{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:50:37Z","timestamp":1788922237030,"version":"build-2803163510"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P30DA018310"],"award-info":[{"award-number":["P30DA018310"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2022-38420-38610"],"award-info":[{"award-number":["2022-38420-38610"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.mcn.2025.104014","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T16:01:01Z","timestamp":1748620861000},"page":"104014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Peroxisome, neuropeptide, and inflammation signaling pathways uniquely impacted by opioid exposure in the hypothalamus of males and females"],"prefix":"10.1016","volume":"134","author":[{"given":"G.R.","family":"Sunderland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.R.","family":"Southey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.B.","family":"Villamil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Rodriguez-Zas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mcn.2025.104014_bb0005","doi-asserted-by":"crossref","DOI":"10.5812\/jjcmb.121808","article-title":"Region specificity in endogenous opioid peptides and mu-opioid receptor gene expression in rat brain areas involved in addiction after frequent morphine treatment","volume":"12","author":"Ahmadi","year":"2021","journal-title":"Jentashapir J. Cell. Mol. Biol."},{"issue":"5","key":"10.1016\/j.mcn.2025.104014_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2019.05.050","article-title":"Natural and drug rewards engage distinct pathways that converge on coordinated hypothalamic and reward circuits","volume":"103","author":"Alhadeff","year":"2019","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.mcn.2025.104014_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/genes14051007","article-title":"Genes participating in the ensheathment of neurons are affected by postnatal stress and maternal immune activation in the pituitary gland","volume":"14","author":"Alsegehy","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.mcn.2025.104014_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148329","article-title":"Epigenetic disruptions in the offspring hypothalamus in response to maternal infection","volume":"910","author":"Alsegehy","year":"2024","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.mcn.2025.104014_bb0025","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.neuroscience.2010.01.043","article-title":"Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake","volume":"167","author":"Anghel","year":"2010","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.mcn.2025.104014_bb0030","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tips.2010.04.005","article-title":"Activation of the hypothalamic-pituitary-adrenal axis by addictive drugs: different pathways, common outcome","volume":"31","author":"Armario","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0035","doi-asserted-by":"crossref","first-page":"21460","DOI":"10.1038\/s41598-023-46427-y","article-title":"Morphine aggravates inflammatory, behavioral, and hippocampal structural deficits in septic rats","volume":"13","author":"Ayieng\u2019a","year":"2023","journal-title":"Sci. Rep."},{"issue":"18","key":"10.1016\/j.mcn.2025.104014_bb0040","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1523\/JNEUROSCI.4385-14.2015","article-title":"Orexin signaling in the VTA gates morphine-induced synaptic plasticity","volume":"35","author":"Baimel","year":"2015","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.mcn.2025.104014_bb0045","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1534\/genetics.104.036699","article-title":"Quantitative trait loci analysis using the false discovery rate","volume":"171","author":"Benjamini","year":"2005","journal-title":"Genetics"},{"issue":"15","key":"10.1016\/j.mcn.2025.104014_bb0050","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"10","key":"10.1016\/j.mcn.2025.104014_bb0055","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/jnr.25103","article-title":"Sex differences in morphine sensitivity are associated with differential glial expression in the brainstem of rats with neuropathic pain","volume":"100","author":"Boorman","year":"2022","journal-title":"J. Neurosci. Res."},{"issue":"5","key":"10.1016\/j.mcn.2025.104014_bb0060","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0143-21.2021","article-title":"Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice","volume":"8","author":"Borrelli","year":"2021","journal-title":"eNeuro"},{"key":"10.1016\/j.mcn.2025.104014_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1259998","article-title":"HIV-1 and opiates modulate miRNA profiles in extracellular vesicles","volume":"14","author":"Caobi","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mcn.2025.104014_bb0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jocn.2020.03.005","article-title":"Neuroinflammation and depressive disorder: the role of the hypothalamus","volume":"75","author":"Cernackova","year":"2020","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.mcn.2025.104014_bb0075","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ebiom.2019.01.042","article-title":"Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18\u00a0months","volume":"40","author":"Chau","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mcn.2025.104014_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2020.101854","article-title":"From dysregulated microRNAs to structural alterations in the striatal region of METH-injected rats","volume":"109","author":"Chavoshi","year":"2020","journal-title":"J. Chem. Neuroanat."},{"issue":"4","key":"10.1016\/j.mcn.2025.104014_bb0085","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s11033-014-3075-z","article-title":"Identification of differentially expressed genes in hypothalamus of chicken during cold stress","volume":"41","author":"Chen","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.mcn.2025.104014_bb0090","series-title":"edgeR: Differential Analysis of Sequence Read Count Data User's Guide","first-page":"1","author":"Chen","year":"2020"},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2013.09.013","article-title":"Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques","volume":"265","author":"Cornwell","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.mcn.2025.104014_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2023.103841","article-title":"Circular RNA regulation and function in drug seeking phenotypes","volume":"125","author":"Daws","year":"2023","journal-title":"Mol. Cell. Neurosci."},{"issue":"10","key":"10.1016\/j.mcn.2025.104014_bb0105","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1210\/en.2004-1520","article-title":"Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus","volume":"146","author":"De Souza","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mcn.2025.104014_bb0110","series-title":"Data Mining Techniques for the Life Sciences","first-page":"245","article-title":"Optimizing RNA-Seq mapping with STAR","author":"Dobin","year":"2016"},{"issue":"2","key":"10.1016\/j.mcn.2025.104014_bb0115","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","article-title":"Cytoscape StringApp: network analysis and visualization of proteomics data","volume":"18","author":"Doncheva","year":"2019","journal-title":"J. Proteome Res."},{"issue":"12","key":"10.1016\/j.mcn.2025.104014_bb0120","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1523\/JNEUROSCI.2906-16.2017","article-title":"Sex differences in microglia activity within the periaqueductal gray of the rat: a potential mechanism driving the dimorphic effects of morphine","volume":"37","author":"Doyle","year":"2017","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-023-02382-w","article-title":"Mu-opioid receptor-expressing neurons in the paraventricular thalamus modulate chronic morphine-induced wake alterations","volume":"13","author":"Eacret","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.mcn.2025.104014_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00101","article-title":"The lateral hypothalamus: an uncharted territory for processing peripheral neurogenic inflammation","volume":"14","author":"Fakhoury","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mcn.2025.104014_bb0135","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.imlet.2016.12.002","article-title":"Gender differences of B cell signature related to estrogen-induced IFI44L\/BAFF in systemic lupus erythematosus","volume":"181","author":"Fan","year":"2017","journal-title":"Immunol. Lett."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0140","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac757","article-title":"GSEApy: a comprehensive package for performing gene set enrichment analysis in Python","volume":"39","author":"Fang","year":"2023","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.mcn.2025.104014_bb0145","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.neuroscience.2009.08.023","article-title":"The absence of a functional peroxisome proliferator-activated receptor-alpha gene in mice enhances motor sensitizing effects of morphine, but not cocaine","volume":"164","author":"Fernandez-Espejo","year":"2009","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.mcn.2025.104014_bb0150","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1046\/j.0953-816X.2000.01334.x","article-title":"Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal, and phenotypic identification of the striatal neurons involved","volume":"12","author":"Georges","year":"2000","journal-title":"Eur. J. Neurosci."},{"issue":"8","key":"10.1016\/j.mcn.2025.104014_bb0155","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1523\/JNEUROSCI.23-08-03106.2003","article-title":"Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal","volume":"23","author":"Georgescu","year":"2003","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0160","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pharep.2014.08.003","article-title":"Pioglitazone prevents morphine antinociceptive tolerance via ameliorating neuroinflammation in rat cerebral cortex","volume":"67","author":"Ghavimi","year":"2015","journal-title":"Pharmacol. Rep."},{"issue":"2","key":"10.1016\/j.mcn.2025.104014_bb0165","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00213-009-1730-1","article-title":"Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity","volume":"208","author":"Gieryk","year":"2010","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.mcn.2025.104014_bb0170","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.pbb.2012.02.015","article-title":"Morphine administration and abrupt cessation alter the behavioral diurnal activity pattern","volume":"101","author":"Glaser","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.mcn.2025.104014_bb0175","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/adb.12250","article-title":"Effects of drugs of abuse on the central neuropeptide Y system","volume":"21","author":"Gon\u00e7alves","year":"2016","journal-title":"Addict. Biol."},{"key":"10.1016\/j.mcn.2025.104014_bb0180","doi-asserted-by":"crossref","DOI":"10.1177\/1177932218815152","article-title":"Interplay between amphetamine and activity level in gene networks of the mouse striatum","volume":"12","author":"Goncalves","year":"2018","journal-title":"Bioinformatics and Biology Insights"},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbr.2007.05.025","article-title":"Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward","volume":"183","author":"Harris","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.mcn.2025.104014_bb0190","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.brainresbull.2015.10.007","article-title":"Morphine-induced antinociception and reward in \u201chumanized\u201d mice expressing the mu opioid receptor A118G polymorphism","volume":"123","author":"Henderson-Redmond","year":"2016","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0195","article-title":"Peripheral injection of SB203580 inhibits the inflammatory-dependent synthesis of proinflammatory cytokines in the hypothalamus","volume":"2014","author":"Herman","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0200","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1186\/1471-2164-15-874","article-title":"Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression","volume":"15","author":"Herrero-Turri\u00f3n","year":"2014","journal-title":"BMC Genomics"},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0205","article-title":"Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward","volume":"7","author":"Hutchinson","year":"2007","journal-title":"Sci. World J."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0210","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbi.2009.08.004","article-title":"Evidence that opioids may have toll-like receptor 4 and MD-2 effects","volume":"24","author":"Hutchinson","year":"2010","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.mcn.2025.104014_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003731","article-title":"iRegulon: from a gene list to a gene regulatory network using large motif and track collections","volume":"10","author":"Janky","year":"2014","journal-title":"PLoS Comput. Biol."},{"issue":"8","key":"10.1016\/j.mcn.2025.104014_bb0220","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2023.08.023","article-title":"Genetically regulated gene expression in the brain associated with chronic pain: relationships with clinical traits and potential for drug repurposing","volume":"95","author":"Johnston","year":"2024","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.mcn.2025.104014_bb0225","doi-asserted-by":"crossref","DOI":"10.1093\/g3journal\/jkab113","article-title":"Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs","author":"Keever-Keigher","year":"2021","journal-title":"G3 (Bethesda, Md.)"},{"key":"10.1016\/j.mcn.2025.104014_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108469","article-title":"Sexually dimorphic neuroimmune response to chronic opioid treatment and withdrawal","volume":"186","author":"Kumar","year":"2021","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0235","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bbrc.2009.11.074","article-title":"Toll-like receptor 2 is required for opioids-induced neuronal apoptosis","volume":"391","author":"Li","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"null","key":"10.1016\/j.mcn.2025.104014_bb0240","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.2147\/JPR.S125264","article-title":"Upregulation of miR-375 level ameliorates morphine analgesic tolerance in mouse dorsal root ganglia by inhibiting the JAK2\/STAT3 pathway","volume":"10","author":"Li","year":"2017","journal-title":"J. Pain Res."},{"key":"10.1016\/j.mcn.2025.104014_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2021.108598","article-title":"Repeated morphine exposure activates synaptogenesis and other neuroplasticity-related gene networks in the dorsomedial prefrontal cortex of male and female rats","volume":"221","author":"Liu","year":"2021","journal-title":"Drug Alcohol Depend."},{"issue":"621","key":"10.1016\/j.mcn.2025.104014_bb0250","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd5758","article-title":"Importance of the pig as a human biomedical model","volume":"13","author":"Lunney","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.mcn.2025.104014_bb0255","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00018-011-0817-0","article-title":"The hypothalamus and the neurobiology of drug seeking","volume":"69","author":"Marchant","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.mcn.2025.104014_bb0260","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0306-4522(02)00105-7","article-title":"Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal","volume":"112","author":"McNally","year":"2002","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.mcn.2025.104014_bb0265","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/PL00005096","article-title":"Differential regulation of corticotropin-releasing factor and vasopressin in discrete brain regions after morphine administration: correlations with hypothalamic noradrenergic activity and pituitary-adrenal response","volume":"356","author":"Milan\u00e9s","year":"1997","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0270","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1124\/jpet.105.083410","article-title":"D1 dopamine receptors modulate \u0394FosB induction in rat striatum after intermittent morphine administration","volume":"314","author":"Muller","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0275","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13148-020-00955-w","article-title":"Morphine leads to global genome changes in H3K27me3 levels via a Polycomb repressive complex 2 (PRC2) self-regulatory mechanism in mESCs","volume":"12","author":"Mu\u00f1oa-Hoyos","year":"2020","journal-title":"Clin. Epigenetics"},{"issue":"5525","key":"10.1016\/j.mcn.2025.104014_bb0280","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1126\/science.1063024","article-title":"Total recall\u2014the memory of addiction","volume":"292","author":"Nestler","year":"2001","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.mcn.2025.104014_bb0285","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/j.1471-4159.2006.04421.x","article-title":"Activation of stress-related hypothalamic neuropeptide gene expression during morphine withdrawal","volume":"101","author":"Nunez","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mcn.2025.104014_bb0290","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nutres.2018.06.006","article-title":"Altered expression of inflammation-associated genes in the hypothalamus of obesity mouse models","volume":"70","author":"Park","year":"2019","journal-title":"Nutr. Res."},{"issue":"5","key":"10.1016\/j.mcn.2025.104014_bb0295","doi-asserted-by":"crossref","first-page":"R48","DOI":"10.1186\/gb-2010-11-5-r48","article-title":"The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum","volume":"11","author":"Piechota","year":"2010","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.mcn.2025.104014_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067027","article-title":"Differential changes in expression of stress- and metabolic-related neuropeptides in the rat hypothalamus during morphine dependence and withdrawal","volume":"8","author":"Pint\u00e9r-K\u00fcbler","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mcn.2025.104014_bb0305","series-title":"Hypothalamus in Health and Diseases","article-title":"Anatomy and function of the hypothalamus","author":"Pop","year":"2018"},{"issue":"3","key":"10.1016\/j.mcn.2025.104014_bb0310","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s12031-019-01375-z","article-title":"The impact of morphine on reproductive activity in male rats is regulated by Rf-amid-related peptide-3 and substance P adjusting hypothalamic kisspeptin expression","volume":"69","author":"Rahdar","year":"2019","journal-title":"J. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.mcn.2025.104014_bb0315","doi-asserted-by":"crossref","DOI":"10.1002\/ajpa.24888","article-title":"Sex-biased gene regulation varies across human populations as a result of adaptive evolution","volume":"183","author":"Reynolds","year":"2024","journal-title":"American Journal of Biological Anthropology"},{"issue":"3","key":"10.1016\/j.mcn.2025.104014_bb0320","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0091-3057(92)90411-8","article-title":"Acute and chronic morphine administration in swine","volume":"43","author":"Risdahl","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.mcn.2025.104014_bb0325","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbi.2014.09.018","article-title":"Advancing the understanding of behaviors associated with Bacille Calmette Gu\u00e9rin infection using multivariate analysis","volume":"44","author":"Rodriguez-Zas","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"10","key":"10.1016\/j.mcn.2025.104014_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0292952","article-title":"Prenatal and postnatal challenges affect the hypothalamic molecular pathways that regulate hormonal levels","volume":"18","author":"Rodriguez-Zas","year":"2023","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.mcn.2025.104014_bb0335","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0304-3940(96)13033-0","article-title":"Downregulation of \u03bc-opioid receptor mRNA in the mediobasal hypothalamus of the female guinea pig following morphine treatment","volume":"216","author":"R\u00f8nnekleiv","year":"1996","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.mcn.2025.104014_bb0340","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1067\/msy.2001.116033","article-title":"Morphine directs T cells toward Th2 differentiation","volume":"130","author":"Roy","year":"2001","journal-title":"Surgery"},{"key":"10.1016\/j.mcn.2025.104014_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.561151","article-title":"Long-lasting impact of maternal immune activation and interaction with a second immune challenge on pig behavior","volume":"7","author":"Rymut","year":"2020","journal-title":"Front. Vet. Sci."},{"issue":"8","key":"10.1016\/j.mcn.2025.104014_bb0350","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.3390\/ani11082274","article-title":"The combined effect of weaning stress and immune activation during pig gestation on serum cytokine and analyte concentrations","volume":"11","author":"Rymut","year":"2021","journal-title":"Animals"},{"issue":"8","key":"10.1016\/j.mcn.2025.104014_bb0355","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3390\/genes13081371","article-title":"Prefrontal cortex response to prenatal insult and postnatal opioid exposure","volume":"13","author":"Rymut","year":"2022","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0360","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13041-018-0365-8","article-title":"Identification of lncRNA expression profiles and ceRNA analysis in the spinal cord of morphine-tolerant rats","volume":"11","author":"Shao","year":"2018","journal-title":"Mol. Brain"},{"issue":"7","key":"10.1016\/j.mcn.2025.104014_bb0365","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1089\/brain.2019.0673","article-title":"Pig brains have homologous resting-state networks with human brains","volume":"9","author":"Simchick","year":"2019","journal-title":"Brain Connect."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0370","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12859-018-2246-7","article-title":"Gene length corrected trimmed mean of M-values (GeTMM) processing of RNA-seq data performs similarly in intersample analyses while improving intrasample comparisons","volume":"19","author":"Smid","year":"2018","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"10.1016\/j.mcn.2025.104014_bb0375","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0238-22.2022","article-title":"Perinatal morphine exposure leads to sex-dependent executive function deficits and microglial changes in mice","volume":"9","author":"Smith","year":"2022","journal-title":"eNeuro"},{"issue":"5","key":"10.1016\/j.mcn.2025.104014_bb0380","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/ALN.0000000000004522","article-title":"Single-nucleus atlas of sevoflurane-induced hippocampal cell type\u2013 and sex-specific effects during development in mice","volume":"138","author":"Song","year":"2023","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0385","doi-asserted-by":"crossref","first-page":"21","DOI":"10.31083\/j.jin.2021.01.332","article-title":"Effects of maternal immune activation in porcine transcript isoforms of neuropeptide and receptor genes","volume":"20","author":"Southey","year":"2021","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.mcn.2025.104014_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2023.103824","article-title":"Histone H3 dopaminylation in nucleus accumbens, but not medial prefrontal cortex, contributes to cocaine-seeking following prolonged abstinence","volume":"125","author":"Stewart","year":"2023","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2025.104014_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1003300","article-title":"Multi-omics analysis reveals GABAergic dysfunction after traumatic brainstem injury in rats","volume":"16","author":"Su","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mcn.2025.104014_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173105","article-title":"Circadian rhythms and substance use disorders: a bidirectional relationship","volume":"201","author":"Tamura","year":"2021","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.mcn.2025.104014_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148428","article-title":"Protracted morphine withdrawal induces upregulation of peroxiredoxin II and reduces 14-3-3 protein levels in the rat brain cortex and hippocampus","volume":"1813","author":"Ujcikova","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.mcn.2025.104014_bb0410","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2014.00466","article-title":"Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction","volume":"8","author":"van Huijstee","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2025.104014_bb0415","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.expneurol.2014.05.004","article-title":"Prenatal poly I:C age-dependently alters cannabinoid type 1 receptors in offspring: a longitudinal small animal PET study using [18F]MK-9470","volume":"257","author":"Verdurand","year":"2014","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.mcn.2025.104014_bb0420","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/mp.2009.99","article-title":"The neurobiology of D-amino acid oxidase and its involvement in schizophrenia","volume":"15","author":"Verrall","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.mcn.2025.104014_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2023.103838","article-title":"Transcriptional and epigenetic regulation of microglia in substance use disorders","volume":"125","author":"Vilca","year":"2023","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2025.104014_bb0430","article-title":"Identification of key genes and therapeutic drugs for cocaine addiction using integrated bioinformatics analysis","volume":"17","author":"Wang","year":"2023","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.mcn.2025.104014_bb0435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000595","article-title":"A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown","volume":"18","author":"Wat","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mcn.2025.104014_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2023.103825","article-title":"Early life adversity: epigenetic regulation underlying drug addiction susceptibility","volume":"125","author":"Winter","year":"2023","journal-title":"Mol. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.mcn.2025.104014_bb0445","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1254\/jphs.08030FP","article-title":"Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase","volume":"107","author":"Yoshikawa","year":"2008","journal-title":"J. Pharmacol. Sci."},{"issue":"15","key":"10.1016\/j.mcn.2025.104014_bb0450","doi-asserted-by":"crossref","first-page":"9028","DOI":"10.1073\/pnas.1533224100","article-title":"The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal","volume":"100","author":"Zachariou","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.mcn.2025.104014_bb0455","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201773","article-title":"Brain region-dependent gene networks associated with selective breeding for increased voluntary wheel-running behavior","volume":"13","author":"Zhang","year":"2018","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.mcn.2025.104014_bb0460","doi-asserted-by":"crossref","DOI":"10.1097\/j.pain.0000000000001633","article-title":"Repressor element 1\u2013silencing transcription factor drives the development of chronic pain states","volume":"160","author":"Zhang","year":"2019","journal-title":"Pain"},{"issue":"12","key":"10.1016\/j.mcn.2025.104014_bb0465","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1007\/s12035-019-01650-5","article-title":"Opioid-induced hyperalgesia is associated with dysregulation of circadian rhythm and adaptive immune pathways in the mouse trigeminal ganglia and nucleus accumbens","volume":"56","author":"Zhang","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.mcn.2025.104014_bb0470","doi-asserted-by":"crossref","DOI":"10.3390\/genes12101570","article-title":"Alternative splicing mechanisms underlying opioid-induced hyperalgesia","volume":"12","author":"Zhang","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.mcn.2025.104014_bb0475","first-page":"49","article-title":"Enhanced understanding of molecular interactions and function underlying pain processes through networks of transcript isoforms, genes, and gene families","volume":"14","author":"Zhang","year":"2021","journal-title":"Adv. Appl. Bioinforma. Chem."},{"key":"10.1016\/j.mcn.2025.104014_bb0480","article-title":"Integration of molecular inflammatory interactome analyses reveals dynamics of circulating cytokines and extracellular vesicle long non-coding RNAs and mRNAs in heroin addicts during acute and protracted withdrawal","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"issue":"36","key":"10.1016\/j.mcn.2025.104014_bb0485","doi-asserted-by":"crossref","first-page":"14519","DOI":"10.1073\/pnas.0705740104","article-title":"Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward","volume":"104","author":"Zhao","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mcn.2025.104014_bb0490","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neulet.2017.03.044","article-title":"CXCL13 regulates the trafficking of GluN2B-containing NMDA receptor via IL-17 in the development of remifentanil-induced hyperalgesia in rats","volume":"648","author":"Zhu","year":"2017","journal-title":"Neurosci. Lett."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743125000247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743125000247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:50:46Z","timestamp":1778795446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743125000247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":98,"alternative-id":["S1044743125000247"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2025.104014","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peroxisome, neuropeptide, and inflammation signaling pathways uniquely impacted by opioid exposure in the hypothalamus of males and females","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2025.104014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104014"}}