0095","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.nicl.2017.03.011","article-title":"Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson\u2019s disease","volume":"14","author":"Caminiti","year":"2017","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.mcn.2023.103853_bb0100","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1527-3458.2006.00135.x","article-title":"Involvement of calpain activation in neurodegenerative processes","volume":"12","author":"Camins","year":"2006","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.mcn.2023.103853_bb0105","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neuron.2017.01.019","article-title":"Parkinson sac domain mutation in synaptojanin 1 impairs clathrin uncoating at synapses and triggers dystrophic changes in dopaminergic axons","volume":"93","author":"Cao","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2023.103853_bb0110","doi-asserted-by":"crossref","first-page":"13059","DOI":"10.3390\/ijms222313059","article-title":"Mitochondrial biogenesis in neurons: how and where","volume":"22","author":"Cardanho-Ramos","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcn.2023.103853_bb0115","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbabio.2009.02.021","article-title":"Mitochondria, calcium and cell death: a deadly triad in neurodegeneration","volume":"1787","author":"Celsi","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcn.2023.103853_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/546163","article-title":"The dual role of calcium as messenger and stressor in cell damage, death, and survival","volume":"2010","author":"Cerella","year":"2010","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0125","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ana.21995","article-title":"Clinical progression in parkinson disease and the neurobiology of axons","volume":"67","author":"Cheng","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mcn.2023.103853_bb0130","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jalz.2018.01.015","article-title":"The effects of the TOMM40 poly-T alleles on Alzheimer\u2019s disease phenotypes","volume":"14","author":"Chiba-Falek","year":"2018","journal-title":"Alzheimers Dement. J. Alzheimers Assoc."},{"key":"10.1016\/j.mcn.2023.103853_bb0135","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3233\/JAD-121621","article-title":"Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer\u2019s disease","volume":"34","author":"Chong","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mcn.2023.103853_bb0140","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1523\/JNEUROSCI.5427-08.2009","article-title":"Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy","volume":"29","author":"Chung","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2023.103853_bb0145","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tcb.2016.11.004","article-title":"Bax and bak pores: are we closing the circle?","volume":"27","author":"Cosentino","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0150","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ceca.2011.04.001","article-title":"A dual role for Ca(2+) in autophagy regulation","volume":"50","author":"Decuypere","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mcn.2023.103853_bb0155","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nbd.2012.06.015","article-title":"Mitochondrial trafficking in neuropsychiatric diseases","volume":"51","author":"Deheshi","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2023.103853_bb0160","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.4161\/auto.25367","article-title":"Ca2+ in quality control: an unresolved riddle critical to autophagy and mitophagy","volume":"9","author":"East","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.mcn.2023.103853_bb0165","series-title":"The Oxford Handbook of the Neurobiology of Pain","article-title":"Dorsal root ganglion neuron types and their functional specialization","author":"Emery","year":"2020"},{"key":"10.1016\/j.mcn.2023.103853_bb0170","doi-asserted-by":"crossref","first-page":"E255","DOI":"10.1038\/ncb1101-e255","article-title":"Organelle-specific initiation of cell death pathways","volume":"3","author":"Ferri","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0175","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0960-9822(03)00206-9","article-title":"Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease","volume":"13","author":"Ferri","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0180","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.neuron.2021.02.009","article-title":"SARM1 is a metabolic sensor activated by an increased NMN\/NAD+ ratio to trigger axon degeneration","volume":"109","author":"Figley","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2023.103853_bb0185","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1207385","article-title":"ER tubules mark sites of mitochondrial division","volume":"334","author":"Friedman","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.mcn.2023.103853_bb0190","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/toxsci\/kfaa193","article-title":"Tributyltin alters calcium levels, mitochondrial dynamics, and activates calpains within dorsal root ganglion neurons","volume":"180","author":"Fross","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.mcn.2023.103853_bb0195","doi-asserted-by":"crossref","first-page":"607","DOI":"10.4161\/auto.6.5.11964","article-title":"Ca 2+ -dependent autophagy is enhanced by the pharmacological agent PK11195","volume":"6","author":"Gastaldello","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.mcn.2023.103853_bb0200","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.1258366","article-title":"SARM1 activation triggers axon degeneration locally via NAD+ destruction","volume":"348","author":"Gerdts","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.mcn.2023.103853_bb0205","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3233\/JAD-141590","article-title":"TOMM40 alterations in Alzheimer\u2019s disease over a 2-year follow-up period","volume":"44","author":"Goh","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mcn.2023.103853_bb0210","first-page":"12","article-title":"The broad impact of TOM40 on neurodegenerative diseases in aging","volume":"1","author":"Gottschalk","year":"2014","journal-title":"J. Park. Dis. Alzheimers Dis."},{"key":"10.1016\/j.mcn.2023.103853_bb0215","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature11910","article-title":"Autophagosomes form at ER-mitochondria contact sites","volume":"495","author":"Hamasaki","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2023.103853_bb0220","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.3390\/biom12111595","article-title":"Metabolic regulation of mitochondrial protein biogenesis from a neuronal perspective","volume":"12","author":"Hees","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.mcn.2023.103853_bb0225","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/dna.2018.4292","article-title":"Underappreciated roles of the translocase of the outer and inner mitochondrial membrane protein complexes in human disease","volume":"38","author":"Heinemeyer","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0230","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/dna.2018.4292","article-title":"Underappreciated roles of the translocase of the outer and inner mitochondrial membrane protein complexes in human disease","volume":"38","author":"Heinemeyer","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0235","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1242\/jcs.02745","article-title":"The axonal transport of mitochondria","volume":"118","author":"Hollenbeck","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mcn.2023.103853_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108588","article-title":"Small molecule SARM1 inhibitors recapitulate the SARM1-\/- phenotype and allow recovery of a metastable Pool of axons fated to degenerate","volume":"34","author":"Hughes","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcn.2023.103853_bb0245","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/emboj.2010.346","article-title":"Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction","volume":"30","author":"Iwasawa","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.mcn.2023.103853_bb0250","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.bbabio.2008.12.005","article-title":"Calcium regulation of mitochondria motility and morphology","volume":"1787","author":"Jeyaraju","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcn.2023.103853_bb0255","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s12640-017-9766-1","article-title":"Huntington\u2019s disease and mitochondria","volume":"32","author":"Jodeiri Farshbaf","year":"2017","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.mcn.2023.103853_bb0260","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/35069004","article-title":"Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death","volume":"410","author":"Joza","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2023.103853_bb0265","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.expneurol.2012.06.003","article-title":"Axonal degeneration in Alzheimer\u2019s disease: when signaling abnormalities meet the axonal transport system","volume":"246","author":"Kanaan","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mcn.2023.103853_bb0270","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","article-title":"The beclin 1 network regulates autophagy and apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mcn.2023.103853_bb0275","article-title":"The role of mitophagy in various neurological diseases as a therapeutic approach","author":"Kaur","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.mcn.2023.103853_bb0280","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.1074\/jbc.M106802200","article-title":"Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore","volume":"277","author":"Kidd","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2023.103853_bb0285","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3233\/JAD-2011-111343","article-title":"Antibodies against the tom40 subunit of the translocase of the outer mitochondrial membrane complex and cognitive impairment in Alzheimer\u2019s disease","volume":"29","author":"Kimura","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mcn.2023.103853_bb0290","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201912047","article-title":"SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration","volume":"219","author":"Ko","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0295","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1046\/j.1432-1327.1999.00724.x","article-title":"Thapsigargin directly induces the mitochondrial permeability transition","volume":"265","author":"Korge","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.mcn.2023.103853_bb0300","first-page":"864","article-title":"Endoplasmic reticulum-mitochondrial cross-talk in neurodegenerative and eye diseases","volume":"11","author":"Kumar","year":"2019","journal-title":"Neurol E-Cronicon"},{"key":"10.1016\/j.mcn.2023.103853_bb0305","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s10495-007-0749-1","article-title":"Bax activation and mitochondrial insertion during apoptosis","volume":"12","author":"Lalier","year":"2007","journal-title":"Apoptosis Int. J. Program Cell Death"},{"key":"10.1016\/j.mcn.2023.103853_bb0310","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jpsychires.2012.03.006","article-title":"Downregulation of TOMM40 expression in the blood of alzheimer disease subjects compared with matched controls","volume":"46","author":"Lee","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.mcn.2023.103853_bb0315","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3390\/genes12060871","article-title":"TOMM40 RNA transcription in Alzheimer\u2019s disease brain and its implication in mitochondrial dysfunction","volume":"12","author":"Lee","year":"2021","journal-title":"Genes"},{"issue":"3","key":"10.1016\/j.mcn.2023.103853_bb0320","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s13258-022-01359-1","article-title":"Genetic mutations affecting mitochondrial function in cancer drug resistance","volume":"45","author":"Lee","year":"2023","journal-title":"Genes Genomics"},{"issue":"Pt 1","key":"10.1016\/j.mcn.2023.103853_bb0325","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1113\/jphysiol.1996.sp021669","article-title":"The relationship between mitochondrial state, ATP hydrolysis, [Mg2+]i and [Ca2+]i studied in isolated rat cardiomyocytes","volume":"496","author":"Leyssens","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.mcn.2023.103853_bb0330","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1080\/15548627.2018.1474991","article-title":"Mitochondrial protein import regulates cytosolic protein homeostasis and neuronal integrity","volume":"14","author":"Liu","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.mcn.2023.103853_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101678","article-title":"Interrelation between ROS and Ca2+ in aging and age-related diseases","volume":"36","author":"Madreiter-Sokolowski","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0340","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1038\/sj.emboj.7601689","article-title":"Functional and physical interaction between bcl-X(L) and a BH3-like domain in Beclin-1","volume":"26","author":"Maiuri","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.mcn.2023.103853_bb0345","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1750-1326-4-20","article-title":"Calcium signaling in neurodegeneration","volume":"4","author":"Marambaud","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcn.2023.103853_bb0350","doi-asserted-by":"crossref","first-page":"18361","DOI":"10.1074\/jbc.M100655200","article-title":"Bcl-2 prevents bax oligomerization in the mitochondrial outer membrane","volume":"276","author":"Mikhailov","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2023.103853_bb0355","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/35023579","article-title":"Neurodegenerative stimuli induce persistent ADF\/cofilin-actin rods that disrupt distal neurite function","volume":"2","author":"Minamide","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0360","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3233\/JAD-170361","article-title":"TOMM40 and APOE gene expression and cognitive decline in Japanese Alzheimer\u2019s disease subjects","volume":"60","author":"Mise","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mcn.2023.103853_bb0365","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a036319","article-title":"BAX, BAK, and BOK: a coming of age for the BCL-2 family effector proteins","volume":"12","author":"Moldoveanu","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0370","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw1386","article-title":"BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites","volume":"5","author":"Namba","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mcn.2023.103853_bb0375","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.celrep.2013.09.020","article-title":"CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress","volume":"5","author":"Namba","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcn.2023.103853_bb0380","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1083\/jcb.139.2.327","article-title":"p28 Bap31, a bcl-2\/bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum","volume":"139","author":"Ng","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mcn.2023.103853_bb0385","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/35083608","article-title":"Mitochondrial endonuclease G is important for apoptosis in C. Elegans","volume":"412","author":"Parrish","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2023.103853_bb0390","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","article-title":"Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2023.103853_bb0395","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ceca.2017.06.008","article-title":"Calcium signaling and molecular mechanisms underlying neurodegenerative diseases","volume":"70","author":"Pchitskaya","year":"2018","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mcn.2023.103853_bb0400","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/febs.14186","article-title":"Bax, bak and beyond - mitochondrial performance in apoptosis","volume":"285","author":"Pe\u00f1a-Blanco","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.mcn.2023.103853_bb0405","doi-asserted-by":"crossref","first-page":"21634","DOI":"10.1038\/s41598-022-23280-z","article-title":"An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration","volume":"12","author":"Periasamy","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcn.2023.103853_bb0410","doi-asserted-by":"crossref","first-page":"19250","DOI":"10.1523\/JNEUROSCI.2148-13.2013","article-title":"Sodium channels contribute to degeneration of dorsal root ganglion neurites induced by mitochondrial dysfunction in an in vitro model of axonal injury","volume":"33","author":"Persson","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2023.103853_bb0415","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3390\/cells10061402","article-title":"Neuroprotection in glaucoma: NAD+\/NADH redox state as a potential biomarker and therapeutic target","volume":"10","author":"Petriti","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.mcn.2023.103853_bb0420","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neuint.2018.09.010","article-title":"Nicotinamide mononucleotide adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of golgi structure","volume":"121","author":"Pottorf","year":"2018","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.mcn.2023.103853_bb0425","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1086\/689592","article-title":"Imaging adenosine triphosphate (ATP)","volume":"231","author":"Rajendran","year":"2016","journal-title":"Biol. Bull."},{"key":"10.1016\/j.mcn.2023.103853_bb0430","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4103\/1673-5374.322430","article-title":"Mitochondrial dysfunctions in neurodegenerative diseases: role in disease pathogenesis, strategies for analysis and therapeutic prospects","volume":"17","author":"Rey","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.mcn.2023.103853_bb0435","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1126\/science.8235595","article-title":"Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria","volume":"262","author":"Rizzuto","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.mcn.2023.103853_bb0440","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.schres.2017.01.056","article-title":"Postmortem studies on mitochondria in schizophrenia","volume":"187","author":"Roberts","year":"2017","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.mcn.2023.103853_bb0445","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916674472","article-title":"A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels","volume":"12","author":"Rolyan","year":"2016","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mcn.2023.103853_bb0450","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/tpj.2009.69","article-title":"A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer\u2019s disease","volume":"10","author":"Roses","year":"2010","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.mcn.2023.103853_bb0455","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.bbamcr.2018.10.016","article-title":"Calcium, mitochondria and cell metabolism: a functional triangle in bioenergetics","volume":"1866","author":"Rossi","year":"2019","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.mcn.2023.103853_bb0460","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/13543784.2021.1849138","article-title":"Therapeutic considerations for APOE and TOMM40 in alzheimers disease: a tribute to Allen roses MD","volume":"30","author":"Sabbagh","year":"2021","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.mcn.2023.103853_bb0465","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.581767","article-title":"Axonal degeneration in AD: the contribution of A\u03b2 and tau","volume":"12","author":"Salvadores","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.mcn.2023.103853_bb0470","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1007\/s11010-021-04253-8","article-title":"Mitochondrial dysfunction in perinatal asphyxia: role in pathogenesis and potential therapeutic interventions","volume":"476","author":"Samaiya","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.mcn.2023.103853_bb0475","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s12035-014-8893-4","article-title":"The impact of mitochondrial fusion and fission modulation in sporadic Parkinson\u2019s disease","volume":"52","author":"Santos","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mcn.2023.103853_bb0480","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1523\/JNEUROSCI.1429-09.2009","article-title":"Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo","volume":"29","author":"Sasaki","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2023.103853_bb0485","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0272511","article-title":"Exosome mediated Tom40 delivery protects against hydrogen peroxide-induced oxidative stress by regulating mitochondrial function","volume":"17","author":"Sayeed","year":"2022","journal-title":"PloS One"},{"key":"10.1016\/j.mcn.2023.103853_bb0490","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1042\/BST20220323","article-title":"Protein-protein and protein-lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation","volume":"50","author":"Sekar","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mcn.2023.103853_bb0495","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/biology10040268","article-title":"Genetic neuropathy due to impairments in mitochondrial dynamics","volume":"10","author":"Sharma","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.mcn.2023.103853_bb0500","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2174\/156652413804810772","article-title":"The role of calcium stores in apoptosis and autophagy","volume":"13","author":"Smaili","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.mcn.2023.103853_bb0505","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/dneu.22546","article-title":"The role of mitochondria in axon development and regeneration","volume":"78","author":"Smith","year":"2018","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.mcn.2023.103853_bb0510","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/193461","article-title":"Endoplasmic reticulum is at the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in the pathogenesis of diabetes mellitus","volume":"2013","author":"Su","year":"2013","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.mcn.2023.103853_bb0515","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.chest.2019.08.2182","article-title":"Mitochondria and critical illness","volume":"157","author":"Supinski","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.mcn.2023.103853_bb0520","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.bbamcr.2006.04.002","article-title":"Mitochondrial dynamics and Ca2+ signaling","volume":"1763","author":"Szabadkai","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcn.2023.103853_bb0525","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.nbd.2015.07.009","article-title":"An early axonopathy in a hLRRK2(R1441G) transgenic model of parkinson disease","volume":"82","author":"Tagliaferro","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2023.103853_bb0530","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2022.12.003","article-title":"Mitochondrial dysfunction in down syndrome: from pathology to therapy","volume":"511","author":"Tan","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.mcn.2023.103853_bb0535","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1016\/S0021-9258(19)39106-9","article-title":"Phospholipid synthesis in a membrane fraction associated with mitochondria","volume":"265","author":"Vance","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2023.103853_bb0540","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-2613.2000.00169.x","article-title":"The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states: pathogenic activation of calpain","volume":"81","author":"Vanderklish","year":"2004","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.mcn.2023.103853_bb0545","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(00)00009-X","article-title":"Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins","volume":"102","author":"Verhagen","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.mcn.2023.103853_bb0550","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1007\/s11064-018-2649-x","article-title":"Enteric neurodegeneration is mediated through independent neuritic and somal mechanisms in rotenone and MPP+ toxicity","volume":"43","author":"Virga","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mcn.2023.103853_bb0555","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.nbd.2006.04.018","article-title":"Activation of apoptotic pathways at muscle fiber synapses is circumscribed and reversible in a slow-channel syndrome model","volume":"23","author":"Vohra","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2023.103853_bb0560","doi-asserted-by":"crossref","first-page":"13729","DOI":"10.1523\/JNEUROSCI.2939-10.2010","article-title":"Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway","volume":"30","author":"Vohra","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2023.103853_bb0565","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/brain\/awab426","article-title":"Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention","volume":"145","author":"van de Wal","year":"2022","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.mcn.2023.103853_bb0570","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.3390\/biom12121891","article-title":"Calcium overload and mitochondrial metabolism","volume":"12","author":"Walkon","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.mcn.2023.103853_bb0575","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bbamcr.2010.12.019","article-title":"Molecular biology of bax and bak activation and action","volume":"1813","author":"Westphal","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcn.2023.103853_bb0580","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3390\/cancers12051329","article-title":"TOM40 inhibits ovarian cancer cell growth by modulating mitochondrial function including intracellular ATP and ROS levels","volume":"12","author":"Yang","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.mcn.2023.103853_bb0585","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1016\/j.bbadis.2017.07.031","article-title":"The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer\u2019s disease","volume":"1863","author":"Zeitlow","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.mcn.2023.103853_bb0590","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1038\/s41598-017-02825-7","article-title":"Release of cytochrome C from bax pores at the mitochondrial membrane","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcn.2023.103853_bb0595","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.mcn.2023.103853_bb0600","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1089\/ars.2010.3359","article-title":"Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection","volume":"14","author":"Z\u00fcndorf","year":"2011","journal-title":"Antioxid. Redox Signal."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743123000477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743123000477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T03:22:27Z","timestamp":1715224947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743123000477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":120,"alternative-id":["S1044743123000477"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2023.103853","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Translocase of the Outer Mitochondrial Membrane (TOM40) is required for mitochondrial dynamics and neuronal integrity in Dorsal Root Ganglion Neurons","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2023.103853","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103853"}}