{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:48:52Z","timestamp":1793609332424,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.mcn.2025.103994","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T13:02:52Z","timestamp":1737982972000},"page":"103994","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A microglial kinase ITK mediating neuroinflammation and behavioral deficits in traumatic brain injury"],"prefix":"10.1016","volume":"132","author":[{"given":"Ruqayya","family":"Afridi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Bhusal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Mi","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Heon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungho","family":"Suk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2025.103994_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098101","article-title":"Inhibition of ITK signaling causes amelioration in sepsis-associated neuroinflammation and depression-like state in mice","volume":"24","author":"Algahtani","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcn.2025.103994_bb0010","article-title":"T-cell signaling regulated by the Tec family kinase","volume":"2","author":"Andreotti","year":"2010","journal-title":"Itk. Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.mcn.2025.103994_bb0015","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1146\/annurev.immunol.22.012703.104743","article-title":"Tec family kinases in T lymphocyte development and function","volume":"23","author":"Berg","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.mcn.2025.103994_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113813","article-title":"The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes","volume":"43","author":"Bhusal","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcn.2025.103994_bb0025","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/nprot.2009.125","article-title":"The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice","volume":"4","author":"Bouet","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcn.2025.103994_bb0030","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fnagi.2017.00208","article-title":"Microglial activation in traumatic brain injury","volume":"9","author":"Donat","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.mcn.2025.103994_bb0035","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1089\/neu.2018.6019","article-title":"Sex differences in acute neuroinflammation after experimental traumatic brain injury are mediated by infiltrating myeloid cells","volume":"36","author":"Doran","year":"2019","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mcn.2025.103994_bb0040","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025825118","article-title":"Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK","volume":"118","author":"Gallagher","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mcn.2025.103994_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10857","article-title":"Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4","volume":"7","author":"Gomez-Rodriguez","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcn.2025.103994_bb0050","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-075049","article-title":"Global, regional and national burden of traumatic brain injury and spinal cord injury, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"13","author":"Guan","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.mcn.2025.103994_bb0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.brainres.2012.05.008","article-title":"Microglia activation along the corticospinal tract following traumatic brain injury in the rat: a neuroanatomical study","volume":"1465","author":"Jacobowitz","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.mcn.2025.103994_bb0060","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/brain\/aws322","article-title":"Inflammation and white matter degeneration persist for years after a single traumatic brain injury","volume":"136","author":"Johnson","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.mcn.2025.103994_bb0065","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1523\/JNEUROSCI.1957-14.2015","article-title":"Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking","volume":"35","author":"Kannan","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2025.103994_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113239","article-title":"GABAergic-like dopamine synapses in the brain","volume":"42","author":"Kim","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcn.2025.103994_bb0075","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201605","article-title":"A multiplexed siRNA screen identifies key kinase signaling networks of brain glia","volume":"6","author":"Kim","year":"2023","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.mcn.2025.103994_bb0080","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00109-020-01958-z","article-title":"Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis","volume":"98","author":"Lechner","year":"2020","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.mcn.2025.103994_bb0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1742-2094-9-39","article-title":"Microglial TIR-domain-containing adapter-inducing interferon-beta (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-kappaB","volume":"9","author":"Lin","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mcn.2025.103994_bb0090","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/s41592-022-01547-7","article-title":"Directed evolution of adeno-associated virus for efficient gene delivery to microglia","volume":"19","author":"Lin","year":"2022","journal-title":"Nat. Methods"},{"issue":"Pt 3","key":"10.1016\/j.mcn.2025.103994_bb0095","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.expneurol.2015.08.018","article-title":"Microglia in the TBI brain: the good, the bad, and the dysregulated","volume":"275","author":"Loane","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mcn.2025.103994_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75835-7","article-title":"A versatile toolbox for semi-automatic cell-by-cell object-based colocalization analysis","volume":"10","author":"Lunde","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcn.2025.103994_bb0105","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13195-015-0148-8","article-title":"Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study","volume":"7","author":"Mez","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.mcn.2025.103994_bb0110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.immuni.2004.06.009","article-title":"Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet","volume":"21","author":"Miller","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.mcn.2025.103994_bb0115","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1089\/neu.2007.0377","article-title":"Prolonged microgliosis in the rhesus monkey central nervous system after traumatic brain injury","volume":"24","author":"Nagamoto-Combs","year":"2007","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mcn.2025.103994_bb0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.it.2013.02.002","article-title":"A new look at T cell receptor signaling to nuclear factor-kappaB","volume":"34","author":"Paul","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.mcn.2025.103994_bb0125","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1093\/brain\/awab231","article-title":"MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response","volume":"144","author":"Pellerin","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.mcn.2025.103994_bb0130","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.22455","article-title":"Inflammation after trauma: microglial activation and traumatic brain injury","volume":"70","author":"Ramlackhansingh","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mcn.2025.103994_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.56","article-title":"Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy","volume":"49","author":"Seo","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mcn.2025.103994_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.825086","article-title":"Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration","volume":"14","author":"Shao","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.mcn.2025.103994_bb0145","doi-asserted-by":"crossref","first-page":"11194","DOI":"10.1073\/pnas.89.23.11194","article-title":"itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2","volume":"89","author":"Siliciano","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mcn.2025.103994_bb0150","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1128\/MCB.24.6.2455-2466.2004","article-title":"Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec","volume":"24","author":"Tomlinson","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mcn.2025.103994_bb0155","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10561-008-9079-y","article-title":"Twenty-first century brain banking: practical prerequisites and lessons from the past: the experience of New York Brain Bank, Taub Institute, Columbia University","volume":"9","author":"Vonsattel","year":"2008","journal-title":"Cell Tissue Bank."},{"key":"10.1016\/j.mcn.2025.103994_bb0160","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1158\/1078-0432.CCR-16-1996","article-title":"T-cell receptor signaling activates an ITK\/NF-kappaB\/GATA-3 axis in T-cell lymphomas facilitating resistance to chemotherapy","volume":"23","author":"Wang","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mcn.2025.103994_bb0165","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1523\/JNEUROSCI.2469-20.2020","article-title":"Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia","volume":"41","author":"Witcher","year":"2021","journal-title":"J. Neurosci."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743125000041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743125000041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T03:34:38Z","timestamp":1741664078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743125000041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":33,"alternative-id":["S1044743125000041"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2025.103994","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A microglial kinase ITK mediating neuroinflammation and behavioral deficits in traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2025.103994","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103994"}}