{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:52:03Z","timestamp":1792191123481,"version":"4.4.0"},"reference-count":138,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10 OD016281"],"award-info":[{"award-number":["1S10 OD016281"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99 AG065484"],"award-info":[{"award-number":["K99 AG065484"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-NS100529"],"award-info":[{"award-number":["R01-NS100529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD028654"],"award-info":[{"award-number":["S10 OD028654"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.mcpro.2023.100534","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:44:38Z","timestamp":1679445878000},"page":"100534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Proteomic Analysis of Huntington\u2019s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-2391","authenticated-orcid":false,"given":"Kizito-Tshitoko","family":"Tshilenge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Galicia","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-4193","authenticated-orcid":false,"given":"Joanna","family":"Bons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos A.","family":"Gerencser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Basisty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7819-4605","authenticated-orcid":false,"given":"Jacob","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Lopez-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Naphade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6396-7364","authenticated-orcid":false,"given":"Ashley","family":"Loureiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Battistoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus","family":"Milani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Wehrfritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-002X","authenticated-orcid":false,"given":"Anja","family":"Holtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Hetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean D.","family":"Mooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9907-2749","authenticated-orcid":false,"given":"Birgit","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-7977","authenticated-orcid":false,"given":"Lisa M.","family":"Ellerby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2023.100534_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nrg2748","article-title":"Repeat expansion disease: progress and puzzles in disease pathogenesis","volume":"11","author":"La Spada","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mcpro.2023.100534_bib2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A\u00a0novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2023.100534_bib3","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanisms and potential therapeutical targets in Huntington's disease","volume":"90","author":"Zuccato","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mcpro.2023.100534_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-71779-1_1","article-title":"Clinical features of Huntington's disease","volume":"1049","author":"Ghosh","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mcpro.2023.100534_bib5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/bpa.12426","article-title":"Huntington's disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain","volume":"26","author":"Rub","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.mcpro.2023.100534_bib6","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The biology of huntingtin","volume":"89","author":"Saudou","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.mcpro.2023.100534_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0030082","article-title":"Huntingtin interacting proteins are genetic modifiers of neurodegeneration","volume":"3","author":"Kaltenbach","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mcpro.2023.100534_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa066","article-title":"Subcellular localization and formation of huntingtin aggregates correlates with symptom onset and progression in a Huntington's disease model","volume":"2","author":"Landles","year":"2020","journal-title":"Brain Commun."},{"key":"10.1016\/j.mcpro.2023.100534_bib9","doi-asserted-by":"crossref","first-page":"19287","DOI":"10.1074\/jbc.M114.623561","article-title":"Integration-independent transgenic Huntington disease fragment mouse models reveal distinct phenotypes and life span in\u00a0vivo","volume":"290","author":"O'Brien","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2023.100534_bib10","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1080\/15548627.2021.1904489","article-title":"Modulating FKBP5\/FKBP51 and autophagy lowers HTT (huntingtin) levels","volume":"17","author":"Bailus","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.mcpro.2023.100534_bib11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40478-021-01172-z","article-title":"Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease","volume":"9","author":"Zhou","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.mcpro.2023.100534_bib12","doi-asserted-by":"crossref","first-page":"25441","DOI":"10.1074\/jbc.M109.038174","article-title":"Calpain-1 cleaves and activates caspase-7","volume":"284","author":"Gafni","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2023.100534_bib13","doi-asserted-by":"crossref","first-page":"20211","DOI":"10.1074\/jbc.M401267200","article-title":"Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain\/caspase fragments in the nucleus","volume":"279","author":"Gafni","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2023.100534_bib14","doi-asserted-by":"crossref","first-page":"7454","DOI":"10.1523\/JNEUROSCI.6379-11.2012","article-title":"Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment","volume":"32","author":"Gafni","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib15","doi-asserted-by":"crossref","first-page":"23686","DOI":"10.1074\/jbc.M513507200","article-title":"Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity","volume":"281","author":"Schilling","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2023.100534_bib16","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1523\/JNEUROSCI.22-18-07862.2002","article-title":"Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease","volume":"22","author":"Wellington","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib17","doi-asserted-by":"crossref","first-page":"9158","DOI":"10.1074\/jbc.273.15.9158","article-title":"Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract","volume":"273","author":"Wellington","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2023.100534_bib18","doi-asserted-by":"crossref","first-page":"19831","DOI":"10.1074\/jbc.M001475200","article-title":"Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells","volume":"275","author":"Wellington","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2023.100534_bib19","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","article-title":"Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin","volume":"125","author":"Graham","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2023.100534_bib20","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1093\/hmg\/ddi340","article-title":"Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease","volume":"14","author":"Benn","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2023.100534_bib21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington's disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mcpro.2023.100534_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature19949","article-title":"Mass-spectrometric exploration of proteome structure and function","volume":"537","author":"Aebersold","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100534_bib23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.molcel.2013.01.029","article-title":"The coming age of complete, accurate, and ubiquitous proteomes","volume":"49","author":"Mann","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mcpro.2023.100534_bib24","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1021\/acs.jproteome.6b00448","article-title":"Quantitative proteomic analysis reveals similarities between Huntington's disease (HD) and Huntington's disease-like 2 (HDL2) human brains","volume":"15","author":"Ratovitski","year":"2016","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.mcpro.2023.100534_bib25","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.celrep.2017.10.097","article-title":"Spatiotemporal proteomic profiling of Huntington's disease inclusions reveals widespread loss of protein function","volume":"21","author":"Hosp","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2023.100534_bib26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3233\/JHD-200465","article-title":"Taming the Huntington's disease proteome: what have we learned?","volume":"10","author":"Seeley","year":"2021","journal-title":"J.\u00a0Huntingtons Dis."},{"key":"10.1016\/j.mcpro.2023.100534_bib27","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s13311-019-00810-8","article-title":"Modeling polyglutamine expansion diseases with induced pluripotent stem cells","volume":"16","author":"Naphade","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.mcpro.2023.100534_bib28","doi-asserted-by":"crossref","first-page":"16707","DOI":"10.1073\/pnas.0808488105","article-title":"Striatal progenitors derived from human ES cells mature into DARPP32 neurons in\u00a0vitro and in quinolinic acid-lesioned rats","volume":"105","author":"Aubry","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2023.100534_bib29","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1007\/s00018-011-0770-y","article-title":"Specification of neuronal and glial subtypes from human pluripotent stem cells","volume":"68","author":"Liu","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mcpro.2023.100534_bib30","doi-asserted-by":"crossref","first-page":"6583","DOI":"10.1113\/JP270655","article-title":"Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA","volume":"594","author":"Kemp","year":"2016","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.mcpro.2023.100534_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.stem.2012.04.026","article-title":"Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells","volume":"11","author":"An","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mcpro.2023.100534_bib32","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.stemcr.2015.11.005","article-title":"Genomic analysis reveals disruption of striatal neuronal development and therapeutic targets in human Huntington's disease neural stem cells","volume":"5","author":"Ring","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.mcpro.2023.100534_bib33","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nn.4532","article-title":"Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice","volume":"20","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/currents.RRN1193","article-title":"Characterization of human Huntington's disease cell model from induced pluripotent stem cells","volume":"2","author":"Zhang","year":"2010","journal-title":"PLoS Curr."},{"key":"10.1016\/j.mcpro.2023.100534_bib35","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.brainres.2015.09.020","article-title":"iPSC-based drug screening for Huntington's disease","volume":"1638","author":"Zhang","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.mcpro.2023.100534_bib36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1042\/BJ20111495","article-title":"Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient","volume":"446","author":"Chae","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.mcpro.2023.100534_bib37","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1021\/pr500649m","article-title":"Proteomics of Huntington's disease-affected human embryonic stem cells reveals an evolving pathology involving mitochondrial dysfunction and metabolic disturbances","volume":"13","author":"McQuade","year":"2014","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.mcpro.2023.100534_bib38","doi-asserted-by":"crossref","first-page":"9529","DOI":"10.1021\/acs.analchem.8b02233","article-title":"Comprehensive single-shot proteomics with FAIMS on a hybrid orbitrap mass spectrometer","volume":"90","author":"Hebert","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.mcpro.2023.100534_bib39","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.016717","article-title":"Targeted data extraction of the MS\/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis","volume":"11","author":"Gillet","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.mcpro.2023.100534_bib40","article-title":"A simple differentiation protocol for generation of induced pluripotent stem cell-derived basal forebrain-like cholinergic neurons for Alzheimer's disease and frontotemporal dementia disease modeling","volume":"9","author":"Sanz Munoz","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mcpro.2023.100534_bib41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41467-017-00249-5","article-title":"Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry","volume":"8","author":"Collins","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2023.100534_bib42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-1-4939-6747-6_16","article-title":"Generation of high-quality SWATH((R)) acquisition data for label-free quantitative proteomics studies using TripleTOF((R)) mass spectrometers","volume":"1550","author":"Schilling","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mcpro.2023.100534_bib43","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmeth1113","article-title":"Semi-supervised learning for peptide identification from shotgun proteomics datasets","volume":"4","author":"Kall","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2023.100534_bib44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/bioinformatics\/btw580","article-title":"DAPAR & ProStaR: software to perform statistical analyses in quantitative discovery proteomics","volume":"33","author":"Wieczorek","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2023.100534_bib45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/bioinformatics\/btq650","article-title":"Slim: a sliding linear model for estimating the proportion of true null hypotheses in datasets with dependence structures","volume":"27","author":"Wang","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2023.100534_bib46","doi-asserted-by":"crossref","first-page":"140031","DOI":"10.1038\/sdata.2014.31","article-title":"A\u00a0repository of assays to quantify 10,000 human proteins by SWATH-MS","volume":"1","author":"Rosenberger","year":"2014","journal-title":"Sci. Data"},{"key":"10.1016\/j.mcpro.2023.100534_bib47","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nmeth.1584","article-title":"mProphet: automated data processing and statistical validation for large-scale SRM experiments","volume":"8","author":"Reiter","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2023.100534_bib48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/acs.jproteome.7b00170","article-title":"Gentle introduction to the statistical foundations of false discovery rate in quantitative proteomics","volume":"17","author":"Burger","year":"2018","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.mcpro.2023.100534_bib49","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.micron.2008.01.001","article-title":"Hydrophobic characterization of intracellular lipids in situ by nile red red\/yellow emission ratio","volume":"39","author":"Diaz","year":"2008","journal-title":"Micron"},{"key":"10.1016\/j.mcpro.2023.100534_bib50","doi-asserted-by":"crossref","first-page":"777728","DOI":"10.3389\/fcomp.2022.777728","article-title":"Labkit: labeling and segmentation toolkit for big image data","volume":"4","author":"Arzt","year":"2022","journal-title":"Front. Comput. Sci."},{"key":"10.1016\/j.mcpro.2023.100534_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013984","article-title":"Enrichment map: a network-based method for gene-set enrichment visualization and interpretation","volume":"5","author":"Merico","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2023.100534_bib52","article-title":"Transforming L1000 profiles to RNA-seq-like profiles with deep learning","volume":"13","author":"Jeon","year":"2022","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.mcpro.2023.100534_bib53","doi-asserted-by":"crossref","first-page":"C520","DOI":"10.1152\/ajpcell.00166.2015","article-title":"Forced cell cycle exit and modulation of GABAA, CREB, and GSK3beta signaling promote functional maturation of induced pluripotent stem cell-derived neurons","volume":"310","author":"Telezhkin","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mcpro.2023.100534_bib54","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1242\/dev.117093","article-title":"Activin a directs striatal projection neuron differentiation of human pluripotent stem cells","volume":"142","author":"Arber","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.mcpro.2023.100534_bib55","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1073\/pnas.120166397","article-title":"Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice","volume":"97","author":"Bibb","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2023.100534_bib56","doi-asserted-by":"crossref","first-page":"10156","DOI":"10.1073\/pnas.86.24.10156","article-title":"Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain","volume":"86","author":"Seeman","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2023.100534_bib57","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1097\/00001756-200011270-00032","article-title":"N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice","volume":"11","author":"van Dellen","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.mcpro.2023.100534_bib58","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1074\/mcp.TIR119.001906","article-title":"A\u00a0compact quadrupole-orbitrap mass spectrometer with FAIMS interface improves proteome coverage in short LC gradients","volume":"19","author":"Bekker-Jensen","year":"2020","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.mcpro.2023.100534_bib59","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1021\/acs.jproteome.9b00759","article-title":"Optimized workflow for multiplexed phosphorylation analysis of TMT-labeled peptides using high-field asymmetric waveform ion mobility spectrometry","volume":"19","author":"Schweppe","year":"2020","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.mcpro.2023.100534_bib60","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13226","article-title":"FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16(INK4a) increase","volume":"19","author":"Voisin","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.mcpro.2023.100534_bib61","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fnins.2018.00476","article-title":"Insulin-like growth factor binding protein 2 is associated with biomarkers of Alzheimer's disease pathology and shows differential expression in transgenic mice","volume":"12","author":"Bonham","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib62","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1007\/s11682-016-9636-0","article-title":"Insulin-like growth factor binding protein-2 interactions with Alzheimer's disease biomarkers","volume":"11","author":"Lane","year":"2017","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.mcpro.2023.100534_bib63","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1002\/cne.24263","article-title":"Altered expression of IGF-I system in neurons of the inflamed spinal cord during acute experimental autoimmune encephalomyelitis","volume":"525","author":"Parvaneh Tafreshi","year":"2017","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.mcpro.2023.100534_bib64","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00401-015-1446-8","article-title":"Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy","volume":"130","author":"Simon","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mcpro.2023.100534_bib65","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10048-019-00600-6","article-title":"Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease","volume":"21","author":"Hetmanczyk-Sawicka","year":"2020","journal-title":"Neurogenetics"},{"key":"10.1016\/j.mcpro.2023.100534_bib66","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005133","article-title":"IGFBP7 (insulin-like growth factor-binding protein-7) and neprilysin inhibition in patients with heart failure","volume":"11","author":"Januzzi","year":"2018","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.mcpro.2023.100534_bib67","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.kint.2019.01.020","article-title":"Tissue inhibitor metalloproteinase-2 (TIMP-2) \u2217 IGF-binding protein-7 (IGFBP7) levels are associated with adverse outcomes in patients in the intensive care unit with acute kidney injury","volume":"95","author":"Xie","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.mcpro.2023.100534_bib68","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1007\/s00018-013-1515-x","article-title":"OCIAD2 activates gamma-secretase to enhance amyloid beta production by interacting with nicastrin","volume":"71","author":"Han","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mcpro.2023.100534_bib69","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1038\/s41598-018-25667-3","article-title":"A double helical motif in OCIAD2 is essential for its localization, interactions and STAT3 activation","volume":"8","author":"Sinha","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2023.100534_bib70","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9187195","article-title":"Blood oxidative stress marker aberrations in patients with Huntington's disease: a meta-analysis study","author":"Tang","year":"2020","journal-title":"Oxid. Med. Cell Longev"},{"key":"10.1016\/j.mcpro.2023.100534_bib71","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/ng.2732","article-title":"Glutathione peroxidase activity is neuroprotective in models of Huntington's disease","volume":"45","author":"Mason","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mcpro.2023.100534_bib72","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1073\/pnas.1417231112","article-title":"Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease","volume":"112","author":"Shema","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2023.100534_bib73","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:profiler, GSEA, cytoscape and enrichmentmap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcpro.2023.100534_bib74","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nmeth.3440","article-title":"Pathway and network analysis of cancer genomes","volume":"12","author":"Creixell","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2023.100534_bib75","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2023.100534_bib76","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(09)70178-4","article-title":"Beyond the brain: widespread pathology in Huntington's disease","volume":"8","author":"van der Burg","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mcpro.2023.100534_bib77","article-title":"Huntington's disease is a multi-system disorder","volume":"3","author":"Mielcarek","year":"2015","journal-title":"Rare Dis."},{"key":"10.1016\/j.mcpro.2023.100534_bib78","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-4939-9873-9_13","article-title":"Perform pathway enrichment analysis using ReactomeFIViz","volume":"2074","author":"Haw","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mcpro.2023.100534_bib79","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuron.2010.06.021","article-title":"Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease","volume":"67","author":"Miller","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.mcpro.2023.100534_bib80","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3389\/fnins.2017.00736","article-title":"Altered expression of matrix metalloproteinases and their endogenous inhibitors in a human isogenic stem cell model of Huntington's disease","volume":"11","author":"Naphade","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib81","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pharmthera.2011.12.008","article-title":"Integrins as receptor targets for neurological disorders","volume":"134","author":"Wu","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.mcpro.2023.100534_bib82","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100534_bib83","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100534_bib84","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson's disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2023.100534_bib85","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1089\/rej.2018.2155","article-title":"Cellular senescence as the key intermediate in tau-mediated neurodegeneration","volume":"21","author":"Mendelsohn","year":"2018","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.mcpro.2023.100534_bib86","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.diabres.2016.10.024","article-title":"An updated meta-analysis of cohort studies: diabetes and risk of Alzheimer's disease","volume":"124","author":"Zhang","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.mcpro.2023.100534_bib87","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1515\/hsz-2013-0233","article-title":"Septin functions in organ system physiology and pathology","volume":"395","author":"Dolat","year":"2014","journal-title":"Biol. Chem."},{"key":"10.1016\/j.mcpro.2023.100534_bib88","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrm3284","article-title":"Septins: the fourth component of the cytoskeleton","volume":"13","author":"Mostowy","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mcpro.2023.100534_bib89","doi-asserted-by":"crossref","first-page":"12203","DOI":"10.1038\/ncomms12203","article-title":"Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV","volume":"7","author":"Akil","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2023.100534_bib90","doi-asserted-by":"crossref","first-page":"104288","DOI":"10.1016\/j.isci.2022.104288","article-title":"Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets","volume":"25","author":"Song","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.mcpro.2023.100534_bib91","article-title":"Striatal synapse degeneration and dysfunction are reversed by reactivation of Wnt signaling, Front","volume":"13","author":"Galli","year":"2021","journal-title":"Synaptic Neurosci"},{"key":"10.1016\/j.mcpro.2023.100534_bib92","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.stemcr.2020.01.015","article-title":"Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation","volume":"14","author":"Smith-Geater","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.mcpro.2023.100534_bib93","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001895","article-title":"The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity","volume":"12","author":"Tourette","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mcpro.2023.100534_bib94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209573","article-title":"Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau","volume":"14","author":"Huynh","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2023.100534_bib95","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jacl.2009.11.003","article-title":"Altered cholesterol and fatty acid metabolism in Huntington disease","volume":"4","author":"Block","year":"2010","journal-title":"J.\u00a0Clin. Lipidol."},{"key":"10.1016\/j.mcpro.2023.100534_bib96","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/hmg\/ddz298","article-title":"Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import","volume":"29","author":"Di Pardo","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2023.100534_bib97","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1523\/JNEUROSCI.3355-05.2005","article-title":"Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease","volume":"25","author":"Valenza","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib98","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fnins.2020.00073","article-title":"Uric acid as a potential peripheral biomarker for disease features in Huntington's patients","volume":"14","author":"Corey-Bloom","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib99","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2019.06.036","article-title":"CAG repeat not polyglutamine length determines timing of Huntington's disease onset","volume":"178","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2023.100534_bib100","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1080\/15384101.2018.1553336","article-title":"Destabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks","volume":"17","author":"Drissi","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mcpro.2023.100534_bib101","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1128\/MMBR.68.1.109-131.2004","article-title":"Eukaryotic MCM proteins: beyond replication initiation","volume":"68","author":"Forsburg","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.mcpro.2023.100534_bib102","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1266\/ggs.18-00026","article-title":"Regulation of MCM2-7 function","volume":"93","author":"Ishimi","year":"2018","journal-title":"Genes Genet. Syst."},{"key":"10.1016\/j.mcpro.2023.100534_bib103","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nn.4256","article-title":"Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice","volume":"19","author":"Langfelder","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib104","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbapap.2012.07.017","article-title":"A\u00a0ternary complex consisting of AICD, FE65, and TIP60 down-regulates stathmin1","volume":"1834","author":"Muller","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcpro.2023.100534_bib105","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0002-9440(10)64866-3","article-title":"Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems","volume":"160","author":"Liedtke","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mcpro.2023.100534_bib106","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1093\/hmg\/ddz188","article-title":"AAV9-Stathmin1 gene delivery improves disease phenotype in an intermediate mouse model of spinal muscular atrophy","volume":"28","author":"Villalon","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2023.100534_bib107","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202012519","article-title":"Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice","volume":"12","author":"Birolini","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mcpro.2023.100534_bib108","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1111\/jnc.15325","article-title":"An imaging mass spectrometry atlas of lipids in the human neurologically normal and Huntington's disease caudate nucleus","volume":"157","author":"Hunter","year":"2021","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.mcpro.2023.100534_bib109","doi-asserted-by":"crossref","first-page":"797220","DOI":"10.3389\/fnagi.2022.797220","article-title":"Altered cholesterol homeostasis in Huntington's disease","volume":"14","author":"Kacher","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib110","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nn.2528","article-title":"Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease","volume":"13","author":"Martinez-Vicente","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib111","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1080\/15548627.2021.1904489","article-title":"Modulating FKBP5\/FKBP51 and autophagy lowers HTT (huntingtin) levels","volume":"17","author":"Bailus","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.mcpro.2023.100534_bib112","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0896-6273(00)80562-0","article-title":"Regulation of class I MHC gene expression in the developing and mature CNS by neural activity","volume":"21","author":"Corriveau","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.mcpro.2023.100534_bib113","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.mcn.2012.11.004","article-title":"MHC class I protein is expressed by neurons and neural progenitors in mid-gestation mouse brain","volume":"52","author":"Chacon","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib114","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuron.2009.09.044","article-title":"MHC class I: an unexpected role in neuronal plasticity","volume":"64","author":"Shatz","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.mcpro.2023.100534_bib115","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.1073\/pnas.0702023104","article-title":"Regulation of CNS synapses by neuronal MHC class I","volume":"104","author":"Goddard","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2023.100534_bib116","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1073\/pnas.1507125112","article-title":"A\u00a0survey of human brain transcriptome diversity at the single cell level","volume":"112","author":"Darmanis","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2023.100534_bib117","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023333118","article-title":"Early role for a Na(+),K(+)-ATPase (ATP1A3) in brain development","volume":"118","author":"Smith","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2023.100534_bib118","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fnins.2015.00098","article-title":"Proteoglycans and neuronal migration in the cerebral cortex during development and disease","volume":"9","author":"Maeda","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib119","doi-asserted-by":"crossref","first-page":"8513","DOI":"10.1038\/s41598-017-09148-7","article-title":"Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease","volume":"7","author":"Jesse","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2023.100534_bib120","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42988","article-title":"Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription","volume":"8","author":"Gao","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.mcpro.2023.100534_bib121","doi-asserted-by":"crossref","first-page":"16015","DOI":"10.1038\/npjsba.2016.15","article-title":"L1000CDS(2): LINCS L1000 characteristic direction signatures search engine","volume":"2","author":"Duan","year":"2016","journal-title":"NPJ Syst. Biol. Appl."},{"key":"10.1016\/j.mcpro.2023.100534_bib122","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1523\/JNEUROSCI.0037-07.2007","article-title":"Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation","volume":"27","author":"Dompierre","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib123","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027746","article-title":"SAHA decreases HDAC 2 and 4 levels in\u00a0vivo and improves molecular phenotypes in the R6\/2 mouse model of Huntington's disease","volume":"6","author":"Mielcarek","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2023.100534_bib124","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fcell.2017.00003","article-title":"The mammalian septin interactome","volume":"5","author":"Neubauer","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mcpro.2023.100534_bib125","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.devcel.2018.06.026","article-title":"InterSEPTIN' kinesins in dendrites","volume":"46","author":"Gomez","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mcpro.2023.100534_bib126","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/hmg\/ddl467","article-title":"Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space","volume":"16","author":"Strehlow","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2023.100534_bib127","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fcell.2019.00135","article-title":"Mechanochemical signaling of the extracellular matrix in epithelial-mesenchymal transition","volume":"7","author":"Scott","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mcpro.2023.100534_bib128","doi-asserted-by":"crossref","first-page":"21900","DOI":"10.1073\/pnas.0912171106","article-title":"Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease","volume":"106","author":"Molero","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2023.100534_bib129","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41593-022-01033-5","article-title":"Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset","volume":"25","author":"McAllister","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib130","doi-asserted-by":"crossref","first-page":"837576","DOI":"10.3389\/fncel.2022.837576","article-title":"Polyglutamine expansion in huntingtin and mechanism of DNA damage repair defects in Huntington's disease","volume":"16","author":"Pradhan","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib131","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000599","article-title":"A\u00a0proteomic atlas of senescence-associated secretomes for aging biomarker development","volume":"18","author":"Basisty","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mcpro.2023.100534_bib132","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2014.12.019","article-title":"Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration","volume":"160","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2023.100534_bib133","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/glia.23978","article-title":"Astrocytes in stress accumulate lipid droplets","volume":"69","author":"Smolic","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.mcpro.2023.100534_bib134","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007627","article-title":"Physiological and pathological roles of FATP-mediated lipid droplets in drosophila and mice retina","volume":"14","author":"Van Den Brink","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mcpro.2023.100534_bib135","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fnins.2020.00742","article-title":"Lipid droplets in neurodegenerative disorders","volume":"14","author":"Farmer","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mcpro.2023.100534_bib136","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1080\/15384101.2015.1039365","article-title":"Selective autophagy and huntingtin: learning from disease","volume":"14","author":"Cuervo","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mcpro.2023.100534_bib137","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1074\/jbc.M113.523696","article-title":"A\u00a0large scale huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease","volume":"289","author":"Tourette","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2023.100534_bib138","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuron.2012.05.024","article-title":"Network organization of the huntingtin proteomic interactome in mammalian brain","volume":"75","author":"Shirasaki","year":"2012","journal-title":"Neuron"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947623000440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947623000440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:12:12Z","timestamp":1761527532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947623000440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":138,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1535947623000440"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2023.100534","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.05.11.491152","asserted-by":"object"}]},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic Analysis of Huntington\u2019s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2023.100534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100534"}}