{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:20:47Z","timestamp":1759159247598},"reference-count":50,"publisher":"Elsevier BV","issue":"4","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Probes"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.mcp.2013.11.003","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T11:45:42Z","timestamp":1386071142000},"page":"123-132","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Development and usage of protein microarrays for the quantitative measurement of Panton-Valentine leukocidin"],"prefix":"10.1016","volume":"28","author":[{"given":"Bettina","family":"Stieber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Monecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vico","family":"Baier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"W. Coombs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Ehricht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcp.2013.11.003_bib1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1600-065X.2008.00681.x","article-title":"The bacterial superantigen and superantigen-like proteins","volume":"225","author":"Fraser","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1016\/j.mcp.2013.11.003_bib2","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1271\/bbb.68.981","article-title":"Bacterial two-component and hetero-heptameric pore-forming cytolytic toxins: structures, pore-forming mechanism, and organization of the genes","volume":"68","author":"Kaneko","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.mcp.2013.11.003_bib3","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1086\/313461","article-title":"Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia","volume":"29","author":"Lina","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mcp.2013.11.003_bib4","first-page":"401","article-title":"Etude sur le m\u00e9canisme de la virulence du Staphylocoque pyog\u00e8ne","volume":"10","author":"Van de Velde","year":"1894","journal-title":"La Cellule"},{"key":"10.1016\/j.mcp.2013.11.003_bib5","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0140-6736(01)24468-7","article-title":"Staphylococcal toxin","volume":"1","author":"Panton","year":"1932","journal-title":"Lancet"},{"key":"10.1016\/j.mcp.2013.11.003_bib6","first-page":"1123","article-title":"Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus-Minnesota and North Dakota","volume":"282","author":"CDC","year":"1999","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.mcp.2013.11.003_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1471-2180-11-215","article-title":"Evolution and diversity of community-associated methicillin-resistant Staphylococcus aureus in a geographical region","volume":"11","author":"Coombs","year":"2011","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/jac\/dkp386","article-title":"Polyclonal multiply antibiotic-resistant methicillin-resistant Staphylococcus aureus with Panton-Valentine leucocidin in England","volume":"65","author":"Ellington","year":"2010","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.mcp.2013.11.003_bib9","doi-asserted-by":"crossref","first-page":"e17936","DOI":"10.1371\/journal.pone.0017936","article-title":"A\u00a0field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus","volume":"6","author":"Monecke","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mcp.2013.11.003_bib10","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3201\/eid0908.030089","article-title":"Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence","volume":"9","author":"Vandenesch","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.mcp.2013.11.003_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10096-005-1341-7","article-title":"Healthcare-associated outbreaks and community-acquired infections due to MRSA carrying the Panton-Valentine leucocidin gene in southeastern Germany","volume":"24","author":"Linde","year":"2005","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.mcp.2013.11.003_bib12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0140-6736(06)68231-7","article-title":"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus","volume":"367","author":"Diep","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.mcp.2013.11.003_bib13","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1128\/JCM.00985-06","article-title":"Predominance of clones carrying Panton-Valentine leukocidin genes among methicillin-resistant Staphylococcus aureus strains isolated in Japanese hospitals from 1979 to 1985","volume":"44","author":"Ma","year":"2006","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10096-010-1087-8","article-title":"High prevalence of ST121 in community-associated methicillin-susceptible Staphylococcus aureus lineages responsible for skin and soft tissue infections in Portuguese children","volume":"30","author":"Conceicao","year":"2011","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.mcp.2013.11.003_bib15","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/j.1469-0691.2011.03534.x","article-title":"Virulence factors and genotypes of Staphylococcus aureus from infection and carriage in Gabon","author":"Schaumburg","year":"2011","journal-title":"Clin Microbiol Infect 17,"},{"key":"10.1016\/j.mcp.2013.11.003_bib16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1600-0463.2008.01092.x","article-title":"Clinical isolates of Staphylococcus aureus from the Arkhangelsk region, Russia: antimicrobial susceptibility, molecular epidemiology, and distribution of Panton-Valentine leukocidin genes","volume":"116","author":"Vorobieva","year":"2008","journal-title":"Apmis"},{"key":"10.1016\/j.mcp.2013.11.003_bib17","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1469-0691.2007.01833.x","article-title":"High diversity of Panton-Valentine leucocidin-positive, methicillin-susceptible isolates of Staphylococcus aureus and implications for the evolution of community-associated MRSA","volume":"13","author":"Monecke","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.mcp.2013.11.003_bib18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1128\/JCM.02285-12","article-title":"Rapid detection of Panton-Valentine leukocidin in Staphylococcus aureus cultures by use of a lateral flow assay based on monoclonal antibodies","volume":"51","author":"Monecke","year":"2013","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib19","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1128\/JCM.02274-09","article-title":"Rapid detection of Staphylococcus aureus Panton-Valentine leukocidin in clinical specimens by enzyme-linked immunosorbent assay and immunochromatographic tests","volume":"48","author":"Badiou","year":"2010","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1469-0691.2010.03199.x","article-title":"Molecular diversity within clonal complex 22 methicillin-resistant Staphylococcus aureus encoding Panton-Valentine leukocidin in England and Wales","volume":"17","author":"Boakes","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.mcp.2013.11.003_bib21","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1128\/JCM.01917-10","article-title":"Distinct bacteriophages encoding Panton-Valentine leukocidin (PVL) among international methicillin-resistant Staphylococcus aureus clones harboring PVL","volume":"49","author":"Boakes","year":"2012","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib22","series-title":"Measuring S.\u00a0aureus exotoxin concentrations using protein microarrays with antibodies generated by phage display","author":"Monecke","year":"2011"},{"key":"10.1016\/j.mcp.2013.11.003_bib23","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1469-0691.2009.02792.x","article-title":"The molecular epidemiology and evolution of the Panton-Valentine leukocidin-positive, methicillin-resistant Staphylococcus aureus strain USA300 in Western Australia","volume":"15","author":"Monecke","year":"2009","journal-title":"Clin Microbiol Infect"},{"issue":"S22","key":"10.1016\/j.mcp.2013.11.003_bib24","article-title":"Differentiation of CC59 community-acquired MRSA strains","volume":"15","author":"Monecke","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.mcp.2013.11.003_bib25","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1469-0691.2006.01635.x","article-title":"Comparative genomics and DNA-array-based genotyping of pandemic Staphylococcus aureus strains carrying Panton-Valentine leucocidin","volume":"13","author":"Monecke","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.mcp.2013.11.003_bib26","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1469-0691.2006.01420.x","article-title":"Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus","volume":"12","author":"Monecke","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.mcp.2013.11.003_bib27","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1469-0691.2008.01986.x","article-title":"Microarray based genotyping of MRSA strains from Eastern Saxony","volume":"14","author":"Monecke","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.mcp.2013.11.003_bib28","series-title":"Genetic fingerprinting of MRSA from Abu Dhabi","author":"Weber","year":"2010"},{"key":"10.1016\/j.mcp.2013.11.003_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1752-1947-5-157","article-title":"Methicillin sensitive Staphylococcus aureus producing Panton-Valentine leukocidin toxin in Trinidad & Tobago: a case report","volume":"5","author":"Akpaka","year":"2011","journal-title":"J\u00a0Med Case Rep"},{"key":"10.1016\/j.mcp.2013.11.003_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1471-2180-12-146","article-title":"Characterisation of MRSA strains isolated from patients in a hospital in Riyadh, Kingdom of Saudi Arabia","volume":"12","author":"Monecke","year":"2012","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1574-695X.2008.00426.x","article-title":"Assignment of Staphylococcus aureus isolates to clonal complexes based on microarray analysis and pattern recognition","volume":"53","author":"Monecke","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib32","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/JCM.38.3.1008-1015.2000","article-title":"Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus","volume":"38","author":"Enright","year":"2000","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0076-6879(88)65007-5","article-title":"Purification and crystallization of staphylococcal leukocidin","volume":"165","author":"Noda","year":"1988","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.mcp.2013.11.003_bib34","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/MAJ.0b013e3181e95fdc","article-title":"Increasing threat of community-acquired methicillin-resistant Staphylococcus aureus","volume":"340","author":"Bukharie","year":"2010","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.mcp.2013.11.003_bib35","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1128\/AAC.01287-09","article-title":"Differentiation of CC59 community-associated methicillin-resistant Staphylococcus aureus in Western Australia","volume":"54","author":"Coombs","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mcp.2013.11.003_bib36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1201-9712(03)90104-4","article-title":"Emergence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infection in Queensland, Australia","volume":"7","author":"Munckhof","year":"2003","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.mcp.2013.11.003_bib37","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1469-0691.2009.02891.x","article-title":"Molecular characterization and susceptibility of methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates from hospitals and the community in Vladivostok, Russia","volume":"16","author":"Baranovich","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.mcp.2013.11.003_bib38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1471-2180-11-92","article-title":"Antibiotic resistance and molecular epidemiology of Staphylococcus aureus in Nigeria","volume":"11","author":"Shittu","year":"2011","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib39","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1128\/JB.01947-07","article-title":"The carriage population of Staphylococcus aureus from Mali is composed of a combination of pandemic clones and the divergent Panton-Valentine leukocidin-positive genotype ST152","volume":"190","author":"Ruimy","year":"2008","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.mcp.2013.11.003_bib40","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3201\/eid1408.071427","article-title":"Infection with Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus t034","volume":"14","author":"Welinder-Olsson","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.mcp.2013.11.003_bib41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1469-0691.2007.01927.x","article-title":"Prevalence of Staphylococcus aureus carrying Panton-Valentine leukocidin genes among isolates from hospitalised patients in China","volume":"14","author":"Yu","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.mcp.2013.11.003_bib42","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1128\/AAC.01563-09","article-title":"Rapid change of methicillin-resistant Staphylococcus aureus clones in a Chinese tertiary care hospital over a 15-year period","volume":"54","author":"Chen","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mcp.2013.11.003_bib43","series-title":"R: a language and environment for statistical computing","author":"R Development Core Team","year":"2011"},{"key":"10.1016\/j.mcp.2013.11.003_bib44","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/01621459.1952.10483441","article-title":"Use of ranks in one-criterion variance analysis","volume":"47","author":"Kruskal","year":"1952","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.mcp.2013.11.003_bib45","doi-asserted-by":"crossref","first-page":"10102","DOI":"10.1073\/pnas.152152499","article-title":"Global repression of exotoxin synthesis by staphylococcal superantigens","volume":"99","author":"Vojtov","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mcp.2013.11.003_bib46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0147-619X(02)00157-9","article-title":"Mobile genetic elements and bacterial toxinoses: the superantigen-encoding pathogenicity islands of Staphylococcus aureus","volume":"49","author":"Novick","year":"2003","journal-title":"Plasmid"},{"issue":"S55","key":"10.1016\/j.mcp.2013.11.003_bib47","article-title":"A\u00a0fatal case of toxigenic Staphylococcus aureus infection","volume":"298","author":"Monecke","year":"2008","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.mcp.2013.11.003_bib48","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/S0140-6736(02)08713-5","article-title":"Genome and virulence determinants of high virulence community-acquired MRSA","volume":"359","author":"Baba","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.mcp.2013.11.003_bib49","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/jac\/dkm206","article-title":"Is Panton-Valentine leucocidin associated with the pathogenesis of Staphylococcus aureus bacteraemia in the UK?","volume":"60","author":"Ellington","year":"2007","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.mcp.2013.11.003_bib50","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1128\/JB.00866-06","article-title":"SarA is a repressor of hla (alpha hemolysin) transcription in Staphylococcus aureus: its apparent role as an activator of hla in the prototype strain NCTC 8325 depends on reduced expression of sarS","volume":"188","author":"Oscarsson","year":"2006","journal-title":"J\u00a0Bacteriol"}],"container-title":["Molecular and Cellular Probes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850813000649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850813000649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T07:41:21Z","timestamp":1597131681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890850813000649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0890850813000649"],"URL":"https:\/\/doi.org\/10.1016\/j.mcp.2013.11.003","relation":{},"ISSN":["0890-8508"],"issn-type":[{"value":"0890-8508","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and usage of protein microarrays for the quantitative measurement of Panton-Valentine leukocidin","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Probes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcp.2013.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}