{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:47:10Z","timestamp":1790214430873,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["803565"],"award-info":[{"award-number":["803565"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["390339347"],"award-info":[{"award-number":["390339347"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003495","name":"Ministry for Science and Art Hessen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003495","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.mcpro.2023.100537","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T21:24:08Z","timestamp":1680125048000},"page":"100537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7925-5529","authenticated-orcid":false,"given":"Melinda","family":"Metzler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7745-1190","authenticated-orcid":false,"given":"Rebecca George","family":"Tharyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Klann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-078X","authenticated-orcid":false,"given":"Katharina","family":"Grikscheit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa","family":"Bojkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindrich","family":"Cinatl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5907-3947","authenticated-orcid":false,"given":"Georg","family":"Tascher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-7565","authenticated-orcid":false,"given":"Sandra","family":"Ciesek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-090X","authenticated-orcid":false,"given":"Christian","family":"M\u00fcnch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2023.100537_bib1","doi-asserted-by":"crossref","first-page":"104158","DOI":"10.1016\/j.ebiom.2022.104158","article-title":"Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA.1 and BA.2 by convalescent and vaccine serum and monoclonal antibodies","volume":"82","author":"Wilhelm","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mcpro.2023.100537_bib2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1056\/NEJMc2119236","article-title":"SARS-CoV-2 Omicron variant neutralization in serum from vaccinated and convalescent persons","volume":"386","author":"R\u00f6ssler","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.mcpro.2023.100537_bib3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41586-021-04387-1","article-title":"Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization","volume":"602","author":"Cele","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100537_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/science.abn4947","article-title":"Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa","volume":"376","author":"Pulliam","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2023.100537_bib5","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1056\/NEJMc2200133","article-title":"Protection against the Omicron variant from previous SARS-CoV-2 infection","volume":"386","author":"Altarawneh","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.mcpro.2023.100537_bib6","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41591-021-01678-y","article-title":"An infectious SARS-CoV-2 B.1.1.529 omicron virus escapes neutralization by therapeutic monoclonal antibodies","volume":"28","author":"VanBlargan","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.mcpro.2023.100537_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41422-022-00619-9","article-title":"Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates","volume":"32","author":"Bojkova","year":"2022","journal-title":"Cell Res"},{"key":"10.1016\/j.mcpro.2023.100537_bib8","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41586-022-04462-1","article-title":"Attenuated fusogenicity and pathogenicity of SARS-CoV-2 omicron variant","volume":"603","author":"Suzuki","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100537_bib9","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-022-04442-5","article-title":"Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron","volume":"603","author":"Shuai","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100537_bib10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41586-022-04441-6","article-title":"SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters","volume":"603","author":"Halfmann","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100537_bib11","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/tmi.13752","article-title":"Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa","volume":"27","author":"Davies","year":"2022","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.mcpro.2023.100537_bib12","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1038\/s41591-022-01887-z","article-title":"Clinical Outcomes Associated with Omicron (B.1.1.529) Variant and BA.1\/BA.1.1 or BA.2 Subvariant Infection in Southern California","volume":"28","author":"Lewnard","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.mcpro.2023.100537_bib13","article-title":"Risk of severe clinical outcomes among persons with SARS-CoV-2 infection with differing levels of vaccination during widespread Omicron (B.1.1.529) and Delta (B.1.617.2) variant circulation in northern California: a retrospective cohort study","volume":"12","author":"Skarbinski","year":"2022","journal-title":"Lancet Reg. Health Am."},{"key":"10.1016\/j.mcpro.2023.100537_bib14","article-title":"Differences in incidence and fatality of COVID-19 by SARS-CoV-2 Omicron variant versus Delta variant in relation to vaccine coverage: a world-wide review","author":"Wang","year":"2022","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.mcpro.2023.100537_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28098","article-title":"Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkers","author":"Ali","year":"2022","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.mcpro.2023.100537_bib16","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.immuni.2011.05.003","article-title":"Immune signaling by RIG-I-like receptors","volume":"34","author":"Loo","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.mcpro.2023.100537_bib17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ni921","article-title":"IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway","volume":"4","author":"Fitzgerald","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mcpro.2023.100537_bib18","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s12276-021-00592-0","article-title":"Type I and III interferon responses in SARS-CoV-2 infection","volume":"53","author":"Kim","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mcpro.2023.100537_bib19","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal. Transduct. Target Ther."},{"key":"10.1016\/j.mcpro.2023.100537_bib20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.coviro.2011.11.001","article-title":"Induction and function of type I and III interferon in response to viral infection","volume":"1","author":"Levy","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.mcpro.2023.100537_bib21","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Met."},{"key":"10.1016\/j.mcpro.2023.100537_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124396","article-title":"Optimized qRT-PCR approach for the detection of intra- and extra-cellular SARS-CoV-2 RNAs","volume":"21","author":"Toptan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcpro.2023.100537_bib23","first-page":"227","article-title":"The methof of \u2018right and wrong cases\u2019 (\u2018constant stimuli\u2019) without gauss's formulae","volume":"2","author":"Spearman","year":"1908","journal-title":"Br. J. Psychol."},{"key":"10.1016\/j.mcpro.2023.100537_bib24","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF01863914","article-title":"Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche","volume":"162","author":"K\u00e4rber","year":"1931","journal-title":"Archiv F. Experiment. Pathol. U. Pharmakol"},{"key":"10.1016\/j.mcpro.2023.100537_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/v13091693","article-title":"Antibody-mediated neutralization of authentic SARS-CoV-2 B.1.617 variants harboring L452R and T478K\/E484Q","volume":"13","author":"Wilhelm","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.mcpro.2023.100537_bib26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00430-021-00716-3","article-title":"Evaluation of stability and inactivation methods of SARS-CoV-2 in context of laboratory settings","volume":"210","author":"Widera","year":"2021","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.mcpro.2023.100537_bib27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.molcel.2020.08.006","article-title":"Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication","volume":"80","author":"Klann","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mcpro.2023.100537_bib28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41586-020-2332-7","article-title":"Proteomics of SARS-CoV-2-infected host cells reveals therapy targets","volume":"583","author":"Bojkova","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100537_bib29","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1074\/mcp.M116.065524","article-title":"Extended multiplexing of tandem mass tags (TMT) labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue","volume":"16","author":"Plubell","year":"2017","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2023.100537_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcpro.2023.100537_bib31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.12688\/f1000research.22280.1","article-title":"Visualize omics data on networks with Omics Visualizer, A Cytoscape App","volume":"9","author":"Legeay","year":"2020","journal-title":"F1000res"},{"key":"10.1016\/j.mcpro.2023.100537_bib32","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3389\/fimmu.2020.01949","article-title":"Overview of immune response during SARS-CoV-2 infection: lessons from the past","volume":"11","author":"Shah","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mcpro.2023.100537_bib33","series-title":"Medical Virology: From Pathogenesis to Disease Control","article-title":"Coronavirus disease 2019 (COVID-19)","year":"2020"},{"key":"10.1016\/j.mcpro.2023.100537_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104232","article-title":"Replication of SARS-CoV-2 Omicron BA.2 variant in ex\u00a0vivo cultures of the human upper and lower respiratory tract","volume":"83","author":"Hui","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mcpro.2023.100537_bib35","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41586-022-04479-6","article-title":"SARS-CoV-2 Omicron variant replication in human bronchus and lung ex\u00a0vivo","volume":"603","author":"Hui","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100537_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade1860","article-title":"SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta","volume":"8","author":"van Doremalen","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mcpro.2023.100537_bib37","doi-asserted-by":"crossref","first-page":"316","DOI":"10.31083\/j.fbl2711316","article-title":"Comparison of the pathogenicity of SARS-CoV-2 Delta and Omicron variants by analyzing the expression patterns of immune response genes in K18-hACE2 transgenic mice","volume":"27","author":"Kuruppuarachchi","year":"2022","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.mcpro.2023.100537_bib38","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41586-022-04474-x","article-title":"Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity","volume":"603","author":"Meng","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2023.100537_bib39","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/s41591-022-01816-0","article-title":"Infectious viral load in unvaccinated and vaccinated individuals infected with ancestral, Delta or Omicron SARS-CoV-2","volume":"28","author":"Puhach","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcpro.2023.100537_bib40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41421-022-00418-x","article-title":"Proteomic characterization of Omicron SARS-CoV-2 host response","volume":"8","author":"Bao","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.mcpro.2023.100537_bib41","doi-asserted-by":"crossref","first-page":"e152","DOI":"10.1016\/j.jinf.2022.07.029","article-title":"Infection with the Omicron variant of SARS-CoV-2 is associated with less severe disease in hospitalized patients with COVID-19","volume":"85","author":"Aiello","year":"2022","journal-title":"J.\u00a0Infect."},{"key":"10.1016\/j.mcpro.2023.100537_bib42","article-title":"A\u00a0comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristics","volume":"12","author":"Li","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2023.100537_bib43","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1038\/s41467-020-17665-9","article-title":"Activation and evasion of type I interferon responses by SARS-CoV-2","volume":"11","author":"Lei","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2023.100537_bib44","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1080\/22221751.2020.1780953","article-title":"SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists","volume":"9","author":"Yuen","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.mcpro.2023.100537_bib45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/22221751.2020.1870414","article-title":"SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species","volume":"10","author":"Moustaqil","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.mcpro.2023.100537_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108234","article-title":"Evasion of type I interferon by SARS-CoV-2","volume":"33","author":"Xia","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2023.100537_bib47","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41421-022-00408-z","article-title":"SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment","volume":"8","author":"Bojkova","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.mcpro.2023.100537_bib48","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201371","article-title":"Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells","volume":"5","author":"Kohli","year":"2022","journal-title":"Life Sci. Alliance"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947623000476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947623000476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:11:45Z","timestamp":1761527505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947623000476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1535947623000476"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2023.100537","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2023.100537","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100537"}}