{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:15:54Z","timestamp":1788264954454,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031935","name":"Xi'an Jiaotong University","doi-asserted-by":"publisher","award":["XJYG2025-SFJJ033"],"award-info":[{"award-number":["XJYG2025-SFJJ033"]}],"id":[{"id":"10.13039\/100031935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2022SF-056"],"award-info":[{"award-number":["2022SF-056"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2022SF-588"],"award-info":[{"award-number":["2022SF-588"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2022JQ-863"],"award-info":[{"award-number":["2022JQ-863"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Probes"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.mcp.2026.102082","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T23:37:31Z","timestamp":1786059451000},"page":"102082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrative multi-omics and experimental validation reveal the oncogenic role of DDX52 in liver hepatocellular carcinoma"],"prefix":"10.1016","volume":"90","author":[{"given":"Chongyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiankun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinggong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wunai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-2475","authenticated-orcid":false,"given":"Nanbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10512","key":"10.1016\/j.mcp.2026.102082_bib1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0140-6736(25)01635-6","article-title":"The global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the global burden of disease study 2023","volume":"406","author":"Force","year":"2025","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.mcp.2026.102082_bib2","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.mcp.2026.102082_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"issue":"9","key":"10.1016\/j.mcp.2026.102082_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41571-020-0363-5","article-title":"The tumor microenvironment in pancreatic cancer-clinical challenges and opportunities","volume":"17","author":"Ho","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.mcp.2026.102082_bib5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.canlet.2019.11.009","article-title":"Immune cells within the tumor microenvironment: biological functions and roles in cancer immunotherapy","volume":"470","author":"Lei","year":"2019","journal-title":"Cancer Lett."},{"issue":"9","key":"10.1016\/j.mcp.2026.102082_bib6","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1172\/JCI83871","article-title":"Cancer immunotherapy: harnessing the immune system to battle cancer","volume":"125","author":"Yang","year":"2015","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.mcp.2026.102082_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.immuni.2019.12.011","article-title":"Top 10 challenges in cancer immunotherapy","volume":"52","author":"Hegde","year":"2020","journal-title":"Immunity"},{"issue":"Suppl","key":"10.1016\/j.mcp.2026.102082_bib8","doi-asserted-by":"crossref","first-page":"S228","DOI":"10.3350\/cmh.2024.0824","article-title":"Hepatocellular carcinoma: updates on epidemiology, surveillance, diagnosis and treatment","volume":"31","author":"Hwang","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"issue":"1","key":"10.1016\/j.mcp.2026.102082_bib9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/gutjnl-2024-333227","article-title":"Epidemiology of gastrointestinal cancers: a systematic analysis from the global burden of disease study 2021","volume":"74","author":"Danpanichkul","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.mcp.2026.102082_bib10","doi-asserted-by":"crossref","DOI":"10.1159\/000550163","article-title":"The emerging challenge of Non-Cirrhotic MASLD-related hepatocellular carcinoma: etiology, immunopathology, and precision oncology","author":"Liu","year":"2025","journal-title":"Liver Cancer"},{"issue":"4","key":"10.1016\/j.mcp.2026.102082_bib11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.12965\/jer.2550482.241","article-title":"Spectrum of therapeutic options in hepatocellular carcinoma","volume":"21","author":"Shin","year":"2025","journal-title":"J. Exerc. Rehabil."},{"issue":"15","key":"10.1016\/j.mcp.2026.102082_bib12","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1200\/JCO.23.02745","article-title":"Systemic therapy for advanced hepatocellular carcinoma: ASCO guideline update","volume":"42","author":"Gordan","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.mcp.2026.102082_bib13","article-title":"Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.mcp.2026.102082_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00040-24","article-title":"DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunity","volume":"98","author":"Tapescu","year":"2024","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.mcp.2026.102082_bib15","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12964-025-02225-9","article-title":"Role of DEAD\/DEAH-box helicases in immunity, infection and cancers","volume":"23","author":"Devasahayam Arokia Balaya","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"16","key":"10.1016\/j.mcp.2026.102082_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70793","article-title":"DDX42 enhances hepatocellular carcinoma cell proliferation, radiation and sorafenib resistance via regulating GRB2 RNA maturation and activating PI3K\/AKT pathway","volume":"29","author":"Liu","year":"2025","journal-title":"J. Cell Mol. Med."},{"issue":"17","key":"10.1016\/j.mcp.2026.102082_bib17","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/hmg\/ddaf110","article-title":"The RNA-binding protein DDX39B promotes colorectal adenocarcinoma progression by stabilizing DCLK1","volume":"34","author":"Liu","year":"2025","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcp.2026.102082_bib18","doi-asserted-by":"crossref","first-page":"697","DOI":"10.34133\/research.0697","article-title":"DDX10 exacerbates exosomal PD-L1-dependent T cell exhaustion via phase separation of Rab27b in oral squamous cell carcinoma","volume":"8","author":"Li","year":"2025","journal-title":"Research"},{"issue":"1","key":"10.1016\/j.mcp.2026.102082_bib19","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1186\/s12935-021-02128-y","article-title":"DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling","volume":"21","author":"Yu","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"1","key":"10.1016\/j.mcp.2026.102082_bib20","article-title":"DDX52 gene expression in LUAD tissues indicates potential as a prognostic biomarker and therapeutic target","volume":"13","author":"Xu","year":"2023","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.mcp.2026.102082_bib21","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1158\/0008-5472.CAN-23-2650","article-title":"The web-based portal spatialTME integrates histological images with single-cell and spatial transcriptomics to explore the tumor microenvironment","volume":"84","author":"Shi","year":"2024","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.mcp.2026.102082_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac558","article-title":"GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels","volume":"24","author":"Liu","year":"2023","journal-title":"Briefings Bioinf."},{"issue":"20","key":"10.1016\/j.mcp.2026.102082_bib23","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","article-title":"TISIDB: an integrated repository portal for tumor-immune system interactions","volume":"35","author":"Ru","year":"2019","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.mcp.2026.102082_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101302","article-title":"Systematic analysis of the aberrances and functional implications of ferroptosis in cancer","volume":"23","author":"Liu","year":"2020","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.mcp.2026.102082_bib25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12943-019-1066-3","article-title":"Molecular characterization and clinical relevance of m6A regulators across 33 cancer types","volume":"18","author":"Li","year":"2019","journal-title":"Mol. Cancer"},{"issue":"D1","key":"10.1016\/j.mcp.2026.102082_bib26","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.mcp.2026.102082_bib27","doi-asserted-by":"crossref","first-page":"D1425","DOI":"10.1093\/nar\/gkac959","article-title":"TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment","volume":"51","author":"Han","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.mcp.2026.102082_bib28","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00294-019-00980-0","article-title":"An evolving view of copy number variants","volume":"65","author":"Lauer","year":"2019","journal-title":"Curr. Genet."},{"issue":"7793","key":"10.1016\/j.mcp.2026.102082_bib29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-cancer analysis of whole genomes","volume":"578","author":"Campbell","year":"2020","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.mcp.2026.102082_bib30","doi-asserted-by":"crossref","first-page":"859","DOI":"10.4049\/jimmunol.2200660","article-title":"Multiomics empowers predictive pancreatic cancer immunotherapy","volume":"210","author":"Montagne","year":"2023","journal-title":"J. Immunol."}],"container-title":["Molecular and Cellular Probes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850826000228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890850826000228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:35:07Z","timestamp":1788262507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890850826000228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":30,"alternative-id":["S0890850826000228"],"URL":"https:\/\/doi.org\/10.1016\/j.mcp.2026.102082","relation":{},"ISSN":["0890-8508"],"issn-type":[{"value":"0890-8508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative multi-omics and experimental validation reveal the oncogenic role of DDX52 in liver hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Probes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcp.2026.102082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102082"}}