{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:05:04Z","timestamp":1775257504475,"version":"3.50.1"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.mcn.2024.103982","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:53:05Z","timestamp":1733187185000},"page":"103982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Microfluidics in neural extracellular vesicles characterization for early Alzheimer's disease diagnosis"],"prefix":"10.1016","volume":"132","author":[{"given":"Hossein","family":"Zare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Kasdorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirala","family":"Bakhshian Nik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0005","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JAD-191016","article-title":"A new serum biomarker set to detect mild cognitive impairment and Alzheimer\u2019s disease by peptidome technology","volume":"73","author":"Abe","year":"2020","journal-title":"J. Alzheimers Dis."},{"issue":"10","key":"10.1016\/j.mcn.2024.103982_bb0010","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1007\/s12035-020-02013-1","article-title":"Extracellular vesicles of Alzheimer\u2019s disease patients as a biomarker for disease progression","volume":"57","author":"Aharon","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mcn.2024.103982_bb0015","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fcvm.2017.00078","article-title":"Extracellular vesicles as mediators of cardiovascular calcification","volume":"4","author":"Bakhshian Nik","year":"2017","journal-title":"Front Cardiovasc Med"},{"issue":"9","key":"10.1016\/j.mcn.2024.103982_bb0020","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mcn.2024.103982_bb0025","article-title":"ImmunoInertial microfluidics: a novel strategy for isolation of small EV subpopulations","volume":"30","author":"Bazaz","year":"2023","journal-title":"Appl. Mater. Today"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0030","article-title":"Apolipoprotein E4\u2013driven effects on inflammatory and neurotrophic factors in peripheral extracellular vesicles from cognitively impaired, no dementia participants who converted to Alzheimer's disease","volume":"7","author":"Ben Khedher","year":"2021","journal-title":"Alzheimer's & Dementia: Translational Research & Clinical Interventions"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0035","doi-asserted-by":"crossref","first-page":"19656","DOI":"10.1038\/s41598-020-72355-2","article-title":"Extracellular vesicles from amyloid-beta exposed cell cultures induce severe dysfunction in cortical neurons","volume":"10","author":"Beretta","year":"2020","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.mcn.2024.103982_bb0040","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3390\/cells11121882","article-title":"MicroRNA networks in cognition and dementia","volume":"11","author":"Blount","year":"2022","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.mcn.2024.103982_bb0045","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1002\/alz.13134","article-title":"Alzheimer\u2019s disease brain-derived extracellular vesicles reveal altered synapse-related proteome and induce cognitive impairment in mice","volume":"19","author":"Bodart-Santos","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"9","key":"10.1016\/j.mcn.2024.103982_bb0055","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/aps.2017.28","article-title":"Amyloid beta: structure, biology and structure-based therapeutic development","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.mcn.2024.103982_bb0060","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bios.2018.09.033","article-title":"Detection of exosomes by ZnO nanowires coated three-dimensional scaffold chip device","volume":"122","author":"Chen","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"19","key":"10.1016\/j.mcn.2024.103982_bb0065","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1039\/C8LC00386F","article-title":"Detecting miRNA biomarkers from extracellular vesicles for cardiovascular disease with a microfluidic system","volume":"18","author":"Cheng","year":"2018","journal-title":"Lab Chip"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0070","doi-asserted-by":"crossref","first-page":"1766822","DOI":"10.1080\/20013078.2020.1766822","article-title":"Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles","volume":"9","author":"Cheng","year":"2020","journal-title":"Journal of Extracellular Vesicles"},{"key":"10.1016\/j.mcn.2024.103982_bb0075","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bios.2017.10.039","article-title":"Hydrogel micropost-based qPCR for multiplex detection of miRNAs associated with Alzheimer\u2019s disease","volume":"101","author":"Choi","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.mcn.2024.103982_bb0080","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/519816","article-title":"Magnetic resonance spectroscopy: an in vivo molecular imaging biomarker for Parkinson\u2019s disease?","volume":"2014","author":"Ciurleo","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.mcn.2024.103982_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.766082","article-title":"Multi-omics analysis of microglial extracellular vesicles from human Alzheimer\u2019s disease brain tissue reveals disease-associated signatures","volume":"12","author":"Cohn","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"21","key":"10.1016\/j.mcn.2024.103982_bb0090","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1039\/C7LC00592J","article-title":"Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine","volume":"17","author":"Contreras-Naranjo","year":"2017","journal-title":"Lab Chip"},{"issue":"19","key":"10.1016\/j.mcn.2024.103982_bb0095","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1007\/s00216-019-01621-8","article-title":"Advanced methods for microRNA biosensing: a problem-solving perspective","volume":"411","author":"D\u2019Agata","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"issue":"24","key":"10.1016\/j.mcn.2024.103982_bb0100","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1039\/c2lc41006k","article-title":"Microfluidic filtration system to isolate extracellular vesicles from blood","volume":"12","author":"Davies","year":"2012","journal-title":"Lab Chip"},{"key":"10.1016\/j.mcn.2024.103982_bb0105","series-title":"The Dementias: Hope Through Research","author":"Disorders, N.I.o.N., Stroke, and N.I.o. Aging","year":"2013"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0110","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/15421406.2015.1097003","article-title":"The detection of apolipoprotein E-epsilon 4 gene (APOE \u03f54) via fluorescence quenching of quantum dots incorporated magnetic beads in micro-fluidic chip","volume":"622","author":"Do","year":"2015","journal-title":"Mol. Cryst. Liq. Cryst."},{"key":"10.1016\/j.mcn.2024.103982_bb0115","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/625659","article-title":"Serum MicroRNA profiles serve as novel biomarkers for the diagnosis of Alzheimer\u2019s disease","volume":"2015","author":"Dong","year":"2015","journal-title":"Dis. Markers"},{"key":"10.1016\/j.mcn.2024.103982_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.580199","article-title":"Circulating exosome microRNAs as diagnostic biomarkers of dementia","volume":"12","author":"Dong","year":"2020","journal-title":"Front. Aging Neurosci."},{"issue":"6","key":"10.1016\/j.mcn.2024.103982_bb0125","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1007\/s12031-022-02012-y","article-title":"Alteration of miRNAs in small neuron-derived extracellular vesicles of Alzheimer\u2019s disease patients and the effect of extracellular vesicles on microglial immune responses","volume":"72","author":"Durur","year":"2022","journal-title":"J. Mol. Neurosci."},{"issue":"9","key":"10.1016\/j.mcn.2024.103982_bb0130","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/alz.12130","article-title":"Extracellular vesicle biomarkers of Alzheimer\u2019s disease associated with sub-clinical cognitive decline in late middle age","volume":"16","author":"Eren","year":"2020","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.mcn.2024.103982_bb0135","first-page":"1","article-title":"Advancement in analytical techniques for determining the activity of \u03b2-site amyloid precursor protein cleaving enzyme 1","author":"Fan","year":"2022","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.mcn.2024.103982_bb0140","first-page":"1","article-title":"Tau filaments are tethered within brain extracellular vesicles in Alzheimer\u2019s disease","author":"Fowler","year":"2024","journal-title":"Nat. Neurosci."},{"issue":"8","key":"10.1016\/j.mcn.2024.103982_bb0145","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1093\/brain\/awac083","article-title":"Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease","volume":"145","author":"Gabrielli","year":"2022","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13195-020-00623-4","article-title":"Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles","volume":"12","author":"Gallart-Palau","year":"2020","journal-title":"Alzheimers Res Ther"},{"issue":"8","key":"10.1016\/j.mcn.2024.103982_bb0155","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.neurobiolaging.2009.08.013","article-title":"Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer\u2019s disease","volume":"32","author":"Ghidoni","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mcn.2024.103982_bb0160","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1038\/ncomms3123","article-title":"Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma","volume":"4","author":"Grapp","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcn.2024.103982_bb0165","doi-asserted-by":"crossref","first-page":"240 e1","DOI":"10.1016\/j.neurobiolaging.2019.01.024","article-title":"Plasma microRNA profiling distinguishes patients with frontotemporal dementia from healthy subjects","volume":"84","author":"Grasso","year":"2019","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.mcn.2024.103982_bb0170","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jalz.2016.08.012","article-title":"Neuronal exosomes reveal Alzheimer\u2019s disease biomarkers in Down syndrome","volume":"13","author":"Hamlett","year":"2017","journal-title":"Alzheimers Dement."},{"issue":"8","key":"10.1016\/j.mcn.2024.103982_bb0175","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","article-title":"Association of amyloid and tau with cognition in preclinical Alzheimer disease: a longitudinal study","volume":"76","author":"Hanseeuw","year":"2019","journal-title":"JAMA Neurol."},{"issue":"19","key":"10.1016\/j.mcn.2024.103982_bb0180","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1039\/C4CS00026A","article-title":"Metal complexes designed to bind to amyloid-beta for the diagnosis and treatment of Alzheimer\u2019s disease","volume":"43","author":"Hayne","year":"2014","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"10.1016\/j.mcn.2024.103982_bb0185","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-210307","article-title":"Novel plasma miRNAs as biomarkers and therapeutic targets of Alzheimer\u2019s disease at the prodromal stage","volume":"83","author":"He","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"12","key":"10.1016\/j.mcn.2024.103982_bb0190","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13025","article-title":"Abeta and the dementia syndrome: simple versus complex perspectives","volume":"48","author":"Hunter","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.mcn.2024.103982_bb0195","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3892\/ijmm.2016.2488","article-title":"Role of Alix in miRNA packaging during extracellular vesicle biogenesis","volume":"37","author":"Iavello","year":"2016","journal-title":"Int. J. Mol. Med."},{"issue":"7","key":"10.1016\/j.mcn.2024.103982_bb0200","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1021\/acsnano.7b00549","article-title":"Rapid isolation and detection of exosomes and associated biomarkers from plasma","volume":"11","author":"Ibsen","year":"2017","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.mcn.2024.103982_bb0205","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"issue":"6","key":"10.1016\/j.mcn.2024.103982_bb0210","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.bbamem.2016.02.011","article-title":"Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases","volume":"1858","author":"Janas","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.mcn.2024.103982_bb0215","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/acn3.274","article-title":"CSF Abeta42\/Abeta40 and Abeta42\/Abeta38 ratios: better diagnostic markers of Alzheimer disease","volume":"3","author":"Janelidze","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0220","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s40478-023-01637-3","article-title":"Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer\u2019s disease","volume":"11","author":"Jang","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.mcn.2024.103982_bb0225","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.dadm.2018.01.002","article-title":"Cerebrospinal fluid and serum MHPG improve Alzheimer's disease versus dementia with Lewy bodies differential diagnosis","volume":"10","author":"Janssens","year":"2018","journal-title":"Alzheimers Dement (Amst)"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0230","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s12035-013-8544-1","article-title":"Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics","volume":"49","author":"Kalani","year":"2014","journal-title":"Mol. Neurobiol."},{"issue":"6106","key":"10.1016\/j.mcn.2024.103982_bb0235","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/325733a0","article-title":"The precursor of Alzheimer\u2019s disease amyloid A4 protein resembles a cell-surface receptor","volume":"325","author":"Kang","year":"1987","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.mcn.2024.103982_bb0240","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1039\/C4LC00136B","article-title":"Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes","volume":"14","author":"Kanwar","year":"2014","journal-title":"Lab Chip"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0245","doi-asserted-by":"crossref","first-page":"15437","DOI":"10.1038\/s41598-019-51837-y","article-title":"Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer\u2019s disease","volume":"9","author":"Kenny","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.mcn.2024.103982_bb0250","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","article-title":"The role of apolipoprotein E in Alzheimer's disease","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2024.103982_bb0255","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.bios.2014.10.042","article-title":"Magnetic bead droplet immunoassay of oligomer amyloid beta for the diagnosis of Alzheimer\u2019s disease using micro-pillars to enhance the stability of the oil-water interface","volume":"67","author":"Kim","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"23","key":"10.1016\/j.mcn.2024.103982_bb0260","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1039\/C8LC00672E","article-title":"Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles","volume":"18","author":"Ko","year":"2018","journal-title":"Lab Chip"},{"issue":"10","key":"10.1016\/j.mcn.2024.103982_bb0265","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1111\/j.1349-7006.2010.01650.x","article-title":"Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis","volume":"101","author":"Kosaka","year":"2010","journal-title":"Cancer Sci."},{"issue":"11","key":"10.1016\/j.mcn.2024.103982_bb0270","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1002\/alz.13055","article-title":"MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer\u2019s disease","volume":"19","author":"Kumar","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"10","key":"10.1016\/j.mcn.2024.103982_bb0275","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/bies.201100076","article-title":"Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers","volume":"33","author":"Lakhal","year":"2011","journal-title":"Bioessays"},{"issue":"3","key":"10.1016\/j.mcn.2024.103982_bb0280","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1021\/nn506538f","article-title":"Acoustic purification of extracellular microvesicles","volume":"9","author":"Lee","year":"2015","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0285","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1038\/s41467-023-43995-5","article-title":"Amplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer\u2019s disease from tear fluid","volume":"14","author":"Lee","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcn.2024.103982_bb0290","series-title":"Microfluidic Devices for Biomedical Applications","author":"Li","year":"2013"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0295","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13195-022-01010-x","article-title":"beta-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer\u2019s disease and predicts cerebral amyloidosis","volume":"14","author":"Li","year":"2022","journal-title":"Alzheimers Res. Ther."},{"issue":"11","key":"10.1016\/j.mcn.2024.103982_bb0300","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1039\/C5LC00240K","article-title":"Exosome isolation: a microfluidic road-map","volume":"15","author":"Liga","year":"2015","journal-title":"Lab Chip"},{"issue":"9","key":"10.1016\/j.mcn.2024.103982_bb0305","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201903916","article-title":"Progress in microfluidics-based exosome separation and detection technologies for diagnostic applications","volume":"16","author":"Lin","year":"2020","journal-title":"Small"},{"issue":"7","key":"10.1016\/j.mcn.2024.103982_bb0310","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1021\/acsnano.7b02277","article-title":"Field-free isolation of exosomes from extracellular vesicles by microfluidic viscoelastic flows","volume":"11","author":"Liu","year":"2017","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0315","doi-asserted-by":"crossref","first-page":"229","DOI":"10.14336\/AD.2022.0607","article-title":"Long RNA profiles of human brain extracellular vesicles provide new insights into the pathogenesis of Alzheimer\u2019s disease","volume":"14","author":"Luo","year":"2023","journal-title":"Aging Dis."},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0320","article-title":"Biomarkers for the diagnosis of Alzheimer's disease, dementia Lewy body, frontotemporal dementia and vascular dementia","volume":"32","author":"Maclin","year":"2019","journal-title":"Gen Psychiatr"},{"key":"10.1016\/j.mcn.2024.103982_bb0325","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.snb.2017.09.003","article-title":"Single-step immunoassays and microfluidic droplet operation: towards a versatile approach for detection of amyloid-\u03b2 peptide-based biomarkers of Alzheimer\u2019s disease","volume":"255","author":"Mai","year":"2018","journal-title":"Sensors and Actuators B-Chemical"},{"key":"10.1016\/j.mcn.2024.103982_bb0330","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neuint.2016.04.011","article-title":"Exosomes in Alzheimer\u2019s disease","volume":"97","author":"Malm","year":"2016","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0335","doi-asserted-by":"crossref","first-page":"11953","DOI":"10.1038\/s41598-020-68436-x","article-title":"Microdomains form on the luminal face of neuronal extracellular vesicle membranes","volume":"10","author":"Matthies","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0340","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1038\/s41598-017-01947-2","article-title":"\u201cTORNADO\u201d - theranostic one-step RNA detector; microfluidic disc for the direct detection of microRNA-134 in plasma and cerebrospinal fluid","volume":"7","author":"McArdle","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcn.2024.103982_bb0345","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bios.2013.10.069","article-title":"On-chip magneto-immunoassay for Alzheimer\u2019s biomarker electrochemical detection by using quantum dots as labels","volume":"54","author":"Medina-S\u00e1nchez","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.mcn.2024.103982_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135583","article-title":"Droplet microfluidic platform for extracellular vesicle isolation based on magnetic bead handling","volume":"409","author":"Meggiolaro","year":"2024","journal-title":"Sensors and Actuators B-Chemical"},{"issue":"40","key":"10.1016\/j.mcn.2024.103982_bb0355","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi5296","article-title":"Direct isolation of small extracellular vesicles from human blood using viscoelastic microfluidics","volume":"9","author":"Meng","year":"2023","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.mcn.2024.103982_bb0360","doi-asserted-by":"crossref","DOI":"10.1063\/1.4931394","article-title":"An integrated microfluidic chip for immunocapture, preconcentration and separation of beta-amyloid peptides","volume":"9","author":"Mohamadi","year":"2015","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.mcn.2024.103982_bb0365","series-title":"Electrophoretic Separation of Proteins","first-page":"327","article-title":"Microchip electrophoresis, with respect to profiling of A\u03b2 peptides in the cerebrospinal fluid of patients with Alzheimer\u2019s disease","author":"Mohamadi","year":"2019"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0370","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13024-023-00596-6","article-title":"The Alzheimer\u2019s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130","volume":"18","author":"M\u00fcller","year":"2023","journal-title":"Mol. Neurodegener."},{"issue":"6","key":"10.1016\/j.mcn.2024.103982_bb0375","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/alz.12089","article-title":"Proteomic and biological profiling of extracellular vesicles from Alzheimer\u2019s disease human brain tissues","volume":"16","author":"Muraoka","year":"2020","journal-title":"Alzheimers Dement."},{"issue":"9","key":"10.1016\/j.mcn.2024.103982_bb0380","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.3390\/cells9091959","article-title":"Proteomic profiling of extracellular vesicles derived from cerebrospinal fluid of Alzheimer\u2019s disease patients: a pilot study","volume":"9","author":"Muraoka","year":"2020","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.mcn.2024.103982_bb0385","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3233\/JAD-180578","article-title":"Extracellular vesicle biomarkers track cognitive changes following intranasal insulin in Alzheimer\u2019s disease","volume":"69","author":"Mustapic","year":"2019","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0390","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3233\/JAD-170278","article-title":"Increased release of apolipoprotein E in extracellular vesicles following amyloid-beta protofibril exposure of neuroglial co-cultures","volume":"60","author":"Nikitidou","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0395","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41380-022-01792-4","article-title":"Incretin and insulin signaling as novel therapeutic targets for Alzheimer\u2019s and Parkinson\u2019s disease","volume":"28","author":"Nowell","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.mcn.2024.103982_bb0400","doi-asserted-by":"crossref","first-page":"340","DOI":"10.20517\/evcna.2022.22","article-title":"Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells","volume":"3","author":"Osborne","year":"2022","journal-title":"Extracell Vesicles Circ Nucl Acids"},{"issue":"12","key":"10.1016\/j.mcn.2024.103982_bb0405","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1039\/C6LC00013D","article-title":"Droplet-based magnetic bead immunoassay using microchannel-connected multiwell plates (muCHAMPs) for the detection of amyloid beta oligomers","volume":"16","author":"Park","year":"2016","journal-title":"Lab Chip"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0410","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/brain\/awy289","article-title":"Apolipoprotein E4 genotype compromises brain exosome production","volume":"142","author":"Peng","year":"2019","journal-title":"Brain"},{"issue":"2 Dementia","key":"10.1016\/j.mcn.2024.103982_bb0415","first-page":"404","article-title":"Mild cognitive impairment","volume":"22","author":"Petersen","year":"2016","journal-title":"Continuum (Minneap Minn)"},{"issue":"3","key":"10.1016\/j.mcn.2024.103982_bb0050","article-title":"Assessing Alzheimer\u2019s disease via plasma extracellular vesicle\u2013derived mRNA. Alzheimer\u2019s & Dementia","volume":"16","author":"Pham","year":"2024","journal-title":"Diagnosis, Assessment & Disease Monitoring"},{"issue":"7","key":"10.1016\/j.mcn.2024.103982_bb0420","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.3390\/ijms25073830","article-title":"Microfluidic isolation of neuronal-enriched extracellular vesicles shows distinct and common neurological proteins in long COVID, HIV infection and Alzheimer\u2019s disease","volume":"25","author":"Pulliam","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"30","key":"10.1016\/j.mcn.2024.103982_bb0425","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1073\/pnas.0603838103","article-title":"Alzheimer\u2019s disease beta-amyloid peptides are released in association with exosomes","volume":"103","author":"Rajendran","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2024.103982_bb0430","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fnmol.2018.00388","article-title":"MicroRNA-210-5p contributes to cognitive impairment in early vascular dementia rat model through targeting Snap25","volume":"11","author":"Ren","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mcn.2024.103982_bb0435","series-title":"Alzheimer's Disease Decoded: The History, Present, and Future of Alzheimer's Disease and Dementia","author":"Ronald","year":"2016"},{"key":"10.1016\/j.mcn.2024.103982_bb0440","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/alz.13016","article-title":"2023 Alzheimer's disease facts and figures","volume":"19","author":"Roy","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0445","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/brain\/awaa376","article-title":"Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons","volume":"144","author":"Ruan","year":"2021","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0450","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/brain\/awaa376","article-title":"Alzheimer\u2019s disease brain-derived extracellular vesicles spread tau pathology in interneurons","volume":"144","author":"Ruan","year":"2021","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.mcn.2024.103982_bb0455","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1074\/jbc.M111.277061","article-title":"Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease","volume":"287","author":"Saman","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcn.2024.103982_bb0460","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.neuron.2018.02.015","article-title":"1: CAS: 528: DC% 2BC1cXlsV2lu78% 3D: Tau kinetics in neurons and the human central nervous system","volume":"97","author":"Sato","year":"2018","journal-title":"Neuron"},{"issue":"18","key":"10.1016\/j.mcn.2024.103982_bb0465","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.3390\/ijms22189987","article-title":"Insulin and insulin resistance in Alzheimer\u2019s disease","volume":"22","author":"Sedzikowska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.mcn.2024.103982_bb0470","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3390\/cells9061443","article-title":"MiRNA profiling in plasma neural-derived small extracellular vesicles from patients with Alzheimer\u2019s disease","volume":"9","author":"Serpente","year":"2020","journal-title":"Cells"},{"issue":"583","key":"10.1016\/j.mcn.2024.103982_bb0475","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz4564","article-title":"APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia","volume":"13","author":"Sienski","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"24","key":"10.1016\/j.mcn.2024.103982_bb0480","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1039\/C8LC01017J","article-title":"Integrated nanoscale deterministic lateral displacement arrays for separation of extracellular vesicles from clinically-relevant volumes of biological samples","volume":"18","author":"Smith","year":"2018","journal-title":"Lab Chip"},{"issue":"6","key":"10.1016\/j.mcn.2024.103982_bb0485","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3109\/09540261.2013.859128","article-title":"Rapid cognitive decline in Alzheimer\u2019s disease: a literature review","volume":"25","author":"Sona","year":"2013","journal-title":"Int. Rev. Psychiatry"},{"issue":"7","key":"10.1016\/j.mcn.2024.103982_bb0490","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12089","article-title":"Characterization of brain-derived extracellular vesicle lipids in Alzheimer's disease","volume":"10","author":"Su","year":"2021","journal-title":"J Extracell Vesicles"},{"issue":"9","key":"10.1016\/j.mcn.2024.103982_bb0495","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.1007\/s12035-019-1500-y","article-title":"Systematic review of miRNA as biomarkers in Alzheimer\u2019s disease","volume":"56","author":"Swarbrick","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.mcn.2024.103982_bb0500","doi-asserted-by":"crossref","first-page":"25746","DOI":"10.3390\/s151025746","article-title":"Integration of a miniature quartz crystal microbalance with a microfluidic chip for amyloid beta-Abeta42 quantitation","volume":"15","author":"Tao","year":"2015","journal-title":"Sensors (Basel)"},{"issue":"16","key":"10.1016\/j.mcn.2024.103982_bb0505","doi-asserted-by":"crossref","first-page":"9004","DOI":"10.3390\/ijms23169004","article-title":"Microfluidic approaches for affinity-based exosome separation","volume":"23","author":"Theel","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.mcn.2024.103982_bb0510","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/alz.12723","article-title":"Blood extracellular vesicles carrying synaptic function-and brain-related proteins as potential biomarkers for Alzheimer\u2019s disease","volume":"19","author":"Tian","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"5","key":"10.1016\/j.mcn.2024.103982_bb0515","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/gim.2015.117","article-title":"The genetic landscape of Alzheimer disease: clinical implications and perspectives","volume":"18","author":"Van Cauwenberghe","year":"2016","journal-title":"Genet. Med."},{"key":"10.1016\/j.mcn.2024.103982_bb0520","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jns.2015.12.005","article-title":"Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer\u2019s disease","volume":"360","author":"Van Giau","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.mcn.2024.103982_bb0525","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.587989","article-title":"Differential profile of systemic extracellular vesicles from sporadic and familial Alzheimer\u2019s disease leads to neuroglial and endothelial cell degeneration","volume":"12","author":"Villar-Vesga","year":"2020","journal-title":"Front. Aging Neurosci."},{"issue":"3","key":"10.1016\/j.mcn.2024.103982_bb0530","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.pneurobio.2011.01.003","article-title":"Multivesicular bodies in neurons: distribution, protein content, and trafficking functions","volume":"93","author":"Von Bartheld","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.mcn.2024.103982_bb0535","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fnagi.2016.00112","article-title":"Abnormal changes of brain cortical anatomy and the association with plasma MicroRNA107 level in amnestic mild cognitive impairment","volume":"8","author":"Wang","year":"2016","journal-title":"Front. Aging Neurosci."},{"issue":"3","key":"10.1016\/j.mcn.2024.103982_bb0540","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tibtech.2017.11.004","article-title":"Point-of-care devices using disease biomarkers to diagnose neurodegenerative disorders","volume":"36","author":"Wei","year":"2018","journal-title":"Trends Biotechnol."},{"issue":"40","key":"10.1016\/j.mcn.2024.103982_bb0545","doi-asserted-by":"crossref","first-page":"10584","DOI":"10.1073\/pnas.1709210114","article-title":"Isolation of exosomes from whole blood by integrating acoustics and microfluidics","volume":"114","author":"Wu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcn.2024.103982_bb0550","series-title":"18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014","article-title":"Exosomal micro-RNA analysis in urine or serum using nanowire structures","author":"Yasui","year":"2014"},{"issue":"1","key":"10.1016\/j.mcn.2024.103982_bb0555","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1038\/s41598-017-09370-3","article-title":"A highly sensitive plasma-based amyloid-beta detection system through medium-changing and noise cancellation system for early diagnosis of the Alzheimer\u2019s disease","volume":"7","author":"Yoo","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.mcn.2024.103982_bb0560","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/asia.201501355","article-title":"Detection of Abeta monomers and oligomers: early diagnosis of Alzheimer\u2019s disease","volume":"11","author":"Zhou","year":"2016","journal-title":"Chem. Asian J."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743124000678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743124000678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T03:34:40Z","timestamp":1741664080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743124000678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":112,"alternative-id":["S1044743124000678"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2024.103982","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microfluidics in neural extracellular vesicles characterization for early Alzheimer's disease diagnosis","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2024.103982","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103982"}}