{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:27:58Z","timestamp":1786753678041,"version":"build-2736575974"},"reference-count":139,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Probes"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mcp.2026.102081","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:43:29Z","timestamp":1785167009000},"page":"102081","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["R-loops: Biological functions, regulatory mechanisms, and therapeutic implications in brain diseases\u2014A review"],"prefix":"10.1016","volume":"89","author":[{"given":"Ruonan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21\u201322","key":"10.1016\/j.mcp.2026.102081_bib1","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1007\/s00018-021-03926-3","article-title":"DNA damage responses that enhance resilience to replication stress","volume":"78","author":"Yoshida","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mcp.2026.102081_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2023.102618","article-title":"Repair and tolerance of DNA damage at the replication fork: a structural perspective","volume":"81","author":"Eichman","year":"2023","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"5087","key":"10.1016\/j.mcp.2026.102081_bib3","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1126\/science.1279808","article-title":"Stability and properties of double and triple helices: dramatic effects of RNA or DNA backbone composition","volume":"258","author":"Roberts","year":"1992","journal-title":"Science"},{"issue":"35","key":"10.1016\/j.mcp.2026.102081_bib4","doi-asserted-by":"crossref","first-page":"11211","DOI":"10.1021\/bi00035a029","article-title":"Thermodynamic parameters to predict stability of RNA\/DNA hybrid duplexes","volume":"34","author":"Sugimoto","year":"1995","journal-title":"Biochemistry"},{"issue":"11","key":"10.1016\/j.mcp.2026.102081_bib5","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1089\/dna.2020.5906","article-title":"R-Loop physiology and pathology: a brief review","volume":"39","author":"Mackay","year":"2020","journal-title":"DNA Cell Biol."},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib6","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cell.2017.07.044","article-title":"Replication-transcription conflicts generate R-Loops that orchestrate bacterial stress survival and pathogenesis","volume":"170","author":"Lang","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-biochem-030222-115809","article-title":"Replication-transcription conflicts: a perpetual war on the chromosome","volume":"93","author":"Browning","year":"2024","journal-title":"Annu. Rev. Biochem."},{"issue":"12","key":"10.1016\/j.mcp.2026.102081_bib8","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.molcel.2022.04.014","article-title":"Walking a tightrope: the complex balancing act of R-loops in genome stability","volume":"82","author":"Brickner","year":"2022","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-38924-x","article-title":"Human PNPase causes RNA stabilization and accumulation of R-loops in the Escherichia coli model system","volume":"13","author":"Falchi","year":"2023","journal-title":"Sci. Rep."},{"issue":"22","key":"10.1016\/j.mcp.2026.102081_bib10","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021109711","article-title":"AATF\/Che-1 localizes to paraspeckles and suppresses R-loops accumulation and interferon activation in Multiple Myeloma","volume":"41","author":"Bruno","year":"2022","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib11","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1038\/s41467-020-17503-y","article-title":"BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage","volume":"11","author":"Lam","year":"2020","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.mcp.2026.102081_bib12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41580-022-00474-x","article-title":"Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids","volume":"23","author":"Petermann","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.mcp.2026.102081_bib13","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.cell.2019.08.055","article-title":"From physiological to pathological roles","volume":"179","author":"Garcia-Muse","year":"2019","journal-title":"Cell."},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/21541264.2016.1198298","article-title":"Regulation of chromatin structure and cell fate by R-loops","volume":"7","author":"Fazzio","year":"2016","journal-title":"Transcription"},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010754","article-title":"Characterization of a pathway of genomic instability induced by R-loops and its regulation by topoisomerases in E. coli","volume":"19","author":"Brochu","year":"2023","journal-title":"PLoS Genet."},{"issue":"12","key":"10.1016\/j.mcp.2026.102081_bib16","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1093\/nar\/gkaa477","article-title":"5' modifications to CRISPR-Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage","volume":"48","author":"Mullally","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"16","key":"10.1016\/j.mcp.2026.102081_bib17","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.1128\/MCB.00702-07","article-title":"Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region","volume":"27","author":"Huang","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mcp.2026.102081_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.965312","article-title":"Activation induced cytidine deaminase: an old friend with new faces","volume":"13","author":"Cakan","year":"2022","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.mcp.2026.102081_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072408","article-title":"The mini-chromosome maintenance (Mcm) complexes interact with DNA polymerase alpha-primase and stimulate its ability to synthesize RNA primers","volume":"8","author":"You","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/genes10050331","article-title":"Post-translational modifications of the mini-chromosome maintenance proteins in DNA replication","volume":"10","author":"Li","year":"2019","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib21","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1038\/s41467-024-46547-7","article-title":"Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation","volume":"15","author":"Rombaut","year":"2024","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nsmb.3395","article-title":"DNA-RNA hybrids: the risks of DNA breakage during transcription","volume":"24","author":"Aguilera","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mcp.2026.102081_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-1-0716-2477-7_12","article-title":"R-Loops and mitochondrial DNA metabolism","volume":"2528","author":"Holt","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"52","key":"10.1016\/j.mcp.2026.102081_bib24","doi-asserted-by":"crossref","first-page":"36743","DOI":"10.1074\/jbc.M806174200","article-title":"Native R-loops persist throughout the mouse mitochondrial DNA genome","volume":"283","author":"Brown","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcp.2026.102081_bib25","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fgene.2015.00158","article-title":"R-loops and initiation of DNA replication in human cells: a missing link?","volume":"6","author":"Lombrana","year":"2015","journal-title":"Front. Genet."},{"issue":"7833","key":"10.1016\/j.mcp.2026.102081_bib26","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2815-6","article-title":"RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops","volume":"587","author":"Feretzaki","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2211683120","article-title":"Non-B-form DNA tends to form in centromeric regions and has undergone changes in polyploid oat subgenomes","volume":"120","author":"Liu","year":"2023","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cell.2008.05.031","article-title":"An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity","volume":"134","author":"Fazzio","year":"2008","journal-title":"Cell"},{"issue":"6132","key":"10.1016\/j.mcp.2026.102081_bib29","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1126\/science.1234848","article-title":"R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus","volume":"340","author":"Sun","year":"2013","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-026-04009-2","article-title":"R-loop landscapes in the developing human brain are linked to neural differentiation and cell type-specific transcription","volume":"16","author":"LaMarca","year":"2026","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib33","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41467-024-55579-y","article-title":"NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit","volume":"16","author":"Kang","year":"2025","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.mcp.2026.102081_bib31","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1016\/j.molcel.2025.10.019","article-title":"A role for human senataxin in contending with pausing and backtracking during transcript elongation","volume":"85","author":"Han","year":"2025","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-69479-w","article-title":"SFPQ directs histone H3.3 deposition to R-loops in DNA repeats to protect genome stability","volume":"17","author":"Ferrando","year":"2026","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.mcp.2026.102081_bib34","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.celrep.2018.04.025","article-title":"RNA\/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-Loop-Associated DNA damage","volume":"23","author":"Cristini","year":"2018","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.mcp.2026.102081_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006107","article-title":"XRN2 links transcription termination to DNA damage and replication stress","volume":"12","author":"Morales","year":"2016","journal-title":"PLoS Genet."},{"issue":"12","key":"10.1016\/j.mcp.2026.102081_bib36","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41422-019-0235-7","article-title":"m(6)A promotes R-loop formation to facilitate transcription termination","volume":"29","author":"Yang","year":"2019","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-026-01531-0","article-title":"Regulation of transcription by R loop-nucleated transcription condensate assembly","volume":"16","author":"Ng","year":"2026","journal-title":"Cell Biosci."},{"issue":"8","key":"10.1016\/j.mcp.2026.102081_bib38","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1158\/1541-7786.MCR-20-0833","article-title":"R-Loop-Mediated ssDNA breaks accumulate following short-term exposure to the HDAC inhibitor romidepsin","volume":"19","author":"Safari","year":"2021","journal-title":"Mol. Cancer Res."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib39","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1038\/s41598-017-03936-x","article-title":"Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro","volume":"7","author":"Budzko","year":"2017","journal-title":"Sci. Rep."},{"issue":"29","key":"10.1016\/j.mcp.2026.102081_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg0076","article-title":"The mechanism of gap creation by a multifunctional nuclease during base excision repair","volume":"7","author":"Yoo","year":"2021","journal-title":"Sci. Adv."},{"issue":"47","key":"10.1016\/j.mcp.2026.102081_bib41","doi-asserted-by":"crossref","first-page":"eabj5769","DOI":"10.1126\/sciadv.abj5769","article-title":"R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage","volume":"7","author":"Chatzidoukaki","year":"2021","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.mcp.2026.102081_bib42","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/s41596-019-0159-1","article-title":"High-resolution, strand-specific R-loop mapping via S9.6-based DNA-RNA immunoprecipitation and high-throughput sequencing","volume":"14","author":"Sanz","year":"2019","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.mcp.2026.102081_bib43","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jmb.2017.12.016","article-title":"The affinity of the S9.6 antibody for double-stranded RNAs impacts the accurate mapping of R-Loops in fission yeast","volume":"430","author":"Hartono","year":"2018","journal-title":"J. Mol. Biol."},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib44","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2017.10.008","article-title":"R-ChIP using inactive RNase H reveals dynamic coupling of R-loops with transcriptional pausing at gene promoters","volume":"68","author":"Chen","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mcp.2026.102081_bib45","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28306","article-title":"Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq","volume":"6","author":"Dumelie","year":"2017","journal-title":"eLife"},{"issue":"20","key":"10.1016\/j.mcp.2026.102081_bib46","first-page":"9729","article-title":"GC skew is a conserved property of unmethylated CpG island promoters across vertebrates","volume":"43","author":"Hartono","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"13","key":"10.1016\/j.mcp.2026.102081_bib47","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1101\/gad.242990.114","article-title":"A double-edged sword: r loops as threats to genome integrity and powerful regulators of gene expression","volume":"28","author":"Skourti-Stathaki","year":"2014","journal-title":"Genes Dev."},{"issue":"8","key":"10.1016\/j.mcp.2026.102081_bib48","doi-asserted-by":"crossref","first-page":"eaeb4937","DOI":"10.1126\/sciadv.aeb4937","article-title":"R-loop processing via REXO4-RNaseH1-mediated endo- and exo-cleavage coupling mode prevents genome instability and antitumor immunity","volume":"12","author":"Yang","year":"2026","journal-title":"Sci. Adv."},{"issue":"20","key":"10.1016\/j.mcp.2026.102081_bib49","doi-asserted-by":"crossref","first-page":"11010","DOI":"10.1093\/nar\/gkad812","article-title":"Live-cell imaging unveils distinct R-loop populations with heterogeneous dynamics","volume":"51","author":"Martin","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.mcp.2026.102081_bib50","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/nn.4604","article-title":"C9orf72 expansion disrupts ATM-mediated chromosomal break repair","volume":"20","author":"Walker","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"22","key":"10.1016\/j.mcp.2026.102081_bib51","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf1383","article-title":"Amplification-free cancer diagnosis based on inhibition of Cas12a activity by site-specific 5mC-modified cfDNA","volume":"53","author":"Yang","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib52","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/s41467-017-01196-x","article-title":"Coding and noncoding landscape of extracellular RNA released by human glioma stem cells","volume":"8","author":"Wei","year":"2017","journal-title":"Nat. Commun."},{"issue":"14","key":"10.1016\/j.mcp.2026.102081_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/cells12141911","article-title":"Liquid biopsy in neurological diseases","volume":"12","author":"Malhotra","year":"2023","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.mcp.2026.102081_bib54","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.molcel.2020.12.002","article-title":"Hyperosmotic stress alters the RNA polymerase II interactome and induces readthrough transcription despite widespread transcriptional repression","volume":"81","author":"Rosa-Mercado","year":"2021","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib55","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/s41467-021-22083-6","article-title":"R-loop resolution promotes co-transcriptional chromatin silencing","volume":"12","author":"Xu","year":"2021","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib56","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.molcel.2015.01.011","article-title":"BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair","volume":"57","author":"Hatchi","year":"2015","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib57","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.cell.2017.07.043","article-title":"Transcription-replication conflict orientation modulates R-Loop levels and activates distinct DNA damage responses","volume":"170","author":"Hamperl","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.mcp.2026.102081_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2021.103199","article-title":"Toxic R-loops: cause or consequence of replication stress?","volume":"107","author":"Kemiha","year":"2021","journal-title":"DNA Repair"},{"issue":"21","key":"10.1016\/j.mcp.2026.102081_bib59","doi-asserted-by":"crossref","first-page":"12274","DOI":"10.1093\/nar\/gkac1116","article-title":"DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells","volume":"50","author":"Boleslavska","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"7979","key":"10.1016\/j.mcp.2026.102081_bib60","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41586-023-06515-5","article-title":"R-loop-dependent promoter-proximal termination ensures genome stability","volume":"621","author":"Xu","year":"2023","journal-title":"Nature"},{"issue":"8103","key":"10.1016\/j.mcp.2026.102081_bib61","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/s41586-025-09943-7","article-title":"CFAP20 salvages arrested RNAPII from the path of co-directional replisomes","volume":"650","author":"Uruci","year":"2026","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mcp.2026.102081_bib62","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.molcel.2014.10.020","article-title":"Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability","volume":"56","author":"Sollier","year":"2014","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib63","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1158\/0008-5472.CAN-23-3239","article-title":"R-Loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts","volume":"84","author":"Liu","year":"2024","journal-title":"Cancer Res."},{"issue":"13","key":"10.1016\/j.mcp.2026.102081_bib64","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.molcel.2023.06.005","article-title":"Go along to get along: integrator at active replication forks defuses co-directional transcription-replication conflicts","volume":"83","author":"Dinatto","year":"2023","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.mcp.2026.102081_bib65","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/s41588-021-00867-2","article-title":"The SWI\/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts","volume":"53","author":"Bayona-Feliu","year":"2021","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib66","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00412-023-00804-8","article-title":"Looping out of control: R-loops in transcription-replication conflict","volume":"133","author":"Kumar","year":"2024","journal-title":"Chromosoma"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib67","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/nar\/gkad973","article-title":"ATR phosphorylates DHX9 at serine 321 to suppress R-loop accumulation upon genotoxic stress","volume":"52","author":"Liu","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.mcp.2026.102081_bib68","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.molcel.2019.10.010","article-title":"ATR protects the genome against R loops through a MUS81-Triggered feedback loop","volume":"77","author":"Matos","year":"2020","journal-title":"Mol. Cell"},{"issue":"7851","key":"10.1016\/j.mcp.2026.102081_bib69","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41586-020-03150-2","article-title":"BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52","volume":"591","author":"Hatchi","year":"2021","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.mcp.2026.102081_bib70","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1093\/nar\/gkab178","article-title":"Untangling the crosstalk between BRCA1 and R-loops during DNA repair","volume":"49","author":"San Martin Alonso","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"50","key":"10.1016\/j.mcp.2026.102081_bib71","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2217542119","article-title":"The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops","volume":"119","author":"Chang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.mcp.2026.102081_bib72","first-page":"454","article-title":"DNA damage response: the spliceosome cashes in at the ATM","volume":"16","author":"Zlotorynski","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.mcp.2026.102081_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2016.70","article-title":"The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing","volume":"5","author":"Tanikawa","year":"2016","journal-title":"Oncogenesis"},{"issue":"7558","key":"10.1016\/j.mcp.2026.102081_bib74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature14512","article-title":"The core spliceosome as target and effector of non-canonical ATM signalling","volume":"523","author":"Tresini","year":"2015","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.mcp.2026.102081_bib75","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/ncb1984","article-title":"Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription","volume":"11","author":"Tuduri","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.mcp.2026.102081_bib76","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.molcel.2011.10.017","article-title":"RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability","volume":"44","author":"Wahba","year":"2011","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.mcp.2026.102081_bib77","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1101\/gad.179721.111","article-title":"R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants","volume":"26","author":"Stirling","year":"2012","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib78","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/cr.2014.36","article-title":"Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination","volume":"24","author":"Gao","year":"2014","journal-title":"Cell Res."},{"issue":"12","key":"10.1016\/j.mcp.2026.102081_bib79","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/ncb3643","article-title":"Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks","volume":"19","author":"Michelini","year":"2017","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib80","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1038\/s41467-018-07799-2","article-title":"BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment","volume":"9","author":"D'Alessandro","year":"2018","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.mcp.2026.102081_bib81","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cell.2018.08.056","article-title":"Human Rad52 promotes XPG-mediated R-loop processing to initiate transcription-associated homologous recombination repair","volume":"175","author":"Yasuhara","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.mcp.2026.102081_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2021.103182","article-title":"Defining R-loop classes and their contributions to genome instability","volume":"106","author":"Castillo-Guzman","year":"2021","journal-title":"DNA Repair"},{"issue":"14","key":"10.1016\/j.mcp.2026.102081_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26146951","article-title":"Participants in transcription-replication conflict and their role in formation and resolution of R-Loops","volume":"26","author":"Davletgildeeva","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib84","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106394","article-title":"Best practices for the visualization, mapping, and manipulation of R-loops","volume":"40","author":"Ch\u00e9din","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.mcp.2026.102081_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1552790","article-title":"How do neurons live long and healthy? The mechanism of neuronal genome integrity","volume":"19","author":"Ihara","year":"2025","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.mcp.2026.102081_bib86","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.molcel.2017.12.030","article-title":"Senataxin mutation reveals how R-Loops promote transcription by blocking DNA methylation at gene promoters","volume":"69","author":"Grunseich","year":"2018","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.mcp.2026.102081_bib87","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2217\/epi-2023-0379","article-title":"Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases","volume":"16","author":"Westover","year":"2024","journal-title":"Epigenomics"},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib88","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1093\/nar\/gkq935","article-title":"Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats","volume":"39","author":"Reddy","year":"2011","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004294","article-title":"Transcription-associated R-loop formation across the human FMR1 CGG-repeat region","volume":"10","author":"Loomis","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mcp.2026.102081_bib90","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awae166","article-title":"Shared patterns of glial transcriptional dysregulation link Huntington's disease and schizophrenia","author":"Huynh","year":"2024","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.mcp.2026.102081_bib91","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210129","article-title":"In cis effect of DMPK expanded alleles in myotonic dystrophy type 1 patients carrying variant repeats at 5' and 3' ends of the CTG array","volume":"24","author":"Visconti","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.mcp.2026.102081_bib92","doi-asserted-by":"crossref","first-page":"fcae087","DOI":"10.1093\/braincomms\/fcae087","article-title":"Repeat expansions in AR, ATXN1, ATXN2 and HTT in Norwegian patients diagnosed with amyotrophic lateral sclerosis","volume":"6","author":"Novy","year":"2024","journal-title":"Brain Commun"},{"key":"10.1016\/j.mcp.2026.102081_bib93","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-0716-2477-7_7","article-title":"RNase H1, the Gold standard for R-Loop detection","volume":"2528","author":"Cerritelli","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004318","article-title":"R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome","volume":"10","author":"Groh","year":"2014","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib95","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.molcel.2017.05.014","article-title":"Histone mutants separate R loop formation from genome instability induction","volume":"66","author":"Garcia-Pichardo","year":"2017","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.mcp.2026.102081_bib96","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nchembio815","article-title":"Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia","volume":"2","author":"Herman","year":"2006","journal-title":"Nat. Chem. Biol."},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009523","article-title":"Aicardi-Goutieres syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription-replication conflict regions","volume":"17","author":"Park","year":"2021","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib98","doi-asserted-by":"crossref","DOI":"10.1002\/ajmg.a.63510","article-title":"TREX-1 related Aicardi-Goutieres syndrome improved by Janus kinase inhibitor","volume":"194","author":"Ryckmans","year":"2024","journal-title":"Am. J. Med. Genet."},{"issue":"2","key":"10.1016\/j.mcp.2026.102081_bib99","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4077\/CJP.2014.BAC228","article-title":"Association of genetic variants in senataxin and Alzheimer's disease in a Chinese Han population in Taiwan","volume":"57","author":"Shen","year":"2014","journal-title":"Chin. J. Physiol."},{"issue":"11\u201312","key":"10.1016\/j.mcp.2026.102081_bib100","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1007\/s12031-023-02169-0","article-title":"Role of Senataxin in amyotrophic lateral sclerosis","volume":"73","author":"Tsui","year":"2023","journal-title":"J. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib101","doi-asserted-by":"crossref","first-page":"fcae239","DOI":"10.1093\/braincomms\/fcae239","article-title":"Role of senataxin in R-loop-mediated neurodegeneration","volume":"6","author":"Kannan","year":"2024","journal-title":"Brain Commun"},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib102","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/brain\/awy076","article-title":"Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia","volume":"141","author":"Walker","year":"2018","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.mcp.2026.102081_bib103","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1093\/brain\/awab464","article-title":"Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4","volume":"145","author":"Kannan","year":"2022","journal-title":"Brain"},{"issue":"20","key":"10.1016\/j.mcp.2026.102081_bib104","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1016\/j.molcel.2023.09.024","article-title":"Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2","volume":"83","author":"Appel","year":"2023","journal-title":"Mol. Cell"},{"issue":"11","key":"10.1016\/j.mcp.2026.102081_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078837","article-title":"Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide","volume":"8","author":"Bennett","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.mcp.2026.102081_bib106","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s12031-022-02035-5","article-title":"Unique ataxia-oculomotor apraxia 2 (AOA2) in Israel with novel variants, atypical late presentation, and possible identification of a poison exon","volume":"72","author":"Ponger","year":"2022","journal-title":"J. Mol. Neurosci."},{"issue":"21","key":"10.1016\/j.mcp.2026.102081_bib107","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1016\/j.jmb.2016.08.031","article-title":"R loops and links to human disease","volume":"429","author":"Richard","year":"2017","journal-title":"J. Mol. Biol."},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2026.111348","article-title":"RNA-binding proteins TDP-43 and FUS promote R-loop resolution and regulate transcription termination","volume":"302","author":"Zhao","year":"2026","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.mcp.2026.102081_bib109","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009260","article-title":"TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage","volume":"16","author":"Giannini","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mcp.2026.102081_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.826608","article-title":"R-loop mediated DNA damage and impaired DNA repair in spinal muscular atrophy","volume":"16","author":"Cuartas","year":"2022","journal-title":"Front. Cell. Neurosci."},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114165","article-title":"Small-molecule inhibition of the METTL3\/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation","volume":"43","author":"Pomaville","year":"2024","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib112","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf061","article-title":"Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers","volume":"53","author":"Goncalves","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.mcp.2026.102081_bib113","first-page":"6099","article-title":"Unveiling pathogenic mutations in BRCA1 and BRCA2 genes across head and neck squamous cell carcinoma patients via next generation sequencing","volume":"13","author":"Wei","year":"2023","journal-title":"Am. J. Cancer Res."},{"issue":"3","key":"10.1016\/j.mcp.2026.102081_bib114","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1158\/0008-5472.CAN-05-3593","article-title":"Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas","volume":"66","author":"McChesney","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.mcp.2026.102081_bib115","doi-asserted-by":"crossref","DOI":"10.1177\/2036361320972218","article-title":"Germline BRCA1 mutated esophageal squamous cell carcinoma","volume":"12","author":"Starr","year":"2020","journal-title":"Rare Tumors"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113610","article-title":"The FANCI\/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export","volume":"43","author":"Olazabal-Herrero","year":"2024","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2021.104399","article-title":"Fanconi-like anemia related to a FANCM mutation","volume":"65","author":"Encarnacion","year":"2022","journal-title":"Eur. J. Med. Genet."},{"issue":"12","key":"10.1016\/j.mcp.2026.102081_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105431","article-title":"Evaluation of potential role of R-loop and G-quadruplex DNA in the fragility of c-MYC during chromosomal translocation associated with Burkitt's lymphoma","volume":"299","author":"Kumari","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"15","key":"10.1016\/j.mcp.2026.102081_bib119","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1093\/nar\/gkab642","article-title":"TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution","volume":"49","author":"Yuan","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"21","key":"10.1016\/j.mcp.2026.102081_bib120","article-title":"SRSF1 is required for mitochondrial homeostasis and thermogenic function in brown adipocytes through its control of Ndufs3 splicing","volume":"11","author":"Yuan","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"5","key":"10.1016\/j.mcp.2026.102081_bib121","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1093\/nar\/gkad1242","article-title":"METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma","volume":"52","author":"Vaid","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib122","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12943-024-01994-0","article-title":"Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer","volume":"23","author":"Ying","year":"2024","journal-title":"Mol. Cancer"},{"issue":"24","key":"10.1016\/j.mcp.2026.102081_bib123","doi-asserted-by":"crossref","first-page":"6310","DOI":"10.1038\/s44318-024-00299-8","article-title":"METTL3\/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma","volume":"43","author":"Thombare","year":"2024","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.mcp.2026.102081_bib124","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.molcel.2024.03.006","article-title":"DDX21 mediates co-transcriptional RNA m(6)A modification to promote transcription termination and genome stability","volume":"84","author":"Hao","year":"2024","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.mcp.2026.102081_bib125","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41419-024-06946-6","article-title":"M6A-methylated circPOLR2B forms an R-loop and regulates the biological behavior of glioma stem cells through positive feedback loops","volume":"15","author":"Lin","year":"2024","journal-title":"Cell Death Dis."},{"issue":"7749","key":"10.1016\/j.mcp.2026.102081_bib126","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41586-019-1030-9","article-title":"Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase","volume":"567","author":"Herold","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mcp.2026.102081_bib127","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s43018-020-00171-8","article-title":"Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma","volume":"2","author":"Roeschert","year":"2021","journal-title":"Nat. Cancer"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib128","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12885-025-13623-0","article-title":"Investigator-initiated phase I trial of an oligonucleotide therapeutic targeting long noncoding RNA TUG 1 for recurrent glioblastoma","volume":"25","author":"Deguchi","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mcp.2026.102081_bib129","series-title":"A first-in-class Therapy Targeting Transcription-Replication Conflicts Drives Synthetic Lethality in Homologous Recombination Deficient Cancers","author":"Ali ZaC","year":"2025"},{"issue":"4","key":"10.1016\/j.mcp.2026.102081_bib130","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cell.2017.07.044","article-title":"Replication-Transcription conflicts generate R-Loops that orchestrate bacterial stress survival and pathogenesis","volume":"170","author":"Lang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.mcp.2026.102081_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2026.115778","article-title":"Bioconjugates for improved delivery of oligonucleotide therapeutics to the central nervous system","volume":"230","author":"Lee","year":"2026","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.mcp.2026.102081_bib132","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/1873-3468.14947","article-title":"Looping forward: exploring R-loop processing and therapeutic potential","volume":"599","author":"Stratigi","year":"2025","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mcp.2026.102081_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2026.130701","article-title":"Small molecule inhibition of CPSF3 may impact R-loop distribution and abundance","volume":"139","author":"Hofman","year":"2026","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib134","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-026-05735-w","article-title":"The tale of the guanosine tract in repeat expansion disorders","volume":"63","author":"Karati","year":"2026","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mcp.2026.102081_bib135","article-title":"Small molecule inhibition of CPSF3 impacts R-loop distribution and abundance","author":"Hofman","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.mcp.2026.102081_bib136","article-title":"The role of R-loop aberrations in lower-grade gliomas: prognostic, immune, and metabolic implications from multi-omics and machine learning analysis","volume":"17","author":"Huang","year":"2026","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mcp.2026.102081_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116421","article-title":"A multi-omics R-loop-linked risk program highlights CKS2-positive proliferative tumor cells as drivers of glioma growth","volume":"175","author":"Tang","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mcp.2026.102081_bib138","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2147\/CMAR.S533571","article-title":"Prognostic significance of R-Loops in lung adenocarcinoma: implications for immune response and drug sensitivity","volume":"17","author":"Jiang","year":"2025","journal-title":"Cancer Manag. Res."},{"issue":"1","key":"10.1016\/j.mcp.2026.102081_bib139","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s10020-025-01257-8","article-title":"Developing a disease-specific accessible transcriptional signature as a biomarker for ataxia with oculomotor apraxia type 2","volume":"31","author":"Ngo","year":"2025","journal-title":"Mol. Med"}],"container-title":["Molecular and Cellular Probes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850826000216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850826000216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T23:55:53Z","timestamp":1786751753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890850826000216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":139,"alternative-id":["S0890850826000216"],"URL":"https:\/\/doi.org\/10.1016\/j.mcp.2026.102081","relation":{},"ISSN":["0890-8508"],"issn-type":[{"value":"0890-8508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"R-loops: Biological functions, regulatory mechanisms, and therapeutic implications in brain diseases\u2014A review","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Probes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcp.2026.102081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102081"}}