{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:27:32Z","timestamp":1761528452380,"version":"build-2065373602"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":124,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.mcpro.2021.100091","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T04:02:32Z","timestamp":1620360152000},"page":"100091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia"],"prefix":"10.1016","volume":"20","author":[{"given":"Carolina Hassibe","family":"Thom\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germano Aguiar","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-4311","authenticated-orcid":false,"given":"Diego Antonio","family":"Pereira-Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Augusto dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-9592","authenticated-orcid":false,"given":"Douglas R.","family":"Almeida-Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Weinh\u00e4user","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Ant\u00f4nio de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roos","family":"Houtsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Jacob","family":"Schuringa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-4086","authenticated-orcid":false,"given":"Eduardo M.","family":"Rego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor M.","family":"Fa\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2021.100091_bib1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.biocel.2006.10.018","article-title":"Ntal\/Lab\/Lat2","volume":"39","author":"Iwaki","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mcpro.2021.100091_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ni882","article-title":"Lab: A new membrane-associated adaptor molecule in B cell activation","volume":"4","author":"Janssen","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mcpro.2021.100091_bib3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/ni.2843","article-title":"Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub","volume":"15","author":"Roncagalli","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mcpro.2021.100091_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1182\/blood-2005-06-2273","article-title":"Transmembrane adaptor molecules: A new category of lymphoid-cell markers","volume":"107","author":"Tedoldi","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.mcpro.2021.100091_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.imlet.2003.10.013","article-title":"Transmembrane adaptor proteins in membrane microdomains: Important regulators of immunoreceptor signaling","volume":"92","author":"Horejsi","year":"2004","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.mcpro.2021.100091_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nri1414","article-title":"Transmembrane adaptor proteins: Organizers of immunoreceptor signalling","volume":"4","author":"Horejsi","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mcpro.2021.100091_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.it.2005.01.001","article-title":"NTAL\/LAB and LAT: A balancing act in mast-cell activation and function","volume":"26","author":"Rivera","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1016\/j.mcpro.2021.100091_bib8","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1074\/mcp.M112.019661","article-title":"Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity","volume":"11","author":"Thome","year":"2012","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2021.100091_bib9","doi-asserted-by":"crossref","first-page":"10315","DOI":"10.1038\/s41598-020-66223-2","article-title":"NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia","volume":"10","author":"Thom\u00e9","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2021.100091_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40591-015-0040-8","article-title":"Outlook on PI3K\/AKT\/mTOR inhibition in acute leukemia","volume":"3","author":"Fransecky","year":"2015","journal-title":"Mol. Cell Ther"},{"key":"10.1016\/j.mcpro.2021.100091_bib11","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nmeth924","article-title":"Genome-scale loss-of-function screening with a lentiviral RNAi library","volume":"3","author":"Root","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2021.100091_bib12","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2021.100091_bib13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4132\/jptm.2016.08.08","article-title":"Immunohistochemistry for pathologists: Protocols, pitfalls, and tips","volume":"50","author":"Kim","year":"2016","journal-title":"J.\u00a0Pathol. Transl Med."},{"key":"10.1016\/j.mcpro.2021.100091_bib14","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1021\/ac026117i","article-title":"Stop and go extraction tips for matrix-assisted laser desorption\/ionization, nanoelectrospray, and LC\/MS sample pretreatment in proteomics","volume":"75","author":"Rappsilber","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.mcpro.2021.100091_bib15","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mcpro.2021.100091_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanhausser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2021.100091_bib17","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.mcpro.2021.100091_bib18","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","article-title":"Cytoscape StringApp: Network analysis and visualization of proteomics data","volume":"18","author":"Doncheva","year":"2019","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.mcpro.2021.100091_bib19","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/bioinformatics\/bti551","article-title":"BiNGO: A Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks","volume":"21","author":"Maere","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2021.100091_bib20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2121-9-30","article-title":"Rapid preparation of nuclei-depleted detergent-resistant membrane fractions suitable for proteomics analysis","volume":"9","author":"Adam","year":"2008","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.mcpro.2021.100091_bib21","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nm.3909","article-title":"The prognostic landscape of genes and infiltrating immune cells across human cancers","volume":"21","author":"Gentles","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcpro.2021.100091_bib22","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2021.100091_bib23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.immuni.2004.09.007","article-title":"Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes","volume":"21","author":"Stork","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.mcpro.2021.100091_bib24","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.4049\/jimmunol.180.6.3689","article-title":"Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells","volume":"180","author":"Roget","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.mcpro.2021.100091_bib25","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1084\/jem.20021405","article-title":"Non-T cell activation linker (NTAL): A transmembrane adaptor protein involved in immunoreceptor signaling","volume":"196","author":"Brdicka","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.mcpro.2021.100091_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1182\/blood-2003-08-2769","article-title":"NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation","volume":"104","author":"Tkaczyk","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.mcpro.2021.100091_bib27","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Ley","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.mcpro.2021.100091_bib28","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ccell.2018.08.014","article-title":"Prospective isolation and characterization of genetically and functionally distinct AML subclones","volume":"34","author":"de Boer","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mcpro.2021.100091_bib29","doi-asserted-by":"crossref","first-page":"D881","DOI":"10.1093\/nar\/gky1076","article-title":"BloodSpot: A database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles","volume":"47","author":"Bagger","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2021.100091_bib30","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1080\/10428194.2019.1607326","article-title":"The lipid raft protein NTAL participates in AKT signaling in mantle cell lymphoma","volume":"60","author":"Ferreira","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.mcpro.2021.100091_bib31","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/sj.emboj.7601039","article-title":"RNA-binding IMPs promote cell adhesion and invadopodia formation","volume":"25","author":"Vikesaa","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.mcpro.2021.100091_bib32","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jhep.2009.06.021","article-title":"Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4","volume":"51","author":"Crosby","year":"2009","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.mcpro.2021.100091_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1440-1827.2012.02823.x","article-title":"CD44 in human glioma correlates with histopathological grade and cell migration","volume":"62","author":"Yoshida","year":"2012","journal-title":"Pathol. Int."},{"key":"10.1016\/j.mcpro.2021.100091_bib34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0198-8859(94)90026-4","article-title":"Stimulation of T cells via CD44 requires leukocyte-function-associated antigen interactions and interleukin-2 production","volume":"40","author":"Funaro","year":"1994","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.mcpro.2021.100091_bib35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1165\/rcmb.2008-0073OC","article-title":"Hyaluronan fragments\/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium","volume":"40","author":"Casalino-Matsuda","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.mcpro.2021.100091_bib36","doi-asserted-by":"crossref","first-page":"14824","DOI":"10.1074\/jbc.M113.451336","article-title":"Transforming growth factor-\u03b21 (TGF-\u03b21)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts","volume":"288","author":"Midgley","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2021.100091_bib37","first-page":"235","article-title":"CD44, hyaluronan, the hematopoietic stem cell, and leukemia-initiating cells","volume":"6","author":"Z\u00f6ller","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mcpro.2021.100091_bib38","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1365-2141.2011.08586.x","article-title":"Regulation of the adaptor molecule LAT2, an in\u00a0vivo target gene of AML1\/ETO (RUNX1\/RUNX1T1), during myeloid differentiation","volume":"153","author":"Duque-Afonso","year":"2011","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.mcpro.2021.100091_bib39","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.1038\/sj.onc.1208160","article-title":"Src family kinases, key regulators of signal transduction","volume":"23","author":"Parsons","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.mcpro.2021.100091_bib40","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ccr.2010.12.012","article-title":"Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia","volume":"19","author":"Goardon","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mcpro.2021.100091_bib41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ccell.2016.05.008","article-title":"Epigenetic perturbations by Arg882-mutated DNMT3A potentiate aberrant stem cell gene-expression program and acute leukemia development","volume":"30","author":"Lu","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mcpro.2021.100091_bib42","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1126\/science.aax5863","article-title":"Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia","volume":"367","author":"Uckelmann","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2021.100091_bib43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ccell.2020.02.011","article-title":"It's all about MEis: Menin-MLL inhibition eradicates NPM1-mutated and MLL-rearranged acute leukemias in mice","volume":"37","author":"Gundry","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mcpro.2021.100091_bib44","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1172\/JCI129126","article-title":"Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia","volume":"130","author":"Klossowski","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mcpro.2021.100091_bib45","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizcaino","year":"2016","journal-title":"Nucleic Acids Res."}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947621000645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947621000645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:23:13Z","timestamp":1761528193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947621000645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":45,"alternative-id":["S1535947621000645"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2021.100091","relation":{},"ISSN":["1535-9476"],"issn-type":[{"type":"print","value":"1535-9476"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2021.100091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100091"}}