{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:56:50Z","timestamp":1792155410139,"version":"4.4.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.mcpro.2024.100746","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T03:07:16Z","timestamp":1709608036000},"page":"100746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-9232","authenticated-orcid":false,"given":"Sunayana","family":"Dagar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-2358","authenticated-orcid":false,"given":"George","family":"Tsaprailis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherina Scharager","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6066-9900","authenticated-orcid":false,"given":"Gogce","family":"Crynen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5611-6846","authenticated-orcid":false,"given":"Preksha Sandipkumar","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-4811","authenticated-orcid":false,"given":"Neelam","family":"Shahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa","family":"Subramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2024.100746_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ana.410130116","article-title":"Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain","volume":"13","author":"Sorbi","year":"1983","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mcpro.2024.100746_bib2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1212\/WNL.40.8.1231","article-title":"Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease","volume":"40","author":"Parker","year":"1990","journal-title":"Neurology"},{"key":"10.1016\/j.mcpro.2024.100746_bib3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ana.410390317","article-title":"Mitochondrial defect in Huntington's disease caudate nucleus","volume":"39","author":"Gu","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mcpro.2024.100746_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/ana.410430321","article-title":"Complex I defect in muscle from patients with Huntington's disease","volume":"43","author":"Arenas","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mcpro.2024.100746_bib5","article-title":"Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6\/2 mouse model","volume":"5","author":"Aidt","year":"2013","journal-title":"PLoS Curr."},{"key":"10.1016\/j.mcpro.2024.100746_bib6","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1093\/hmg\/ddt242","article-title":"A\u00a0role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin","volume":"22","author":"Damiano","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2024.100746_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10863-010-9288-5","article-title":"Mitochondrial functional alterations in relation to pathophysiology of Huntington's disease","volume":"42","author":"Pandey","year":"2010","journal-title":"J.\u00a0Bioenerg. Biomembr."},{"key":"10.1016\/j.mcpro.2024.100746_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cmet.2006.10.004","article-title":"Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration","volume":"4","author":"Weydt","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.mcpro.2024.100746_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(99)00578-9","article-title":"Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex","volume":"272","author":"Polidori","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mcpro.2024.100746_bib10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fnmol.2018.00329","article-title":"A\u00a0mitochondria-associated oxidative stress perspective on Huntington's disease","volume":"11","author":"Zheng","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mcpro.2024.100746_bib11","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/13518","article-title":"Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization","volume":"5","author":"Sawa","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcpro.2024.100746_bib12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcpro.2024.100746_bib13","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.bbrc.2004.08.035","article-title":"Deranged neuronal calcium signaling and Huntington disease","volume":"322","author":"Bezprozvanny","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mcpro.2024.100746_bib14","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/hmg\/ddr475","article-title":"Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease","volume":"21","author":"Shirendeb","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2024.100746_bib15","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1089\/ars.2012.4928","article-title":"S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease","volume":"19","author":"Haun","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mcpro.2024.100746_bib16","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1093\/hmg\/ddq306","article-title":"Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease","volume":"19","author":"Kim","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2024.100746_bib17","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1172\/JCI70911","article-title":"Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration","volume":"123","author":"Guo","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mcpro.2024.100746_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12646","article-title":"VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease","volume":"7","author":"Guo","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2024.100746_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.581","article-title":"PINK1-induced mitophagy promotes neuroprotection in Huntington's disease","volume":"6","author":"Khalil","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mcpro.2024.100746_bib20","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.15252\/emmm.201505256","article-title":"Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease","volume":"7","author":"Hwang","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mcpro.2024.100746_bib21","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s12035-019-01734-2","article-title":"Energy metabolism and mitochondrial superoxide anion production in pre-symptomatic striatal neurons derived from human-induced pluripotent stem cells expressing mutant huntingtin","volume":"57","author":"Hamilton","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mcpro.2024.100746_bib22","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/jnc.14852","article-title":"Mutant huntingtin fails to directly impair brain mitochondria","volume":"151","author":"Hamilton","year":"2019","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.mcpro.2024.100746_bib23","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1523\/JNEUROSCI.0106-08.2008","article-title":"N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking","volume":"28","author":"Orr","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.mcpro.2024.100746_bib24","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.4161\/cc.20423","article-title":"Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis","volume":"11","author":"Ratovitski","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mcpro.2024.100746_bib25","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1523\/JNEUROSCI.1867-08.2008","article-title":"Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease","volume":"28","author":"Wang","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.mcpro.2024.100746_bib26","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2024.100746_bib27","doi-asserted-by":"crossref","first-page":"16593","DOI":"10.1073\/pnas.1904101116","article-title":"Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23","volume":"116","author":"Yablonska","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2024.100746_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76088-0","article-title":"Prediction of mitochondrial genome-wide variation through sequencing of mitochondrion-enriched extracts","volume":"10","author":"Fisher","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2024.100746_bib29","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0959-437X(05)80116-9","article-title":"Genetic novelties in mitochondrial genomes of multicellular animals","volume":"2","author":"Wolstenholme","year":"1992","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mcpro.2024.100746_bib30","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbadis.2009.04.003","article-title":"OXPHOS gene expression and control in mitochondrial disorders","volume":"1792","author":"Reinecke","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcpro.2024.100746_bib31","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","article-title":"Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells","volume":"9","author":"Trettel","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2024.100746_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005633","article-title":"Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease","volume":"7","author":"Pryor","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.mcpro.2024.100746_bib33","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"Guo","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2024.100746_bib34","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/nar\/gku1310","article-title":"Modified ribosome profiling reveals high abundance of ribosome protected mRNA fragments derived from 3' untranslated regions","volume":"43","author":"Miettinen","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2024.100746_bib35","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/s41467-021-21637-y","article-title":"Mutant Huntingtin Stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease","volume":"12","author":"Eshraghi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2024.100746_bib36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"10.1016\/j.mcpro.2024.100746_bib37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.mcpro.2024.100746_bib38","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2024.100746_bib39","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcpro.2024.100746_bib40","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nmeth.1714","article-title":"MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics","volume":"8","author":"Ting","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2024.100746_bib41","doi-asserted-by":"crossref","first-page":"i42","DOI":"10.1093\/bioinformatics\/btn294","article-title":"Non-parametric estimation of posterior error probabilities associated with peptides identified by tandem mass spectrometry","volume":"24","author":"K\u00e4ll","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2024.100746_bib42","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A\u00a0statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.mcpro.2024.100746_bib43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1021\/pr700734f","article-title":"Statistical analysis of relative labeled mass spectrometry data from complex samples using ANOVA","volume":"7","author":"Oberg","year":"2008","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.mcpro.2024.100746_bib44","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2024.100746_bib45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature12985","article-title":"Mitochondrial form and function","volume":"505","author":"Friedman","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2024.100746_bib46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genom-082509-141720","article-title":"The mitochondrial proteome and human disease","volume":"11","author":"Calvo","year":"2010","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.mcpro.2024.100746_bib47","doi-asserted-by":"crossref","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2024.100746_bib48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10555-020-09890-x","article-title":"Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer","volume":"39","author":"Simon","year":"2020","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.mcpro.2024.100746_bib49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/hmg\/ddt406","article-title":"Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in\u00a0vivo","volume":"23","author":"Trushina","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2024.100746_bib50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10048-018-0561-9","article-title":"Mitochondrial ribosomal protein PTCD3 mutations cause oxidative phosphorylation defects with Leigh syndrome","volume":"20","author":"Borna","year":"2019","journal-title":"Neurogenetics"},{"key":"10.1016\/j.mcpro.2024.100746_bib51","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.2174\/1566524014666141202144601","article-title":"CD147 interacts with NDUFS6 in regulating mitochondrial complex I activity and the mitochondrial apoptotic pathway in human malignant melanoma cells","volume":"14","author":"Luo","year":"2014","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.mcpro.2024.100746_bib52","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1168978","article-title":"Genome-wide analysis in\u00a0vivo of translation with nucleotide resolution using ribosome profiling","volume":"324","author":"Ingolia","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2024.100746_bib53","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/gb-2003-4-9-117","article-title":"Comparing protein abundance and mRNA expression levels on a genomic scale","volume":"4","author":"Greenbaum","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcpro.2024.100746_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47424-w","article-title":"Extensive post-transcriptional buffering of gene expression in the response to severe oxidative stress in baker's yeast","volume":"9","author":"Blevins","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2024.100746_bib55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1042\/bss0660111","article-title":"Mutations of the mitochondrial genome: clinical overview and possible pathophysiology of cell damage","volume":"66","author":"Rothman","year":"1999","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.mcpro.2024.100746_bib56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-2999(02)01842-3","article-title":"Mitochondria, Ca2+ and neurodegenerative disease","volume":"447","author":"Krieger","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mcpro.2024.100746_bib57","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mehy.2003.12.045","article-title":"A\u00a0\u201cmitochondrial cascade hypothesis\u201d for sporadic Alzheimer's disease","volume":"63","author":"Swerdlow","year":"2004","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.mcpro.2024.100746_bib58","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1073\/pnas.0709336105","article-title":"The PINK1\/Parkin pathway regulates mitochondrial morphology","volume":"105","author":"Poole","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2024.100746_bib59","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1089\/ars.2009.2604","article-title":"Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis","volume":"11","author":"Magrane","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mcpro.2024.100746_bib60","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/cdd.2012.95","article-title":"Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency","volume":"20","author":"Ramonet","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mcpro.2024.100746_bib61","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/BJ20130079","article-title":"Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia","volume":"453","author":"Lane","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.mcpro.2024.100746_bib62","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.nbd.2015.11.002","article-title":"Mitochondrial dynamics and mitophagy in Parkinson's disease: a fly point of view","volume":"90","author":"Von Stockum","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcpro.2024.100746_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2019.183064","article-title":"Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin","volume":"1862","author":"Camilleri","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.mcpro.2024.100746_bib64","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuron.2020.01.004","article-title":"Genome-wide in\u00a0vivo CNS screening identifies genes that modify CNS neuronal survival and mHTT toxicity","volume":"106","author":"Wertz","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.mcpro.2024.100746_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113995","article-title":"Targeting putative components of the mitochondrial permeability transition pore for novel therapeutics","volume":"177","author":"Winquist","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mcpro.2024.100746_bib66","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.410410514","article-title":"Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia","volume":"41","author":"Browne","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mcpro.2024.100746_bib67","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0140-6736(90)92242-A","article-title":"Mitochondrial function and parental sex effect in Huntington's disease","volume":"336","author":"Mann","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.mcpro.2024.100746_bib68","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1111\/j.1471-4159.1985.tb07192.x","article-title":"Regional mitochondrial respiratory activity in Huntington's disease brain","volume":"44","author":"Brennan","year":"1985","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.mcpro.2024.100746_bib69","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","article-title":"Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage","volume":"20","author":"Shirendeb","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2024.100746_bib70","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.freeradbiomed.2018.04.002","article-title":"Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically","volume":"120","author":"Agrawal","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mcpro.2024.100746_bib71","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1196\/annals.1427.018","article-title":"Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models","volume":"1147","author":"Browne","year":"2008","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.mcpro.2024.100746_bib72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/1673-5374.264459","article-title":"Excitatory synapse impairment and mitochondrial dysfunction in Huntington's disease: heat shock factor 1 (HSF1) converging mechanisms","volume":"15","author":"Zarate","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.mcpro.2024.100746_bib73","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1080\/15548627.2020.1728096","article-title":"Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease","volume":"17","author":"Franco-Iborra","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.mcpro.2024.100746_bib74","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.mito.2019.03.004","article-title":"Novel proteomic changes in brain mitochondria provide insights into mitochondrial dysfunction in mouse models of Huntington's disease","volume":"47","author":"Agrawal","year":"2019","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mcpro.2024.100746_bib75","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.bbagrm.2012.03.003","article-title":"Regulation of mammalian mitochondrial translation by post-translational modifications","volume":"1819","author":"Koc","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcpro.2024.100746_bib76","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1101\/gad.1658508","article-title":"Mitochondrial dynamics and apoptosis","volume":"22","author":"Suen","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.mcpro.2024.100746_bib77","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1658","article-title":"Ribosome dynamics and mRNA turnover, a complex relationship under constant cellular scrutiny","volume":"12","author":"Morris","year":"2021","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.mcpro.2024.100746_bib78","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1093\/hmg\/ddaa185","article-title":"Mutant huntingtin does not cross the mitochondrial outer membrane","volume":"29","author":"Hamilton","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2024.100746_bib79","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1523\/JNEUROSCI.23-06-02193.2003","article-title":"Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease","volume":"23","author":"Yu","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.mcpro.2024.100746_bib80","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature18015","article-title":"Synchronized mitochondrial and cytosolic translation programs","volume":"533","author":"Couvillion","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2024.100746_bib81","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1093\/nar\/gkw490","article-title":"Ribosome recycling defects modify the balance between the synthesis and assembly of specific subunits of the oxidative phosphorylation complexes in yeast mitochondria","volume":"44","author":"Ostojic","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2024.100746_bib82","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2016.09.003","article-title":"Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein","volume":"167","author":"Richter-Dennerlein","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2024.100746_bib83","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/s41467-021-21637-y","article-title":"Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease","volume":"12","author":"Eshraghi","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947624000367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947624000367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T10:26:45Z","timestamp":1714300005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947624000367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":83,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1535947624000367"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2024.100746","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2024.100746","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100746"}}