{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T02:04:43Z","timestamp":1794362683847,"version":"4.9.0"},"reference-count":128,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Probes"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mcp.2025.102051","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:24:51Z","timestamp":1758583491000},"page":"102051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Exosome biosensors for detection of ovarian cancer"],"prefix":"10.1016","volume":"84","author":[{"given":"Asma","family":"Vafadar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Nayerain Jazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melika","family":"Eghtesadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajad","family":"Ehtiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Movahedpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Savardashtaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mcp.2025.102051_bib1","first-page":"280","article-title":"Epithelial ovarian cancer: evolution of management in the era of precision medicine","volume":"69","author":"Lheureux","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.mcp.2025.102051_bib2","article-title":"Treatment of epithelial ovarian cancer","volume":"371","author":"Kuroki","year":"2020","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.mcp.2025.102051_bib3","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib4","first-page":"332","article-title":"Early detection, symptoms, and treatment options for ovarian cancer","volume":"10","author":"Baker","year":"2024","journal-title":"Int. J. Adv. Eng. Technol. Innovat."},{"issue":"3","key":"10.1016\/j.mcp.2025.102051_bib5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.amepre.2015.09.023","article-title":"A systematic review of symptoms for the diagnosis of ovarian cancer","volume":"50","author":"Ebell","year":"2016","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.mcp.2025.102051_bib6","series-title":"Seminars in Oncology Nursing","article-title":"Ovarian cancer: an integrated review","author":"Stewart","year":"2019"},{"key":"10.1016\/j.mcp.2025.102051_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112029","article-title":"A novel electrochemical immunosensor for ultrasensitive detection of CA125 in ovarian cancer","volume":"153","author":"Samadi Pakchin","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"27","key":"10.1016\/j.mcp.2025.102051_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade6958","article-title":"Identifying high-grade serous ovarian carcinoma\u2013specific extracellular vesicles by polyketone-coated nanowires","volume":"9","author":"Yokoi","year":"2023","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib9","article-title":"Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer","volume":"1875","author":"Zhang","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"19","key":"10.1016\/j.mcp.2025.102051_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231912041","article-title":"Molecular biomarkers for the early detection of ovarian cancer","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcp.2025.102051_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116060","article-title":"An electrochemical biosensor designed with entropy-driven autocatalytic DNA circuits for sensitive detection of ovarian cancer-derived exosomes","volume":"250","author":"Deng","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.mcp.2025.102051_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-021-00787-y","article-title":"Extracellular vesicles: mediators of intercellular communication in tissue injury and disease","volume":"19","author":"Berumen S\u00e1nchez","year":"2021","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00232-022-00260-y","article-title":"Research development on exosome separation technology","volume":"256","author":"Xu","year":"2023","journal-title":"J. Membr. Biol."},{"issue":"4","key":"10.1016\/j.mcp.2025.102051_bib14","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1021\/acs.chemrev.7b00534","article-title":"New technologies for analysis of extracellular vesicles","volume":"118","author":"Shao","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.mcp.2025.102051_bib15","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.3389\/fimmu.2019.01464","article-title":"Exosome-induced regulation in inflammatory bowel disease","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mcp.2025.102051_bib16","doi-asserted-by":"crossref","first-page":"45080","DOI":"10.1109\/ACCESS.2019.2907123","article-title":"Microfluidic approaches toward the isolation and detection of exosome nanovesicles","volume":"7","author":"Jia","year":"2019","journal-title":"IEEE Access"},{"issue":"8","key":"10.1016\/j.mcp.2025.102051_bib17","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3390\/bios13080802","article-title":"Biogenesis, isolation, and detection of exosomes and their potential in therapeutics and Diagnostics","volume":"13","author":"Sonbhadra","year":"2023","journal-title":"Biosensors"},{"key":"10.1016\/j.mcp.2025.102051_bib18","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2147\/IJN.S453545","article-title":"Exosomes as powerful biomarkers in cancer: recent advances in isolation and detection techniques","author":"Zhang","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"19","key":"10.1016\/j.mcp.2025.102051_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29194672","article-title":"Nanoparticle tracking analysis: an effective tool to characterize extracellular vesicles","volume":"29","author":"Kowkabany","year":"2024","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.mcp.2025.102051_bib20","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.7150\/thno.41580","article-title":"Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.mcp.2025.102051_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.811971","article-title":"Review on strategies and technologies for exosome isolation and purification","volume":"9","author":"Chen","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mcp.2025.102051_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cobme.2019.08.003","article-title":"Recent developments in fluorescent aptasensors for detection of antibiotics","volume":"13","author":"Zhou","year":"2020","journal-title":"Curr. Opin. Biomed. Eng."},{"key":"10.1016\/j.mcp.2025.102051_bib23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.snb.2017.10.135","article-title":"Aptamer adaptive binding assessed by stilbene photoisomerization towards regenerating aptasensors","volume":"257","author":"Zhou","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.mcp.2025.102051_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.120092","article-title":"Biosensors for the detection of celiac disease","volume":"567","author":"Vafadar","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.mcp.2025.102051_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.120001","article-title":"Electrochemical biosensors in early detection of Parkinson disease","volume":"565","author":"Khatami","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.mcp.2025.102051_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.119923","article-title":"Electrochemical biosensors for early detection of breast cancer","volume":"564","author":"Kiani","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.mcp.2025.102051_bib27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/bs.acc.2015.12.005","article-title":"Tumor-derived exosomes and their role in cancer progression","volume":"74","author":"Whiteside","year":"2016","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.mcp.2025.102051_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.117796","article-title":"MicroRNA biosensors for the detection of liver cancer","volume":"554","author":"Fattahi","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.mcp.2025.102051_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.128095","article-title":"Dual-antibody functionalized transistor biosensor for specific diagnosis of liver cancer","volume":"293","author":"Yu","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.mcp.2025.102051_bib30","series-title":"Enrichment-detection Integrated Exosome Profiling Biosensors Promising for Early Diagnosis of Cancer","author":"Song","year":"2021"},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41378-021-00293-8","article-title":"Electrochemical micro-aptasensors for exosome detection based on hybridization chain reaction amplification","volume":"7","author":"Zhang","year":"2021","journal-title":"Microsyst. Nanoeng."},{"issue":"19","key":"10.1016\/j.mcp.2025.102051_bib32","doi-asserted-by":"crossref","first-page":"12733","DOI":"10.1021\/acs.analchem.0c02745","article-title":"Advances in exosome analysis methods with an emphasis on electrochemistry","volume":"92","author":"Bagheri Hashkavayi","year":"2020","journal-title":"Anal. Chem."},{"issue":"9","key":"10.1016\/j.mcp.2025.102051_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201903916","article-title":"Progress in microfluidics\u2010based exosome separation and detection technologies for diagnostic applications","volume":"16","author":"Lin","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.mcp.2025.102051_bib34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00216-020-03000-0","article-title":"Recent advances in nanomaterial-based biosensors for the detection of exosomes","volume":"413","author":"Zhang","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib35","doi-asserted-by":"crossref","DOI":"10.59400\/n-c.v2i2.1254","article-title":"Recent progress in Nanomaterial based biosensors for the detection of cancer biomarkers in human fluids","volume":"2","author":"Shahazi","year":"2024","journal-title":"Nano Carbons"},{"key":"10.1016\/j.mcp.2025.102051_bib36","first-page":"1","article-title":"Advancements in nano-mediated biosensors: targeting cancer exosome detection","author":"Tripathi","year":"2024","journal-title":"J. Cluster Sci."},{"issue":"3","key":"10.1016\/j.mcp.2025.102051_bib37","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1364\/BOE.515563","article-title":"All-fiber label-free optical fiber biosensors: from modern technologies to current applications","volume":"15","author":"Bekmurzayeva","year":"2024","journal-title":"Biomed. Opt. Express"},{"issue":"7","key":"10.1016\/j.mcp.2025.102051_bib38","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.molmed.2017.05.003","article-title":"Exosomes as reconfigurable therapeutic systems","volume":"23","author":"Conlan","year":"2017","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/2211738511666230523114311","article-title":"A comprehensive review on exosome: recent progress and outlook","volume":"12","author":"Agarwal","year":"2024","journal-title":"Pharm. Nanotechnol."},{"issue":"8","key":"10.1016\/j.mcp.2025.102051_bib40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Th\u00e9ry","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"8","key":"10.1016\/j.mcp.2025.102051_bib42","doi-asserted-by":"crossref","first-page":"R435","DOI":"10.1016\/j.cub.2018.01.059","article-title":"Exosomes and ectosomes in intercellular communication","volume":"28","author":"Meldolesi","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mcp.2025.102051_bib43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3389\/fimmu.2015.00203","article-title":"Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications","volume":"6","author":"De Toro","year":"2015","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.mcp.2025.102051_bib44","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1002\/jcp.30697","article-title":"Exosomal microRNAs and long noncoding RNAs: novel mediators of drug resistance in lung cancer","volume":"237","author":"Taghvimi","year":"2022","journal-title":"J. Cell. Physiol."},{"issue":"12","key":"10.1016\/j.mcp.2025.102051_bib45","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1373\/clinchem.2015.240028","article-title":"The role of exosomes in breast cancer","volume":"61","author":"Lowry","year":"2015","journal-title":"Clin. Chem."},{"issue":"8","key":"10.1016\/j.mcp.2025.102051_bib46","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mcp.2025.102051_bib47","article-title":"T cell-derived exosomes in tumor immune modulation and immunotherapy","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mcp.2025.102051_bib48","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","article-title":"Exosomes","volume":"88","author":"Pegtel","year":"2019","journal-title":"Annu. Rev. Biochem."},{"issue":"6","key":"10.1016\/j.mcp.2025.102051_bib49","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/10408363.2016.1190682","article-title":"Extracellular vesicles in blood, milk and body fluids of the female and male urogenital tract and with special regard to reproduction","volume":"53","author":"Foster","year":"2016","journal-title":"Crit. Rev. Clin. Lab Sci."},{"issue":"29","key":"10.1016\/j.mcp.2025.102051_bib50","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1073\/pnas.1304718110","article-title":"Human placental trophoblasts confer viral resistance to recipient cells","volume":"110","author":"Delorme-Axford","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mcp.2025.102051_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1228624","article-title":"Function and clinical application of exosome\u2014how to improve tumor immunotherapy?","volume":"11","author":"Qin","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.mcp.2025.102051_bib52","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846613","article-title":"Extracellular vesicles deliver Mycobacterium RNA to promote host immunity and bacterial killing","volume":"20","author":"Cheng","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mcp.2025.102051_bib53","first-page":"1","article-title":"Biosensor-based assay of exosome biomarker for early diagnosis of cancer","author":"Deng","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.mcp.2025.102051_bib54","first-page":"1","article-title":"Gastrointestinal cancer drug resistance: the role of exosomal miRNAs","author":"Salehi","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"4","key":"10.1016\/j.mcp.2025.102051_bib55","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3390\/cells9040814","article-title":"Pathophysiological role and potential therapeutic exploitation of exosomes in ovarian cancer","volume":"9","author":"Shimizu","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib56","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13048-024-01417-0","article-title":"Exosomes in diagnostic and therapeutic applications of ovarian cancer","volume":"17","author":"Bhavsar","year":"2024","journal-title":"J. Ovarian Res."},{"issue":"14","key":"10.1016\/j.mcp.2025.102051_bib57","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.3390\/ijms25147794","article-title":"Clinical applications of exosomes: a critical review","volume":"25","author":"Lee","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcp.2025.102051_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111111","article-title":"Progress of exosomes in the diagnosis and treatment of lung cancer","volume":"134","author":"Xu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mcp.2025.102051_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1149551","article-title":"Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment","volume":"13","author":"Fang","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mcp.2025.102051_bib60","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ejca.2020.11.033","article-title":"Exosomes and exosomal RNAs in breast cancer: a status update","volume":"144","author":"Lakshmi","year":"2021","journal-title":"Eur. J. Cancer"},{"issue":"5","key":"10.1016\/j.mcp.2025.102051_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ol.2021.12638","article-title":"Role of exosomes in the immune microenvironment of ovarian cancer","volume":"21","author":"Li","year":"2021","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.mcp.2025.102051_bib62","doi-asserted-by":"crossref","first-page":"G397","DOI":"10.1152\/ajpgi.00054.2021","article-title":"The therapeutic potential of exosomes derived from different cell sources in liver diseases","volume":"322","author":"Pan","year":"2022","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.mcp.2025.102051_bib63","article-title":"Potentiality of exosomal proteins as novel cancer biomarkers for liquid biopsy","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Immunol."},{"issue":"30","key":"10.1016\/j.mcp.2025.102051_bib64","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib65","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12943-018-0897-7","article-title":"Effect of exosomal miRNA on cancer biology and clinical applications","volume":"17","author":"Sun","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mcp.2025.102051_bib66","first-page":"1","article-title":"Integrating plasma exosomal miRNAs, ultrasound radiomics and tPSA for the diagnosis and prediction of early prostate cancer: a multi-center study","author":"Wang","year":"2024","journal-title":"Clin. Transl. Oncol."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib67","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s00795-022-00338-5","article-title":"Predictive value of an exosomal microRNA-based signature for tumor immunity in cervical cancer patients treated with chemoradiotherapy","volume":"56","author":"Someya","year":"2023","journal-title":"Med. Mol. Morphol."},{"issue":"6","key":"10.1016\/j.mcp.2025.102051_bib68","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2174\/1566524022666220628160009","article-title":"Advances in exosomal microRNAs and proteins in ovarian cancer diagnosis, prognosis, and treatment","volume":"23","author":"Qin","year":"2023","journal-title":"Curr. Mol. Med."},{"issue":"20","key":"10.1016\/j.mcp.2025.102051_bib69","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.3748\/wjg.v30.i20.2618","article-title":"Exosomal microRNAs in hepatocellular carcinoma, expanding research field","volume":"30","author":"Zheng","year":"2024","journal-title":"World J. Gastroenterol."},{"issue":"7","key":"10.1016\/j.mcp.2025.102051_bib70","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.3390\/ijms25073914","article-title":"MicroRNAs in pancreatic cancer: advances in biomarker discovery and therapeutic implications","volume":"25","author":"Madadjim","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcp.2025.102051_bib71","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cca.2022.10.018","article-title":"Exosomal noncoding RNAs in prostate cancer","volume":"537","author":"Movahedpour","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.mcp.2025.102051_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2022.117216","article-title":"Exosomal lncRNAs in gastrointestinal cancer","volume":"540","author":"Vosough","year":"2023","journal-title":"Clin. Chim. Acta"},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib73","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41576-018-0071-5","article-title":"Current and future perspectives of liquid biopsies in genomics-driven oncology","volume":"20","author":"Heitzer","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mcp.2025.102051_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117472","article-title":"MicroRNA electrochemical biosensors for pancreatic cancer","volume":"548","author":"Rahdan","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.mcp.2025.102051_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.651232","article-title":"Graphene FET sensors for Alzheimer's disease protein biomarker clusterin detection","volume":"8","author":"Bungon","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"9","key":"10.1016\/j.mcp.2025.102051_bib76","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3390\/cancers15092566","article-title":"The application of an extracellular vesicle-based biosensor in early diagnosis and prediction of chemoresponsiveness in ovarian cancer","volume":"15","author":"Asare-Werehene","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.mcp.2025.102051_bib77","doi-asserted-by":"crossref","DOI":"10.1021\/acssensors.3c02776","article-title":"Electrochemical sensor for the detection and accurate early diagnosis of ovarian cancer","author":"Ge","year":"2024","journal-title":"ACS Sens."},{"key":"10.1016\/j.mcp.2025.102051_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112222","article-title":"Optical, electrochemical and electrical (nano) biosensors for detection of exosomes: a comprehensive overview","volume":"161","author":"Xu","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.mcp.2025.102051_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132318","article-title":"Electrochemical aptasensors for clinical diagnosis. A review of the last five years","volume":"369","author":"Villalonga","year":"2022","journal-title":"Sensor. Actuator. B Chem."},{"issue":"8","key":"10.1016\/j.mcp.2025.102051_bib80","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/bios12080566","article-title":"Electrochemical signal amplification strategies and their use in olfactory and taste evaluation","volume":"12","author":"Wang","year":"2022","journal-title":"Biosensors"},{"key":"10.1016\/j.mcp.2025.102051_bib81","article-title":"Aptamer-based electrochemical biosensors: signal transduction mechanisms, application progress, and future trends","author":"Bao","year":"2025","journal-title":"Sens. Acutators Rep."},{"issue":"3","key":"10.1016\/j.mcp.2025.102051_bib82","doi-asserted-by":"crossref","DOI":"10.1149\/2.0252003JES","article-title":"Measurement and analysis of cancer biomarkers based on electrochemical biosensors","volume":"167","author":"Cui","year":"2019","journal-title":"J. Electrochem. Soc."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib83","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3109\/21691401.2014.942456","article-title":"A review on impedimetric biosensors","volume":"44","author":"Bahad\u0131r","year":"2016","journal-title":"Artif. Cell Nanomed. Biotechnol."},{"issue":"8","key":"10.1016\/j.mcp.2025.102051_bib84","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.3390\/s23084106","article-title":"Electrochemical and photoelectrochemical immunosensors for the detection of ovarian cancer biomarkers","volume":"23","author":"Ekwujuru","year":"2023","journal-title":"Sensors"},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib85","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1021\/acsnano.5b07584","article-title":"Integrated magneto\u2013electrochemical sensor for exosome analysis","volume":"10","author":"Jeong","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.mcp.2025.102051_bib86","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12668-018-0589-1","article-title":"Sensitivity study of cancer antigens (CA-125) detection using interdigitated electrodes under microfluidic flow condition","volume":"9","author":"Nunna","year":"2019","journal-title":"BioNanoScience"},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib87","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1021\/acsami.0c14946","article-title":"Label-free electrochemical immunosensor for ultrasensitive detection of carbohydrate antigen 125 based on antibody-immobilized biocompatible MOF-808\/CNT","volume":"13","author":"Biswas","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"16","key":"10.1016\/j.mcp.2025.102051_bib88","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1039\/D2AN00875K","article-title":"Low-cost electrochemical paper-based device for exosome detection","volume":"147","author":"Kasetsirikul","year":"2022","journal-title":"Analyst"},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib89","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1021\/acsanm.0c02807","article-title":"Isolation and detection of exosomes using Fe2O3 nanoparticles","volume":"4","author":"Farhana","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"issue":"21","key":"10.1016\/j.mcp.2025.102051_bib90","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.3390\/molecules27217327","article-title":"Recent progress in biosensors for detection of tumor biomarkers","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib91","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s13206-022-00089-6","article-title":"Recent advances in electrochemical and optical biosensors for cancer biomarker detection","volume":"17","author":"Son","year":"2023","journal-title":"Biochip J."},{"key":"10.1016\/j.mcp.2025.102051_bib92","doi-asserted-by":"crossref","DOI":"10.31661\/gmj.v13i.3180","article-title":"A gold nanoparticle-based aptasensor for specific detection of CA125: an aptasensor for CA125","volume":"13","author":"Ebrahimi","year":"2024","journal-title":"Galen Med. J."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib93","doi-asserted-by":"crossref","DOI":"10.1002\/sstr.202100096","article-title":"Extracellular vesicles for the diagnosis of cancers","volume":"3","author":"Xue","year":"2022","journal-title":"Small Struct."},{"key":"10.1016\/j.mcp.2025.102051_bib94","article-title":"Aptamer-based high-sensitivity optical fiber SPR sensor for label-free detection of berberine hydrochloride","author":"Zhao","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.mcp.2025.102051_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2019.120510","article-title":"Structure-switching aptamer triggering hybridization displacement reaction for label-free detection of exosomes","volume":"209","author":"Chen","year":"2020","journal-title":"Talanta"},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib96","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1021\/acssensors.8b01564","article-title":"A label-free platform for identification of exosomes from different sources","volume":"4","author":"Yan","year":"2019","journal-title":"ACS Sens."},{"key":"10.1016\/j.mcp.2025.102051_bib97","series-title":"Exploration","article-title":"Recent advances of Au@ Ag core\u2013shell SERS\u2010based biosensors","author":"Awiaz","year":"2023"},{"issue":"11","key":"10.1016\/j.mcp.2025.102051_bib98","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1002\/ijc.32762","article-title":"The cancer exosomes: clinical implications, applications and challenges","volume":"146","author":"Tang","year":"2020","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.mcp.2025.102051_bib99","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/bios13030396","article-title":"Surface plasmon resonance (SPR) sensor for cancer biomarker detection","volume":"13","author":"Das","year":"2023","journal-title":"Biosensors"},{"issue":"5","key":"10.1016\/j.mcp.2025.102051_bib100","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nbt.2886","article-title":"Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor","volume":"32","author":"Im","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"16","key":"10.1016\/j.mcp.2025.102051_bib101","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1039\/C6LC00279J","article-title":"Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide\/polydopamine coating","volume":"16","author":"Zhang","year":"2016","journal-title":"Lab Chip"},{"issue":"3","key":"10.1016\/j.mcp.2025.102051_bib102","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1039\/C5LC01117E","article-title":"A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis","volume":"16","author":"Zhao","year":"2016","journal-title":"Lab Chip"},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib103","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1021\/acsphotonics.7b00992","article-title":"Analyses of intravesicular exosomal proteins using a nano-plasmonic system","volume":"5","author":"Park","year":"2018","journal-title":"ACS Photonics"},{"issue":"15","key":"10.1016\/j.mcp.2025.102051_bib104","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1002\/anie.201900092","article-title":"Near\u2010infrared afterglow semiconducting nano\u2010polycomplexes for the multiplex differentiation of cancer exosomes","volume":"58","author":"Lyu","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"issue":"5","key":"10.1016\/j.mcp.2025.102051_bib105","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1021\/acssensors.4c00270","article-title":"Dual-aptamer recognition of DNA Logic Gate Sensor-based specific exosomal proteins for ovarian Cancer diagnosis","volume":"9","author":"Zhao","year":"2024","journal-title":"ACS Sens."},{"issue":"8","key":"10.1016\/j.mcp.2025.102051_bib106","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/bios12080648","article-title":"Introduction of nanomaterials to biosensors for exosome detection: case study for cancer analysis","volume":"12","author":"Lee","year":"2022","journal-title":"Biosensors"},{"issue":"4","key":"10.1016\/j.mcp.2025.102051_bib107","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/14737159.2020.1731308","article-title":"Exosomal biomarkers for cancer diagnosis and patient monitoring","volume":"20","author":"Makler","year":"2020","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-50412-9","article-title":"Chemically functionalised graphene FET biosensor for the label-free sensing of exosomes","volume":"9","author":"Kwong Hong Tsang","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib109","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4068\/cmj.2019.55.2.86","article-title":"Recent advances in biosensors for nucleic acid and exosome detection","volume":"55","author":"Fu","year":"2019","journal-title":"Chonnam Med. J."},{"key":"10.1016\/j.mcp.2025.102051_bib110","article-title":"Nanomaterial-based biosensor developing as a route toward in vitro diagnosis of early ovarian cancer","volume":"13","author":"Yang","year":"2022","journal-title":"Mater. Today Bio"},{"issue":"12","key":"10.1016\/j.mcp.2025.102051_bib111","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3390\/bios11120518","article-title":"Exosomes as powerful engines in cancer: isolation, characterization and detection techniques","volume":"11","author":"Saad","year":"2021","journal-title":"Biosensors"},{"issue":"19","key":"10.1016\/j.mcp.2025.102051_bib112","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.1039\/D1AN01061A","article-title":"Microsphere mediated exosome isolation and ultra-sensitive detection on a dielectrophoresis integrated microfluidic device","volume":"146","author":"Zhao","year":"2021","journal-title":"Analyst"},{"issue":"7","key":"10.1016\/j.mcp.2025.102051_bib113","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1039\/C5LC00036J","article-title":"On-chip surface acoustic wave lysis and ion-exchange nanomembrane detection of exosomal RNA for pancreatic cancer study and diagnosis","volume":"15","author":"Taller","year":"2015","journal-title":"Lab Chip"},{"key":"10.1016\/j.mcp.2025.102051_bib114","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.2147\/IJN.S333969","article-title":"Progress in nanomaterials-based optical and electrochemical methods for the assays of exosomes","author":"Ma","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mcp.2025.102051_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115266","article-title":"Lab-on-a-chip systems for cancer biomarker diagnosis","volume":"226","author":"\u00d6zyurt","year":"2023","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib116","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1039\/D2LC00666A","article-title":"Tailored point-of-care biosensors for liquid biopsy in the field of oncology","volume":"23","author":"Singh","year":"2023","journal-title":"Lab Chip"},{"issue":"11","key":"10.1016\/j.mcp.2025.102051_bib117","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.tibtech.2019.04.008","article-title":"Recent advances in biosensors for detecting cancer-derived exosomes","volume":"37","author":"Cheng","year":"2019","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.mcp.2025.102051_bib118","first-page":"158","article-title":"Recent advances of emerging microfluidic chips for exosome mediated cancer diagnosis","volume":"2","author":"Wang","year":"2021","journal-title":"Smart Mater. Med."},{"issue":"8","key":"10.1016\/j.mcp.2025.102051_bib119","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.3390\/ijms19082213","article-title":"Miniaturized biomedical sensors for enumeration of extracellular vesicles","volume":"19","author":"Pulikkathodi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.mcp.2025.102051_bib120","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1021\/acsnano.7b00549","article-title":"Rapid isolation and detection of exosomes and associated biomarkers from plasma","volume":"11","author":"Ibsen","year":"2017","journal-title":"ACS Nano"},{"issue":"14","key":"10.1016\/j.mcp.2025.102051_bib121","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.7150\/thno.34692","article-title":"Liquid biopsy in ovarian cancer: recent advances in circulating extracellular vesicle detection for early diagnosis and monitoring progression","volume":"9","author":"Chang","year":"2019","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.mcp.2025.102051_bib122","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3390\/ijms23020868","article-title":"Emerging advances of detection strategies for tumor-derived exosomes","volume":"23","author":"Cheng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.mcp.2025.102051_bib123","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1021\/acs.analchem.9b01950","article-title":"Electrical and label-free quantification of exosomes with a reduced graphene oxide field effect transistor biosensor","volume":"91","author":"Yu","year":"2019","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.mcp.2025.102051_bib124","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s00216-022-04362-3","article-title":"Advancement and obstacles in microfluidics-based isolation of extracellular vesicles","volume":"415","author":"Havers","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"issue":"3","key":"10.1016\/j.mcp.2025.102051_bib125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12032-023-02297-y","article-title":"Advancements in biosensors for cancer detection: revolutionizing diagnostics","volume":"41","author":"Mustafa","year":"2024","journal-title":"Med. Oncol."},{"issue":"1","key":"10.1016\/j.mcp.2025.102051_bib126","article-title":"Current nanotechnology advances in diagnostic biosensors","volume":"4","author":"Barbosa","year":"2021","journal-title":"Med. Dev. Sens."},{"issue":"24","key":"10.1016\/j.mcp.2025.102051_bib127","doi-asserted-by":"crossref","DOI":"10.3390\/s24247884","article-title":"Acoustic wave sensor detection of an ovarian cancer biomarker with antifouling surface chemistry","volume":"24","author":"Davoudian","year":"2024","journal-title":"Sensors"},{"issue":"4","key":"10.1016\/j.mcp.2025.102051_bib128","doi-asserted-by":"crossref","DOI":"10.1007\/s13320-024-0706-4","article-title":"Fiber-optic biosensors for cancer theranostics: from in vitro to in vivo","volume":"14","author":"Jin","year":"2024","journal-title":"Photon. Sens."}],"container-title":["Molecular and Cellular Probes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850825000441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850825000441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:02:57Z","timestamp":1765188177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890850825000441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":128,"alternative-id":["S0890850825000441"],"URL":"https:\/\/doi.org\/10.1016\/j.mcp.2025.102051","relation":{},"ISSN":["0890-8508"],"issn-type":[{"value":"0890-8508","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosome biosensors for detection of ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Probes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcp.2025.102051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102051"}}