{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:18:48Z","timestamp":1787242728380,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301599"],"award-info":[{"award-number":["82301599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91849133"],"award-info":[{"award-number":["91849133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271450"],"award-info":[{"award-number":["82271450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.mcn.2025.104029","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T17:48:45Z","timestamp":1752601725000},"page":"104029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["DAPK1 induces motor neuron apoptosis in hSOD1G93A-linked amyotrophic lateral sclerosis via regulating the Xiap\/JNK pathway"],"prefix":"10.1016","volume":"134","author":[{"given":"Xiaoli","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingli","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2025.104029_bb0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13148-018-0563-3","article-title":"The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes","volume":"10","author":"Alvarez","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.mcn.2025.104029_bb0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"CELL"},{"key":"10.1016\/j.mcn.2025.104029_bb0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.biochem.75.103004.142615","article-title":"The death-associated protein kinases: structure, function, and beyond","volume":"75","author":"Bialik","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mcn.2025.104029_bb0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ijdevneu.2014.06.006","article-title":"Endogenous XIAP, but not other members of the inhibitory apoptosis protein family modulates cerebellar granule neurons survival","volume":"37","author":"Blancas","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.mcn.2025.104029_bb0025","doi-asserted-by":"crossref","first-page":"e12665","DOI":"10.1111\/jpi.12665","article-title":"Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer\u2019s disease","volume":"69","author":"Chen","year":"2020","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.mcn.2025.104029_bb0030","doi-asserted-by":"crossref","first-page":"e13003","DOI":"10.1111\/cpr.13003","article-title":"PAK4 suppresses motor neuron degeneration in hSOD1(G93A)-linked amyotrophic lateral sclerosis cell and rat models","volume":"54","author":"Cong","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.mcn.2025.104029_bb0035","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0969-9961(02)00020-7","article-title":"Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice","volume":"12","author":"Crocker","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2025.104029_bb0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1101\/gad.9.1.15","article-title":"Identification of a novel serine\/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death","volume":"9","author":"Deiss","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.mcn.2025.104029_bb0045","doi-asserted-by":"crossref","first-page":"2183658","DOI":"10.1155\/2017\/2183658","article-title":"YCl(3) promotes neuronal cell death by inducing apoptotic pathways in rats","volume":"2017","author":"Ding","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.mcn.2025.104029_bb0050","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1002\/j.1460-2075.1996.tb00629.x","article-title":"A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors","volume":"15","author":"Duckett","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.mcn.2025.104029_bb0055","doi-asserted-by":"crossref","first-page":"9126","DOI":"10.1523\/JNEUROSCI.20-24-09126.2000","article-title":"Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson\u2019s disease","volume":"20","author":"Eberhardt","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2025.104029_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ph15091050","article-title":"Identification of novel aryl carboxamide derivatives as death-associated protein kinase 1 (DAPK1) inhibitors with anti-proliferative activities: design, synthesis, in vitro, and in silico biological studies","volume":"15","author":"Elkamhawy","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.mcn.2025.104029_bb0065","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/med.21518","article-title":"Death-associated protein kinase (DAPK) family modulators: current and future therapeutic outcomes","volume":"39","author":"Farag","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.mcn.2025.104029_bb0070","doi-asserted-by":"crossref","DOI":"10.1186\/2051-5960-1-42","article-title":"Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis","volume":"1","author":"Freischmidt","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.mcn.2025.104029_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126370","article-title":"Blocking ERK-DAPK1 axis attenuates glutamate excitotoxicity in epilepsy","volume":"23","author":"Gan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcn.2025.104029_bb0080","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1227\/01.neu.0000243278.86222.88","article-title":"X-linked inhibitor of apoptosis protein gene-based neuroprotection for the peripheral nervous system","volume":"59","author":"Garrity-Moses","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.mcn.2025.104029_bb0085","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.nbd.2005.10.014","article-title":"PTD-XIAP protects against cerebral ischemia by anti-apoptotic and transcriptional regulatory mechanisms","volume":"22","author":"Guegan","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2025.104029_bb0090","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1007\/s12035-018-1312-5","article-title":"Degradation of Caytaxin causes learning and memory deficits via activation of DAPK1 in aging","volume":"56","author":"Guo","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mcn.2025.104029_bb0095","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.mcn.2025.104029_bb0100","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1111\/febs.14970","article-title":"Apoptotic cell death regulation in neurons","volume":"286","author":"Hollville","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.mcn.2025.104029_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102110","article-title":"Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington\u2019s disease","volume":"204","author":"Hyeon","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.mcn.2025.104029_bb0110","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jinorgbio.2013.09.018","article-title":"A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-kappaB activation pathway","volume":"130","author":"Ishak","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.mcn.2025.104029_bb0115","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbrc.2010.02.084","article-title":"Molecular interaction between HAX-1 and XIAP inhibits apoptosis","volume":"393","author":"Kang","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mcn.2025.104029_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101593","article-title":"Neurodegenerative effect of DAPK1 after cerebral hypoxia-ischemia is associated with its post-transcriptional and signal transduction regulations: a systematic review and meta-analysis","volume":"76","author":"Khan","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mcn.2025.104029_bb0125","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological roles of MAPK signaling pathways in human diseases","volume":"1802","author":"Kim","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcn.2025.104029_bb0130","article-title":"Death-associated protein kinase 1 phosphorylation in neuronal cell death and neurodegenerative disease","volume":"20","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcn.2025.104029_bb0135","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.molmed.2010.12.008","article-title":"Stroke intervention pathways: NMDA receptors and beyond","volume":"17","author":"Lai","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mcn.2025.104029_bb0140","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejphar.2011.08.026","article-title":"DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product","volume":"670","author":"Luo","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mcn.2025.104029_bb0145","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.neuint.2013.03.008","article-title":"Differentiated NSC-34 motoneuron-like cells as experimental model for cholinergic neurodegeneration","volume":"62","author":"Maier","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.mcn.2025.104029_bb0150","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00401-020-02252-5","article-title":"Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis","volume":"141","author":"Mehta","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mcn.2025.104029_bb0155","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3389\/fnins.2019.01310","article-title":"ALS genetics, mechanisms, and therapeutics: where are we now?","volume":"13","author":"Mejzini","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mcn.2025.104029_bb0160","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1089\/scd.2021.0043","article-title":"Reduced DAPK1 expression promotes stem cell-like characteristics of prostate cancer cells by activating ZEB1 via hippo\/YAP signaling pathway","volume":"30","author":"Nong","year":"2021","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.mcn.2025.104029_bb0165","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.mayocp.2018.04.007","article-title":"Amyotrophic lateral sclerosis: an update for 2018","volume":"93","author":"Oskarsson","year":"2018","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.mcn.2025.104029_bb0170","doi-asserted-by":"crossref","first-page":"6546","DOI":"10.1523\/JNEUROSCI.5119-13.2014","article-title":"DAPK1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death","volume":"34","author":"Pei","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2025.104029_bb0175","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/bph.15151","article-title":"Amyotrophic lateral sclerosis (ALS), cancer, autoimmunity and metabolic disorders: an unsolved tantalizing challenge","volume":"178","author":"Riancho","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mcn.2025.104029_bb0180","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ncl.2015.07.012","article-title":"Neuropathology of amyotrophic lateral sclerosis and its variants","volume":"33","author":"Saberi","year":"2015","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.mcn.2025.104029_bb0185","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0169-328X(97)00268-4","article-title":"Molecular cloning and developmental expression of a rat homologue of death-associated protein kinase in the nervous system","volume":"52","author":"Sakagami","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.mcn.2025.104029_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2016.00046","article-title":"Death associated protein kinase 1 (DAPK1): a regulator of apoptosis and autophagy","volume":"9","author":"Singh","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mcn.2025.104029_bb0195","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.18632\/aging.103638","article-title":"Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma","volume":"13","author":"Song","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mcn.2025.104029_bb0200","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41419-019-2122-z","article-title":"DAPK1 loss triggers tumor invasion in colorectal tumor cells","volume":"10","author":"Steinmann","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mcn.2025.104029_bb0205","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.biopsych.2018.12.008","article-title":"MicroRNA-26a\/death-associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinson\u2019s disease","volume":"85","author":"Su","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.mcn.2025.104029_bb0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijdevneu.2019.02.003","article-title":"Role of DAPK1 in neuronal cell death, survival and diseases in the nervous system","volume":"74","author":"Sulaiman","year":"2019","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.mcn.2025.104029_bb0215","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","article-title":"Amyotrophic lateral sclerosis","volume":"390","author":"van Es","year":"2017","journal-title":"LANCET"},{"key":"10.1016\/j.mcn.2025.104029_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103795","article-title":"Unraveling the complex interplay between genes, environment, and climate in ALS","volume":"75","author":"Vasta","year":"2022","journal-title":"EBIOMEDICINE"},{"key":"10.1016\/j.mcn.2025.104029_bb0225","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1093\/hmg\/ddt319","article-title":"The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons","volume":"22","author":"Wang","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcn.2025.104029_bb0230","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1007\/s12035-016-0008-y","article-title":"DAPK1 signaling pathways in stroke: from mechanisms to therapies","volume":"54","author":"Wang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mcn.2025.104029_bb0235","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/SHK.0000000000001831","article-title":"Death-associated protein kinase 1 promotes alveolar epithelial cell apoptosis and ventilator-induced lung injury through P53 pathway","volume":"57","author":"Wang","year":"2022","journal-title":"SHOCK"},{"key":"10.1016\/j.mcn.2025.104029_bb0240","doi-asserted-by":"crossref","DOI":"10.1042\/AN20090005","article-title":"Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury","volume":"1","author":"West","year":"2009","journal-title":"ASN Neuro"},{"key":"10.1016\/j.mcn.2025.104029_bb0245","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.311","article-title":"Loss of XIAP facilitates switch to TNFalpha-induced necroptosis in mouse neutrophils","volume":"7","author":"Wicki","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mcn.2025.104029_bb0250","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.yexcr.2006.02.021","article-title":"XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice","volume":"312","author":"Wootz","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mcn.2025.104029_bb0255","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jns.2018.01.003","article-title":"DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells","volume":"387","author":"Xiong","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.mcn.2025.104029_bb0260","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41389-019-0181-8","article-title":"XIAP interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion","volume":"8","author":"Xu","year":"2019","journal-title":"ONCOGENESIS"},{"key":"10.1016\/j.mcn.2025.104029_bb0265","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1007\/s12035-018-1242-2","article-title":"DAPK1: a novel pathology and treatment target for Alzheimer\u2019s disease","volume":"56","author":"Xu","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mcn.2025.104029_bb0270","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/(SICI)1097-4547(19991201)58:5<674::AID-JNR8>3.0.CO;2-3","article-title":"Developmental changes in distribution of death-associated protein kinase mRNAs","volume":"58","author":"Yamamoto","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mcn.2025.104029_bb0275","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.cellsig.2012.03.010","article-title":"DAPk1 inhibits NF-kappaB activation through TNF-alpha and INF-gamma-induced apoptosis","volume":"24","author":"Yoo","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mcn.2025.104029_bb0280","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1044-7431(02)00038-6","article-title":"Regulation of sympathetic neuron and neuroblastoma cell death by XIAP and its association with proteasomes in neural cells","volume":"22","author":"Yu","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2025.104029_bb0285","first-page":"9651092","article-title":"Death-associated protein kinase 1 (DAPK1) protects against myocardial injury induced by myocardial infarction in rats via inhibition of inflammation and oxidative stress","volume":"2022","author":"Zhang","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.mcn.2025.104029_bb0290","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuroscience.2023.06.024","article-title":"Mechanism of cAMP response element-binding protein 1\/death-associated protein kinase 1 Axis-mediated hippocampal neuron apoptosis in rat brain injury after cardiopulmonary resuscitation","volume":"526","author":"Zhou","year":"2023","journal-title":"NEUROSCIENCE"}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743125000399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743125000399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:50:45Z","timestamp":1778583045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743125000399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":58,"alternative-id":["S1044743125000399"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2025.104029","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DAPK1 induces motor neuron apoptosis in hSOD1G93A-linked amyotrophic lateral sclerosis via regulating the Xiap\/JNK pathway","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2025.104029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104029"}}