{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:19:11Z","timestamp":1791991151649,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.mcpro.2023.100510","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T20:45:49Z","timestamp":1676580349000},"page":"100510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comprehensive Proteomics Analysis Identifies CD38-Mediated NAD+ Decline Orchestrating Renal Fibrosis in Pediatric Patients With Obstructive Nephropathy"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-103X","authenticated-orcid":false,"given":"Yuandong","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexue","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0071-011X","authenticated-orcid":false,"given":"Shouqing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-0292","authenticated-orcid":false,"given":"Zhichun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiubin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2841-5342","authenticated-orcid":false,"given":"Fuquan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2023.100510_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/MOP.0000000000000994","article-title":"Ureteropelvic junction obstruction: diagnosis and management","volume":"33","author":"Vemulakonda","year":"2021","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.mcpro.2023.100510_bib2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1053\/j.ackd.2015.01.012","article-title":"Congenital urinary tract obstruction: the long view","volume":"22","author":"Chevalier","year":"2015","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.mcpro.2023.100510_bib3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cnur.2018.07.007","article-title":"Obstructive kidney disease","volume":"53","author":"Stevens","year":"2018","journal-title":"Nurs. Clin. North Am."},{"key":"10.1016\/j.mcpro.2023.100510_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mcpro.2023.100510_bib5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00467-017-3629-0","article-title":"The molecular biology of pelvi-ureteric junction obstruction","volume":"33","author":"Jackson","year":"2018","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.mcpro.2023.100510_bib6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1046\/j.1523-1755.2003.00775.x","article-title":"Ureteral obstruction in neonatal mice elicits segment-specific tubular cell responses leading to nephron loss","volume":"63","author":"Cachat","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.mcpro.2023.100510_bib7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41581-019-0110-2","article-title":"Macrophages: versatile players in renal inflammation and fibrosis","volume":"15","author":"Tang","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.mcpro.2023.100510_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41581-019-0216-6","article-title":"NAD(+) homeostasis in renal health and disease","volume":"16","author":"Ralto","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.mcpro.2023.100510_bib9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NAD(+) intermediates: the biology and therapeutic potential of NMN and NR","volume":"27","author":"Yoshino","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.mcpro.2023.100510_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s42255-019-0161-5","article-title":"NAD(+) homeostasis in health and disease","volume":"2","author":"Katsyuba","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.mcpro.2023.100510_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD(+) metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mcpro.2023.100510_bib12","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41591-018-0138-z","article-title":"De novo NAD(+) biosynthetic impairment in acute kidney injury in humans","volume":"24","author":"Poyan Mehr","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcpro.2023.100510_bib13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41586-018-0645-6","article-title":"De novo NAD(+) synthesis enhances mitochondrial function and improves health","volume":"563","author":"Katsyuba","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100510_bib14","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1681\/ASN.2016040385","article-title":"Nicotinamide mononucleotide, an NAD(+) precursor, rescues age-associated susceptibility to AKI in a sirtuin 1-dependent manner","volume":"28","author":"Guan","year":"2017","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.mcpro.2023.100510_bib15","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature17184","article-title":"PGC1alpha drives NAD biosynthesis linking oxidative metabolism to renal protection","volume":"531","author":"Tran","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100510_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.tips.2018.02.001","article-title":"The pharmacology of CD38\/NADase: an emerging target in cancer and diseases of aging","volume":"39","author":"Chini","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mcpro.2023.100510_bib17","doi-asserted-by":"crossref","first-page":"597959","DOI":"10.3389\/fimmu.2020.597959","article-title":"CD38: an immunomodulatory molecule in inflammation and autoimmunity","volume":"11","author":"Piedra-Quintero","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mcpro.2023.100510_bib18","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/s42255-020-00305-3","article-title":"Senescent cells promote tissue NAD(+) decline during ageing via the activation of CD38(+) macrophages","volume":"2","author":"Covarrubias","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.mcpro.2023.100510_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12664","article-title":"CD38 protein deficiency induces autoimmune characteristics and its activation enhances IL-10 production by regulatory B cells","volume":"87","author":"Dominguez-Pantoja","year":"2018","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.mcpro.2023.100510_bib20","doi-asserted-by":"crossref","first-page":"11325","DOI":"10.18632\/aging.103410","article-title":"CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD(+)\/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats","volume":"12","author":"Ogura","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mcpro.2023.100510_bib21","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41467-019-09046-8","article-title":"Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair","volume":"10","author":"Yang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2023.100510_bib22","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2023.100510_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-981-13-6657-4_11","article-title":"Periostin in the kidney","volume":"1132","author":"Wallace","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mcpro.2023.100510_bib24","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrneph.2014.114","article-title":"Inflammatory processes in renal fibrosis","volume":"10","author":"Meng","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.mcpro.2023.100510_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2017.12.016","article-title":"Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets","volume":"820","author":"Lv","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mcpro.2023.100510_bib26","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41581-020-00343-w","article-title":"WNT-beta-catenin signalling - a versatile player in kidney injury and repair","volume":"17","author":"Schunk","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.mcpro.2023.100510_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3762","article-title":"Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development","volume":"21","author":"Kang","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcpro.2023.100510_bib28","doi-asserted-by":"crossref","first-page":"F1105","DOI":"10.1152\/ajprenal.00285.2020","article-title":"Mitochondrial dysfunction and the AKI-to-CKD transition","volume":"319","author":"Jiang","year":"2020","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.mcpro.2023.100510_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140695","article-title":"Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis","volume":"131","author":"Miguel","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mcpro.2023.100510_bib30","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ki.2009.86","article-title":"Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy","volume":"75","author":"Chevalier","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.mcpro.2023.100510_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-020-2941-1","article-title":"Decoding myofibroblast origins in human kidney fibrosis","volume":"589","author":"Kuppe","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100510_bib32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/kisup.2014.16","article-title":"Wnt\/beta-catenin signaling and kidney fibrosis","volume":"4","author":"Tan","year":"2014","journal-title":"Kidney Int. Suppl. (2011)"},{"key":"10.1016\/j.mcpro.2023.100510_bib33","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1681\/ASN.2020060806","article-title":"Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease","volume":"31","author":"Conway","year":"2020","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.mcpro.2023.100510_bib34","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.bbrc.2006.05.042","article-title":"Regulation of intracellular levels of NAD: a novel role for CD38","volume":"345","author":"Aksoy","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mcpro.2023.100510_bib35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fcell.2020.00191","article-title":"CD38 causes autophagic flux inhibition and cardiac dysfunction through a transcriptional inhibition pathway under hypoxia\/ischemia conditions","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mcpro.2023.100510_bib36","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cmet.2018.03.016","article-title":"A\u00a0potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD(+) decline","volume":"27","author":"Tarrago","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.mcpro.2023.100510_bib37","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1089\/neu.2013.3252","article-title":"CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury","volume":"31","author":"Hsieh","year":"2014","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.mcpro.2023.100510_bib38","doi-asserted-by":"crossref","first-page":"8736949","DOI":"10.1155\/2018\/8736949","article-title":"CD38 deficiency promotes inflammatory response through activating Sirt1\/NF-kappaB-mediated inhibition of TLR2 expression in macrophages","volume":"2018","author":"Qian","year":"2018","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.mcpro.2023.100510_bib39","doi-asserted-by":"crossref","first-page":"F209","DOI":"10.1152\/ajprenal.00252.2014","article-title":"Theobromine increases NAD(+)\/Sirt-1 activity and protects the kidney under diabetic conditions","volume":"308","author":"Papadimitriou","year":"2015","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.mcpro.2023.100510_bib40","first-page":"4181","article-title":"Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-kappaB p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt","volume":"14","author":"Chen","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.mcpro.2023.100510_bib41","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1111\/jcmm.14285","article-title":"Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation","volume":"23","author":"Zheng","year":"2019","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.mcpro.2023.100510_bib42","doi-asserted-by":"crossref","first-page":"101902","DOI":"10.1016\/j.isci.2020.101902","article-title":"Targeting CD38-dependent NAD(+) metabolism to mitigate multiple organ fibrosis","volume":"24","author":"Shi","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.mcpro.2023.100510_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126007","article-title":"CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation","volume":"10","author":"Schneider","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2023.100510_bib44","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrneph.2017.107","article-title":"Mitochondrial energetics in the kidney","volume":"13","author":"Bhargava","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.mcpro.2023.100510_bib45","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cmet.2016.05.006","article-title":"CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism","volume":"23","author":"Camacho-Pereira","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.mcpro.2023.100510_bib46","doi-asserted-by":"crossref","first-page":"110928","DOI":"10.1016\/j.biopha.2020.110928","article-title":"Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson's disease","volume":"132","author":"Shen","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mcpro.2023.100510_bib47","doi-asserted-by":"crossref","first-page":"D1211","DOI":"10.1093\/nar\/gky869","article-title":"iProX: an integrated proteome resource","volume":"47","author":"Ma","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2023.100510_bib48","doi-asserted-by":"crossref","first-page":"D1522","DOI":"10.1093\/nar\/gkab1081","article-title":"iProX in 2021: connecting proteomics data sharing with big data","volume":"50","author":"Chen","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947623000191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947623000191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:11:22Z","timestamp":1761527482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947623000191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1535947623000191"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2023.100510","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive Proteomics Analysis Identifies CD38-Mediated NAD+ Decline Orchestrating Renal Fibrosis in Pediatric Patients With Obstructive Nephropathy","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2023.100510","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100510"}}