{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:20:42Z","timestamp":1791015642629,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Clinics of North America"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.mcna.2021.05.008","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T18:26:44Z","timestamp":1626114404000},"page":"859-870","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Acute and Chronic Sinusitis"],"prefix":"10.1016","volume":"105","author":[{"given":"Benjamin S.","family":"Bleier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianella","family":"Paz-Lansberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3 Suppl","key":"10.1016\/j.mcna.2021.05.008_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/hn.2003.v128.amhn0312811","article-title":"Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology","volume":"129","author":"Benninger","year":"2003","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.mcna.2021.05.008_bib2","doi-asserted-by":"crossref","unstructured":"Orlandi RR, Kingdom TT, Smith TL, et al. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis 2021. Int Forum Allergy Rhinol 2021;11(3):213-739.","DOI":"10.1002\/alr.22741"},{"issue":"2 Suppl","key":"10.1016\/j.mcna.2021.05.008_bib3","first-page":"S1","article-title":"Clinical practice guideline (update): adult sinusitis","volume":"152","author":"Rosenfeld","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"6 Suppl","key":"10.1016\/j.mcna.2021.05.008_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaci.2004.09.029","article-title":"Rhinosinusitis: establishing definitions for clinical research and patient care","volume":"114","author":"Meltzer","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.mcna.2021.05.008_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0194-5998(00)70135-5","article-title":"Diagnosis and treatment of uncomplicated acute bacterial rhinosinusitis: summary of the Agency for Health Care Policy and Research evidence-based report","volume":"122","author":"Benninger","year":"2000","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"10.1016\/j.mcna.2021.05.008_bib6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.otohns.2006.06.1247","article-title":"Disease severity in acute bacterial rhinosinusitis is greater in patients infected with Streptococcus pneumoniae than in those infected with Haemophilus influenzae","volume":"135","author":"Benninger","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1016\/j.mcna.2021.05.008_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11882-008-0023-9","article-title":"Intranasal corticosteroids in the treatment of acute rhinosinusitis","volume":"8","author":"Meltzer","year":"2008","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"10.1016\/j.mcna.2021.05.008_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4193\/Rhino13.225","article-title":"Efficacy and side effects of antibiotics in the treatment of acute rhinosinusitis: a systematic review","volume":"53","author":"Sng","year":"2015","journal-title":"Rhinology"},{"issue":"9","key":"10.1016\/j.mcna.2021.05.008_bib9","article-title":"Antibiotics for acute rhinosinusitis in adults","volume":"9","author":"Lemiengre","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"3 Suppl","key":"10.1016\/j.mcna.2021.05.008_bib10","first-page":"S32","article-title":"Systematic review of antimicrobial therapy in patients with acute rhinosinusitis","volume":"137","author":"Rosenfeld","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"Suppl S29","key":"10.1016\/j.mcna.2021.05.008_bib11","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal Polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"1","key":"10.1016\/j.mcna.2021.05.008_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/MOO.0b013e3283350053","article-title":"Perspectives on the etiology of chronic rhinosinusitis","volume":"18","author":"Tan","year":"2010","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.mcna.2021.05.008_bib13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/1945892418787132","article-title":"Biologics in chronic rhinosinusitis: an update and thoughts for future directions","volume":"32","author":"Smith","year":"2018","journal-title":"Am J Rhinol Allergy"},{"issue":"4","key":"10.1016\/j.mcna.2021.05.008_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2001.112374","article-title":"Total and specific IgE in nasal polyps is related to local eosinophilic inflammation","volume":"107","author":"Bachert","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.mcna.2021.05.008_bib15","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.jaip.2019.02.037","article-title":"Sinus surgery improves lower respiratory tract reactivity during aspirin desensitization for AERD","volume":"7","author":"Huang","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.mcna.2021.05.008_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/alr.21064","article-title":"Antimicrobials and chronic rhinosinusitis with or without polyposis in adults: an evidenced-based review with recommendations","volume":"3","author":"Soler","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"issue":"2","key":"10.1016\/j.mcna.2021.05.008_bib17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/lary.20064","article-title":"The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study","volume":"119","author":"Ebbens","year":"2009","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.mcna.2021.05.008_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2500\/ajr.2008.22.3115","article-title":"Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study","volume":"22","author":"Liang","year":"2008","journal-title":"Am J Rhinol"},{"issue":"1","key":"10.1016\/j.mcna.2021.05.008_bib19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jaci.2018.06.010","article-title":"NAVIGATE II: Randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis","volume":"143","author":"Leopold","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"11","key":"10.1016\/j.mcna.2021.05.008_bib20","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.clinthera.2019.09.013","article-title":"A\u00a0randomized comparison of the pharmacokinetics and bioavailability of fluticasone propionate delivered via xhance exhalation delivery system versus flonase nasal spray and flovent HFA inhalational aerosol","volume":"41","author":"Messina","year":"2019","journal-title":"Clin Ther"},{"issue":"5","key":"10.1016\/j.mcna.2021.05.008_bib21","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/alr.21309","article-title":"Steroid-eluting sinus implant for in-office treatment of recurrent nasal polyposis: a prospective, multicenter study","volume":"4","author":"Lavigne","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"issue":"11","key":"10.1016\/j.mcna.2021.05.008_bib22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/alr.21426","article-title":"RESOLVE: a randomized, controlled, blinded study of bioabsorbable steroid-eluting sinus implants for in-office treatment of recurrent sinonasal polyposis","volume":"4","author":"Han","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"issue":"11","key":"10.1016\/j.mcna.2021.05.008_bib23","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1177\/0003489417731782","article-title":"Anti-IgE and anti-IL5 biologic therapy in the treatment of nasal polyposis: a systematic review and meta-analysis","volume":"126","author":"Rivero","year":"2017","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"3","key":"10.1016\/j.mcna.2021.05.008_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2500\/105065800782102717","article-title":"Macrolide treatment decreased the size of nasal polyps and IL-8 levels in nasal lavage","volume":"14","author":"Yamada","year":"2000","journal-title":"Am J Rhinol"},{"issue":"1","key":"10.1016\/j.mcna.2021.05.008_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/lary.26169","article-title":"Cost utility analysis of endoscopic sinus surgery for chronic rhinosinusitis with and without nasal polyposis","volume":"127","author":"Scangas","year":"2017","journal-title":"Laryngoscope"},{"issue":"4","key":"10.1016\/j.mcna.2021.05.008_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/alr.22264","article-title":"Long-term revision rates for endoscopic sinus surgery","volume":"9","author":"Smith","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"issue":"5","key":"10.1016\/j.mcna.2021.05.008_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/alr.21047","article-title":"Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis","volume":"2","author":"Snidvongs","year":"2012","journal-title":"Int Forum Allergy Rhinol"},{"issue":"1","key":"10.1016\/j.mcna.2021.05.008_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/alr.22034","article-title":"Evaluation of patient nasal saline irrigation practices following endoscopic sinus surgery","volume":"8","author":"Yoo","year":"2018","journal-title":"Int Forum Allergy Rhinol"}],"container-title":["Medical Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025712521000766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025712521000766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:45:46Z","timestamp":1758419146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025712521000766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0025712521000766"],"URL":"https:\/\/doi.org\/10.1016\/j.mcna.2021.05.008","relation":{},"ISSN":["0025-7125"],"issn-type":[{"value":"0025-7125","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute and Chronic Sinusitis","name":"articletitle","label":"Article Title"},{"value":"Medical Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcna.2021.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}