{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:03:28Z","timestamp":1770743008104,"version":"3.49.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012645","name":"Kentucky Spinal Cord and Head Injury Research Trust","doi-asserted-by":"publisher","award":["6-12"],"award-info":[{"award-number":["6-12"]}],"id":[{"id":"10.13039\/100012645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","award":["P30 NS051220"],"award-info":[{"award-number":["P30 NS051220"]}],"id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","award":["P01 NS058484"],"award-info":[{"award-number":["P01 NS058484"]}],"id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","award":["F31 NS071804"],"award-info":[{"award-number":["F31 NS071804"]}],"id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","award":["T32 DA0222738"],"award-info":[{"award-number":["T32 DA0222738"]}],"id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DA0222738"],"award-info":[{"award-number":["T32 DA0222738"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 NS071804"],"award-info":[{"award-number":["F31 NS071804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.mcn.2025.104032","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T06:46:28Z","timestamp":1753166788000},"page":"104032","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ubiquitous calpastatin overexpression in brain-injured mice attenuates motor and cognitive behavioral deficits without overt neuroprotection"],"prefix":"10.1016","volume":"134","author":[{"given":"Kathleen M.","family":"Schoch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic N.","family":"Nthenge-Ngumbau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Brelsfoard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory S.","family":"Hawk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn E.","family":"Saatman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mcn.2025.104032_bb0005","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1089\/neu.2006.0224","article-title":"Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury","volume":"24","author":"Ai","year":"2007","journal-title":"J. Neurotrauma"},{"issue":"5","key":"10.1016\/j.mcn.2025.104032_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2023.100543","article-title":"N-Terminomic changes in neurons during excitotoxicity reveal proteolytic events associated with synaptic dysfunctions and potential targets for neuroprotection","volume":"22","author":"Ameen","year":"2023","journal-title":"Mol. Cell. Proteomics"},{"issue":"13","key":"10.1016\/j.mcn.2025.104032_bb0015","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1523\/JNEUROSCI.4247-12.2013","article-title":"Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury","volume":"33","author":"Amini","year":"2013","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.mcn.2025.104032_bb0020","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1074\/jbc.M706851200","article-title":"N terminus of calpain 1 is a mitochondrial targeting sequence","volume":"283","author":"Badugu","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.mcn.2025.104032_bb0025","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2174\/1570159X17666190228112451","article-title":"Calpain-1 and Calpain-2 in the brain: Dr. Jekill and Mr Hyde?","volume":"17","author":"Baudry","year":"2019","journal-title":"Curr. Neuropharmacol."},{"issue":"4","key":"10.1016\/j.mcn.2025.104032_bb0030","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.tins.2016.01.007","article-title":"Calpain-1 and Calpain-2: the Yin and Yang of synaptic plasticity and neurodegeneration","volume":"39","author":"Baudry","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.mcn.2025.104032_bb0035","doi-asserted-by":"crossref","first-page":"1337850","DOI":"10.3389\/fnmol.2024.1337850","article-title":"Revisiting the calpain hypothesis of learning and memory 40 years later","volume":"17","author":"Baudry","year":"2024","journal-title":"Front. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.mcn.2025.104032_bb0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.vascn.2006.04.001","article-title":"The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity","volume":"54","author":"Bertaina-Anglade","year":"2006","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"3","key":"10.1016\/j.mcn.2025.104032_bb0045","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/089771503321532842","article-title":"Preinjury administration of the calpain inhibitor MDL-28170 attenuates traumatically induced axonal injury","volume":"20","author":"Buki","year":"2003","journal-title":"J. Neurotrauma"},{"issue":"13","key":"10.1016\/j.mcn.2025.104032_bb0050","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1089\/neu.2017.5374","article-title":"Central infusion of insulin-like growth factor-1 increases hippocampal neurogenesis and improves neurobehavioral function after traumatic brain injury","volume":"35","author":"Carlson","year":"2018","journal-title":"J. Neurotrauma"},{"issue":"5","key":"10.1016\/j.mcn.2025.104032_bb0055","first-page":"1","article-title":"Surveillance for traumatic brain injury-related deaths--United States, 1997-2007","volume":"60","author":"Coronado","year":"2011","journal-title":"Morbidity and mortality weekly report. Surveillance summaries"},{"issue":"6","key":"10.1016\/j.mcn.2025.104032_bb0060","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0892-0362(94)90033-7","article-title":"Use of an amino-cupric-silver technique for the detection of early and semiacute neuronal degeneration caused by neurotoxicants, hypoxia, and physical trauma","volume":"16","author":"de Olmos","year":"1994","journal-title":"Neurotoxicol. Teratol."},{"issue":"1","key":"10.1016\/j.mcn.2025.104032_bb0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0006-8993(90)90660-4","article-title":"Development of hippocampal long-term potentiation is reduced by recently introduced calpain inhibitors","volume":"530","author":"del Cerro","year":"1990","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.mcn.2025.104032_bb0070","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0006-8993(90)90148-5","article-title":"Calpain inhibitors block long-term potentiation","volume":"534","author":"Denny","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.mcn.2025.104032_bb0075","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.brainresbull.2018.08.016","article-title":"Controlled cortical impact-induced neurodegeneration decreases after administration of the novel calpain-inhibitor Gabadur","volume":"142","author":"Dugue","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mcn.2025.104032_bb0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0079-6123(06)61004-2","article-title":"Cellular and subcellular change evoked by diffuse traumatic brain injury: a complex web of change extending far beyond focal damage","volume":"161","author":"Farkas","year":"2007","journal-title":"Prog. Brain Res."},{"issue":"5","key":"10.1016\/j.mcn.2025.104032_bb0085","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/neu.1999.16.377","article-title":"Behavioral responses of C57BL\/6, FVB\/N, and 129\/SvEMS mouse strains to traumatic brain injury: implications for gene targeting approaches to neurotrauma","volume":"16","author":"Fox","year":"1999","journal-title":"J. Neurotrauma"},{"issue":"Pt 17","key":"10.1016\/j.mcn.2025.104032_bb0090","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1242\/jcs.02562","article-title":"Regulating cell migration: calpains make the cut","volume":"118","author":"Franco","year":"2005","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.mcn.2025.104032_bb0095","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.00029.2002","article-title":"The calpain system","volume":"83","author":"Goll","year":"2003","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.mcn.2025.104032_bb0100","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201900563","article-title":"Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease","volume":"2","author":"Granatiero","year":"2019","journal-title":"Life Sci Alliance"},{"issue":"2","key":"10.1016\/j.mcn.2025.104032_bb0105","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1089\/neu.2005.22.252","article-title":"Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury","volume":"22","author":"Hall","year":"2005","journal-title":"J. Neurotrauma"},{"issue":"7220","key":"10.1016\/j.mcn.2025.104032_bb0110","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature07451","article-title":"Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin","volume":"456","author":"Hanna","year":"2008","journal-title":"Nature"},{"issue":"41","key":"10.1016\/j.mcn.2025.104032_bb0115","doi-asserted-by":"crossref","first-page":"43126","DOI":"10.1074\/jbc.M408100200","article-title":"Differential compartmentalization of the calpain\/calpastatin network with the endoplasmic reticulum and Golgi apparatus","volume":"279","author":"Hood","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.mcn.2025.104032_bb0120","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10571-014-0123-0","article-title":"Knockdown of STIM1 improves neuronal survival after traumatic neuronal injury through regulating mGluR1-dependent Ca(2+) signaling in mouse cortical neurons","volume":"35","author":"Hou","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.mcn.2025.104032_bb0125","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1089\/089771501317095269","article-title":"The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury","volume":"18","author":"Kupina","year":"2001","journal-title":"J. Neurotrauma"},{"issue":"4","key":"10.1016\/j.mcn.2025.104032_bb0130","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3892\/etm.2025.12834","article-title":"Incidence and mortality related risk factors in patients with severe traumatic brain injury: a meta-analysis","volume":"29","author":"Liu","year":"2025","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.mcn.2025.104032_bb0135","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuropharm.2016.02.022","article-title":"A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation","volume":"105","author":"Liu","year":"2016","journal-title":"Neuropharmacology"},{"issue":"12","key":"10.1016\/j.mcn.2025.104032_bb0140","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1021\/jm0210717","article-title":"Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability","volume":"46","author":"Lubisch","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.mcn.2025.104032_bb0145","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fnmol.2017.00060","article-title":"Calpastatin overexpression preserves cognitive function following seizures, while maintaining post-injury neurogenesis","volume":"10","author":"Machado","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"37","key":"10.1016\/j.mcn.2025.104032_bb0150","doi-asserted-by":"crossref","first-page":"25565","DOI":"10.1021\/acsnano.4c06052","article-title":"Spatial measurement and inhibition of calpain activity in traumatic brain injury with an activity-based nanotheranostic platform","volume":"18","author":"Madias","year":"2024","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.mcn.2025.104032_bb0155","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/zeb.2015.1188","article-title":"A model of excitotoxic brain injury in larval zebrafish: potential application for high-throughput drug evaluation to treat traumatic brain injury","volume":"13","author":"McCutcheon","year":"2016","journal-title":"Zebrafish"},{"issue":"9","key":"10.1016\/j.mcn.2025.104032_bb0160","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.tins.2021.07.003","article-title":"The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration","volume":"44","author":"Metwally","year":"2021","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.mcn.2025.104032_bb0165","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0361-9230(01)00635-9","article-title":"Behavioral and neuroanatomical characterization of FVB\/N inbred mice","volume":"57","author":"Mineur","year":"2002","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.mcn.2025.104032_bb0170","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.mcn.2025.104032_bb0175","series-title":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research (U.S.), and National Academies Press (U.S.). Guide for the care and use of laboratory animals","author":"National Research Council (U.S.)","year":"2011"},{"issue":"2","key":"10.1016\/j.mcn.2025.104032_bb0180","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1124\/jpet.108.142679","article-title":"Inhibition of calpain prevents N-methyl-D-aspartate-induced degeneration of the nucleus basalis and associated behavioral dysfunction","volume":"327","author":"Nimmrich","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.mcn.2025.104032_bb0185","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0006-8993(89)91448-0","article-title":"The protease inhibitor leupeptin interferes with the development of LTP in hippocampal slices","volume":"505","author":"Oliver","year":"1989","journal-title":"Brain Res."},{"issue":"12","key":"10.1016\/j.mcn.2025.104032_bb0190","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd.2016.212","article-title":"Calpain research for drug discovery: challenges and potential","volume":"15","author":"Ono","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mcn.2025.104032_bb0195","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"issue":"11","key":"10.1016\/j.mcn.2025.104032_bb0200","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1089\/neu.2010.1499","article-title":"Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: implications for mechanistic and therapeutic studies","volume":"28","author":"Pleasant","year":"2011","journal-title":"J. Neurotrauma"},{"issue":"3","key":"10.1016\/j.mcn.2025.104032_bb0205","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2174\/1568007033482887","article-title":"Calpain and its involvement in the pathophysiology of CNS injuries and diseases: therapeutic potential of calpain inhibitors for prevention of neurodegeneration","volume":"2","author":"Ray","year":"2003","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"issue":"4","key":"10.1016\/j.mcn.2025.104032_bb0210","first-page":"1137","article-title":"Molecular mechanisms in the pathogenesis of traumatic brain injury","volume":"17","author":"Ray","year":"2002","journal-title":"Histol. Histopathol."},{"issue":"7","key":"10.1016\/j.mcn.2025.104032_bb0215","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1097\/00005072-199607000-00010","article-title":"Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat","volume":"55","author":"Saatman","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"1","key":"10.1016\/j.mcn.2025.104032_bb0220","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00004647-200001000-00010","article-title":"Behavioral efficacy of posttraumatic calpain inhibition is not accompanied by reduced spectrin proteolysis, cortical lesion, or apoptosis","volume":"20","author":"Saatman","year":"2000","journal-title":"J. Cereb. Blood Flow Metabol."},{"issue":"1","key":"10.1016\/j.mcn.2025.104032_bb0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.nurt.2009.11.002","article-title":"Calpain as a therapeutic target in traumatic brain injury","volume":"7","author":"Saatman","year":"2010","journal-title":"Neurotherapeutics"},{"issue":"2","key":"10.1016\/j.mcn.2025.104032_bb0230","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.expneurol.2012.04.022","article-title":"Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury","volume":"236","author":"Schoch","year":"2012","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.mcn.2025.104032_bb0235","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/jnc.12144","article-title":"Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse","volume":"125","author":"Schoch","year":"2013","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.mcn.2025.104032_bb0240","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/(SICI)1097-4547(19980815)53:4<482::AID-JNR10>3.0.CO;2-4","article-title":"Calpain expression varies among different rat and bovine central nervous system regions","volume":"53","author":"Shields","year":"1998","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.mcn.2025.104032_bb0245","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/neu.1995.12.169","article-title":"A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects","volume":"12","author":"Smith","year":"1995","journal-title":"J. Neurotrauma"},{"issue":"7","key":"10.1016\/j.mcn.2025.104032_bb0250","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0007-24.2024","article-title":"Trauma in neonatal acute brain slices alters calcium and network dynamics and causes Calpain-mediated cell death","volume":"11","author":"Suryavanshi","year":"2024","journal-title":"eNeuro"},{"issue":"3","key":"10.1016\/j.mcn.2025.104032_bb0255","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/0006-291X(92)90247-I","article-title":"Calpain may produce a Ca(2+)-independent form of kinase C in long-term potentiation","volume":"189","author":"Suzuki","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.mcn.2025.104032_bb0260","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/019262330002800109","article-title":"Application of silver degeneration stains for neurotoxicity testing","volume":"28","author":"Switzer","year":"2000","journal-title":"Toxicol. Pathol."},{"issue":"6","key":"10.1016\/j.mcn.2025.104032_bb0265","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1073\/pnas.88.6.2065","article-title":"FVB\/N: an inbred mouse strain preferable for transgenic analyses","volume":"88","author":"Taketo","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.mcn.2025.104032_bb0270","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1089\/neu.2010.1474","article-title":"A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model","volume":"27","author":"Thompson","year":"2010","journal-title":"J. Neurotrauma"},{"issue":"4","key":"10.1016\/j.mcn.2025.104032_bb0275","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1089\/neu.2007.0452","article-title":"Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions","volume":"25","author":"Tsenter","year":"2008","journal-title":"J. Neurotrauma"},{"issue":"2\u20133","key":"10.1016\/j.mcn.2025.104032_bb0280","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1101\/lm.3.2-3.209","article-title":"Translational suppression of calpain blocks long-term potentiation","volume":"3","author":"Vanderklish","year":"1996","journal-title":"Learn. Mem."},{"key":"10.1016\/j.mcn.2025.104032_bb0285","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1038\/ncomms4051","article-title":"A molecular brake controls the magnitude of long-term potentiation","volume":"5","author":"Wang","year":"2014","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mcn.2025.104032_bb0290","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/neu.2017.5024","article-title":"Protection against TBI-induced neuronal death with post-treatment with a selective Calpain-2 inhibitor in mice","volume":"35","author":"Wang","year":"2018","journal-title":"J. Neurotrauma"},{"issue":"27","key":"10.1016\/j.mcn.2025.104032_bb0295","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba5547","article-title":"Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"issue":"12","key":"10.1016\/j.mcn.2025.104032_bb0300","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.3390\/cells9122698","article-title":"Calpain-1 and Calpain-2 in the brain: new evidence for a critical role of Calpain-2 in neuronal death","volume":"9","author":"Wang","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mcn.2025.104032_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105149","article-title":"Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology","volume":"147","author":"Wang","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2025.104032_bb0310","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fphar.2012.00060","article-title":"Altered calcium signaling following traumatic brain injury","volume":"3","author":"Weber","year":"2012","journal-title":"Front. Pharmacol."},{"issue":"16","key":"10.1016\/j.mcn.2025.104032_bb0315","doi-asserted-by":"crossref","first-page":"13182","DOI":"10.1074\/jbc.M111.302612","article-title":"Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress","volume":"287","author":"Yamada","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.mcn.2025.104032_bb0320","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.neuron.2013.08.034","article-title":"Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin","volume":"80","author":"Yang","year":"2013","journal-title":"Neuron"},{"issue":"15","key":"10.1016\/j.mcn.2025.104032_bb0325","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1089\/neu.2012.2511","article-title":"Comparing the predictive value of multiple cognitive, affective, and motor tasks after rodent traumatic brain injury","volume":"29","author":"Zhao","year":"2012","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.mcn.2025.104032_bb0330","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1523\/JNEUROSCI.2193-14.2015","article-title":"Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways","volume":"35","author":"Zhu","year":"2015","journal-title":"J. Neurosci."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743125000429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743125000429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:51:39Z","timestamp":1762354299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743125000429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":66,"alternative-id":["S1044743125000429"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2025.104032","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ubiquitous calpastatin overexpression in brain-injured mice attenuates motor and cognitive behavioral deficits without overt neuroprotection","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2025.104032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104032"}}