{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:23:08Z","timestamp":1767651788099,"version":"build-2065373602"},"reference-count":94,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"am","delay-in-days":357,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["2U01AG032984-06","2P50AG008702-26","2RF1AG015473-16A1"],"award-info":[{"award-number":["2U01AG032984-06","2P50AG008702-26","2RF1AG015473-16A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH"],"award-info":[{"award-number":["W81XWH"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UF1AG047133","P50 AG08702","U01AG032984","RF1AG015473"],"award-info":[{"award-number":["UF1AG047133","P50 AG08702","U01AG032984","RF1AG015473"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Probes"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.mcp.2016.09.001","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T15:04:54Z","timestamp":1473865494000},"page":"397-403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genomics of Alzheimer's disease: Value of high-throughput genomic technologies to dissect its etiology"],"prefix":"10.1016","volume":"30","author":[{"given":"Giuseppe","family":"Tosto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Reitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcp.2016.09.001_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.neuro.26.043002.094919","article-title":"Epidemiology of neurodegeneration","volume":"26","author":"Mayeux","year":"2003","journal-title":"Annu. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.mcp.2016.09.001_bib2","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3233\/JAD-150244","article-title":"Progression of extrapyramidal signs in Alzheimer's disease: clinical and neuropathological correlates","volume":"49","author":"Tosto","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"issue":"6","key":"10.1016\/j.mcp.2016.09.001_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/ane.12415","article-title":"Neuropsychological predictors of rapidly progressive Alzheimer's disease","volume":"132","author":"Tosto","year":"2015","journal-title":"Acta Neurol. Scand."},{"issue":"6311","key":"10.1016\/j.mcp.2016.09.001_bib4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"issue":"5226","key":"10.1016\/j.mcp.2016.09.001_bib5","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer's disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"issue":"6534","key":"10.1016\/j.mcp.2016.09.001_bib6","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"issue":"5123","key":"10.1016\/j.mcp.2016.09.001_bib7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.mcp.2016.09.001_bib8","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.mcp.2016.09.001_bib9","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/archneur.55.7.964","article-title":"Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study","volume":"55","author":"Slooter","year":"1998","journal-title":"Arch. Neurol."},{"issue":"3","key":"10.1016\/j.mcp.2016.09.001_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3233\/JAD-2002-4307","article-title":"Non-familial Alzheimer's disease is mainly due to genetic factors","volume":"4","author":"Ashford","year":"2002","journal-title":"J.\u00a0Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1212\/WNL.53.2.321","article-title":"APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the cache county study","volume":"53","author":"Breitner","year":"1999","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.mcp.2016.09.001_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/ana.410390110","article-title":"Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease","volume":"39","author":"Gomez-Isla","year":"1996","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.mcp.2016.09.001_bib13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/jnnp.61.6.580","article-title":"Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease","volume":"61","author":"Holmes","year":"1996","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"issue":"6","key":"10.1016\/j.mcp.2016.09.001_bib14","first-page":"452","article-title":"Apolipoprotein E type 4 allele and Alzheimer's disease: effect on age at onset and relative risk in different age groups","volume":"243","author":"Kurz","year":"1996","journal-title":"J.\u00a0Neurol."},{"issue":"11","key":"10.1016\/j.mcp.2016.09.001_bib15","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1001\/jama.298.11.1300","article-title":"Association of apolipoprotein E genotypes with lipid levels and coronary risk","volume":"298","author":"Bennet","year":"2007","journal-title":"JAMA"},{"issue":"36","key":"10.1016\/j.mcp.2016.09.001_bib16","doi-asserted-by":"crossref","first-page":"14813","DOI":"10.1073\/pnas.1106420108","article-title":"Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions","volume":"108","author":"Chen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"20","key":"10.1016\/j.mcp.2016.09.001_bib17","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","volume":"90","author":"Schmechel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.mcp.2016.09.001_bib18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0896-6273(93)90070-8","article-title":"Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions","volume":"11","author":"Rebeck","year":"1993","journal-title":"Neuron"},{"issue":"17","key":"10.1016\/j.mcp.2016.09.001_bib19","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1073\/pnas.90.17.8098","article-title":"Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6501","key":"10.1016\/j.mcp.2016.09.001_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/372092a0","article-title":"Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments","volume":"372","author":"Ma","year":"1994","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib21","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1172\/JCI117407","article-title":"Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3","volume":"94","author":"Sanan","year":"1994","journal-title":"J.\u00a0Clin. Invest."},{"issue":"26","key":"10.1016\/j.mcp.2016.09.001_bib22","doi-asserted-by":"crossref","first-page":"15233","DOI":"10.1073\/pnas.96.26.15233","article-title":"Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease","volume":"96","author":"Bales","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.mcp.2016.09.001_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/ng1197-263","article-title":"Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition","volume":"17","author":"Bales","year":"1997","journal-title":"Nat. Genet."},{"issue":"19","key":"10.1016\/j.mcp.2016.09.001_bib24","doi-asserted-by":"crossref","first-page":"E1807","DOI":"10.1073\/pnas.1220484110","article-title":"ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE\/Abeta association in physiological conditions","volume":"110","author":"Verghese","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"19","key":"10.1016\/j.mcp.2016.09.001_bib25","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.1434398100","article-title":"Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice","volume":"100","author":"Harris","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.mcp.2016.09.001_bib26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/jama.279.10.751","article-title":"The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics","volume":"279","author":"Tang","year":"1998","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.mcp.2016.09.001_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1001\/archneur.59.1.87","article-title":"Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE","volume":"59","author":"Romas","year":"2002","journal-title":"Arch. Neurol."},{"issue":"12","key":"10.1016\/j.mcp.2016.09.001_bib28","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jalz.2015.07.487","article-title":"Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease","volume":"11","author":"Barral","year":"2015","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.mcp.2016.09.001_bib29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jalz.2015.05.020","article-title":"Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease","volume":"12","author":"Kunkle","year":"2016","journal-title":"Alzheimers Dement."},{"issue":"6","key":"10.1016\/j.mcp.2016.09.001_bib30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2217\/fnl.15.42","article-title":"Novel susceptibility loci for Alzheimer's disease","volume":"10","author":"Reitz","year":"2015","journal-title":"Future Neurol."},{"issue":"5","key":"10.1016\/j.mcp.2016.09.001_bib31","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.mcp.2016.09.001_bib32","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.mcp.2016.09.001_bib33","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"issue":"18","key":"10.1016\/j.mcp.2016.09.001_bib34","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-wide analysis of genetic loci associated with Alzheimer disease","volume":"303","author":"Seshadri","year":"2010","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.mcp.2016.09.001_bib35","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.mcp.2016.09.001_bib36","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib37","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","article-title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease","volume":"39","author":"Rogaeva","year":"2007","journal-title":"Nat. Genet."},{"issue":"14","key":"10.1016\/j.mcp.2016.09.001_bib38","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1001\/jama.2013.2973","article-title":"Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4,and the risk of late-onset Alzheimer disease in African Americans","volume":"309","author":"Reitz","year":"2013","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.mcp.2016.09.001_bib39","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/acn3.223","article-title":"F-box\/LRR-repeat protein 7 is genetically associated with Alzheimer's disease","volume":"2","author":"Tosto","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"1","key":"10.1016\/j.mcp.2016.09.001_bib40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12035-014-9015-z","article-title":"Validating GWAS-identified risk loci for Alzheimer's disease in Han Chinese populations","volume":"53","author":"Wang","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.mcp.2016.09.001_bib41","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/mp.2012.14","article-title":"Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease","volume":"18","author":"Lambert","year":"2013","journal-title":"Mol. Psychiatry"},{"issue":"11","key":"10.1016\/j.mcp.2016.09.001_bib42","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/nbt.2422","article-title":"Interpreting noncoding genetic variation in complex traits and human disease","volume":"30","author":"Ward","year":"2012","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"10.1016\/j.mcp.2016.09.001_bib43","doi-asserted-by":"crossref","first-page":"e33923","DOI":"10.1371\/journal.pone.0033923","article-title":"Genetics of clusterin isoform expression and Alzheimer's disease risk","volume":"7","author":"Ling","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.mcp.2016.09.001_bib44","doi-asserted-by":"crossref","first-page":"e50976","DOI":"10.1371\/journal.pone.0050976","article-title":"Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains","volume":"7","author":"Karch","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.mcp.2016.09.001_bib45","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuron.2013.04.014","article-title":"Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta","volume":"78","author":"Griciuc","year":"2013","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib46","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/mp.2011.24","article-title":"Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b\/C4b binding sites","volume":"17","author":"Brouwers","year":"2012","journal-title":"Mol. Psychiatry"},{"issue":"7265","key":"10.1016\/j.mcp.2016.09.001_bib47","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"issue":"7409","key":"10.1016\/j.mcp.2016.09.001_bib48","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature11283","article-title":"A\u00a0mutation in APP protects against Alzheimer's disease and age-related cognitive decline","volume":"488","author":"Jonsson","year":"2012","journal-title":"Nature"},{"issue":"1779","key":"10.1016\/j.mcp.2016.09.001_bib49","first-page":"e1715","article-title":"Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease","volume":"35(7)","author":"Bamne","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib50","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/jamaneurol.2014.2157","article-title":"Rarity of the Alzheimer disease-protective APP A673T variant in the United States","volume":"72","author":"Wang","year":"2015","journal-title":"JAMA Neurol."},{"issue":"935","key":"10.1016\/j.mcp.2016.09.001_bib51","first-page":"e911","article-title":"Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals","volume":"35(4)","author":"Liu","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"2441","key":"10.1016\/j.mcp.2016.09.001_bib52","first-page":"e2447","article-title":"Absence of A673T amyloid-beta precursor protein variant in Alzheimer's disease and other neurological diseases","volume":"34(10)","author":"Ting","year":"2013","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer's disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib54","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"1510","key":"10.1016\/j.mcp.2016.09.001_bib55","first-page":"e1519","article-title":"Missense variant in TREML2 protects against Alzheimer's disease","volume":"35(6)","author":"Benitez","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"21","key":"10.1016\/j.mcp.2016.09.001_bib56","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1093\/hmg\/ddu277","article-title":"Coding variants in TREM2 increase risk for Alzheimer's disease","volume":"23","author":"Jin","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcp.2016.09.001_bib57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-015-0016-9","article-title":"TREM2 is associated with increased risk for Alzheimer's disease in African Americans","volume":"10","author":"Jin","year":"2015","journal-title":"Mol. Neurodegener."},{"issue":"16","key":"10.1016\/j.mcp.2016.09.001_bib58","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJMc1306509","article-title":"TREM2 and neurodegenerative disease","volume":"369","author":"Reitz","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"8","key":"10.1016\/j.mcp.2016.09.001_bib59","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1001\/jamaneurol.2015.0979","article-title":"R47H variant of TREM2 associated with Alzheimer Disease in a large late-onset family: clinical, genetic, and neuropathological study","volume":"72","author":"Korvatska","year":"2015","journal-title":"JAMA Neurol."},{"issue":"2443","key":"10.1016\/j.mcp.2016.09.001_bib60","first-page":"e2421","article-title":"More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk","volume":"36(8)","author":"Rosenthal","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"6","key":"10.1016\/j.mcp.2016.09.001_bib61","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.neurobiolaging.2013.11.013","article-title":"Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention","volume":"35","author":"Engelman","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.mcp.2016.09.001_bib62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-122311","article-title":"TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease","volume":"35","author":"Pottier","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.mcp.2016.09.001_bib63","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ana.24466","article-title":"Rare coding mutations identified by sequencing of Alzheimer's disease GWAS loci","volume":"78","author":"Vardarajan","year":"2015","journal-title":"Ann. Neurol."},{"issue":"1781","key":"10.1016\/j.mcp.2016.09.001_bib64","first-page":"e1781","article-title":"Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals","volume":"35(7)","author":"Tan","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"7484","key":"10.1016\/j.mcp.2016.09.001_bib65","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature12825","article-title":"Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease","volume":"505","author":"Cruchaga","year":"2014","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.mcp.2016.09.001_bib66","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.bbalip.2010.04.004","article-title":"Phospholipase D in brain function and Alzheimer's disease","volume":"1801","author":"Oliveira","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"7545","key":"10.1016\/j.mcp.2016.09.001_bib67","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1038\/nature14040","article-title":"PLD3 gene variants and Alzheimer's disease","volume":"520","author":"Hooli","year":"2015","journal-title":"Nature"},{"issue":"7545","key":"10.1016\/j.mcp.2016.09.001_bib68","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.1038\/nature14039","article-title":"PLD3 in non-familial Alzheimer's disease","volume":"520","author":"Heilmann","year":"2015","journal-title":"Nature"},{"issue":"7545","key":"10.1016\/j.mcp.2016.09.001_bib69","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1038\/nature14036","article-title":"PLD3 and sporadic Alzheimer's disease risk","volume":"520","author":"Lambert","year":"2015","journal-title":"Nature"},{"issue":"7545","key":"10.1016\/j.mcp.2016.09.001_bib70","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.1038\/nature14038","article-title":"PLD3 variants in population studies","volume":"520","author":"van der Lee","year":"2015","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.mcp.2016.09.001_bib71","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1515\/BC.2002.193","article-title":"Characterization of the VPS10 domain of SorLA\/LR11 as binding site for the neuropeptide HA","volume":"383","author":"Lintzel","year":"2002","journal-title":"Biol. Chem."},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib72","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ana.24305","article-title":"Coding mutations in SORL1 and Alzheimer disease","volume":"77","author":"Vardarajan","year":"2015","journal-title":"Ann. Neurol."},{"issue":"15","key":"10.1016\/j.mcp.2016.09.001_bib73","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1093\/hmg\/dds161","article-title":"Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases","volume":"21","author":"Coppola","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib74","doi-asserted-by":"crossref","first-page":"e31039","DOI":"10.1371\/journal.pone.0031039","article-title":"Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families","volume":"7","author":"Cruchaga","year":"2012","journal-title":"PLoS One."},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib75","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3233\/JAD-2011-110824","article-title":"The role of variation at AbetAPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease","volume":"28","author":"Gerrish","year":"2012","journal-title":"J.\u00a0Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.mcp.2016.09.001_bib76","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/alzrt137","article-title":"Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort","volume":"4","author":"Jin","year":"2012","journal-title":"Alzheimers Res. Ther."},{"issue":"4","key":"10.1016\/j.mcp.2016.09.001_bib77","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/WAD.0b013e31828cc357","article-title":"Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease","volume":"27","author":"Lee","year":"2013","journal-title":"Alzheimer Dis. Assoc. Disord."},{"issue":"4","key":"10.1016\/j.mcp.2016.09.001_bib78","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3233\/JAD-131121","article-title":"The role of ABCA1 gene sequence variants on risk of Alzheimer's disease","volume":"38","author":"Lupton","year":"2014","journal-title":"J.\u00a0Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib79","doi-asserted-by":"crossref","first-page":"e17298","DOI":"10.1371\/journal.pone.0017298","article-title":"Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease","volume":"6","author":"Lupton","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.mcp.2016.09.001_bib80","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jalz.2014.06.010","article-title":"Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans","volume":"10","author":"Logue","year":"2014","journal-title":"Alzheimers Dement."},{"issue":"1008","key":"10.1016\/j.mcp.2016.09.001_bib81","first-page":"e1017","article-title":"Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease","volume":"33(5)","author":"Guerreiro","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.mcp.2016.09.001_bib82","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.neurobiolaging.2010.03.003","article-title":"Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease","volume":"33","author":"Cai","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"20","key":"10.1016\/j.mcp.2016.09.001_bib83","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1093\/hmg\/ddp323","article-title":"Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity","volume":"18","author":"Kim","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"16","key":"10.1016\/j.mcp.2016.09.001_bib84","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1212\/WNL.0b013e3182515972","article-title":"Role of common and rare APP DNA sequence variants in Alzheimer disease","volume":"78","author":"Hooli","year":"2012","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.mcp.2016.09.001_bib85","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/mp.2013.77","article-title":"Rare autosomal copy number variations in early-onset familial Alzheimer's disease","volume":"19","author":"Hooli","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.mcp.2016.09.001_bib86","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1534\/g3.111.000869","article-title":"Genome-wide survey of large rare copy number variants in Alzheimer's disease among Caribbean hispanics","volume":"2","author":"Ghani","year":"2012","journal-title":"G3 (Bethesda)"},{"issue":"8","key":"10.1016\/j.mcp.2016.09.001_bib87","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S1474-4422(15)00133-7","article-title":"Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study","volume":"14","author":"Cuyvers","year":"2015","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.mcp.2016.09.001_bib88","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrg3706","article-title":"Statistical power and significance testing in large-scale genetic studies","volume":"15","author":"Sham","year":"2014","journal-title":"Nat. Rev. Genet."},{"issue":"18","key":"10.1016\/j.mcp.2016.09.001_bib89","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1001\/jama.2010.609","article-title":"Reaching the limits of genome-wide significance in Alzheimer disease: back to the environment","volume":"303","author":"Pedersen","year":"2010","journal-title":"JAMA"},{"issue":"Pt 12","key":"10.1016\/j.mcp.2016.09.001_bib90","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1093\/brain\/awv268","article-title":"Common polygenic variation enhances risk prediction for Alzheimer's disease","volume":"138","author":"Escott-Price","year":"2015","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.mcp.2016.09.001_bib91","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.jalz.2015.02.013","article-title":"A\u00a022-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Abeta42","volume":"11","author":"Sleegers","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.mcp.2016.09.001_bib92","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1038\/srep05737","article-title":"Long-range PCR in next-generation sequencing: comparison of six enzymes and evaluation on the MiSeq sequencer","volume":"4","author":"Jia","year":"2014","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.mcp.2016.09.001_bib93","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/nmeth.3201","article-title":"Short reads join hands","volume":"11","author":"Nawy","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcp.2016.09.001_bib94","doi-asserted-by":"crossref","first-page":"17","DOI":"10.12688\/f1000research.6037.2","article-title":"Long read nanopore sequencing for detection of HLA and CYP2D6 variants and haplotypes","volume":"4","author":"Ammar","year":"2015","journal-title":"F1000Res."}],"container-title":["Molecular and Cellular Probes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850816300743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850816300743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:14:15Z","timestamp":1760192055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890850816300743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":94,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0890850816300743"],"URL":"https:\/\/doi.org\/10.1016\/j.mcp.2016.09.001","relation":{},"ISSN":["0890-8508"],"issn-type":[{"type":"print","value":"0890-8508"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomics of Alzheimer's disease: Value of high-throughput genomic technologies to dissect its etiology","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Probes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcp.2016.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}