{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:02:34Z","timestamp":1781064154392,"version":"3.54.1"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mcn.2026.104096","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:29:05Z","timestamp":1776871745000},"page":"104096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Occurrence of neuronal dysfunction in mice with virus- or toxic-induced lesions in the central nervous system"],"prefix":"10.1016","volume":"137","author":[{"given":"Martin","family":"Dembowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Burigk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Baumg\u00e4rtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Hansmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcn.2026.104096_bb0005","doi-asserted-by":"crossref","DOI":"10.1038\/srep13659","article-title":"Architecture of the synaptophysin\/synaptobrevin complex: structural evidence for an entropic clustering function at the synapse","volume":"5","author":"Adams","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcn.2026.104096_bb0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fncel.2017.00076","article-title":"Neuroplastic changes following brain ischemia and their contribution to stroke recovery: novel approaches in neurorehabilitation","volume":"11","author":"Alia","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2026.104096_bb0015","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1152\/jn.00272.2025","article-title":"Synaptic PSD-95 biology: from localization and interactors to N-terminus function","volume":"134","author":"Alkaas","year":"2025","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.mcn.2026.104096_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2014.00281","article-title":"Anti-apoptotic BCL-2 family proteins in acute neural injury","volume":"8","author":"Anilkumar","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"7","key":"10.1016\/j.mcn.2026.104096_bb0025","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/embor.2013.75","article-title":"Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses","volume":"14","author":"Antonucci","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mcn.2026.104096_bb0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fnsyn.2016.00007","article-title":"SNAP-25, a known presynaptic protein with emerging postsynaptic functions","volume":"8","author":"Antonucci","year":"2016","journal-title":"Front. Synaptic Neurosci."},{"issue":"4","key":"10.1016\/j.mcn.2026.104096_bb0035","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/cne.20449","article-title":"Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses","volume":"483","author":"Aoki","year":"2005","journal-title":"J. Comp. Neurol."},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0882-4010(87)90002-7","article-title":"Identification of Theiler\u2019s virus infected cells in the central nervous system of the mouse during demyelinating disease","volume":"3","author":"Aubert","year":"1987","journal-title":"Microb. Pathog."},{"issue":"1","key":"10.1016\/j.mcn.2026.104096_bb0045","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1523\/JNEUROSCI.08-01-00339.1988","article-title":"Anatomical distribution of the growth-associated protein GAP-43\/B-50 in the adult rat brain","volume":"8","author":"Benowitz","year":"1988","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.mcn.2026.104096_bb0050","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1117\/1.1755721","article-title":"Interaction of PSD-95 with potassium channels visualized by fluorescence lifetime-based resonance energy transfer imaging","volume":"9","author":"Biskup","year":"2004","journal-title":"J. Biomed. Opt."},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0055","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2990.1982.tb00305.x","article-title":"Ethidium bromide induced demyelination in the spinal cord of the cat","volume":"8","author":"Blakemore","year":"1982","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.mcn.2026.104096_bb0060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.nbd.2016.01.007","article-title":"Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis","volume":"88","author":"Cacabelos","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0065","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2004.08.013","article-title":"Docosahexaenoic acid protects from dendritic pathology in an Alzheimer\u2019s disease mouse model","volume":"43","author":"Calon","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2026.104096_bb0070","doi-asserted-by":"crossref","first-page":"60S","DOI":"10.2967\/jnumed.121.263201","article-title":"Imaging of synaptic density in neurodegenerative disorders","volume":"63","author":"Carson","year":"2022","journal-title":"J. Nucl. Med."},{"issue":"11","key":"10.1016\/j.mcn.2026.104096_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.309","article-title":"Cracking the code of neuronal apoptosis and survival","volume":"6","author":"Cavallaro","year":"2015","journal-title":"Cell Death Dis."},{"issue":"9696","key":"10.1016\/j.mcn.2026.104096_bb0080","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(09)61460-4","article-title":"Ageing populations: the challenges ahead","volume":"374","author":"Christensen","year":"2009","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.mcn.2026.104096_bb0085","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","article-title":"Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)","volume":"164","author":"Constantinescu","year":"2011","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.mcn.2026.104096_bb0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1083\/jcb.150.1.131","article-title":"Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization","volume":"150","author":"Deshmukh","year":"2000","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.mcn.2026.104096_bb0095","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s12276-025-01470-9","article-title":"Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond","volume":"57","author":"Dho","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0306-4522(94)00586-T","article-title":"Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia","volume":"66","author":"Eastwood","year":"1995","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00318874","article-title":"Mice lacking synaptophysin reproduce and form typical synaptic vesicles","volume":"282","author":"Eshkind","year":"1995","journal-title":"Cell Tissue Res."},{"issue":"7664","key":"10.1016\/j.mcn.2026.104096_bb0110","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1038\/nature22293","article-title":"Can we predict protein from mRNA levels?","volume":"547","author":"Fortelny","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.mcn.2026.104096_bb0115","article-title":"Differential changes in postsynaptic density proteins in postmortem Huntington\u2019s disease and Parkinson\u2019s disease human brains","volume":"2014","author":"Fourie","year":"2014","journal-title":"J. Neurodegener. Dis."},{"issue":"7","key":"10.1016\/j.mcn.2026.104096_bb0120","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1083\/jcb.149.7.1443","article-title":"Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity","volume":"149","author":"Frey","year":"2000","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.mcn.2026.104096_bb0125","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1440-1789.2002.00459.x","article-title":"The reaction of glial progenitor cells in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord","volume":"22","author":"Fushimi","year":"2002","journal-title":"Neuropathology"},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0130","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1440-1789.2004.00561.x","article-title":"Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord","volume":"24","author":"Fushimi","year":"2004","journal-title":"Neuropathology"},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0135","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s10495-018-1448-9","article-title":"Dynamic changes and molecular analysis of cell death in the spinal cord of SJL mice infected with the BeAn strain of Theiler's murine encephalomyelitis virus","volume":"23","author":"Gerhauser","year":"2018","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0140","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3390\/ijms20020448","article-title":"Facets of Theiler\u2019s murine encephalomyelitis virus-induced diseases: an update","volume":"20","author":"Gerhauser","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"39","key":"10.1016\/j.mcn.2026.104096_bb0145","doi-asserted-by":"crossref","first-page":"14032","DOI":"10.1523\/JNEUROSCI.3162-11.2011","article-title":"Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosis","volume":"31","author":"Gordon","year":"2011","journal-title":"J. Neurosci."},{"issue":"6A","key":"10.1016\/j.mcn.2026.104096_bb0150","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1111\/j.1582-4934.2008.00402.x","article-title":"Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling","volume":"12","author":"Gorman","year":"2008","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0155","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/jnen\/nlw114","article-title":"Synaptophysin is a reliable marker for axonal damage","volume":"76","author":"Gudi","year":"2017","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.mcn.2026.104096_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1551449","article-title":"Neuroprotection unveiled: melatonin mitigates apoptotic pathways in traumatic brain injury","volume":"16","author":"Gunara","year":"2025","journal-title":"Front. Neurol."},{"issue":"6","key":"10.1016\/j.mcn.2026.104096_bb0165","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/00005072-199906000-00008","article-title":"Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease","volume":"58","author":"Hatanp\u00e4\u00e4","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"32","key":"10.1016\/j.mcn.2026.104096_bb0170","doi-asserted-by":"crossref","first-page":"20300","DOI":"10.1074\/jbc.273.32.20300","article-title":"Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic \u03b2-cell line \u03b2HC9*","volume":"273","author":"Hayakawa","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.mcn.2026.104096_bb0175","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1523\/JNEUROSCI.17-10-03515.1997","article-title":"Modulation of actin filament behavior by GAP-43 (neuromodulin) is dependent on the phosphorylation status of serine 41, the protein kinase C site","volume":"17","author":"He","year":"1997","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0180","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0920-1211(96)00024-1","article-title":"A comparison of health-related quality of life in patients with epilepsy, diabetes and multiple sclerosis","volume":"25","author":"Hermann","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.mcn.2026.104096_bb0185","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fncel.2017.00266","article-title":"A shift from a pivotal to supporting role for the growth-associated protein (GAP-43) in the coordination of axonal structural and functional plasticity","volume":"11","author":"Holahan","year":"2017","journal-title":"Front. Cell. Neurosci."},{"issue":"17","key":"10.1016\/j.mcn.2026.104096_bb0190","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1111\/febs.14970","article-title":"Apoptotic cell death regulation in neurons","volume":"286","author":"Hollville","year":"2019","journal-title":"FEBS J."},{"issue":"10","key":"10.1016\/j.mcn.2026.104096_bb0195","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0200","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.neuron.2013.10.025","article-title":"AMPARs and synaptic plasticity: the last 25 years","volume":"80","author":"Huganir","year":"2013","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0205","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/00005072-199509000-00009","article-title":"Quantitative study of synaptophysin immunoreactivity of cerebral cortex and spinal cord in motor neuron disease","volume":"54","author":"Ince","year":"1995","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"5331","key":"10.1016\/j.mcn.2026.104096_bb0210","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1126\/science.277.5331.1511","article-title":"Binding of neuroligins to PSD-95","volume":"277","author":"Irie","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.mcn.2026.104096_bb0215","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-4-431-56550-5_12","article-title":"Drebrin in Alzheimer\u2019s disease","volume":"1006","author":"Ishizuka","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0220","doi-asserted-by":"crossref","first-page":"205","DOI":"10.15171\/apb.2019.024","article-title":"Understanding apoptosis and apoptotic pathways targeted cancer therapeutics","volume":"9","author":"Jan","year":"2019","journal-title":"Adv. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0225","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0896-6273(00)81122-8","article-title":"Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I","volume":"24","author":"Janz","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.mcn.2026.104096_bb0230","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/neuro.02.004.2008","article-title":"Excitation control: balancing PSD-95 function at the synapse","volume":"1","author":"Keith","year":"2008","journal-title":"Front. Mol. Neurosci."},{"issue":"Pt 2","key":"10.1016\/j.mcn.2026.104096_bb0235","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1242\/jcs.113.2.325","article-title":"Isoform specific expression of the neuronal F-actin binding protein, drebrin, in specialized cells of stomach and kidney epithelia","volume":"113","author":"Keon","year":"2000","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0240","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.nbd.2009.11.010","article-title":"Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients","volume":"37","author":"Kim","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcn.2026.104096_bb0245","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuroscience.2016.03.015","article-title":"Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice","volume":"324","author":"Kojima","year":"2016","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.mcn.2026.104096_bb0250","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jnc.14797","article-title":"Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels","volume":"151","author":"Kokotos","year":"2019","journal-title":"J. Neurochem."},{"issue":"7\u20138","key":"10.1016\/j.mcn.2026.104096_bb0255","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10495-023-01848-y","article-title":"Apoptosis in Alzheimer\u2019s disease: insight into the signaling pathways and therapeutic avenues","volume":"28","author":"Kumari","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.mcn.2026.104096_bb0260","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.expneurol.2013.02.014","article-title":"Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord","volume":"247","author":"Kuypers","year":"2013","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0265","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.neuron.2011.04.001","article-title":"Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons","volume":"70","author":"Kwon","year":"2011","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0270","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0165-3806(89)90279-4","article-title":"GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system","volume":"46","author":"La Monte","year":"1989","journal-title":"Brain Res. Dev. Brain Res."},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0275","doi-asserted-by":"crossref","first-page":"426","DOI":"10.4049\/jimmunol.1401442","article-title":"Cutting edge: drebrin-regulated actin dynamics regulate IgE-dependent mast cell activation and allergic responses","volume":"195","author":"Law","year":"2015","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.mcn.2026.104096_bb0280","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/syn.21578","article-title":"Presenilin conditional double knockout mice exhibit decreases in drebrin a at hippocampal CA1 synapses","volume":"66","author":"Lee","year":"2012","journal-title":"Synapse"},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0285","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.nbd.2008.02.012","article-title":"Postsynaptic density protein PSD-95 expression in Alzheimer\u2019s disease and okadaic acid induced neuritic retraction","volume":"30","author":"Leuba","year":"2008","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0290","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1128\/iai.11.5.1147-1155.1975","article-title":"Theiler\u2019s virus infection in mice: an unusual biphasic disease process leading to demyelination","volume":"11","author":"Lipton","year":"1975","journal-title":"Infect. Immun."},{"issue":"1\u20132","key":"10.1016\/j.mcn.2026.104096_bb0295","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.brainres.2005.10.012","article-title":"Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes","volume":"1064","author":"Mahadomrongkul","year":"2005","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0300","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1083\/jcb.144.5.883","article-title":"The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event","volume":"144","author":"Martinou","year":"1999","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.mcn.2026.104096_bb0305","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.56.1.127","article-title":"Altered expression of synaptic proteins occurs early during progression of Alzheimer\u2019s disease","volume":"56","author":"Masliah","year":"2001","journal-title":"Neurology"},{"issue":"1\u20132","key":"10.1016\/j.mcn.2026.104096_bb0310","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0165-3806(88)90189-7","article-title":"Light-microscopic immunolocalization of the growth- and plasticity-associated protein GAP-43 in the developing rat brain","volume":"469","author":"McGuire","year":"1988","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.mcn.2026.104096_bb0315","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008656","article-title":"Caspase functions in cell death and disease","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"10","key":"10.1016\/j.mcn.2026.104096_bb0320","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1073\/pnas.93.10.4760","article-title":"Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release","volume":"93","author":"McMahon","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.mcn.2026.104096_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085367","article-title":"Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines","volume":"9","author":"Mizui","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mcn.2026.104096_bb0330","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.782599","article-title":"Synaptic loss in multiple sclerosis: a systematic review of human post-mortem studies","volume":"12","author":"M\u00f6ck","year":"2021","journal-title":"Front. Neurol."},{"issue":"22","key":"10.1016\/j.mcn.2026.104096_bb0335","doi-asserted-by":"crossref","DOI":"10.3390\/cells13221838","article-title":"Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications","volume":"13","author":"Mustafa","year":"2024","journal-title":"Cells"},{"issue":"19","key":"10.1016\/j.mcn.2026.104096_bb0340","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1523\/JNEUROSCI.18-19-07757.1998","article-title":"The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis","volume":"18","author":"Neve","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcn.2026.104096_bb0345","series-title":"Molecular Mechanisms of Neurotransmitter Release","first-page":"63","article-title":"SNARE proteins in synaptic vesicle fusion","author":"Palfreyman","year":"2023"},{"key":"10.1016\/j.mcn.2026.104096_bb0350","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2024.1419108","article-title":"Parkinson\u2019s disease models and death signaling: what do we know until now?","volume":"18","author":"Pedr\u00e3o","year":"2024","journal-title":"Front. Neuroanat."},{"issue":"9","key":"10.1016\/j.mcn.2026.104096_bb0355","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1078\/0171-9335-00194","article-title":"Drebrin particles: components in the ensemble of proteins regulating actin dynamics of lamellipodia and filopodia","volume":"80","author":"Peitsch","year":"2001","journal-title":"Eur. J. Cell Biol."},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0360","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/febs.14186","article-title":"Bax, Bak and beyond - mitochondrial performance in apoptosis","volume":"285","author":"Pe\u00f1a-Blanco","year":"2018","journal-title":"FEBS J."},{"issue":"Pt 7","key":"10.1016\/j.mcn.2026.104096_bb0365","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1242\/jcs.064238","article-title":"F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse","volume":"123","author":"P\u00e9rez-Mart\u00ednez","year":"2010","journal-title":"J. Cell Sci."},{"issue":"11","key":"10.1016\/j.mcn.2026.104096_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111156","article-title":"SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neurons","volume":"27","author":"Raveendran","year":"2024","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0375","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF00296180","article-title":"Decreased synaptophysin immunoreactivity of the anterior horns in motor neuron disease","volume":"87","author":"Sasaki","year":"1994","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mcn.2026.104096_bb0380","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.arr.2014.09.004","article-title":"A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer\u2019s disease","volume":"18","author":"Savioz","year":"2014","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.mcn.2026.104096_bb0385","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/s41467-021-21662-x","article-title":"Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking","volume":"12","author":"Schiweck","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0390","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuroscience.2009.04.046","article-title":"Detection of behavioral alterations and learning deficits in mice lacking synaptophysin","volume":"162","author":"Schmitt","year":"2009","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0395","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.mcn.2005.11.003","article-title":"Activation of N-methyl-D-aspartate receptor induces a shift of drebrin distribution: disappearance from dendritic spines and appearance in dendritic shafts","volume":"31","author":"Sekino","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.mcn.2026.104096_bb0400","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.796129","article-title":"Imaging synaptic density: the next holy grail of neuroscience?","volume":"16","author":"Serrano","year":"2022","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0405","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0165-3806(86)90099-4","article-title":"Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution","volume":"394","author":"Shirao","year":"1986","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.mcn.2026.104096_bb0410","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/jnc.13988","article-title":"The role of drebrin in neurons","volume":"141","author":"Shirao","year":"2017","journal-title":"J. Neurochem."},{"issue":"9","key":"10.1016\/j.mcn.2026.104096_bb0415","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1002\/glia.70048","article-title":"Drebrin upregulation regulates astrocyte polarization and supports tissue recovery after spinal cord injury in mice","volume":"73","author":"Smejkalov\u00e1","year":"2025","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.mcn.2026.104096_bb0420","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0092-8674(03)00477-X","article-title":"Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23","volume":"114","author":"S\u00f8rensen","year":"2003","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0425","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41418-024-01403-5","article-title":"Apoptosis signaling is activated as a transient pulse in neurons","volume":"32","author":"Spiess","year":"2025","journal-title":"Cell Death Differ."},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0430","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1074\/jbc.M008944200","article-title":"Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route","volume":"276","author":"Stoka","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0435","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ng.367","article-title":"A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation","volume":"41","author":"Tarpey","year":"2009","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.mcn.2026.104096_bb0440","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.72.1.49","article-title":"Encephalomyelitis of mice: I. Characteristics and pathogenesis of the virus","volume":"72","author":"Theiler","year":"1940","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.mcn.2026.104096_bb0445","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1006\/viro.1996.8382","article-title":"Apoptosis in acute and chronic central nervous system disease induced by Theiler's murine encephalomyelitis virus","volume":"228","author":"Tsunoda","year":"1997","journal-title":"Virology"},{"issue":"1\u20132","key":"10.1016\/j.mcn.2026.104096_bb0450","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1582-4934.2008.00646.x","article-title":"Machine learning approach identifies new pathways associated with demyelination in a viral model of multiple sclerosis","volume":"14","author":"Ulrich","year":"2010","journal-title":"J. Cell. Mol. Med."},{"issue":"8","key":"10.1016\/j.mcn.2026.104096_bb0455","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.leukres.2011.03.028","article-title":"High expression of cytoskeletal protein drebrin in TEL\/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody","volume":"35","author":"Vaskova","year":"2011","journal-title":"Leuk. Res."},{"issue":"14","key":"10.1016\/j.mcn.2026.104096_bb0460","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler."},{"key":"10.1016\/j.mcn.2026.104096_bb0465","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2021.740318","article-title":"Room for two: the synaptophysin\/synaptobrevin complex","volume":"13","author":"White","year":"2021","journal-title":"Front. Synaptic Neurosci."},{"issue":"4","key":"10.1016\/j.mcn.2026.104096_bb0470","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41419-023-05786-0","article-title":"Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways","volume":"14","author":"Xie","year":"2023","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.mcn.2026.104096_bb0475","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.0013-9580.2004.37703.x","article-title":"Increased numbers of coassembled PSD-95 to NMDA-receptor subunits NR2B and NR1 in human epileptic cortical dysplasia","volume":"45","author":"Ying","year":"2004","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0480","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","article-title":"A guide to cell death pathways","volume":"25","author":"Yuan","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mcn.2026.104096_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2025.120236","article-title":"SNAP-25: a biomarker of synaptic loss in neurodegeneration","volume":"571","author":"Zhang","year":"2025","journal-title":"Clin. Chim. Acta"},{"issue":"3","key":"10.1016\/j.mcn.2026.104096_bb0490","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s11596-025-00043-1","article-title":"Vitamin D activates Nrf2 to prevent nerve injury and reduce brain damage in acute cerebral infarction","volume":"45","author":"Zhao","year":"2025","journal-title":"Curr. Med. Sci."},{"issue":"5","key":"10.1016\/j.mcn.2026.104096_bb0495","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0002-9440(10)64298-8","article-title":"Dendritic and synaptic pathology in experimental autoimmune encephalomyelitis","volume":"162","author":"Zhu","year":"2003","journal-title":"Am. J. Pathol."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743126000266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743126000266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:35:01Z","timestamp":1781062501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743126000266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":99,"alternative-id":["S1044743126000266"],"URL":"https:\/\/doi.org\/10.1016\/j.mcn.2026.104096","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Occurrence of neuronal dysfunction in mice with virus- or toxic-induced lesions in the central nervous system","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcn.2026.104096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104096"}}