{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:59:22Z","timestamp":1777388362120,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"5-6","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Probes"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.mcp.2011.05.004","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T04:11:43Z","timestamp":1307938303000},"page":"255-259","source":"Crossref","is-referenced-by-count":15,"title":["Polymorphisms in genes encoding leptin, ghrelin and their receptors in German multiple sclerosis patients"],"prefix":"10.1016","volume":"25","author":[{"given":"Linda K.","family":"Rey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Wieczorek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis A.","family":"Akkad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf A.","family":"Linker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Hoffjan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcp.2011.05.004_bib1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/hmg\/ddn388","article-title":"Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis","volume":"18","author":"Baranzini","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mcp.2011.05.004_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1212\/WNL.48.3.572","volume":"48","author":"Lublin","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.mcp.2011.05.004_bib3","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1093\/brain\/awn081","article-title":"The complex genetics of multiple sclerosis: pitfalls and prospects","volume":"131","author":"Sawcer","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.mcp.2011.05.004_bib4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/sj.gene.6364237","article-title":"Multiple sclerosis genetics: leaving no stone unturned","volume":"6","author":"Oksenberg","year":"2005","journal-title":"Genes Immun"},{"key":"10.1016\/j.mcp.2011.05.004_bib5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nrg2395","article-title":"The genetics of multiple sclerosis: SNPs to pathways to pathogenesis","volume":"9","author":"Oksenberg","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.mcp.2011.05.004_bib6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.mcp.2010.04.006","article-title":"The genetics of multiple sclerosis: an update 2010","volume":"24","author":"Hoffjan","year":"2010","journal-title":"Mol Cell Probes"},{"key":"10.1016\/j.mcp.2011.05.004_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1196\/annals.1433.054","article-title":"Central nervous system regulation of energy metabolism: ghrelin versus leptin","volume":"1126","author":"Nogueiras","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.mcp.2011.05.004_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1399-0039.2007.00886.x","article-title":"Leptin in autoimmunity: many questions, some answers","volume":"70","author":"Matarese","year":"2007","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.mcp.2011.05.004_bib9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/rheumatology\/kem389","article-title":"Leptin and ANCA-associated vasculitis: a healthy link?","volume":"47","author":"Thewissen","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.mcp.2011.05.004_bib10","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1172\/JCI26523","article-title":"Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis","volume":"116","author":"De Rosa","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.mcp.2011.05.004_bib11","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1073\/pnas.0408995102","article-title":"Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells","volume":"102","author":"Matarese","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mcp.2011.05.004_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1172\/JCI200316721","article-title":"Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses","volume":"111","author":"Sanna","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.mcp.2011.05.004_bib13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0165-5728(03)00154-1","article-title":"Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta","volume":"139","author":"Batocchi","year":"2003","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.mcp.2011.05.004_bib14","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nm0502-500","article-title":"Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis","volume":"8","author":"Lock","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.mcp.2011.05.004_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jaut.2004.05.007","article-title":"Leptin and its soluble receptor in plasma of patients suffering from remitting\u2013relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients","volume":"23","author":"Chatzantoni","year":"2004","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.mcp.2011.05.004_bib16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jneuroim.2007.08.008","article-title":"The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing\u2013remitting multiple sclerosis","volume":"192","author":"Frisullo","year":"2007","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.mcp.2011.05.004_bib17","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.4049\/jimmunol.0803362","article-title":"Suppression of experimental autoimmune encephalomyelitis by ghrelin","volume":"183","author":"Theil","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.mcp.2011.05.004_bib18","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/rheumatology\/kep420","article-title":"Contrasting association of a non-synonymous leptin receptor gene polymorphism with Wegener\u2019s granulomatosis and Churg\u2013Strauss syndrome","volume":"49","author":"Wieczorek","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.mcp.2011.05.004_bib19","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ana.20703","article-title":"Diagnostic criteria for multiple sclerosis: 2005 revisions to the \u201cMcDonald Criteria\u201d","volume":"58","author":"Polman","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.mcp.2011.05.004_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/gene.2009.44","article-title":"Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener\u2019s granulomatosis and confirmation for multiple sclerosis in German patients","volume":"10","author":"Wieczorek","year":"2009","journal-title":"Genes Immun"},{"key":"10.1016\/j.mcp.2011.05.004_bib21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/aje\/155.5.478","article-title":"Sample size requirements for association studies of gene\u2013gene interaction","volume":"155","author":"Gauderman","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.mcp.2011.05.004_bib22","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1189\/jlb.0108022","article-title":"The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis?","volume":"84","author":"Matarese","year":"2008","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.mcp.2011.05.004_bib23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nri1350","article-title":"The weight of leptin in immunity","volume":"4","author":"La Cava","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.mcp.2011.05.004_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrg2489","article-title":"Detecting shared pathogenesis from the shared genetics of immune-related diseases","volume":"10","author":"Zhernakova","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.mcp.2011.05.004_bib25","doi-asserted-by":"crossref","first-page":"R116","DOI":"10.1093\/hmg\/ddn246","article-title":"Autoimmune diseases: insights from genome-wide association studies","volume":"17","author":"Lettre","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mcp.2011.05.004_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/WAD.0b013e3181b982dc","article-title":"Lack of association between the leptin receptor gene (LEPR) Gln223Arg polymorphism and late-onset Alzheimer disease","volume":"24","author":"Utsunomiya","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.mcp.2011.05.004_bib27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1530\/EJE-09-0122","article-title":"The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes","volume":"161","author":"Garcia","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.mcp.2011.05.004_bib28","first-page":"25","article-title":"Association study of ghrelin receptor gene polymorphisms in rheumatoid arthritis","volume":"28","author":"Robledo","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.mcp.2011.05.004_bib29","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/sj.ejhg.5201818","article-title":"Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method","volume":"15","author":"Hermanowski","year":"2007","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.mcp.2011.05.004_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/gene.2010.30","article-title":"The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis","volume":"11","author":"Alcina","year":"2010","journal-title":"Genes Immun"},{"key":"10.1016\/j.mcp.2011.05.004_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tig.2007.12.007","article-title":"The impact of next-generation sequencing technology on genetics","volume":"24","author":"Mardis","year":"2008","journal-title":"Trends Genet"},{"key":"10.1016\/j.mcp.2011.05.004_bib32","doi-asserted-by":"crossref","first-page":"e4565","DOI":"10.1371\/journal.pone.0004565","article-title":"The causal cascade to multiple sclerosis: a model for MS pathogenesis","volume":"4","author":"Goodin","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.mcp.2011.05.004_bib33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/9780470696781.ch2","article-title":"Gene-environment interaction: overcoming methodological challenges","volume":"293","author":"Uher","year":"2008","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.mcp.2011.05.004_bib34","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.humimm.2007.05.005","article-title":"Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA","volume":"68","author":"Martinez","year":"2007","journal-title":"Hum Immunol"}],"container-title":["Molecular and Cellular Probes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089085081100034X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089085081100034X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T08:21:55Z","timestamp":1543738915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089085081100034X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":34,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S089085081100034X"],"URL":"https:\/\/doi.org\/10.1016\/j.mcp.2011.05.004","relation":{},"ISSN":["0890-8508"],"issn-type":[{"value":"0890-8508","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}